10118662430479Pediatr Blood CancerPediatr Blood CancerPediatric blood & cancer1545-50091545-501730350913631402010.1002/pbc.27501HHSPA995376ArticleRacial and ethnic differences in survival of pediatric patients with brain and central nervous system cancer in the United StatesSiegelDavid A.http://orcid.org/0000-0003-1394-078212LiJun2DingHelen3SinghSimple D.2KingJessica B.2PollackLori A.2Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GeorgiaDivision of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GeorgiaDB Consulting Group, Inc., Atlanta, GeorgiaCorrespondence: David A. Siegel, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE; Mailstop F-76, Atlanta, GA 30341. DSiegel@cdc.gov211201823102018220190122020662e27501e27501Background:

Brain and central nervous system (CNS) cancer is the leading cause of cancer death among children and adolescents in the United States. Data from earlier studies suggested racial and ethnic differences in survival among pediatric patients with brain tumor. This study examined racial/ethnic difference in survival using national data and considered the effects of demographic and clinical factors.

Methods:

Using National Program of Cancer Registries data, 1-, 3-, and 5-year relative survival (cancer survival in the absence of other causes of death) was calculated for patients with brain and CNS cancer aged < 20 years diagnosed during 2001–2008 and followed up through 2013. Racial and ethnic differences in survival were measured by sex, age, economic status, stage, anatomic location, and histology. Adjusted racial and ethnic difference in 5-year cancer specific survival was estimated using multivariable Cox regression analysis.

Results:

Using data from 11 302 patients, 5-year relative survival was 77.6% for non-Hispanic white patients, 69.8% for non-Hispanic black patients, and 72.9% for Hispanic patients. Differences in relative survival by race/ethnicity existed within all demographic groups. Based on multivariable analysis, non-Hispanic black patients had a higher risk of death at 5 years after diagnosis compared to non-Hispanic white patients (adjusted hazard ratio = 1.2, 95% confidence interval, 1.1–1.4).

Conclusions:

Pediatric brain and CNS cancer survival differed by race/ethnicity, with non-Hispanic black patients having a higher risk of death than non-Hispanic white patients. Future investigation of access to care, social and economic barriers, and host genetic factors might identify reasons for disparities in survival.

brain tumorsCNS tumorsepidemiologyoutcomes researchpediatric oncologytumors (brain)INTRODUCTION

Brain and central nervous system (CNS) cancer in the United States is the second most common form of pediatric cancer after leukemia and is the leading cause of death from pediatric cancer.1 Survival for patients with many different types of pediatric brain and CNS cancer has increased over the past four decades.2–4 However, one in four children with brain cancer still dies within 5 years of his/her diagnosis, and survival is worse for some brain and CNS cancer histologic types.5 Although it is well known that survival of patients with pediatric brain and CNS cancer is dependent on several factors, including age at diagnosis, stage, histology type, anatomic location, grade, and treatment, the association of race and ethnicity with survival is less well known.

Although differences in survival by race and ethnicity are described in pediatric populations with cancers other than brain and CNS cancer4,6–9 and among adults with brain and CNS cancer,10,11 differences are less well described for pediatric brain and CNS cancer.6 Past reports of pediatric brain and CNS cancer and race and ethnicity have documented differences in survival by race and ethnicity for specific histology types12,13 or in specific US states.14,15 National reports of pediatric brain and CNS cancer have documented worse outcomes among black patients compared to white patients, but have used <28% population coverage16–19 and older data,16–18 and some did not assess Hispanic ethnicity.17,18 Given geographic differences in pediatric brain cancer incidence and survival,5,20 a national study with higher percent population coverage can better describe regional variation by race/ethnicity.

The purpose of this study is to describe racial and ethnic differences in pediatric brain and CNS cancer survival by utilizing newly available data from the Centers for Disease Control and Prevention’s National Program of Cancer Registries (NPCR) and to better understand the impact of demographic and clinical factors on racial and ethnic differences in survival. An analysis of pediatric brain and CNS cancer survival using recent data, higher population coverage than past studies, and data on Hispanic versus non-Hispanic ethnicity could help researchers better understand differences in survival based upon race and ethnicity and identify target areas for monitoring and intervention to address health disparities.

