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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties manuscript?><front><journal-meta><journal-id journal-id-type="nlm-journal-id">0140524</journal-id><journal-id journal-id-type="pubmed-jr-id">1166</journal-id><journal-id journal-id-type="nlm-ta">Biomed Sci Instrum</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Sci Instrum</journal-id><journal-title-group><journal-title>Biomedical sciences instrumentation</journal-title></journal-title-group><issn pub-type="ppub">0067-8856</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25405433</article-id><article-id pub-id-type="pmc">6615543</article-id><article-id pub-id-type="manuscript">HHSPA937919</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>AGREEMENT IN GAIT SPEED FROM SMARTPHONE AND STOPWATCH FOR FIVE METER WALK IN LABORATORY AND CLINICAL ENVIRONMENTS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Soangra</surname><given-names>Rahul</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lockhart</surname><given-names>Thurmon E</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University</aff><aff id="A2"><label>2</label>Industrial &#x00026; Systems Engineering, Virginia Tech</aff><pub-date pub-type="nihms-submitted"><day>28</day><month>6</month><year>2019</year></pub-date><pub-date pub-type="ppub"><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>7</month><year>2019</year></pub-date><volume>50</volume><fpage>254</fpage><lpage>264</lpage><abstract id="ABS1"><p id="P1">Gait speed is suggested as an independent predictor of post-operative morbidity and mortality in elderly cardiovascular disease (CVD) patients. Society of thoracic surgeons has recently classified gait speed as the only important indicator of health for CVD patients. It has been seen that patients with slow gait speed above 70 years of age, taking more than 6 seconds to walk 5 meters are particularly at high risk for adverse outcomes. Twelve young participants walked in their self-selected, slow and fast speed with five reflective markers at sternum and heels and toes of both feet in laboratory environment. A smartphone was affixed at the pelvis using a smartphone holster. Simultaneously, an examiner used stopwatch to record the elapsed time necessary to cross 5 meter distance. Smartphone based app also computed gait speed. Intra-class correlation coefficients comparing velocities from camera system, smartphone and stopwatch systems were found to be highly reliable (ICC (3,k)=0.82) for slow walking speed. Similarly, fairly good reliability were found for fast (ICC(3,k)=0.70) and normal walking speed (ICC(3,k)=0.66). Five CVD patients were tested in clinical environment with smartphone and its feasibility was assessed for gait speed. This study shows that the smartphone and stopwatch gait speed methods have clinically acceptable agreement for the measurement of gait velocity in the two different environments. The smartphone based reliable measurements could help patients on their own to assess operative risks and health during perioperative period.</p></abstract><kwd-group><kwd>Inertial Sensors</kwd><kwd>Cardiovascular Disease CVD</kwd><kwd>gait speed</kwd></kwd-group></article-meta></front><body><sec id="S1"><title>INTRODUCTION</title><p id="P2">In the year 2010, 35% (223 patients) of adult cardiac surgeries were performed on patients 70 years of age and older at Carilion Roanoke Memorial Hospital (CRMH). Considering mortality at old age, it is observed that patient age is an independent risk factor for postoperative complications including major morbidity and death [<xref rid="R1" ref-type="bibr">1</xref>]. With aging there is decline in physical functioning [<xref rid="R2" ref-type="bibr">2</xref>, <xref rid="R3" ref-type="bibr">3</xref>], and this leads to higher rates of disability, institutionalization and mortality [<xref rid="R4" ref-type="bibr">4</xref>&#x02013;<xref rid="R6" ref-type="bibr">6</xref>]. Clinical researchers have suggested that there is significant need for a more accurate prediction of surgical risk in elderly patients considering cardiac surgery [<xref rid="R7" ref-type="bibr">7</xref>]. Frailty has been investigated as a predictor of disability and adverse outcomes in older adults, and it has recently been investigated as a risk factor for patients undergoing cardiac surgery [<xref rid="R7" ref-type="bibr">7</xref>].</p><p id="P3">Gait speed, as a clinical indicator of frailty, has been identified as the strongest predictor of mortality in individuals with coronary artery disease [<xref rid="R8" ref-type="bibr">8</xref>, <xref rid="R9" ref-type="bibr">9</xref>]. Gait speed is a simple, but also a potential clinical indicator of functional status in older adults [<xref rid="R10" ref-type="bibr">10</xref>, <xref rid="R11" ref-type="bibr">11</xref>] and is known to be associated with key health outcomes in elderly [<xref rid="R12" ref-type="bibr">12</xref>]. Gait speed is found to be associated with survival among older adults [<xref rid="R13" ref-type="bibr">13</xref>&#x02013;<xref rid="R17" ref-type="bibr">17</xref>] with 12% higher mortality with every 0.1-m/s slower gait speed [<xref rid="R10" ref-type="bibr">10</xref>]. Some researchers have recommended gait speed as &#x0201c;sixth vital sign&#x0201d; from its ability to predict about one&#x02019;s health status in future, with its ease of administration, grading, interpretation and minimal cost involved in its determination[<xref rid="R18" ref-type="bibr">18</xref>]. Studenski et. al. considered gait speed as a simple and accessible summary indicator of vitality which integrates disturbances in multiple organ systems such as heart, lungs, circulatory, nervous, and musculoskeletal systems which affect survival[<xref rid="R10" ref-type="bibr">10</xref>]. An objective gait speed measurement in clinical environments may refine survival estimates in frail cardiac patients because it is quite informative [<xref rid="R19" ref-type="bibr">19</xref>]. Afilalo et al. (2010) found that elderly patients who walked 5-meter and took more than 6 seconds were associated with a 2- to 3-fold increase in risk of major morbidity and mortality in post-cardiac