Details:

Alternative Title:
Eur J Radiol
Personal Author:
Jirapatnakul, Artit ; Reeves, Anthony P. ; Lewis, Sara ; Chen, Xiangmeng ; Ma, Teng ; ... More +
Jirapatnakul, Artit ; Reeves, Anthony P. ; Lewis, Sara ; Chen, Xiangmeng ; Ma, Teng ; Yip, Rowena ; Chin, Xing ; Liu, Shuang ; Perumalswami, Ponni V. ; Yankelevitz, David F. ; Crane, Michael ; Branch, Andrea D. ; Henschke, Claudia I. Less -
Description:
Purpose:

Develop and validate an automated method for measuring liver attenuation in non-contrast low-dose chest CT (LDCT) scans and compare it to the standard manual method for identifying moderate-to-severe hepatic steatosis (HS).

Method:

The automated method identifies a region below the right lung within the liver and uses statistical sampling techniques to exclude non-liver parenchyma. The method was used to assess moderate-to-severe HS on two IRB-approved cohorts: 1) 24 patients with liver disease examined between 1/2013-1/2017 with non-contrast chest CT and abdominal MRI scans obtained within three months of liver biopsy, and 2) 319 lung screening participants with baseline LDCT performed between 8/2011-1/2017. Agreement between the manual and automated CT methods, the manual MRI method, and pathology for determining moderate-to-severe HS was assessed using Cohen’s Kappa by applying a 40 HU threshold to the CT method and 17.4% fat fraction to MRI. Agreement between the manual and automated CT methods was assessed using the intraclass correlation coefficient (ICC). Variability was assessed using Bland-Altman limits of agreement (LoA).

Results:

In the first cohort, the manual and automated CT methods had almost perfect agreement (ICC=0.97, κ=1.00) with LoA of −7.6—4.7 HU. Both manual and automated CT methods had almost perfect agreement with MRI (κ=0.90) and substantial agreement with pathology (κ=0.77). In the second cohort, the manual and automated CT methods had almost perfect agreement (ICC=0.94, κ = 0.87). LoA were −10.6—5.2 HU.

Conclusion:

Automated measurements of liver attenuation from LDCT scans can be used to identify moderate-to-severe HS on LDCT.


Subjects:
[+]
Article Fatty Liver Female Hepatic Steatosis Humans Image Analysis Low-dose CT Lung Lung Screening Magnetic Resonance Imaging Male Middle Aged Prospective Studies Reproducibility Of Results Tomography, X-Ray Computed
Source:
Eur J Radiol. 122:108723
Pubmed ID:
31778964
Pubmed Central ID:
PMC7179816
Document Type:
Journal Article
Funding:
U01 OH011489/OH/NIOSH CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:78eeca85e33bc485fe13d134919eed4367faa26ae03070210f7db0fe8e86b10c
Download URL:
https://stacks.cdc.gov/view/cdc/87165/cdc_87165_DS1.pdf
File Type:

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