Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Carriquiriborde, Francisco ; Regidor, Victoria ; Aispuro, Pablo M. ; Magali, Gabrielli ; Bartel, Erika ; Bottero, Daniela ; Hozbor, Daniela
• Description:
  Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
• Subjects:
  Bacterial Outer Membrane Proteins Bordetella Pertussis Child Child, Preschool Gene Deletion Genotype Humans Infant Pertussis Vaccine Public Health Surveillance Serogroup Virulence Factors, Bordetella Whooping Cough

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• Source:
  Emerg Infect Dis. 25(11):2048-2054
• Pubmed ID:
  31625838
• Pubmed Central ID:
  PMC6810201
• Document Type:
  Journal Article
• Place as Subject:
  Argentina
• Volume:
  25
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0c56648d25516d9c1d6c6ab7c86e907d9ab6c3edb7c07f2a49382911507aee88
• Download URL:
  https://stacks.cdc.gov/view/cdc/82995/cdc_82995_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]