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Zika Virus Infects Human Placental Macrophages
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May 27 2016
Source: Cell Host Microbe. 20(1):83-90 -
Alternative Title:Cell Host Microbe
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Description:The recent Zika virus (ZIKV) outbreak in Brazil has been directly linked to increased cases of microcephaly in newborns. Current evidence indicates that ZIKV is transmitted vertically from mother to fetus. However, the mechanism of intrauterine transmission and the cell types involved remain unknown. We demonstrate that the contemporary ZIKV strain PRVABC59 (PR 2015) infects and replicates in primary human placental macrophages, called Hofbauer cells, and to a lesser extent in cytotrophoblasts, isolated from villous tissue of full-term placentae. Viral replication coincides with induction of type I interferon (IFN), pro-inflammatory cytokines, and antiviral gene expression, but with minimal cell death. Our results suggest a mechanism for intrauterine transmission in which ZIKV gains access to the fetal compartment by directly infecting placental cells and disrupting the placental barrier.
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Pubmed ID:27247001
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Pubmed Central ID:PMC5166429
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Funding:R37 AI048638/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; P30 AI050409/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; U19 AI090023/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; U19 AI083019/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R56 AI110516/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; ... More +
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