surgery [<xref rid="R20" ref-type="bibr">20</xref>]. In addition, patients with slower gait speed were more likely to have longer lengths of stay in the hospital and did required discharge to a rehabilitation facility postoperatively [<xref rid="R20" ref-type="bibr">20</xref>, <xref rid="R21" ref-type="bibr">21</xref>]. Although there being considerable variation in gait speed testing procedures including distance of walk [<xref rid="R22" ref-type="bibr">22</xref>]. Bohannon compared gait speed over 2.43 meters (8 feet) and 6.09 meters (20 feet) and found that it was feasible to measure gait speed in non-laboratory setting[<xref rid="R23" ref-type="bibr">23</xref>] for distance less than 20 feet with one step before and after the start and stop mark[<xref rid="R23" ref-type="bibr">23</xref>&#x02013;<xref rid="R25" ref-type="bibr">25</xref>]. In the gait speed assessment protocol defined over short distances (such as 5 meter) there is an acceleration phase and a deceleration phase as part of gait speed [<xref rid="R18" ref-type="bibr">18</xref>, <xref rid="R26" ref-type="bibr">26</xref>]. Inclusion of acceleration and deceleration phases in gait speed estimation is highly correlated to that with its exclusion in estimating gait speed. Inertial sensors have been found to be highly useful in finding temporal gait events of gait [<xref rid="R27" ref-type="bibr">27</xref>, <xref rid="R28" ref-type="bibr">28</xref>].</p><p id="P4">Thus, there is a need to establish objective and reliable gait speed testing protocols in clinics. We hereby evaluated and established smartphone based technique of measuring gait speed which could feasibly be implemented as a routine measurement in outpatient clinics.</p></sec><sec id="S2"><title>METHODS</title><sec id="S3"><title>Subjects</title><p id="P5">Twelve healthy young adults (6 males and 6 females) participated in laboratory study. The participants mean age was 28&#x000b1;4 years, height was 177&#x000b1;13 cm, and weight was 69&#x000b1;11 kg. All participants were healthy, independent and non-sedentary. Participants were formally screened for major musculoskeletal, cardiovascular, and neurological disorders by a research coordinator during initial participant contact. Exclusion criteria of this study were factors that could interfere with gait, such as medication use, presence of neuromuscular disease and, balance and vision disorders. Informed consent was approved by the Institutional Review Board (IRB) of Virginia Tech and Carilion Clinic IRB and was signed by all participants prior to the study.</p><p id="P6">Five cardiac patients were recruited from outpatient care in the cardiac department in Carilion Roanoke Memorial Hospital (CRMH) for feasibility portion of the study. After all patients had provided written consent and anthropometric data was collected, they had their vital signs performed by clinical nursing research staff (heart rate, blood pressure, etc.).</p></sec><sec id="S4"><title>Equipment and data acquisition</title><sec id="S5"><title>Laboratory Data Collection</title><p id="P7">In the laboratory, the data acquisition was carried out using a smartphone (iPhone 5, Apple Inc. Cupertino, CA95014) based application. The smartphone was used to measure motion data from in-built accelerometer and gyroscope signals. Stopwatch was used by one of the experimenter to time when participants crossed start and finish line. A six-camera ProReflex system (Qualysis, Gothenburg, Sweden) was used to collect three-dimensional movement data of participants using passive infra-red markers (<xref rid="F1" ref-type="fig">figure 1</xref>). A total of six reflective markers were attached on both heel, sacrum, sternum of the participants and start and finish mark of walking track. The camera frame rate was set to 120Hz. The marker positioned at sacrum was used to find the walking velocity. The data was processed using custom software written in MATLAB (MATLAB version 6.5.1, 2003, computer software, The MathWorks Inc., Natick, Massachusetts).</p></sec><sec id="S6"><title>Participants</title><p id="P8">Twelve healthy participants participated in Locomotion Research Laboratory, Virginia Tech and were instructed to walk at three different speeds on the walking track: comfortable self-preferred pace [<xref rid="R29" ref-type="bibr">29</xref>], fast (or maximum) gait speed &#x0201c;as fast as safely possible&#x0201d;; and slower than normal walking speed. The walking track had a starting and finish mark five meters apart. Participants were instructed to stand still with their feet behind and just touching the starting line marked with grey duct tape and then to walk at their normal pace along a 5-m course until a step past the finish line after an audio signal was provided to start walking (at either fast, slow or normal speed). The app and motion capture data collection was started before providing the audio signal to the participants. Stopwatch timing started with the first footfall and stopped with participant&#x02019;s first footfall after crossing the 5-m end line. Five walking trials were collected at all three walking speed using this protocol from each subject in laboratory.</p></sec></sec><sec id="S7"><title>Gait speed estimation using smartphone signals</title><p id="P9">Gait velocity is determined by computing the time taken to walk a specified distance (default as 5m) where
<disp-formula id="FD1"><label>(1)</label><mml:math display="block" id="M1" overflow="scroll"><mml:mrow><mml:mi>G</mml:mi><mml:mi>a</mml:mi><mml:mi>i</mml:mi><mml:mi>t</mml:mi><mml:mspace width="0.25em"/><mml:mi>V</mml:mi><mml:mi>e</mml:mi><mml:mi>l</mml:mi><mml:mi>o</mml:mi><mml:mi>c</mml:mi><mml:mi>i</mml:mi><mml:mi>t</mml:mi><mml:mi>y</mml:mi><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>D</mml:mi><mml:mi>i</mml:mi><mml:mi>s</mml:mi><mml:mi>t</mml:mi><mml:mi>a</mml:mi><mml:mi>n</mml:mi><mml:mi>c</mml:mi><mml:mi>e</mml:mi><mml:mspace width="0.25em"/><mml:mi>w</mml:mi><mml:mi>a</mml:mi><mml:mi>l</mml:mi><mml:mi>k</mml:mi><mml:mi>e</mml:mi><mml:mi>d</mml:mi></mml:mrow><mml:mrow><mml:mi>T</mml:mi><mml:mi>o</mml:mi><mml:mi>t</mml:mi><mml:mi>a</mml:mi><mml:mi>l</mml:mi><mml:mspace width="0.25em"/><mml:mi>T</mml:mi><mml:mi>i</mml:mi><mml:mi>m</mml:mi><mml:mi>e</mml:mi></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula></p><p id="P10">To determine the start and stop events, the resultant acceleration is analyzed for distinct transition periods (<xref rid="F2" ref-type="fig">figure 2</xref>)[<xref rid="R27" ref-type="bibr">27</xref>]. The resultant acceleration is computed over a window or 1 second using the following equation