METHODSData

Survival data were available from cancer registries affiliated with the Centers for Disease Control and Prevention’s NPCR November, 2016 submission.21 Data were abstracted from patient medical records and were collected from 34 NPCR central cancer registries that met the publication criteria for inclusion in United States Cancer Statistics22 and conducted linkage with the National Death Index or conducted active patient follow-up. The state cancer registries included in the analysis were from Alabama, Alaska, Arizona, California, Colorado, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maine, Maryland, Michigan, Minnesota, Mississippi, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Oregon, Pennsylvania, Rhode Island, South Carolina, Vermont, West Virginia, Wisconsin, and Wyoming. These data cover 67% of the US population.

This study includes patients with brain and CNS cancer diagnosed at <20 years of age. Brain cancer was defined by International Classification of Diseases for Oncology, Third Edition (ICD-O-3) codes.23 Anatomic status (Supplementary Table S1) and malignant histology (Supplementary Table S2) ICD-O-3 codes were grouped as has been done previously by the Central Brain Tumor Registry of the United States,24 except lymphoma and other hematopoietic neoplasms were excluded from this study. Only malignant tumors were included in our analysis as defined by a behavior recode value of 3.25 Only microscopically confirmed cancer cases were included in accordance with NPCR survival database protocol. Patients with multiple cancers were included in this study only if the first primary diagnosis was a brain and CNS cancer. Patients with unknown sex, age, race, or ethnicity and those identified solely on the basis of a death certificate or autopsy were not included in the dataset. To improve the quality of cause-specific survival analysis, 30 patients were excluded that were associated with two cancer diagnoses and also had a cancer-related cause of death, as study authors could not verify which of the two cancers was the cause of death. Two additional patients with discrepant behavior codes were excluded.

Analysis

Using state-specific annual US life tables stratified by sex and race/ethnicity (all races, non-Hispanic white, non-Hispanic black, Hispanic, non-Hispanic Asian/Pacific Islander, and non-Hispanic American Indian/Alaska Native), obtained from the National Center for Health Statistics,26 we calculated 1-, 3-, and 5-year relative survival for patients with brain and CNS cancer diagnosed during 2001–2008 with follow-up through December 31, 2013. Relative survival is the ratio of the observed all-cause survival in a group of individuals with cancer to the expected all-cause survival of a similar group of individuals who do not have cancer.27,28 Survival time for each patient was calculated using date of start of follow-up (month, day, and year) as date of diagnosis and date of last follow-up (month, day, and year) as date of death if the case was matched to the state death files or to the National Death Index. Patients with data not linking to the state death files or to the National Death Index were presumed to be alive at the end of the study period. Where day or month for date of diagnosis, date of death, or date of last contact were missing, the full date was imputed using a standard algorithm.29 Relative survival for pediatric brain cancer was calculated using the Ederer II method, by sex, age groups (0–4, 5–9, 10–14, and 15–19 years), race, ethnicity, US census region, county-based economic status, stage (Summary Stage 2000), anatomic site, and histology.30,31 Differences between relative survival estimates were made by comparison of 95% confidence intervals (CIs), which allows for an informal, yet conservative, comparison of estimates between two groups, as has been done previously.28

The non-Hispanic Asian/Pacific Islander and non-Hispanic American Indian/Alaska Native categories were grouped together to create an “other, non-Hispanic” grouping. Additionally, due to small sample sizes, anatomic sites C71.8, C71.9, and C75.1–C75.3 were analyzed together as one “other brain” variable, and anatomic sites C30.0, C70.0–C70.9, C72.0–C72.5, and C72.8–C72.9 were analyzed together as one “other CNS” variable. NPCR grouped economic status into five categories, which included “attainment” (top 10% of US counties), “competitive” (top 10+ to 25th percentile), “transitional” (25–75th percentile), “at-risk” (bottom 10+ to 25th percentile), and “distressed” (bottom 10%), as is defined by the Appalachian Regional Commission index-based county economic classification system.32 The two lowest and two highest socioeconomic status levels were each combined due to small sample sizes. Per the 2010 US Census, US counties and equivalent areas contained an average population of 98 262 individuals, with a range of 82 individuals (Loving County, TX) to 9.8 million individuals (Los Angeles County, CA).33 Relative survival analyses were performed using SEER*Stat 8.3.4 (https://seer.cancer.gov/seerstat/).

