CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Investigation of hospital-onset meticillin-resistant Staphylococcus aureus bloodstream infections at eight high-burden acute care facilities in the USA, 2016
-
4 10 2020
-
-
Source: J Hosp Infect.
Details:
-
Alternative Title:J Hosp Infect
-
Personal Author:
-
Description:Background:
Despite large reductions from 2005 to 2012, hospital-onset meticillin-resistant Staphylococcus aureus bloodstream infections (HO MRSA BSIs) continue to be a major source of morbidity and mortality.
Aim:
To describe risk factors for and underlying sources of HO MRSA BSIs.
Methods:
This study investigated HO MRSA BSIs at eight high-burden short-stay acute care hospitals. A case was defined as first isolation of MRSA from a blood specimen collected in 2016 on or after hospital day 4 from a patient without an MRSA-positive blood culture in the preceding 2 weeks. Case demographics and risk factors were reviewed by medical record abstraction. The potential clinical source(s) of infection were determined by consensus by a clinician panel.
Findings:
Of the 195 eligible cases, 186 were investigated. Cases were predominantly male (63%) and the median age was 57 years (range 0–92 years). In the 2 weeks preceding BSI, 88% of cases had indwelling devices, 31% underwent a surgical procedure and 18% underwent dialysis. The most common locations of attribution were intensive care units (ICUs) (46%) and step-down units (19%). The most commonly identified non-mutually exclusive clinical sources were central venous catheters (46%), non-surgical wounds (17%), surgical site infections (16%), non-ventilator healthcare-associated pneumonia (13%) and ventilator-associated pneumonia (11%).
Conclusions:
Device- and procedure-related infections were common sources of HO MRSA BSIs. Prevention strategies focused on improving adherence to existing prevention bundles for device-and procedure-associated infections and on source control for ICU patients, patients with certain indwelling devices, and patients undergoing certain high-risk surgeries are being pursued to decrease the burden of HO MRSA BSIs at these facilities.
-
Keywords:
-
Source:
-
Pubmed ID:32283173
-
Pubmed Central ID:PMC7857529
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: