Details:

Alternative Title:
J Allergy Clin Immunol
Personal Author:
Su, John R. ; Moro, Pedro L. ; Ng, Carmen S. ; Lewis, Paige W. ; Said, Maria A. ; ... More +
Su, John R. ; Moro, Pedro L. ; Ng, Carmen S. ; Lewis, Paige W. ; Said, Maria A. ; Cano, Maria V. Less -
Description:
Background:

Anaphylaxis, a rare and potentially life-threatening hypersensitivity reaction, can occur after vaccination.

Objective:

We sought to describe reports of anaphylaxis after vaccination made to the Vaccine Adverse Event Reporting System (VAERS) during 1990–2016.

Methods:

We identified domestic reports of anaphylaxis within VAERS using a combination of Medical Dictionary for Regulatory Activity queries and Preferred Terms. We performed a descriptive analysis, including history of hypersensitivity (anaphylaxis, respiratory allergies, and drug allergies) and vaccines given. We reviewed all serious reports and all nonserious reports with available medical records to determine if they met the Brighton Collaboration case definition for anaphylaxis or received a physician’s diagnosis.

Results:

During the analytic period, VAERS received 467,960 total reports; 828 met the Brighton Collaboration case definition or received a physician’s diagnosis of anaphylaxis: 654 (79%) were classified as serious, and 669 (81%) had medical records available. Of 478 reports in children aged less than 19 years, 65% were male; childhood vaccines were most commonly reported. Of 350 reports in persons aged 19 years or greater, 80% were female, and influenza vaccines were most frequently reported. Overall, 41% of reports described persons with no history of hypersensitivity. We identified 8 deaths, 4 among persons with no history of hypersensitivity.

Conclusion:

Anaphylaxis after vaccination is rare in the United States and can occur among persons with no history of hypersensitivity. Most persons recover fully with treatment, but serious complications, including death, can occur. (J Allergy Clin Immunol 2019;143:1465–73.)


Subjects:
[+]
Adverse Event Anaphylaxis Article Brighton Epidemiology Hypersensitivity Vaccine Vaccine Adverse Event Reporting System
Source:
J Allergy Clin Immunol. 143(4):1465-1473
Pubmed ID:
30654049
Pubmed Central ID:
PMC6580415
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f138047f6b437d2ae7a00e8015dcaa6e4722c665a2d5912b07008396fe549da5
Download URL:
https://stacks.cdc.gov/view/cdc/79150/cdc_79150_DS1.pdf
File Type:

Supporting Files

• nihms-1032255.nxml

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