<disp-formula id="FD2"><label>(2)</label><mml:math display="block" id="M2" overflow="scroll"><mml:mrow><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:msqrt><mml:mrow><mml:msup><mml:msub><mml:mi>a</mml:mi><mml:mi>x</mml:mi></mml:msub><mml:mn>2</mml:mn></mml:msup><mml:mo>+</mml:mo><mml:msup><mml:msub><mml:mi>a</mml:mi><mml:mi>y</mml:mi></mml:msub><mml:mn>2</mml:mn></mml:msup><mml:mo>+</mml:mo><mml:msup><mml:msub><mml:mi>a</mml:mi><mml:mi>z</mml:mi></mml:msub><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:msqrt></mml:mrow></mml:math></disp-formula>
where <italic>a</italic><sub><italic>x</italic></sub>, <italic>a</italic><sub><italic>y</italic></sub>, and <italic>a</italic><sub><italic>z</italic></sub> are the components of acceleration</p><p id="P11">The acceleration signal is analyzed in one second blocks during the initial standing period to determine the activation threshold. This threshold is calculated using the variance of the resultant acceleration blocks for the initial standing period. Nominally, this threshold has been calculated using the mean plus two standard deviations of the variance recorded during the first 5 seconds of standing prior to walking. The start time is then defined as the time at which the variance of the resultant acceleration exceeds the threshold value. The stop time is similarly defined as the time at which the variance of the acceleration drops below the threshold. The start and stop events are illustrated in <xref rid="F1" ref-type="fig">Figure 1</xref>.</p><sec id="S8"><title>Clinical Data Collection</title><p id="P12">To determine the feasibility of measuring gait speed in clinics using smartphone, we recruited a separate convenience sample of five patients, receiving outpatient care in the cardiac department in CMRH for feasibility portion of the study. The participants mean age was 76.8&#x000b1;6 years, height was 175.2&#x000b1;12.2 cm, and weight was 81.2&#x000b1;11 kg. The participants consisted of three females and two males. After all subjects had provided written consent and had their vital signs performed by clinical research staff (heart rate, blood pressure, etc.). The demographics of the subjects were collected. Then subjects were approached by clinical research staff and asked to perform 5 m walk at their normal walking pace. Light sensors were used to determine time taken by participants for crossing start and finish line in the clinic (<xref rid="F3" ref-type="fig">figure 3</xref>). Subjects were verbally asked about their acceptability for smartphone at their waist. This feasibility study also involved training clinical research staff in using smartphone. The time to train clinical staff in using App, time to mount smartphone at appropriate position and time to administer subjects was also evaluated.</p></sec></sec><sec id="S9"><title>Statistical Analysis</title><p id="P13">All data analyses was done using MedCalc Statistical Software version 12.7.7 (MedCalc Software bvba, Ostend, Belgium; <ext-link ext-link-type="uri" xlink:href="http://www.medcalc.org/">http://www.medcalc.org</ext-link>; 2013). Intra-class correlation ICC(3,k) for three measurement systems (same raters for all subjects): smartphone, stopwatch and motion capture was assessed for consistency and absolute agreement for all three kinds of walking speed. Consistency is important when systematic differences between raters are irrelevant and absolute agreement when systematic difference is relevant. Two intra-class correlation coefficients (ICC) models have been used to measure reliability. By assuming the three measurement systems as judges and considering them as fixed effects, the consistency of the three ratings obtained from the three systems is measured by ICC(3,k) [<xref rid="R30" ref-type="bibr">30</xref>]. ICCs were interpreted as Fleiss suggested: ICC&#x0003e;0.75 as excellent reliability, 0.4&#x0003c;ICC&#x0003c;0.75 as fair to good reliability and ICC&#x0003c;0.4 as poor reliability [<xref rid="R31" ref-type="bibr">31</xref>].</p></sec></sec><sec id="S10"><title>RESULTS</title><p id="P14">It was found that slow walking speed had excellent reliability (ICC=0.82) and fast (ICC=0.70) and normal walking (ICC=0.66) speed had good reliability as well. The absolute agreement reliability coefficient (measure of systematic errors in measurement systems) among three velocities was also found to be fairly good as seen in <xref rid="T1" ref-type="table">Table 1</xref>. It was also found that systematic difference for all three walking speed differed with the ground truth velocity as determined by camera system in laboratory (<xref rid="F5" ref-type="fig">figure 5</xref>). This was evident when velocities were fitted through the regression line (<xref rid="F4" ref-type="fig">figure 4</xref>).</p><p id="P15">It was evident from clinical feasibility experiment that velocity estimation using stopwatch was not found to be accurate when compared to the ground truth velocity (through light sensors) whereas smartphones always under-estimated the walking velocities in patients (<xref rid="F3" ref-type="fig">figure 3</xref> and <xref rid="F6" ref-type="fig">figure 6</xref>).