i
Early Diagnosis of Tularemia by Flow Cytometry, Czech Republic, 2003–20151
-
October 2019
Source: Emerg Infect Dis. 25(10):1919-1927
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:We retrospectively assessed the utility of a flow cytometry-based test quantifying the percentage of CD3+ T cells with the CD4-/CD8- phenotype for predicting tularemia diagnoses in 64 probable and confirmed tularemia patients treated during 2003-2015 and 342 controls with tularemia-like illnesses treated during 2012-2015 in the Czech Republic. The median percentage of CD3+/CD4-/CD8- T cells in peripheral blood was higher in tularemia patients (19%, 95% CI 17%-22%) than in controls (3%, 95% CI 2%-3%). When we used 8% as the cutoff, this test's sensitivity was 0.953 and specificity 0.895 for distinguishing cases from controls. The CD3+/CD4-/CD8- T cells increased a median of 7 days before tularemia serologic test results became positive. This test supports early presumptive diagnosis of tularemia for clinically suspected cases 7-14 days before diagnosis can be confirmed by serologic testing in regions with low prevalences of tularemia-like illnesses.
-
Subjects:
-
Pubmed ID:31538915
-
Pubmed Central ID:PMC6759275
-
Document Type:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
Supporting Files
-
gif jpeg gif jpeg gif jpeg xml gif jpeg gif jpeg gif jpeg gif jpeg
More +