Initiatives to Scale Up and Expand Reach of Cancer Genomic Services Outside of Specialty Clinical Settings: A Systematic Review
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Initiatives to Scale Up and Expand Reach of Cancer Genomic Services Outside of Specialty Clinical Settings: A Systematic Review

Filetype[PDF-700.19 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Am J Prev Med
    • Personal Author:
    • Description:
      Context:

      This systematic review aims to: (1) characterize strategies used to identify individuals at increased risk for hereditary breast and ovarian cancer syndrome and Lynch syndrome outside of oncology and clinical genetic settings, (2) describe the extent to which these strategies have extended the reach of genetic services to underserved target populations; and (3) summarize indicators of the potential scalability of these strategies.

      Evidence acquisition:

      Investigators searched PubMed, Embase, and PsycINFO for manuscripts published from October 2005 to August 2019. Eligible manuscripts were: published in English, described strategies to identify those at risk for hereditary breast and ovarian cancer syndrome or Lynch syndrome, implemented outside of an oncology or genetic specialty clinic, and included measures of cancer genetic services uptake. This study assessed strategies used to increase the reach of genetic risk screening and counseling services. Each study was evaluated using the 16-item quality assessment tool and results were reported according to PRISMA guidelines.

      Evidence synthesis:

      Of the 16 eligible studies, 11 were conducted in clinical settings and 5 in public health settings. Regardless of setting, most (63%, 10/16) used brief screening tools to identify people with a family history suggestive of hereditary breast and ovarian cancer syndrome or Lynch syndrome. When reported, genetic risk screening reach (range=11%–100%) and genetic counseling reach (range=11%–100%) varied widely across studies. Strategies implemented in public health settings appeared to be more successful (median counseling reach=65%) compared with those implemented in clinical settings (median counseling reach=26%). Most studies did not describe fundamental components relevant for broad scalability.

      Conclusions:

      Efforts to expand cancer genomic services are limited outside of traditional oncology and genetic clinics. This is a missed opportunity, as evidence thus far suggests these efforts can be successful in expanding reach of genetic services with the potential to reduce health inequities in access. This review highlights the need for accelerating research that applies evidence-based implementation strategies and frameworks along with process evaluation to understand barriers and facilitators to scalability of strategies with high reach.

    • Subjects:
    • Source:
      Am J Prev Med. 60(2):e85-e94
    • Pubmed ID:
      33168338
    • Pubmed Central ID:
      PMC7855907
    • Document Type:
      Journal Article
    • Funding:
    • Collection(s):
    • Main Document Checksum:
    • Download URL:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov