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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

CITE Title : Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex Personal Author(s) : Konermann, Silvana;Brigham, Mark D.;Trevino, Alexandro E.;Joung, Julia;Abudayyeh, Omar O.;Barcena, Clea;Hsu, Patrick D.;Habib, Naomi;Gootenberg, Jonathan S.;Nishimasu, Hiroshi;Nureki, Osamu;Zhang, Feng; Published Date : Dec 10 2014 Source : Nature. 517(7536):583-588. URL : https://stacks.cdc.gov/view/cdc/30833 Konermann, Silvana et al. (2014). Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. 517(7536). Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" 517, no. 7536 (2014) Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" vol. 517, no. 7536, 2014 Export RIS Citation Information.

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Konermann, Silvana ;

Brigham, Mark D.

Dec 10 2014 | Nature. 517(7536):583-588.

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Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe struc...
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

CITE Title : In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy Personal Author(s) : Nelson, Christopher E.;Hakim, Chady H.;Ousterout, David G.;Thakore, Pratiksha I.;Moreb, Eirik A.;Rivera, Ruth M. Castellanos;Madhavan, Sarina;Pan, Xiufang;Ran, F. Ann;Yan, Winston X.;Asokan, Aravind;Zhang, Feng;Duan, Dongsheng;Gersbach, Charles A.; Published Date : Dec 31 2015 Source : Science. 351(6271):403-407. URL : https://stacks.cdc.gov/view/cdc/39629 Nelson, Christopher E. et al. (2015). In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. 351(6271). Nelson, Christopher E. et al. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy" 351, no. 6271 (2015) Nelson, Christopher E. et al. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy" vol. 351, no. 6271, 2015 Export RIS Citation Information.

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Nelson, Christopher E. ;

Hakim, Chady H.

Dec 31 2015 | Science. 351(6271):403-407.

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Duchenne muscular dystrophy (DMD) is a devastating disease affecting about 1 out of 5000 male births and caused by mutations in the dystrophin gene. G...
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

CITE Title : Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells Personal Author(s) : Lee, Mark N.;Ye, Chun;Villani, Alexandra-Chloé;Raj, Towfique;Li, Weibo;Eisenhaure, Thomas M.;Imboywa, Selina H.;Chipendo, Portia I.;Ran, F. Ann;Slowikowski, Kamil;Ward, Lucas D.;Raddassi, Khadir;McCabe, Cristin;Lee, Michelle H.;Frohlich, Irene Y.;Hafler, David A.;Kellis, Manolis;Raychaudhuri, Soumya;Zhang, Feng;Stranger, Barbara E.;Benoist, Christophe O.;De Jager, Philip L.;Regev, Aviv;Hacohen, Nir; Published Date : Mar 7 2014 Source : Science. 343(6175):1246980. URL : https://stacks.cdc.gov/view/cdc/30067 Lee, Mark N. et al. (2014). Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells. 343(6175). Lee, Mark N. et al. "Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells" 343, no. 6175 (2014) Lee, Mark N. et al. "Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells" vol. 343, no. 6175, 2014 Export RIS Citation Information.

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Lee, Mark N. ;

Ye, Chun

Mar 7 2014 | Science. 343(6175):1246980.

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Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and ...
DNA targeting specificity of RNA-guided Cas9 nucleases

CITE Title : DNA targeting specificity of RNA-guided Cas9 nucleases Personal Author(s) : Hsu, Patrick D.;Scott, David A.;Weinstein, Joshua A;Ran, F. Ann;Konermann, Silvana;Agarwala, Vineeta;Li, Yinqing;Fine, Eli J.;Wu, Xuebing;Shalem, Ophir;Cradick, Thomas J.;Marraffini, Luciano A.;Bao, Gang;Zhang, Feng; Published Date : Jul 21 2013 Source : Nat Biotechnol. 2013; 31(9):827-832. URL : https://stacks.cdc.gov/view/cdc/29899 Hsu, Patrick D. et al. (2013). DNA targeting specificity of RNA-guided Cas9 nucleases. 31(9). Hsu, Patrick D. et al. "DNA targeting specificity of RNA-guided Cas9 nucleases" 31, no. 9 (2013) Hsu, Patrick D. et al. "DNA targeting specificity of RNA-guided Cas9 nucleases" vol. 31, no. 9, 2013 Export RIS Citation Information.

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Hsu, Patrick D. ;

Scott, David A.

Jul 21 2013 | Nat Biotechnol. 2013; 31(9):827-832.

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The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs (sgRNAs) to enable genome ...
Optical Control of Mammalian Endogenous Transcription and Epigenetic States

CITE Title : Optical Control of Mammalian Endogenous Transcription and Epigenetic States Personal Author(s) : Konermann, Silvana;Brigham, Mark D.;Trevino, Alexandro;Hsu, Patrick D.;Heidenreich, Matthias;Cong, Le;Platt, Randall J.;Scott, David A.;Church, George M.;Zhang, Feng; Published Date : Aug 23 2013 Source : Nature. 500(7463):472-476. URL : https://stacks.cdc.gov/view/cdc/22509 Konermann, Silvana et al. (2013). Optical Control of Mammalian Endogenous Transcription and Epigenetic States. 500(7463). Konermann, Silvana et al. "Optical Control of Mammalian Endogenous Transcription and Epigenetic States" 500, no. 7463 (2013) Konermann, Silvana et al. "Optical Control of Mammalian Endogenous Transcription and Epigenetic States" vol. 500, no. 7463, 2013 Export RIS Citation Information.

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Konermann, Silvana ;

Brigham, Mark D.

Aug 23 2013 | Nature. 500(7463):472-476.

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The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal g...
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

CITE Title : Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects Personal Author(s) : Zhou, Yang;Kaiser, Tobias;Monteiro, Patrícia;Zhang, Xiangyu;Van der Goes, Marie. S.;Wang, Dongqing;Barak, Boaz;Zeng, Menglong;Li, Chenchen;Lu, Congyi;Wells, Michael;Amaya, Aldo;Nguyen, Shannon;Lewis, Michael;Sanjana, Neville;Zhou, Yongdi;Zhang, Mingjie;Zhang, Feng;Fu, Zhanyan;Feng, Guoping; Published Date : Dec 10 2015 Source : Neuron. 89(1):147-162. URL : https://stacks.cdc.gov/view/cdc/39218 Zhou, Yang et al. (2015). Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects. 89(1). Zhou, Yang et al. "Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects" 89, no. 1 (2015) Zhou, Yang et al. "Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects" vol. 89, no. 1, 2015 Export RIS Citation Information.

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Zhou, Yang ;

Kaiser, Tobias

Dec 10 2015 | Neuron. 89(1):147-162.

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Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the ...