There has been remarkable progress in confronting the global HIV epidemic. More than 19.5 million people living with HIV (PLHIV) have received access to antiretroviral therapy, and the number of new HIV infections appears to be decreasing in several countries [1]. Investments in research, particularly in identifying effective HIV prevention and treatment methods, have played a significant role in this success [1]. As the scale-up of HIV treatment has enabled PLHIV to live longer, noncommunicable diseases (NCDs), often referred to as non-AIDS events, have become major causes of morbidity and mortality [2–4]. This new reality is consistent with the overall emerging crisis of NCDs in sub-Saharan Africa (SSA) [5]. In response, global health agencies, such as the WHO and the Joint United Nations Program on HIV/AIDS, have recently called for eliminating parallel health systems and suggested integrating care for NCDs into existing HIV care platforms, and the Council on Foreign Relations suggested that HIV platforms could be expanded to include treatment for NCDs [5–7]. This particular approach to developing an enhanced health system avoids making duplicate platforms by creating one that applies the lessons learned from HIV care and treatment to NCDs. To address the developing threat of NCDs among PLHIV through integrated HIV/NCD care, programs need new evidence-based models and guidance. Little is known about the extent to which NCDs are being managed in HIV care settings and what needs to be done to ensure that such care is delivered. In response, we designed a consensus process to assess current evidence and experience and to establish a research agenda for enhancing NCD management in HIV care settings in SSA.

The Center for Global Health Studies at the US National Institutes of Health’s (NIH) Fogarty International Center (FIC) established an interagency, interdisciplinary team to develop a research agenda focused on the prevention and management of selected, high-burden NCDs in PLHIV in SSA. This effort entitled, ‘Research to Guide Practice: Enhancing HIV/AIDS Platforms to Address NCDs in SSA’ (the HIV/NCD project), was managed through an interagency group and guided by an interdisciplinary, international Steering Committee led by select members of the FIC Advisory Board. More than 40 individuals (project members) involved in global health research, policy development, community engagement, research funding, and program design and management in SSA countries provided input on currently available evidence regarding prevention, care, and treatment for HIV and four selected NCDs in SSA: cardiovascular diseases, cervical cancer, depression, and type 2 diabetes. These NCDs were selected based on the following: available data of the condition or related risk factors in PLHIV; known patho-physiological connection with HIV; association with reported HIV outcomes including morbidity and mortality amongst PLHIV; known costeffective interventions to prevent and treat the selected NCD in low-resource settings [8–16]; and NIH institute interest in and ability to engage specific areas of focus. Although the focus of this effort was on countries in SSA, it was anticipated that the lessons and strategies that emerge from these countries will likely be relevant to other low-resource settings globally.

Through a process outlined in Table 1, we performed literature reviews and conducted priority setting meetings and workshops culminating with the writing and publication of the articles in this supplement: Research to Guide Practice: Enhancing HIV/AIDS Platform to Address Non-Communicable Diseases in sub-Saharan Africa. Project members conducted scoping reviews ofwhat is currently being done in the field of NCD prevention, care, and treatment for PLHIV in SSA by examining peer-reviewed and gray literature focused on the four selected NCDs [17]. We searched the bibliographic databases PubMed/MEDLINE and Scopus in February, April, and November of 2015, and March of 2016 to identify peer-reviewed literature, published after 2010, on PLHIV and NCDs in low-income and middle-income countries. Search terms used included controlled vocabulary terms (Medical Subject Headings) and keywords recommended by subject matter experts and by reviewing key articles and included variations of key concepts such as PLHIV, NCDs, SSA, continuum of care, prevalence, health systems, behavior change, and dissemination. In addition to literature searches, the bibliographies of key articles and systematic reviews were examined for relevant literature, and gray literature was identified via searches of Google, Google Scholar, and key organizational websites. Project members reviewed the relevant articles related to the four NCDs of interest among PLHIV. The resulting analysis reported and identified gaps for integration of NCDs into the HIV clinical continuum of care, piloting and scaling-up an integrated chronic care health system, and enhancing HIV/NCD community engagement and health promotion efforts.

Project members examined the scoping reviews and identified research gaps that informed the development of the prioritized research agenda presented in this article. Through the analysis and discussion, they identified pilot HIV/NCD programs in SSA that were critically examined at a subsequent workshop as potential scalable models. The result of the reviews, workshop, and supplement planning is a series of 11 articles developed by the project members and their collaborators that articulate the urgent research and capacity-building priorities associated with managing NCDs among PLHIV Each article presents the state of the science, lessons learned, and key research questions pertaining to specific aspects of building and sustaining an integrated chronic care platform [18].

