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Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics
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6 24 2020
Source: Clin Infect Dis. 71(1):201-204 -
Alternative Title:Clin Infect Dis
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Description:Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.
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Pubmed ID:31630171
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Pubmed Central ID:PMC7167332
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