Survival curves for race/ethnicity were generated using the Kaplan-Meier method. Statistical testing for survival curves was performed using logrank test, and 95% Hall-Wellner confidence bands34 were computed for each survival curve. A multivariable Cox regression model was conducted to examine the effect of race/ethnicity adjusting for specific sociodemographic (sex, age, region, and economic status) and clinical factors (stage, anatomic location, and histology type) on 5-year cause-specific survival, where brain and CNS cancer was reported as the cause of death. A brain and CNS cancer related cause of death was defined by the cause of death cancer registry codes35 for “brain and other nervous system,” “miscellaneous malignant cancer,” or “in situ, benign, or unknown behavior neoplasm.” Patients with other causes of death during the follow-up period were censored from date of non-cancer-related cause of death. Due to small sample sizes, in the multivariable analysis, histology variables were grouped by larger categories (see Supplementary Table S2 for detailed information). Adjusted hazard ratio (aHR) and 95% CIs were generated for each of the variables in the model. A higher hazard ratio between compared groups indicates a higher risk of death, with statistical significance determined at P < 0.05. Multivariable analysis and generation of survival curves were performed using SAS Version 9.4.

RESULTS

During 2001–2008, 11 302 patients with primary brain and CNS cancers were identified (Table 1). Of those, 54.4% were male, 32.6% were children aged 0–4 years, 66.4% were non-Hispanic white, 12.2% were non-Hispanic black, and 17.3% were Hispanic.

Overall 5-year relative survival was 75.5% (95% CI 74.7–76.3) (Table 2). Five-year relative survival for non-Hispanic white patients (77.6%; 95% CI 76.6–78.5) was higher than the relative survival for non-Hispanic black patients (69.8%; 95% CI 67.3–72.1), Hispanic patients (72.9%; 95% CI 70.8–74.8), and patients in the other, non-Hispanic group (71.2%; 95% CI 66.9–75.1). Survival for non-Hispanic white patients was also higher than that for all other race/ethnicity demographic groups of patients 1 and 3 years after diagnosis (Supplementary Tables S3 and S4).

Non-Hispanic white patients had higher 5-year relative survival than non-Hispanic black patients and Hispanic patients for both sexes. Five-year relative survival was highest among patients aged 10–14 compared to that of all other age groups studied; 5-year relative survival was higher for non-Hispanic white patients compared to non-Hispanic black patients among the 0–4, 5–9, and the 10–14 year age groupings, and was higher for non-Hispanic white patients compared to Hispanic patients among patients aged 0–4 years. By US census region, 5-year relative survival was highest in the Midwest and Northeast US census regions and was higher among non-Hispanic white patients compared to non-Hispanic black patients in the South, and higher among non-Hispanic white patients compared to Hispanic patients in the Midwest. By economic status, 5-year relative survival differences by race and ethnicity were only seen in the middle 25–75% of counties.

By cancer stage, the majority (73.2%) of cancers were localized, 12.1% were regional, and 7.1% were distant. Cancers with a distant stage had the lowest survival. For children and adolescents with localized brain cancers, non-Hispanic white patients had higher 5-year survival than all other race/ethnicity categories. For patients with regional disease, non-Hispanic white patients had higher relative survival than non-Hispanic black patients. Survival estimates by race/ethnicity among children and adolescents with distant disease had overlapping 95% CIs.

