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Utility of the CDR® plus NACC FTLD in Mild FTLD: Data from the ARTFL/LEFFTDS Consortium
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Published Date:
January 06 2020
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Source:Alzheimers Dement. 16(1):79-90
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Language:English
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[PDF-421.36 KB]
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Alternative Title:Alzheimers Dement
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Description:Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of frontotemporal lobar degeneration (FTLD) patients (CDR® plus NACC FTLD). Methods: We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the ARTFL/LEFFTDS Consortium. Results: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR®-sum of boxes (CDR®-SB) =0. The CDR®-SB was not sensitive particularly in the mild non-fluent/agrammatic primary progressive aphasia participants. Familial and sporadic behavioral variant FTD participants exhibited similar CDR® plus NACC FTLD profiles except that, language impairment was more frequent in the mild sporadic participants. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. Discussion: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
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Subject:
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Pubmed ID:31477517
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Pubmed Central ID:PMC6949373
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