</p></sec><sec id="S11"><title>DISCUSSION</title><p id="P16">Gait speed is a commonly used measure in health care research, particularly among preoperative cardiac patients [<xref rid="R19" ref-type="bibr">19</xref>, <xref rid="R21" ref-type="bibr">21</xref>, <xref rid="R32" ref-type="bibr">32</xref>]. Some studies have previously used inertial sensors in fall risk assessment in hemodialysis clinics [<xref rid="R33" ref-type="bibr">33</xref>, <xref rid="R34" ref-type="bibr">34</xref>]. This study demonstrates how gait speed (related to major health related outcomes in frail population) can be measured feasibly using smartphone based methodology in clinical environments. There may be important losses of information when measurement of gait velocity is prone to human timing errors. Thus in clinical practice where gait speed is important predictive of severe health-outcomes such as mortality and a subsequent physical disability, an objective, accurate and reliable way is required for gait speed measurement. Five meter gait speed does not introduce fatigue in patients with cardiovascular impairment awaiting surgery[<xref rid="R32" ref-type="bibr">32</xref>]. Thus predictive validity of gait speed through an objective method of assessment could be used as a prescreening tool for many different kinds of surgical procedures and in turn help clinicians to identify cardiac patients who may need intensive rehab or preplan their longer stay in hospital with specialized nursing care before return to home.</p><p id="P17">Some limitations of current study need to be mentioned. Smartphone based assessments required participants to stand-still before and after 5-m walk. As automatic algorithms developed in smartphone app determined velocity by start and stop times of movement. If any other movement artifact is followed after or prior to the walking task, the movement time may get increased than the actual walking time and thus resulting in reporting of lower velocities by the app.</p></sec><sec id="S12"><title>CONCLUSIONS</title><p id="P18">The accurate measure of gait speed can improve the clinical evaluation of cardiac patients, providing an earlier detection of individuals at higher risk of major health-related events such as physical disability and mortality. Our study demonstrated that 5-m gait speed measurement using smartphone is a reliable objective measure, however adhering to certain protocol is suggested for using smartphone app. Evidence of concurrent validity was demonstrated by showing associations with the speed measurement using stopwatch and motion capture system in laboratory environment and with light sensors in clinical environment. Five meter gait speed was easily implemented in cardiovascular clinical practice with high acceptability by the patients and clinical research staff. Participants started with standing still posture and walked at their usual pace, as if they were walking in their own home, and given no further encouragement or instructions. This data can be readily collected in non-laboratory environments and can be used to help interpret the results for health related events.</p><p id="P19">Although different methods have been used previously to measure gait speed and these have affected clinical interpretation and implementation of the gait speed [<xref rid="R22" ref-type="bibr">22</xref>, <xref rid="R35" ref-type="bibr">35</xref>]. By providing a smartphone based clinically useful gait speed assessment method with a well-defined protocol which is simple, quick, easy to perform in clinics, it is hoped that smartphone for gait speed assessment will be promoted and encouraged in clinical and research settings.</p></sec></body><back><ack id="S13"><title>ACKNOWLEDGMENTS</title><p id="P20">We would like to thank Cathy Jennings, Dr. Rebecca Clark and Dr. Joseph Baker for helping us in developing smartphone app as per need of clinicians. The data collection in Carilion Roanoke Memorial Hospital was done by Cathy and Dr. Clark.</p></ack><ref-list><title>REFERENCES</title><ref id="R1"><label>[1]</label><mixed-citation publication-type="journal"><name><surname>Lee</surname><given-names>DH</given-names></name>, <name><surname>Buth</surname><given-names>KJ</given-names></name>, <name><surname>Martin</surname><given-names>BJ</given-names></name>, <name><surname>Yip</surname><given-names>AM</given-names></name>, and <name><surname>Hirsch</surname><given-names>GM</given-names></name>, &#x0201c;<article-title>Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery</article-title>,&#x0201d; <source>Circulation</source>, vol. <volume>121</volume>, pp. <fpage>973</fpage>&#x02013;<lpage>8</lpage>, <month>3</month>
<day>2</day>
<year>2010</year>.<pub-id pub-id-type="pmid">20159833</pub-id></mixed-citation></ref><ref id="R2"><label>[2]</label><mixed-citation publication-type="journal"><name><surname>Onder</surname><given-names>G</given-names></name>, <name><surname>Penninx</surname><given-names>BW</given-names></name>, <name><surname>Lapuerta</surname><given-names>P</given-names></name>, <name><surname>Fried</surname><given-names>LP</given-names></name>, <name><surname>Ostir</surname><given-names>GV</given-names></name>, <name><surname>Guralnik</surname><given-names>JM</given-names></name>, <etal/>, &#x0201c;<article-title>Change in physical performance over time in older women: the Women&#x02019;s Health and Aging Study</article-title>,&#x0201d; <source>J Gerontol A Biol Sci Med Sci</source>, vol. <volume>57</volume>, pp. <fpage>M289</fpage>&#x02013;<lpage>93</lpage>, <month>5</month>
<year>2002</year>.<pub-id pub-id-type="pmid">11983722</pub-id></mixed-citation></ref><ref id="R3"><label>[3]</label><mixed-citation publication-type="journal"><name><surname>Lindle</surname><given-names>RS</given-names></name>, <name><surname>Metter</surname><given-names>EJ</given-names></name>, <name><surname>Lynch</surname><given-names>NA</given-names></name>, <name><surname>Fleg</surname><given-names>JL</given-names></name>, <name><surname>Fozard</surname><given-names>JL</given-names></name>, <name><surname>Tobin</surname><given-names>J</given-names></name>, <etal/>, &#x0201c;<article-title>Age and gender comparisons of muscle strength in 654 women and men aged 20&#x02013;93 yr</article-title>,&#x0201d; <source>J Appl Physiol (1985)</source>, vol. <volume>83</volume>, pp. <fpage>1581</fpage>&#x02013;<lpage>7</lpage>, <month>11</month>
