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Implications of the Research Domain Criteria Project for Childhood Anxiety and its Disorders
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January 31 2018
Source: Clin Psychol Rev. 64:99-109 -
Alternative Title:Clin Psychol Rev
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Description:Anxiety disorders are among the most prevalent psychiatric disorders in youth; however, progress in treatment for childhood anxiety has stalled over the past decade. The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) project represents a shift toward a dimensional and interdisciplinary approach to psychiatric disorders; this shift can reframe developmental psychopathology for childhood anxiety and facilitate novel advances in its classification and treatment. Here we highlight constructs in the Systems for Social Processes and the Negative Valence System domains of RDoC, as they relate to childhood anxiety disorders. Childhood anxiety relates to both RDoC domains. In terms of social processes, through natural reliance on parents to reduce children's fear, attachment represents one particular social process, which plays a central role in anxiety among youth. In terms of negative valence, considerable research links threat conditioning to pediatric anxiety. Finally, fronto-amygdala circuitry relates to all three entities, as it has been shown to underly both attachment processes and threat learning, while it also has been consistently implicated in anxiety disorders across development. Through integrative and translational approaches, RDoC provides unique opportunities and simultaneous challenges for advancing the understanding and treatment of childhood anxiety disorders.
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Pubmed ID:29526524
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Pubmed Central ID:PMC6668617
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Funding:DP5 OD021370/ODCDC CDC HHS/Office of the Director/United States ; K23 MH103555/NIMH NIH HHS/National Institute of Mental Health/United States ; KL2 TR000140/NCATS NIH HHS/National Center for Advancing Translational Sciences/United States ; ZIA MH002781/NIMH NIH HHS/National Institute of Mental Health/United States
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