By anatomic site, cancer in the cerebellum had the highest 5-year relative survival. Relative survival was higher among non-Hispanic white patients for cancer specific to a specific cerebral lobe (ICD-O-3 codes C71.1–C71.4) compared to non-Hispanic black patients, for ventricular cancer (ICD-O-3 code C71.5) compared to other non-Hispanic patients, and for other brain (ICD-O-3 codes C71.8-C71.9) compared to non-Hispanic black patients. By histology, 5-year relative survival was highest among patients with pilocytic astrocytomas. Five-year relative survival was higher among non-Hispanic white patients compared to non-Hispanic black patients for patients with pilocytic astrocytomas and peripheral neuroectodermal tumor, and was higher among non-Hispanic white patients compared to Hispanic patients for ependymal tumors. Medulloblastoma had higher 5-year survival among non-Hispanic black patients compared to non-Hispanic white patients, but the 95% CIs overlapped.

Plotted survival curves (Figure 1) illustrate cause-specific survival in the 5 years after diagnosis. The 95% Hall-Wellner confidence bands do not overlap between non-Hispanic white patients and non-Hispanic black patients (Figure 2A) and non-Hispanic white patients and Hispanic patients (Figure 2B), starting just after the 1-year mark after diagnosis.

Cox regression analysis of cause-specific 5-year survival of children and adolescents with brain and CNS cancer showed that patients diagnosed at ages of 5–9, 10–14, and 15–19 years had a lower risk of death than patients diagnosed at ages 0–4 years (Table 3). Non-Hispanic black patients had a higher risk of death at 5 years compared to non-Hispanic white patients (aHR 1.2, 95% CI 1.1–1.4). Patients diagnosed in the Midwest had a lower risk of death than patients diagnosed in the Northeast. Patients in the top 75% of counties by economic status had a lower risk of death than those in the bottom 25% of counties. Patients with regional and distant cancer had higher risk of death at 5 years than those with localized cancer. Cancer confined to a specific lobe had lower risk of death compared to all other anatomic groups except for the “other CNS” group, and low-grade gliomas had a lower risk of death compared to all other histology groupings.

DISCUSSION

This study describes pediatric brain and CNS cancer survival by sociodemographic and clinical factors using recent national survival data. Non-Hispanic white patients had the highest relative survival overall when compared to non-Hispanic black patients, Hispanic patients, and other non-Hispanic patients. Non-Hispanic black race/ethnicity was an independent risk marker for worse 5-year cause-specific survival compared to that of non-Hispanic white patients after adjusting for other factors.

This study’s finding of worse survival among non-Hispanic black patients mirrors past reports of racial survival differences in pediatric brain cancer drawn from older and smaller datasets4,12,14,18 or of older age groups.10,17 This study is consistent with some,12,36 but not all,16 past reports in that pediatric astrocytoma has worse survival among black patients (or non-Hispanic black patients). Discrepancies between our study and past reports might occur because of differences in population coverage, study year, or ability to control for associated factors such as treatment regimen. Our study demonstrated difference in survival based upon race and indicated worse survival among non-Hispanic black patients with pilocytic astrocytoma and primitive neuroectodermal tumor. Other cancer histology types, such as medulloblastoma, did not show a racial difference in survival by informal comparisons using 95% CIs.

Five-year relative survival was lower among Hispanic patients than among non-Hispanic white patients when comparing 95% CIs, but the multivariable analysis did not find a significant survival difference between these two groups. Differences in survival after pediatric brain cancer diagnosis by ethnicity have been previously reported in older or smaller studies.4,14,15 Austin et al’s study of racial and ethnic differences among pediatric patients with brain and CNS cancer in Texas showed worse 5-year survival among Hispanic patients.14

Five-year relative survival differences by race and ethnicity were present for patients with local and regional stage cancer but not for those with distant cancer. With respect to location, non-lobe-specific cancers of the cerebrum (ICD-O-3 code C71.0) and brain stem cancer (ICD-O-3 code C71.7) had the lowest 5-year relative survival, which is consistent with current knowledge.5 Among histology classifications, low-grade gliomas had the highest 5-year relative survival and high-grade gliomas and atypical teratoid rhabdoid tumor had the lowest relative survival, which is consistent with past reports.5,16 Survival based upon age of diagnosis is variable depending on histology type,5,12,36–38 but showed 5-year survival differences here by race and ethnicity only for patients aged 0–14.

