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Showing 1141 - 1160 of 82805 results
  • 44Methylene Diphenyl Diisocyanate Exposure Downregulates Endogenous HsamiR2063p Through Induction of hsa_circ_0008726 in Macrophages
    4,4′-Methylene Diphenyl Diisocyanate Exposure Downregulates Endogenous Hsa-miR-206-3p Through Induction of hsa_circ_0008726 in Macrophages
    Hettick JM ;
    Law, Brandon F.
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Exposure to 4,4'-methylene diphenyl diisocyanate (MDI), the most widely used monomeric diisocyanate, in the occupational setting may lead to the development of occupational asthma (OA). Currently, the underlying molecular mechanism(s) by which MDI induces OA have yet to be elucidated. Alveolar macrophage (MØ) dysfunction pla ...
    Public Domain
  • Development of a Controlled Sawing Apparatus for Characterizing Aerosols Generated from Cutting Concrete Composed of Different Formulations
    Development of a Controlled Sawing Apparatus for Characterizing Aerosols Generated from Cutting Concrete Composed of Different Formulations
    Afshari A ;
    Antonini JM
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Concrete, a widely used and cost-effective construction material, often undergoes maintenance and alterations, including cutting, drilling, or grinding. These operations release airborne particles that have been observed to cause respiratory illnesses in construction workers. Additionally, concrete is a material constantly s ...
    Public Domain
  • Analysis of Serum Metabolome of Rats Following Intratracheal Instillation of MultiWalled Carbon Nanotubes
    Analysis of Serum Metabolome of Rats Following Intratracheal Instillation of Multi-Walled Carbon Nanotubes
    Antonini JM ;
    Boyce G
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: While there has been increasing application of nanotechnology in variety of industrial applications, there have been relatively few health effects studies in workers. One of the primary routes of worker exposure to nanomaterials is inhalation. The aim of this study is to identify metabolic phenotypes which can be used to est ...
    Public Domain
  • Local and Systemic Immune Responses Following Aspiration of Nickel Oxide Nanoparticles in a Humanized TollLike Receptor4 Mouse Model
    Local and Systemic Immune Responses Following Aspiration of Nickel Oxide Nanoparticles in a Humanized Toll-Like Receptor-4 Mouse Model
    Aldinger JL ;
    Roach KA
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: It has been estimated that 20% of the global population exhibits contact sensitivity to nickel. Despite such prevalence in humans, recreating nickel allergy in laboratory rodents has proven challenging historically, ultimately limiting our understanding of many underlying immunological mechanisms responsible for the disorder ...
    Public Domain
  • Inhalation Exposure to Wood Sealant with NanoZinc Oxide Elicits Minimal Pulmonary Inflammation in Rats
    Inhalation Exposure to Wood Sealant with Nano-Zinc Oxide Elicits Minimal Pulmonary Inflammation in Rats
    Burrelli L ;
    Cooper M
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Increased use of engineered nanomaterials in construction and manufacturing adds new attributes to products and improves quality. New wood coating sealant products, used in spraying operations, that contain zinc oxide nanoparticles (nano-ZnO) help protect natural wood from UV-light-degradation and weathering. Therefore, a po ...
    Public Domain
  • 1DGuided Differential Rescaling of a Contour Plot in Comprehensive 2D Gas Chromatography
    1D-Guided Differential Rescaling of a Contour Plot in Comprehensive 2D Gas Chromatography
    Fan X ;
    Huang X
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    A 1D-guided differential rescaling algorithm for a contour plot is developed based on our recently proposed comprehensive two-dimensional gas chromatography (GC × GC) system with a first-dimensional (1D) detector added. Chromatograms obtained from 1D and second-dimensional (2D) detectors are both incorporated during the data processing. As compared ...
  • Per and Polyfluoroalkyl Substances and Epigenetic Aging in US Airport Firefighters
    Per- and Polyfluoroalkyl Substances and Epigenetic Aging in U.S. Airport Firefighters
    Beitel S ;
    Burgess JL
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals with water- and oil-resistant properties that have been in use since the mid-twentieth century. PFAS exposure has been associated with adverse health outcomes, including increased risk for cancers, reproductive consequences, obesity, and reductions in immune ...
