Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wu, Wenjing ; Wei, Li ; Feng, Yu ; Xie, Yi ; Zong, Zhiyong
Wu, Wenjing ; Wei, Li ; Feng, Yu ; Xie, Yi ; Zong, Zhiyong Less -
Description:
The clinical importance of Enterobacter spp. remains unclear because phenotype-based Enterobacter species identification is unreliable. We performed a genomic study on 48 cases of Enterobacter-caused bloodstream infection by using in silico DNA-DNA hybridization to identify precise species. Strains belonged to 12 species; Enterobacter xiangfangensis (n = 21) and an unnamed species (taxon 1, n = 8) were dominant. Most (63.5%) Enterobacter strains (n = 349) with genomes in GenBank from human blood are E. xiangfangensis; taxon 1 (19.8%) was next most common. E. xiangfangensis and taxon 1 were associated with increased deaths (20.7% vs. 15.8%), lengthier hospitalizations (median 31 d vs. 19.5 d), and higher resistance to aztreonam, cefepime, ceftriaxone, piperacillin-tazobactam, and tobramycin. Strains belonged to 37 sequence types (STs); ST171 (E. xiangfangensis) was most common (n = 6). Four ST171 strains belonged to a defined clone. Precise species identification has greater implications for epidemiology and infection control than treatment.
Subjects:
[+]
Anti-Bacterial Agents Bacteremia Enterobacter Enterobacteriaceae Infections Humans Microbial Sensitivity Tests
Source:
Emerg Infect Dis. 27(1):161-169
Pubmed ID:
33350909
Pubmed Central ID:
PMC7774573
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c6d4aba631cda6b345c11d8e3c35b1410719e76036290f96a27559e3b9f6bdab
Download URL:
https://stacks.cdc.gov/view/cdc/99959/cdc_99959_DS1.pdf
File Type:

Supporting Files

• 	19-0154-Techapp-s1.pdf	pdf
  	19-0154-Techapp-s2.xlsx	xlsx
  	19-0154-Techapp-s3.pdf	pdf
  	19-0154.nxml	xml

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