Higher mortality in minority populations with different types of cancer in the United States has been linked to both low socioeconomic position and decreased access to care.39,40 Specifically, previous studies looking at racial and ethnic disparity in adults with brain cancer reported that black patients are less often treated by high-volume providers compared to white patients and have higher complications after brain surgery, which might result in worse outcomes.40,41 Racial and ethnic disparity in access to neurooncological surgery has been reported in pediatric patients, although decreased access among black patients was not statistically significant.42 Additionally, among pediatric patients with brain and CNS cancer, Hispanic patients present at a more advanced stage than that of non-Hispanic white patients,14 which might be due to differences in access to care. Some groups of minority patients are also less likely to be enrolled in clinical trials, which might contribute to worse survival.40,43 While lower socioeconomic position has been associated with higher mortality in some, but not all studies,14,19,39,44 our study illustrated racial and ethnic differences in survival within the same economic status (Table 2).

Racial and ethnic differences in brain cancer survival could also be related to differences in tumor biology, as past reports have described variation in tumor biology due to race, although the clinical significance is yet to be fully understood.40 Racial and ethnic differences in drug metabolism, among other host-response factors, might explain additional variation in outcomes.45

Geographic differences in cancer incidence have been previously documented in the United States and Europe using population-based cancer registries.5,20,46 Geographic differences in survival, similar to incidence, might be related to genetic, environmental, economic, or social factors.7,20,47 This study found relative survival differences between non-Hispanic white and black patients in the South and between non-Hispanic white patients, Hispanic patients, and other non-Hispanic patients in the Midwest. Additional research is needed to better understand the effect of geography on racial and ethnicity-based differences in cancer survival while adjusting for other sociodemographic and clinical variables.

The racial/ethnic distribution of cases in this study was 66.4% white non-Hispanic, 12.2% black non-Hispanic, 17.3% Hispanic, and 4.1% other non-Hispanic, whereas the US Census Bureau estimates that 60.7% of children aged 0–17 in the United States are non-Hispanic white, 13.4% are black (of any ethnicity), and 18.1% are Hispanic.48 Of individuals aged 0–19 years in the United States diagnosed with brain and CNS cancer during 2001–2008, 66.4% were non-Hispanic white, 11.6% were non-Hispanic black, 16.7% were Hispanic, and 5.3% were other non-Hispanic races.49 Because pediatric cancer incidence rates differ by race, ethnicity, and geography,5,20 treatment needs and outcome evaluation might not always reflect the racial and ethnic demographics of individuals without cancer in the specific state or region.

This study utilized new NPCR data to describe outcomes of pediatric brain and CNS cancer by race and ethnicity with greater population representation than has been available previously. These data allowed for a more detailed categorization by race, ethnicity, geography, and socioeconomic status as well as anatomic sites and histology classifications. However, this study has several limitations. As with any study that uses NPCR, data might contain misclassification of patient demographics such as race, ethnicity, and socioeconomic position.50 Second, this database included only county-based economic status, and therefore the analysis did not account for individual measures of economic status such as insurance status and household income. Third, analyses were limited to microscopically confirmed cases to reduce misclassification of tumor descriptive elements such as anatomic site and histology. However, as a result, patients with brain cancer diagnosed without pathological confirmation (eg, patients with radiographically diagnosed cancers) were not included in this study. Fourth, other factors that might differentiate groups of patients with cancer, such as treatment, molecular testing, and presence of comorbidities (eg, asthma, endocrinopathies), were not available for analysis. However, relative survival accounts for factors impacting all-cause survival for each racial/ethnic group of individuals with and without cancer.27 Fifth, given the rarity of pediatric brain cancer, survival data were sometimes calculated with small numbers. Because of the sample size, a detailed breakdown of grade, as well as American Indian/Alaska Native or Asian/Pacific Islander populations, was not performed here. Finally, because this study assumes patients are alive if their death was not linked to the National Death Index or they were not actively followed, there is a potential to overestimate survival,29,51 the magnitude of which might differ by race and ethnicity.52

