i
Race/ethnicity and accuracy of self-reported female first-degree family history of breast and other cancers in the Northern California Breast Cancer Family Registry
-
September 05 2019
Source: Cancer Epidemiol Biomarkers Prev. 28(11):1792-1801
Details:
-
Alternative Title:Cancer Epidemiol Biomarkers Prev
-
Personal Author:
-
Description:Background:
Few studies have evaluated accuracy of self-reported family history of breast and other cancers in racial/ethnic minorities.
Methods:
We assessed the accuracy of cancer family history reports by women with breast cancer (probands) from the Northern California Breast Cancer Family Registry compared to two reference standards: personal cancer history reports by female first-degree relatives and California Cancer Registry records.
Results:
Probands reported breast cancer in first-degree relatives with high accuracy, but accuracy was lower for other cancers. Sensitivity (% correctly identifying relatives with cancer) was 93% (95% CI, 89.5–95.4) when compared to the relatives’ self-report of breast cancer as the reference standard and varied little by proband race/ethnicity and other demographic factors, except for marginally lower sensitivity for Hispanic white probands (87.3%, 95% CI, 78.0–93.1, P=0.07) than non-Hispanic white probands (95.1%, 95% CI=88.9–98.0). Accuracy was also high when compared to cancer registry records as the reference standard, with a sensitivity of 95.5% (95% CI, 93.4–96.9) for breast cancer, but lower sensitivity for Hispanic white probands (91.2%, 95% CI, 84.4–95.2, P=0.05) and probands with low English language proficiency (80%, 95% CI, 52.8–93.5, P <0.01).
Conclusions:
Non-Hispanic white, African American, and Asian American probands reported first-degree breast cancer family history with high accuracy, although sensitivity was lower for Hispanic white probands and those with low English language proficiency.
Impact:
Self-reported family history of breast cancer in first-degree relatives is highly accurate and can be used as a reliable standard when other validation methods are not available.
-
Subjects:
-
Pubmed ID:31488412
-
Pubmed Central ID:PMC6825587
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
Supporting Files
More +