    Public Domain
  • In Vitro Toxicity Screening of Different Categories of TwoDimensional 2D Nanomaterials for Genotoxicity and Activation of the NLRP3 Inflammasome
    In Vitro Toxicity Screening of Different Categories of Two-Dimensional (2D) Nanomaterials for Genotoxicity and Activation of the NLRP3 Inflammasome
    Aldinger, Jeffrey A. ;
    Fraser K
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Two-dimensional (2D) nanomaterials are a large class of engineered nanoparticles with a multitude of applications in electronics, biosensors, and more. Increased demand for these materials, including graphene, montmorillonite nanoclay, transition metal dichalcogenides (TMDs), such as WS2 and MoS2, and hexagonal boron nitride ...
    Public Domain
  • Pulmonary Response to Crystalline Silica and Coal Dust Exposure in Rats
    Pulmonary Response to Crystalline Silica and Coal Dust Exposure in Rats
    Beck, Timothy W. ;
    Joseph P
    2024/03/05 | Mining Publications
    Background and Purpose: Passage of the Federal Coal Mine Health and Safety Act (Coal Act) in 1969 together with the establishment of the Coal Workers Health Surveillance Program (CWHSP), managed by the National Institute for Occupational Safety and Health (NIOSH) in association with the Mine Safety and Health Administration (MSHA), has greatly redu ...
    Public Domain
  • In Vitro Toxicity Assessment of Spinel Ferrite Nanoparticles and UVB CoExposure in Human Epidermal Keratinocytes
    In Vitro Toxicity Assessment of Spinel Ferrite Nanoparticles and UVB Co-Exposure in Human Epidermal Keratinocytes
    Friend S ;
    Guppi S
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Spinel ferrite nanoparticles (SFNPs) have attracted significant attention due to their unique characteristics that make them promising candidates for diverse applications in biomedicine, water treatment, catalysts, energy fields and industrial electronic devices. However, before these materials can be considered for potentia ...
    Public Domain
  • Modeling Chemical Sensitivity Prior Exposure to Stress and Pesticide Affects Neuroinflammatory Response to Subsequent Exposures in Mice
    Modeling Chemical Sensitivity: Prior Exposure to Stress and Pesticide Affects Neuroinflammatory Response to Subsequent Exposures in Mice
    Kelly KA ;
    Michalovicz LT
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Chemical sensitivity is a multi-symptom illness that results from sensitization to chemicals or mixtures following an initiating exposure and presents with symptoms including neurologic and cognitive dysfunction, depression, and anxiety, as well as respiratory and gastrointestinal issues. While many chemicals have been assoc ...
    Public Domain
  • Chronic High Physiological Stressor Mimic Corticosterone Primes the Neuroinflammatory Response in Cortex to Dermal Sulfur Mustard Exposure A Potential Contribution to Initiation of Gulf War Illness
    Chronic High Physiological Stressor Mimic, Corticosterone, Primes the Neuroinflammatory Response in Cortex to Dermal Sulfur Mustard Exposure: A Potential Contribution to Initiation of Gulf War Illness
    Billig B ;
    Felton C
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Nearly a third of veterans from the 1991 Gulf War returned with a multi-symptom disorder characterized by debilitating fatigue, cognitive dysfunction, chronic widespread pain, gastrointestinal distress, respiratory problems, skin abnormalities, and other symptoms. Taken together with deployment at that time, this disorder is ...
    Public Domain
  • Systematic Review of the Mechanistic Evidence for TiO2 NP Lung Carcinogenicity
    Systematic Review of the Mechanistic Evidence for TiO2 NP Lung Carcinogenicity
    Bing HL ;
    Camassa LM
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Titanium dioxide nanoparticles (TiO2 NP) are a high production volume material widely used in the paints, cosmetic, food and photovoltaics industry. Their increasing industrial demand and use raises concerns of adverse human exposure and related health effects. Epidemiological and animal studies suggest that TiO2 elicits can ...
    Public Domain
  • Synergistic Effect of World Trade Center WTC Dust Exposure and Chronic Intermittent Hypoxia on Oxidative Stress Inflammation and Proliferation
    Synergistic Effect of World Trade Center (WTC) Dust Exposure and Chronic Intermittent Hypoxia on Oxidative Stress, Inflammation, and Proliferation
    Gow AJ ;
    Hua J
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: The collapse of the World Trade Center (WTC) led to a large dust cloud of particles consisting of highly alkaline crushed concrete, gypsum, and synthetic fibers that were inhaled and deposited in the conducting airways. In earlier studies, we reported a 75% prevalence of obstructive sleep apnea (OSA) leading to chronic inter ...