<year>1997</year>.<pub-id pub-id-type="pmid">9375323</pub-id></mixed-citation></ref><ref id="R4"><label>[4]</label><mixed-citation publication-type="journal"><name><surname>Vasunilashorn</surname><given-names>S</given-names></name>, <name><surname>Coppin</surname><given-names>AK</given-names></name>, <name><surname>Patel</surname><given-names>KV</given-names></name>, <name><surname>Lauretani</surname><given-names>F</given-names></name>, <name><surname>Ferrucci</surname><given-names>L</given-names></name>, <name><surname>Bandinelli</surname><given-names>S</given-names></name>, <etal/>, &#x0201c;<article-title>Use of the Short Physical Performance Battery Score to predict loss of ability to walk 400 meters: analysis from the InCHIANTI study</article-title>,&#x0201d; <source>J Gerontol A Biol Sci Med Sci</source>, vol. <volume>64</volume>, pp. <fpage>223</fpage>&#x02013;<lpage>9</lpage>, <month>2</month>
<year>2009</year>.<pub-id pub-id-type="pmid">19182232</pub-id></mixed-citation></ref><ref id="R5"><label>[5]</label><mixed-citation publication-type="journal"><name><surname>Guralnik</surname><given-names>JM</given-names></name>, <name><surname>Ferrucci</surname><given-names>L</given-names></name>, <name><surname>Pieper</surname><given-names>CF</given-names></name>, <name><surname>Leveille</surname><given-names>SG</given-names></name>, <name><surname>Markides</surname><given-names>KS</given-names></name>, <name><surname>Ostir</surname><given-names>GV</given-names></name>, <etal/>, &#x0201c;<article-title>Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery</article-title>,&#x0201d; <source>J Gerontol A Biol Sci Med Sci</source>, vol. <volume>55</volume>, pp. <fpage>M221</fpage>&#x02013;<lpage>31</lpage>, <month>4</month>
<year>2000</year>.<pub-id pub-id-type="pmid">10811152</pub-id></mixed-citation></ref><ref id="R6"><label>[6]</label><mixed-citation publication-type="journal"><name><surname>Guralnik</surname><given-names>JM</given-names></name>, <name><surname>Ferrucci</surname><given-names>L</given-names></name>, <name><surname>Simonsick</surname><given-names>EM</given-names></name>, <name><surname>Salive</surname><given-names>ME</given-names></name>, and <name><surname>Wallace</surname><given-names>RB</given-names></name>, &#x0201c;<article-title>Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability</article-title>,&#x0201d; <source>N Engl J Med</source>, vol. <volume>332</volume>, pp. <fpage>556</fpage>&#x02013;<lpage>61</lpage>, <month>3</month>
<day>2</day>
<year>1995</year>.<pub-id pub-id-type="pmid">7838189</pub-id></mixed-citation></ref><ref id="R7"><label>[7]</label><mixed-citation publication-type="journal"><name><surname>Sundermann</surname><given-names>S</given-names></name>, <name><surname>Dademasch</surname><given-names>A</given-names></name>, <name><surname>Praetorius</surname><given-names>J</given-names></name>, <name><surname>Kempfert</surname><given-names>J</given-names></name>, <name><surname>Dewey</surname><given-names>T</given-names></name>, <name><surname>Falk</surname><given-names>V</given-names></name>, <etal/>, &#x0201c;<article-title>Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery</article-title>,&#x0201d; <source>Eur J Cardiothorac Surg</source>, vol. <volume>39</volume>, pp. <fpage>33</fpage>&#x02013;<lpage>7</lpage>, <month>1</month>
<year>2011</year>.<pub-id pub-id-type="pmid">20627611</pub-id></mixed-citation></ref><ref id="R8"><label>[8]</label><mixed-citation publication-type="journal"><name><surname>Dumurgier</surname><given-names>J</given-names></name>, <name><surname>Elbaz</surname><given-names>A</given-names></name>, <name><surname>Ducimeti&#x000e8;re</surname><given-names>P</given-names></name>, <name><surname>Tavernier</surname><given-names>B</given-names></name>, <name><surname>Alp&#x000e9;rovitch</surname><given-names>A</given-names></name>, and <name><surname>Tzourio</surname><given-names>C</given-names></name>, &#x0201c;<article-title>Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study</article-title>,&#x0201d; <source>BMJ</source>, vol. <volume>339</volume>, <comment>2009&#x02013;11-10 00:00:00</comment>
<year>2009</year>.</mixed-citation></ref><ref id="R9"><label>[9]</label><mixed-citation publication-type="journal"><name><surname>Purser</surname><given-names>JL</given-names></name>, <name><surname>Kuchibhatla</surname><given-names>MN</given-names></name>, <name><surname>Fillenbaum</surname><given-names>GG</given-names></name>, <name><surname>Harding</surname><given-names>T</given-names></name>, <name><surname>Peterson</surname><given-names>ED</given-names></name>, and <name><surname>Alexander</surname><given-names>KP</given-names></name>, &#x0201c;<article-title>Identifying frailty in hospitalized older adults with significant coronary artery disease</article-title>,&#x0201d; <source>J Am Geriatr Soc</source>, vol. <volume>54</volume>, pp. <fpage>1674</fpage>&#x02013;<lpage>81</lpage>, <month>11</month>
<year>2006</year>.<pub-id pub-id-type="pmid">17087693</pub-id></mixed-citation></ref><ref id="R10"><label>[10]</label><mixed-citation publication-type="journal"><name><surname>Studenski</surname><given-names>S</given-names></name>, <name><surname>Perera</surname><given-names>S</given-names></name>, <name><surname>Patel</surname><given-names>K</given-names></name>, <name><surname>Rosano</surname><given-names>C</given-names></name>, <name><surname>Faulkner</surname><given-names>K</given-names></name>, <name><surname>Inzitari</surname><given-names>M</given-names></name>, <etal/>, &#x0201c;<article-title>Gait speed and survival in older adults</article-title>,&#x0201d; <source>JAMA</source>, vol. <volume>305</volume>, pp. <fpage>50</fpage>&#x02013;<lpage>8</lpage>, <month>1</month>
<day>5</day>
<year>2011</year>.<pub-id pub-id-type="pmid">21205966</pub-id></mixed-citation></ref><ref id="R11"><label>[11]</label><mixed-citation publication-type="journal"><name><surname>Verghese</surname><given-names>J</given-names></name>, <name><surname>Wang</surname><given-names>C</given-names></name>, <name><surname>Lipton</surname><given-names>RB</given-names></name>, <name><surname>Holtzer</surname><given-names>R</given-names></name>, and <name><surname>Xue</surname><given-names>X</given-names></name>, &#x0201c;<article-title>Quantitative gait dysfunction and risk of cognitive decline and dementia</article-title>,&#x0201d; <source>J Neurol Neurosurg Psychiatry</source>, vol. <volume>78</volume>, pp. <fpage>929</fpage>&#x02013;<lpage>35</lpage>, <month>9</month>
