Immediately Dangerous to Life or Health (IDLH) Value Profile: Bromine Trifluoride (CAS No. 7787-71-5)

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Niemeier, R. Todd
• Description:
  IDLH Value: 12 ppm (67 mg/m3). Basis for IDLH Value: Data on bromine trifluoride (BrF3) were inadequate to directly derive an IDLH value for BrF3. Data from studies with chlorine trifluoride (ClF3) were used to develop an IDLH value for BrF3 because their chemical structures, reaction mechanisms, and potencies are similar. Therefore, deriving an IDLH value based on the toxicity data for ClF3 is appropriately health-protective. The IDLH value for ClF3 is based on eye irritation in rats at a concentration of 480 ppm exposed for 5 minutes, which was determined to be escape impairing [Horn and Weir 1955]. The duration-adjusted 30-minute concentration is 121 ppm. An uncertainty factor (UF) of 10 was applied to account for interspecies variability (factor of 3) and human variability (factor of 3), resulting in a derived IDLH value of 12 ppm. Purpose: This IDLH Value Profile presents (1) a brief summary of technical data associated with acute inhalation exposures to ClF3 (a surrogate for BrF3), and (2) the rationale behind the immediately dangerous to life or health (IDLH) value for BrF3, using data from studies with ClF3 as a surrogate. IDLH values are developed based on the scientific rationale and logic outlined in the NIOSH Current Intelligence Bulletin (CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH) Values [NIOSH 2013]. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Chemistry Environmental Exposure Hazardous Substances Laboratories Lung Lung Diseases Morbidity Mortality Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Animals; Laboratory animals; Humans; Lethal concentrations; IDLH; Immediately Dangerous to Life or Health; LD50; Median lethal dose; Lethal concentrations; Exposure levels; Health effects; Chemicals; Chemical structure; Chemical properties; Chemical hazards; Chemical safety; Inhalation; Fatalities; Morbidity rates; Mortality data; Systematic reviews; Respiratory irritants; Lung; Kidneys; Liver; Spleen disorders; Organs; Airborne particles; Pulmonary system; Pulmonary system disorders; Respiratory system disorders; Fatalities; Pathology
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2020-123, 2020 Jul; :1-14
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2020123
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  32 pdf pages
• NIOSHTIC Number:
  nn:20060298
• NTIS Accession Number:
  PB2021-100169
• CAS Registry Number:
  Bromine trifluoride (CAS RN 7787-71-5)
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:318b5f08bdcdc505eb852220f976d22021f7f06704e3dffe36869698b4aef4dbbfb930b5c7442001c3cadc4270b3bde35a13500b74c5478d4e15e8089f7d612f
• Download URL:
  https://stacks.cdc.gov/view/cdc/90837/cdc_90837_DS1.pdf
• File Type:
  [PDF - 732.64 KB ]