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Serological Assessment of 18 Pathogens and Risk for AIDS-associated Non-Hodgkin Lymphoma

Published Date:

Mar 01 2019

Source:

J Acquir Immune Defic Syndr. 80(3):e53-e63

Language:

English

Public Access Version Available on: March 01, 2020

Please check back on the date listed above.

Details:

Personal Authors:

Halec, Gordana ; Waterboer, Tim ; Brenner, Nicole ; Butt, Julia ; Hardy, David W. ; ... More ▼

Keywords:

[+]

Pubmed ID:

30531297

Pubmed Central ID:

PMC6375787

Description:

Background:

HIV infection is associated with increased susceptibility to common pathogens which may trigger chronic antigenic stimulation and hyperactivation of B-cells, events known to precede the development of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL).

Methods:

To explore whether cumulative exposure to infectious agents contributes to AIDS-NHL risk, we tested sera from 199 AIDS-NHL patients (pre-NHL, average lead-time 3.9 years) and 199 matched HIV-infected controls from the Multicenter AIDS Cohort Study (MACS), for anti-IgG responses to 18 pathogens using multiplex serology. Odds ratios and 95% confidence intervals were estimated using conditional logistic regression models.

Results:

We found no association between cumulative exposure to infectious agents and AIDS-NHL risk (OR 1.01, 95% CI 0.91–1.12). However, seropositivity for trichodysplasia spinulosa polyomavirus (TSPyV), defined as presence of antibodies to TSPyV capsid protein VP1, was significantly associated with a 1.6-fold increase in AIDS-NHL risk (OR 1.62, 95% CI 1.02–2.57). High Epstein-Barr virus (EBV) anti-VCA p18 antibody levels closer to the time of AIDS-NHL diagnosis (<4 years) were associated with a 2.6-fold increase in AIDS-NHL risk (OR 2.59, 95% CI 1.17–5.74). Additionally, high EBV anti-EBNA-1 and anti-ZEBRA antibody levels were associated with 2.1-fold (OR 0.47, 95% CI 0.26–0.85) and 1.6-fold (OR 0.57, 95% CI 0.35–0.93) decreased risk for AIDS-NHL, respectively.

Conclusions:

Our results do not support the hypothesis that cumulative exposure to infectious agents contributes to AIDS-NHL development. However, the observed associations with respect to TSPyV seropositivity and EBV antigen antibody levels offer additional insights into the pathogenesis of AIDS-NHL.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Main Document Checksum:

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Supporting Files:

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