<year>2007</year>.<pub-id pub-id-type="pmid">17237140</pub-id></mixed-citation></ref><ref id="R12"><label>[12]</label><mixed-citation publication-type="journal"><name><surname>Abellan van Kan</surname><given-names>G</given-names></name>, <name><surname>Rolland</surname><given-names>Y</given-names></name>, <name><surname>Andrieu</surname><given-names>S</given-names></name>, <name><surname>Bauer</surname><given-names>J</given-names></name>, <name><surname>Beauchet</surname><given-names>O</given-names></name>, <name><surname>Bonnefoy</surname><given-names>M</given-names></name>, <etal/>, &#x0201c;<article-title>Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force</article-title>,&#x0201d; <source>J Nutr Health Aging</source>, vol. <volume>13</volume>, pp. <fpage>881</fpage>&#x02013;<lpage>9</lpage>, <month>12</month>
<year>2009</year>.<pub-id pub-id-type="pmid">19924348</pub-id></mixed-citation></ref><ref id="R13"><label>[13]</label><mixed-citation publication-type="journal"><name><surname>Cesari</surname><given-names>M</given-names></name>, <name><surname>Kritchevsky</surname><given-names>SB</given-names></name>, <name><surname>Newman</surname><given-names>AB</given-names></name>, <name><surname>Simonsick</surname><given-names>EM</given-names></name>, <name><surname>Harris</surname><given-names>TB</given-names></name>, <name><surname>Penninx</surname><given-names>BW</given-names></name>, <etal/>, &#x0201c;<article-title>Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study</article-title>,&#x0201d; <source>J Am Geriatr Soc</source>, vol. <volume>57</volume>, pp. <fpage>251</fpage>&#x02013;<lpage>9</lpage>, <month>2</month>
<year>2009</year>.<pub-id pub-id-type="pmid">19207142</pub-id></mixed-citation></ref><ref id="R14"><label>[14]</label><mixed-citation publication-type="journal"><name><surname>Cesari</surname><given-names>M</given-names></name>, <name><surname>Kritchevsky</surname><given-names>SB</given-names></name>, <name><surname>Penninx</surname><given-names>BW</given-names></name>, <name><surname>Nicklas</surname><given-names>BJ</given-names></name>, <name><surname>Simonsick</surname><given-names>EM</given-names></name>, <name><surname>Newman</surname><given-names>AB</given-names></name>, <etal/>, &#x0201c;<article-title>Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study</article-title>,&#x0201d; <source>J Am Geriatr Soc</source>, vol. <volume>53</volume>, pp. <fpage>1675</fpage>&#x02013;<lpage>80</lpage>, <month>10</month>
<year>2005</year>.<pub-id pub-id-type="pmid">16181165</pub-id></mixed-citation></ref><ref id="R15"><label>[15]</label><mixed-citation publication-type="journal"><name><surname>Ostir</surname><given-names>GV</given-names></name>, <name><surname>Kuo</surname><given-names>YF</given-names></name>, <name><surname>Berges</surname><given-names>IM</given-names></name>, <name><surname>Markides</surname><given-names>KS</given-names></name>, and <name><surname>Ottenbacher</surname><given-names>KJ</given-names></name>, &#x0201c;<article-title>Measures of lower body function and risk of mortality over 7 years of follow-up</article-title>,&#x0201d; <source>Am J Epidemiol</source>, vol. <volume>166</volume>, pp. <fpage>599</fpage>&#x02013;<lpage>605</lpage>, <month>9</month>
<day>1</day>
<year>2007</year>.<pub-id pub-id-type="pmid">17566063</pub-id></mixed-citation></ref><ref id="R16"><label>[16]</label><mixed-citation publication-type="journal"><name><surname>Rolland</surname><given-names>Y</given-names></name>, <name><surname>Lauwers-Cances</surname><given-names>V</given-names></name>, <name><surname>Cesari</surname><given-names>M</given-names></name>, <name><surname>Vellas</surname><given-names>B</given-names></name>, <name><surname>Pahor</surname><given-names>M</given-names></name>, and <name><surname>Grandjean</surname><given-names>H</given-names></name>, &#x0201c;<article-title>Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women</article-title>,&#x0201d; <source>Eur J Epidemiol</source>, vol. <volume>21</volume>, pp. <fpage>113</fpage>&#x02013;<lpage>22</lpage>, <year>2006</year>.<pub-id pub-id-type="pmid">16518679</pub-id></mixed-citation></ref><ref id="R17"><label>[17]</label><mixed-citation publication-type="journal"><name><surname>Woo</surname><given-names>J</given-names></name>, <name><surname>Ho</surname><given-names>SC</given-names></name>, and <name><surname>Yu</surname><given-names>AL</given-names></name>, &#x0201c;<article-title>Walking speed and stride length predicts 36 months dependency, mortality, and institutionalization in Chinese aged 70 and older</article-title>,&#x0201d; <source>J Am Geriatr Soc</source>, vol. <volume>47</volume>, pp. <fpage>1257</fpage>&#x02013;<lpage>60</lpage>, <month>10</month>
<year>1999</year>.<pub-id pub-id-type="pmid">10522962</pub-id></mixed-citation></ref><ref id="R18"><label>[18]</label><mixed-citation publication-type="journal"><name><surname>Fritz</surname><given-names>S</given-names></name> and <name><surname>Lusardi</surname><given-names>M</given-names></name>, &#x0201c;<article-title>White paper: &#x0201c;walking speed: the sixth vital sign</article-title>&#x0201d;,&#x0201d; <source>J Geriatr Phys Ther</source>, vol. <volume>32</volume>, pp. <fpage>46</fpage>&#x02013;<lpage>9</lpage>, <year>2009</year>.<pub-id pub-id-type="pmid">20039582</pub-id></mixed-citation></ref><ref id="R19"><label>[19]</label><mixed-citation publication-type="journal"><name><surname>Afilalo</surname><given-names>J</given-names></name>, <name><surname>Eisenberg</surname><given-names>MJ</given-names></name>, <name><surname>Morin</surname><given-names>JF</given-names></name>, <name><surname>Bergman</surname><given-names>H</given-names></name>, <name><surname>Monette</surname><given-names>J</given-names></name>, <name><surname>Noiseux</surname><given-names>N</given-names></name>, <etal/>, &#x0201c;<article-title>Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery</article-title>,&#x0201d; <source>J Am Coll Cardiol</source>, vol. <volume>56</volume>, pp. <fpage>1668</fpage>&#x02013;<lpage>76</lpage>, <month>11</month>
<day>9</day>