The scoping reviews identified substantial gaps in knowledge and significant opportunities for future research to determine the most effective way to integrate NCD management into existing HIV platforms. One important finding was that data on the prevalence and incidence of NCDs amongst PLHIV in SSA are sparse. Although there are a few published surveys establishing the prevalence of NCDs and related risk factors in the general population [19] and even fewer surveys that have routinely gathered NCD incidence or risk factor prevalence among PLHIV, there is some available information on these NCDs and their risk factors among PLHIV in SSA [20]. Policymakers and implementers reinforced the need for these data to obtain unbiased estimates ofthe magnitude of the NCD threat in PLHIV, without which it is difficult to assess the size of the needed investment in NCD for PLHIV or to determine any progress made once such care is initiated [21].

Members determined that HIV treatment strategies can incorporate NCDs to improve clinical outcomes and primary and secondary prevention for both HIV and NCDs. Although the gradual rise of global NCDs presents a different scenario than the swift and deadly global HIV epidemic, members found that the systems required to address both chronic infections such as HIV and noninfectious chronic diseases have common elements that could leverage existing health system structures heretofore focused solely on HIV prevention and treatment. The review also noted that there were few published studies that described programs that integrated HIV and NCD care which makes it difficult to extrapolate the results to policy recommendations for scale-up. Much research is needed in this area. Recognizing that integrating HIV and NCD services at scale requires leveraging the underlying health system structures, project members further identified the research priorities related to various health system components in SSA including the health workforce [22], supply chain [23], health promotion [24], healthcare delivery models [25], cost and cost-effectiveness [26], and health policy [27].

Another key finding is the need for ongoing engagement between research and programs/policies that will ensure that there is adequate knowledge exchange such that studies take into account the concerns and experiences of implementers and policymakers and research results are translated into new care paradigms. In addition, community and patient engagement is critical to ensuring that implemented activities are acceptable to and embraced by the key stakeholder population. Efforts to combat the global HIV epidemic have relied upon collaborative partnerships and provide many lessons learned about how to form and maintain these collaborations [28]. Thus, implementation science, which relies on key stakeholder involvement, provides an opportunity to study HIV/NCD integration activities in real-world settings and at scale [29].

As an outcome of both the scoping reviews and the articles included in the supplement, members developed robust research agendas that outline the fundamental areas for future development (Table 2). This agenda is presented through a modification of WHO’s health system building blocks (Fig. 1) that represents the foci of research activities necessary for developing an integrated chronic care platform.

The identified research questions map across these health system building blocks and include questions that are cross-cutting in nature. Table 2 outlines the research agenda initially developed through the scoping reviews and project member discussions and the set of research questions from each article in the supplement. These questions fall into four thematic areas:

As countries seek to address the growing NCD epidemic in SSA, new evidence to address gaps in knowledge is urgently needed. If implemented, the research agenda we propose aims to generate this evidence across critical areas of the health system to enable evidence-informed scale up of HIV/NCD care services for PLHIV. We believe that this research will also be relevant to and inform chronic care for the general population beyond PLHIV For instance, the development of a reliable supply chain that can accommodate diagnostic and treatment supplies for a myriad of conditions beyond HIV could be scaled up to the general population. Likewise, a health workforce capable of caring for NCDs among PLHIV could also address chronic diseases in the general population.

The diversity of research questions identified through the HIV/NCD Project requires the engagement of a wide range of scientific disciplines, including clinical research, healthcare management science, health economics, behavioral and communications science, health systems research, policy research, information technology, and epidemiology and surveillance. Implementation science will play a key role in informing efforts to effectively integrate known services and bring such innovations to scale.

There are encouraging signs of efforts to address some of the questions identified in the research agenda. Several NIH institutes and centers, including the National Institute of Mental Health, the National Cancer Institute, the National Heart, Lung and Blood Institute, and the FIC, all members of this project, have established funding announcements and notices that provide support to answer the key questions in the research agenda [30–32].

Additional engagement and support from all relevant stakeholders, including funding agencies, researchers, program implementers, the community, multilateral organizations, and policymakers are needed to systematically answer the many critical questions that stand in the way of moving the integration efforts forward. Timely dissemination of the research results will promote quick uptake of the evidence to inform policies and programs. At all levels – national, international, and multilateral – partnerships need to be established to address the dual challenges of HIV and NCDs. Many of the innovative partnerships developed for the HIV epidemic provide opportunities to evaluate lessons learned that could be applicable to NCD care. Other partnerships may need to be re-envisioned for NCDs and new mechanisms may need to be established.

As efforts continue to address the threat of NCDs among PLHIV, much can be done to build upon the investments to date in strengthening the HIV platform. Implementation of integrated chronic care is critical to sustain the public health gains made through investments in HIV prevention and care. This holistic approach has potential benefits for both HIV and NCD prevention and treatment. However, many gaps in knowledge stand in the way of progress, and policymakers need a solid evidence base to inform their decision-making. The research agenda developed by this HIV/NCD project offers a pathway forward that can serve as a roadmap for funders, policymakers and researchers.