  • Evaluation of Aerosolized 3D Printer Emissions in a Murine Asthma Model
    Evaluation of Aerosolized 3D Printer Emissions in a Murine Asthma Model
    Anderson, Stacey E. ;
    Cooper MP
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Occupational asthma is a serious public health burden caused by exposure to various agents in the workplace. Fused filament fabrication 3D printing is a new and emerging industry that uses a variety of filament materials capable of producing ultrafine particulates and volatile organic compounds. Preliminary studies suggest a ...
    Public Domain
  • Systemic and Immunotoxicity Induced by Topical Application of Perfluoroheptane Sulfonic Acid PFHpS in a Murine Model
    Systemic and Immunotoxicity Induced by Topical Application of Perfluoroheptane Sulfonic Acid (PFHpS) in a Murine Model
    Anderson, Stacey E. ;
    Cooper MP
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Per- and polyfluoroalkyl substances (PFAS) comprise a broad class of synthetic surfactants used in many industrial and consumer products, from firefighting foams and stain-resistant textiles to food packaging, non-stick cookware, cosmetics, and personal care products. The hydrophobic and hydrophilic moieties of PFAS give the ...
    Public Domain
  • Aerosolized NanoZinc Oxide nZnO Exposure Alters the Cellular Composition of the Fully Differentiated Human Airway Epithelium
    Aerosolized Nano-Zinc Oxide (nZnO) Exposure Alters the Cellular Composition of the Fully Differentiated Human Airway Epithelium
    Bodas M ;
    Derk R
    2024/03/05 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Engineered nanomaterials such as metal-oxide nanoparticles (NP) are widely used in numerous industrial and daily use applications, which makes their exposure a common occupational hazard. Nano-zinc oxide particles (nZnO) are used in many industries such as food packaging, rubber, textiles, and leather. Exposure leads to pulm ...
    Public Domain
  • Agricultura Alerta de Peligro Prevencin de Muertes de Trabajadores Agrcolas en Colisiones de Cuatrimotos
    Agricultura Alerta de Peligro: Prevención de Muertes de Trabajadores Agrícolas en Colisiones de Cuatrimotos
    Washington (State). Department of Labor and Industries
    2024/03/04 | Fatality Assessment and Control Evaluation Reports (FACE)
    Dos trabajadores de huertas murieron en colisiones distintas que involucraron cuatrimotos. Otros seis trabajadores han muerto en colisiones de cuatrimotos en Washington desde 2013. Otros 106 sufrieron lesiones graves en el mismo período. En todo el país, más de 300 trabajadores murieron y más de 2000 resultaron heridos al conducir cuatrimotos entre ...
  • Agriculture Hazard Alert Preventing Farm Worker ATV Crash Deaths
    Agriculture Hazard Alert: Preventing Farm Worker ATV Crash Deaths
    Washington (State). Department of Labor and Industries
    2024/03/04 | Fatality Assessment and Control Evaluation Reports (FACE)
    Two orchard workers were killed in separate crashes involving all-terrain vehicles (ATVs). Six more workers have died in ATV crashes in Washington since 2013. Another 106 were seriously injured over the same period. Across the nation, over 300 workers died and over 2000 were injured operating ATVs from 2003 to 2013. Around 60 percent of deaths were ...
  • Estimating Compressive and Shear Forces at L5S1 Exploring the Effects of Load Weight Asymmetry and Height Using Optical and Inertial Motion Capture Systems
    Estimating Compressive and Shear Forces at L5-S1: Exploring the Effects of Load Weight, Asymmetry, and Height Using Optical and Inertial Motion Capture Systems
    Chen H ;
    Gallagher S
    2024/03/02 | National Institute for Occupational Safety and Health (NIOSH)
    This study assesses the agreement of compressive and shear force estimates at the L5-S1 joint using inertial motion capture (IMC) within a musculoskeletal simulation model during manual lifting tasks, compared against a top-down optical motion capture (OMC)-based model. Thirty-six participants completed lifting and lowering tasks while wearing a mo ...
1141 - 1160 / 82805