<year>2010</year>.<pub-id pub-id-type="pmid">21050978</pub-id></mixed-citation></ref><ref id="R20"><label>[20]</label><mixed-citation publication-type="journal"><name><surname>Afilalo</surname><given-names>J</given-names></name>, <name><surname>Eisenberg</surname><given-names>MJ</given-names></name>, <name><surname>Morin</surname><given-names>J-F</given-names></name>, <name><surname>Bergman</surname><given-names>H</given-names></name>, <name><surname>Monette</surname><given-names>J</given-names></name>, <name><surname>Noiseux</surname><given-names>N</given-names></name>, <etal/>, &#x0201c;<article-title>Gait Speed as an Incremental Predictor of Mortality and Major Morbidity in Elderly Patients Undergoing Cardiac Surgery</article-title>,&#x0201d; <source>Journal of the American College of Cardiology</source>, vol. <volume>56</volume>, pp. <fpage>1668</fpage>&#x02013;<lpage>1676</lpage>, <year>2010</year>.<pub-id pub-id-type="pmid">21050978</pub-id></mixed-citation></ref><ref id="R21"><label>[21]</label><mixed-citation publication-type="journal"><name><surname>Afilalo</surname><given-names>J</given-names></name>, &#x0201c;<article-title>Frailty in Patients with Cardiovascular Disease: Why, When, and How to Measure</article-title>,&#x0201d; <source>Curr Cardiovasc Risk Rep</source>, vol. <volume>5</volume>, pp. <fpage>467</fpage>&#x02013;<lpage>472</lpage>, <month>10</month>
<year>2011</year>.<pub-id pub-id-type="pmid">21949560</pub-id></mixed-citation></ref><ref id="R22"><label>[22]</label><mixed-citation publication-type="journal"><name><surname>Graham</surname><given-names>JE</given-names></name>, <name><surname>Ostir</surname><given-names>GV</given-names></name>, <name><surname>Fisher</surname><given-names>SR</given-names></name>, and <name><surname>Ottenbacher</surname><given-names>KJ</given-names></name>, &#x0201c;<article-title>Assessing walking speed in clinical research: a systematic review</article-title>,&#x0201d; <source>J Eval Clin Pract</source>, vol. <volume>14</volume>, pp. <fpage>552</fpage>&#x02013;<lpage>62</lpage>, <month>8</month>
<year>2008</year>.<pub-id pub-id-type="pmid">18462283</pub-id></mixed-citation></ref><ref id="R23"><label>[23]</label><mixed-citation publication-type="journal"><name><surname>Bohannon</surname><given-names>RW</given-names></name>, &#x0201c;<article-title>Population representative gait speed and its determinants</article-title>,&#x0201d; <source>J Geriatr Phys Ther</source>, vol. <volume>31</volume>, pp. <fpage>49</fpage>&#x02013;<lpage>52</lpage>, <year>2008</year>.<pub-id pub-id-type="pmid">19856549</pub-id></mixed-citation></ref><ref id="R24"><label>[24]</label><mixed-citation publication-type="journal"><name><surname>Bohannon</surname><given-names>RW</given-names></name>, &#x0201c;<article-title>Measurement of gait speed of older adults is feasible and informative in a home-care setting</article-title>,&#x0201d; <source>J Geriatr Phys Ther</source>, vol. <volume>32</volume>, pp. <fpage>22</fpage>&#x02013;<lpage>3</lpage>, <year>2009</year>.<pub-id pub-id-type="pmid">19856632</pub-id></mixed-citation></ref><ref id="R25"><label>[25]</label><mixed-citation publication-type="journal"><name><surname>Breniere</surname><given-names>Y</given-names></name> and <name><surname>Do</surname><given-names>MC</given-names></name>, &#x0201c;<article-title>When and how does steady state gait movement induced from upright posture begin?</article-title>,&#x0201d; <source>J Biomech</source>, vol. <volume>19</volume>, pp. <fpage>1035</fpage>&#x02013;<lpage>40</lpage>, <year>1986</year>.<pub-id pub-id-type="pmid">3818673</pub-id></mixed-citation></ref><ref id="R26"><label>[26]</label><mixed-citation publication-type="journal"><name><surname>Bohannon</surname><given-names>RW</given-names></name>, &#x0201c;<article-title>Comfortable and maximum walking speed of adults aged 20&#x02013;79 years: reference values and determinants</article-title>,&#x0201d; <source>Age Ageing</source>, vol. <volume>26</volume>, pp. <fpage>15</fpage>&#x02013;<lpage>9</lpage>, <month>1</month>
<year>1997</year>.</mixed-citation></ref><ref id="R27"><label>[27]</label><mixed-citation publication-type="journal"><name><surname>Soangra</surname><given-names>R</given-names></name>, <name><surname>Lockhart</surname><given-names>TE</given-names></name>, and <name><surname>Van de Berge</surname><given-names>N</given-names></name>, &#x0201c;<article-title>An approach for identifying gait events using wavelet denoising technique and single wireless IMU</article-title>,&#x0201d; <source>Proceedings of the Human Factors and Ergonomics Society Annual Meeting</source>, vol. <volume>55</volume>, pp. <fpage>1990</fpage>&#x02013;<lpage>1994</lpage>, <year>2011</year>.</mixed-citation></ref><ref id="R28"><label>[28]</label><mixed-citation publication-type="journal"><name><surname>Lockhart</surname><given-names>TE</given-names></name>, <name><surname>Soangra</surname><given-names>R</given-names></name>, <name><surname>Zhang</surname><given-names>J</given-names></name>, and <name><surname>Wu</surname><given-names>X</given-names></name>, &#x0201c;<article-title>Wavelet based automated postural event detection and activity classification with single imu - biomed 2013</article-title>,&#x0201d; <source>Biomed Sci Instrum</source>, vol. <volume>49</volume>, pp. <fpage>224</fpage>&#x02013;<lpage>33</lpage>, <year>2013</year>.<pub-id pub-id-type="pmid">23686204</pub-id></mixed-citation></ref><ref id="R29"><label>[29]</label><mixed-citation publication-type="journal"><name><surname>Steffen</surname><given-names>TM</given-names></name>, <name><surname>Hacker</surname><given-names>TA</given-names></name>, and <name><surname>Mollinger</surname><given-names>L</given-names></name>, &#x0201c;<article-title>Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up &#x00026; Go Test, and gait speeds</article-title>,&#x0201d; <source>Phys Ther</source>, vol. <volume>82</volume>, pp. <fpage>128</fpage>&#x02013;<lpage>37</lpage>, <month>2</month>
