Cryptic transmission of SARS-CoV-2 in Washington state

Details

• Alternative Title:
  Science
• Personal Author:
  Bedford, Trevor ; Greninger, Alexander L. ; Roychoudhury, Pavitra ; Starita, Lea M. ; Famulare, Michael ; Huang, Meei-Li ; Nalla, Arun ; Pepper, Gregory ; Reinhardt, Adam ; Xie, Hong ; Shrestha, Lasata ; Nguyen, Truong N. ; Adler, Amanda ; Brandstetter, Elisabeth ; Cho, Shari ; Giroux, Danielle ; Han, Peter D. ; Fay, Kairsten ; Frazar, Chris D. ; Ilcisin, Misja ; Lacombe, Kirsten ; Lee, Jover ; Kiavand, Anahita ; Richardson, Matthew ; Sibley, Thomas R. ; Truong, Melissa ; Wolf, Caitlin R. ; Nickerson, Deborah A. ; Rieder, Mark J. ; Englund, Janet A. ; Hadfield, James ; Hodcroft, Emma B. ; Huddleston, John ; Moncla, Louise H. ; Müller, Nicola F. ; Neher, Richard A. ; Deng, Xianding ; Gu, Wei ; Federman, Scot ; Chiu, Charles ; Duchin, Jeffrey S. ; Gautom, Romesh ; Melly, Geoff ; Hiatt, Brian ; Dykema, Philip ; Lindquist, Scott ; Queen, Krista ; Tao, Ying ; Uehara, Anna ; Tong, Suxiang ; MacCannell, Duncan ; Armstrong, Gregory L. ; Baird, Geoffrey S. ; Chu, Helen Y. ; Shendure, Jay ; Jerome, Keith R.
• Corporate Authors:
  The Seattle Flu Study Investigators‡
• Description:
  After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.
• Subjects:
  Bayes Theorem Betacoronavirus Coronavirus Infections COVID-19 Epidemiology Genome, Viral Humans Likelihood Functions Pandemics Phylogeny Pneumonia, Viral Report Reports SARS-CoV-2 Washington

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• Source:
  Science. 2020; 370(6516):571-575
• Pubmed ID:
  32913002
• Pubmed Central ID:
  PMC7810035
• Document Type:
  Journal Article
• Funding:
  R21 AI129455/AI/NIAID NIH HHS/United States ; RM1 HG010461/HG/NHGRI NIH HHS/United States ; R35 GM119774/GM/NIGMS NIH HHS/United States ; K08 CA230156/CA/NCI NIH HHS/United States ; WT_/Wellcome Trust/United Kingdom
• Volume:
  370
• Issue:
  6516
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3409445b8c0168e370c1095dc6b44fbc2820d080c92df86129150e4c5d2071ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/100841/cdc_100841_DS1.pdf
• File Type:
  [PDF - 676.93 KB ]