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Safety Surveillance of Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) Vaccines
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June 04 2018
Source: Pediatrics. 142(1)
Details:
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Alternative Title:Pediatrics
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Personal Author:
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Description:Objective:
To assess the safety of currently licensed diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines in the US using data from the Vaccine Adverse Event Reporting System (VAERS), a spontaneous reporting surveillance system.
Methods:
We searched VAERS for US reports for DTaP vaccinations occurring during January 1, 1991, through December 31, 2016, and received by March 17, 2017. We reviewed available medical records for all death reports and a random sample of reports classified as non-death serious. We used empirical Bayesian data mining to identify adverse events that were disproportionally reported after DTaP vaccination.
Results:
VAERS received 50,157 reports after DTaP vaccination; 43,984 (87.7%) of them reported concomitant administration of other vaccines, and 5,627 (11%) were serious. Median age at vaccination was 19 months (interquartile range 35 months). The most frequently reported events were injection site erythema (12,695; 25.3%), pyrexia (9,913; 19.8%), injection site swelling (7,542; 15.0%), erythema (5,594; 11.2%), and injection site warmth (4,793; 9.6%). For three of the DTaP vaccines, empirical Bayesian data mining identified elevated values for vaccination errors.
Conclusion:
No new or unexpected AEs were detected. The observed disproportionate reporting for some non-serious vaccination errors calls for better education of vaccine providers on the specific indications for each of the DTaP vaccines.
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Source:
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Pubmed ID:29866795
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Pubmed Central ID:PMC6476554
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