<year>2002</year>.<pub-id pub-id-type="pmid">11856064</pub-id></mixed-citation></ref><ref id="R30"><label>[30]</label><mixed-citation publication-type="journal"><name><surname>Shrout</surname><given-names>PE</given-names></name> and <name><surname>Fleiss</surname><given-names>JL</given-names></name>, &#x0201c;<article-title>Intraclass correlations: Uses in assessing rater reliability</article-title>,&#x0201d; <source>Psychological Bulletin</source>, vol. <volume>86</volume>, pp. <fpage>420</fpage>&#x02013;<lpage>428</lpage>, <year>1979</year>.<pub-id pub-id-type="pmid">18839484</pub-id></mixed-citation></ref><ref id="R31"><label>[31]</label><mixed-citation publication-type="book"><name><surname>Fleiss</surname><given-names>JL</given-names></name>, <source>The design and analysis of clinical experiments</source>: <publisher-name>Wiley</publisher-name>, <year>1986</year>.</mixed-citation></ref><ref id="R32"><label>[32]</label><mixed-citation publication-type="journal"><name><surname>Wilson</surname><given-names>CM</given-names></name>, <name><surname>Kostsuca</surname><given-names>SR</given-names></name>, and <name><surname>Boura</surname><given-names>JA</given-names></name>, &#x0201c;<article-title>Utilization of a 5-Meter Walk Test in Evaluating Self-selected Gait Speed during Preoperative Screening of Patients Scheduled for Cardiac Surgery</article-title>,&#x0201d; <source>Cardiopulm Phys Ther J</source>, vol. <volume>24</volume>, pp. <fpage>36</fpage>&#x02013;<lpage>43</lpage>, <month>9</month>
<year>2013</year>.<pub-id pub-id-type="pmid">23997690</pub-id></mixed-citation></ref><ref id="R33"><label>[33]</label><mixed-citation publication-type="journal"><name><surname>Soangra</surname><given-names>R</given-names></name>, <name><surname>Lockhart</surname><given-names>TE</given-names></name>, <name><surname>Lach</surname><given-names>J</given-names></name>, and <name><surname>Abdel-Rahman</surname><given-names>EM</given-names></name>, &#x0201c;<article-title>Effects of hemodialysis therapy on sit-to-walk characteristics in end stage renal disease patients</article-title>,&#x0201d; <source>Ann Biomed Eng</source>, vol. <volume>41</volume>, pp. <fpage>795</fpage>&#x02013;<lpage>805</lpage>, <month>4</month>
<year>2013</year>.<pub-id pub-id-type="pmid">23212801</pub-id></mixed-citation></ref><ref id="R34"><label>[34]</label><mixed-citation publication-type="journal"><name><surname>Lockhart</surname><given-names>TE</given-names></name>, <name><surname>Barth</surname><given-names>AT</given-names></name>, <name><surname>Zhang</surname><given-names>X</given-names></name>, <name><surname>Songra</surname><given-names>R</given-names></name>, <name><surname>Abdel-Rahman</surname><given-names>E</given-names></name>, and <name><surname>Lach</surname><given-names>J</given-names></name>, &#x0201c;<article-title>Portable, Non-Invasive Fall Risk Assessment in End Stage Renal Disease Patients on Hemodialysis</article-title>,&#x0201d; <source>ACM Trans Comput Hum Interact</source>, pp. <fpage>84</fpage>&#x02013;<lpage>93</lpage>, <year>2010</year>.<pub-id pub-id-type="pmid">22124286</pub-id></mixed-citation></ref><ref id="R35"><label>[35]</label><mixed-citation publication-type="journal"><name><surname>Graham</surname><given-names>JE</given-names></name>, <name><surname>Ostir</surname><given-names>GV</given-names></name>, <name><surname>Kuo</surname><given-names>YF</given-names></name>, <name><surname>Fisher</surname><given-names>SR</given-names></name>, and <name><surname>Ottenbacher</surname><given-names>KJ</given-names></name>, &#x0201c;<article-title>Relationship between test methodology and mean velocity in timed walk tests: a review</article-title>,&#x0201d; <source>Arch Phys Med Rehabil</source>, vol. <volume>89</volume>, pp. <fpage>865</fpage>&#x02013;<lpage>72</lpage>, <month>5</month>
<year>2008</year>.<pub-id pub-id-type="pmid">18452733</pub-id></mixed-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1:</label><caption><p id="P21">Laboratory set-up for determining gait velocity in healthy participants</p></caption><graphic xlink:href="nihms-937919-f0001"/></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2:</label><caption><p id="P22">The start and stop events described by the resultant acceleration and the variance. The start event is triggered when the variance exceeds the threshold (dashed red line). The stop event is triggered when the variance drops below the threshold.</p></caption><graphic xlink:href="nihms-937919-f0002"/></fig><fig id="F3" orientation="portrait" position="float"><label>Figure 3:</label><caption><p id="P23">Clinical set-up for determining gait velocity in cardiac patients.</p></caption><graphic xlink:href="nihms-937919-f0003"/></fig><fig id="F4" orientation="portrait" position="float"><label>Figure 4:</label><caption><p id="P24">Above figure shows relationship among (slow, normal and fast walking) velocities from camera system and that by stopwatch and smartphone in laboratory environment</p></caption><graphic xlink:href="nihms-937919-f0004"/></fig><fig id="F5" orientation="portrait" position="float"><label>Figure 5:</label><caption><p id="P25">Walking speed trials measured concurrently through systems:1. Camera system 2. Stopwatch and 3. Smartphone</p></caption><graphic xlink:href="nihms-937919-f0005"/></fig><fig id="F6" orientation="portrait" position="float"><label>Figure 6:</label><caption><p id="P26">Velocities from three measurement systems in clinical environment</p></caption><graphic xlink:href="nihms-937919-f0006"/></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1:</label><caption><p id="P27">Intra-class correlation for consistency and absolute agreement for three walking speed and three systems (camera, stopwatch and smartphone)</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Walking speed</th><th align="left" valign="top" rowspan="1" colspan="1">Intra-class correlation Consistency</th><th align="left" valign="top" rowspan="1" colspan="1">Intra-class correlation Absolute Agreement</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Slow</bold></td><td align="left" valign="top" rowspan="1" colspan="1">0.821</td><td align="left" valign="top" rowspan="1" colspan="1">0.559</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Normal</bold></td><td align="left" valign="top" rowspan="1" colspan="1">0.666</td><td align="left" valign="top" rowspan="1" colspan="1">0.419</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Fast</bold></td><td align="left" valign="top" rowspan="1" colspan="1">0.701</td><td align="left" valign="top" rowspan="1" colspan="1">0.404</td></tr></tbody></table></table-wrap></floats-group></article>