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Subclinical Markers of Cardiovascular Disease Among Police Officers: A Longitudinal Assessment of the Cortisol Awakening Response and Flow Mediated Artery Dilation
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September 2018
Source: J Occup Environ Med. 60(9):853-859
Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective:
To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a seven-year period.
Methods:
Baseline CAR was obtained from four saliva samples taken fifteen minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend.
Results:
Officers (n=172; 81% men) had a mean±SD age of 41±7.6 years. Men in the lowest AUCI tertile (i.e., atypical waking cortisol pattern) had a significantly larger seven-year mean decline in FMD% (mean±SE: −2.56±0.64) compared to men in the highest tertile (−0.89±0.69) (p=0.0087).
Conclusion:
An awakening cortisol AUCI predicted worsening of FMD% approximately seven years later among male officers.
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Subjects:
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Pubmed ID:29787400
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Pubmed Central ID:PMC6380888
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