This study demonstrated survival differences by race and ethnicity in patients with pediatric brain and CNS cancer. Given these differences in survival, several possible root causes need to be examined. These causes might include treatment type, health insurance status, proximity to care, economic barriers, quality of care, health literacy, clinical trial enrollment, and host or tumor genetic factors. Systemic inequality has been identified as a factor affecting outcomes in other medical fields.53,54 Identifying whether systemic inequality impacts outcomes for pediatric patients with brain and CNS cancer may help health-care providers identify actionable solutions. Further research is critical for identifying and implementing potential effective interventions that could improve long-term outcomes. Potential interventions might include policies that increase access to care among underserved groups and outreach efforts to increase clinical trial enrollment among minority populations.40,55,56 Cancer control planners could develop and evaluate public health interventions to better address the factors influencing disparity of outcomes by race and ethnicity for children and adolescents with brain and CNS cancer. Continued surveillance of survival differences by race and ethnicity using population-based cancer registry data is essential to monitor survival disparities and for gauging the effectiveness of interventions.

Supplementary MaterialACKNOWLEDGMENTS

The authors would like to thank Hannah Weir, Mary White, Reda Wilson, and state and regional cancer registry and health department personnel. The findings and conclusions are those of the authors and do not necessarily represent the official position of their affiliations or the Centers for Disease Control and Prevention.

Previous versions of this study (older data years, different methodology, and without multivariable analysis) were presented as abstracts at the following meetings: Epidemic Intelligence Service Conference (April 24, 2017), 2017 CDC National Cancer Conference (August 15, 2017), and Tenth AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved (September 26, 2017). Abstracts were submitted and then withdrawn before presentation at the 2017 ASPHO National Meeting and the 2017 American College of Epidemiology Annual Meeting, but are available in the published abstracts for those meetings.

CONFLICTS OF INTEREST

The authors have no conflicts of interest to report.

Abbreviations:aHR

adjusted hazard ratio

CI

confidence interval

CNS

central nervous system

ICD-O-3

International Classification of Diseases for Oncology, Third Edition

NPCR

National Program of Cancer Registries

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Cause-specific survival of patients with pediatric brain and central nervous system cancer, United States, diagnosed during 2001–2008; survival is displayed among non-Hispanic white patients, non-Hispanic black patients, Hispanic patients, and other, non-Hispanic grouping. P-value indicates logrank test

Cause-specific survival of patients with pediatric brain and central nervous system cancer, United States, diagnosed during 2001–2008, displayed with 95% Hall-Wellner confidence bands; the 95% Hall-Wellner confidence bands are represented by shaded areas around each line and extend to the last event times for each racial/ethnic group. P-value indicates logrank test. (A) Survival of non-Hispanic white patients compared to non-Hispanic black patients; (B) survival of non-Hispanic white patients compared to Hispanic patients; (C) survival of non-Hispanic white patients compared to the other, non-Hispanic grouping

Demographic characteristics of pediatric brain and central nervous system cancer cases, United States, cases diagnosed during 2001–2008a

CharacteristicCharacteristic SubgroupNo.%b
Total11 302100
SexMale6 15354.4
Female5 14945.6
Age (years)0–43 68732.6
5–92 81824.9
10–142 56022.7
15–192 23719.8
Race/ethnicityWhite, non-Hispanic7 50666.4
Black, non-Hispanic1 37812.2
Hispanic1 95117.3
Other, non-Hispanic4674.1
US census regionNortheast2 54522.5
Midwest2 49522.1
South3 33229.5
West2 93025.9
Economic status by countycBottom 25%1 45712.9
25–75%6 72359.5
Top 25%2 80624.8
StageLocalized8 27373.2
Regional1 37112.1
Distant8087.1
Unknown8507.5
Anatomic siteLobe2 34820.8
Cerebrum9158.1
Ventricle6425.7
Cerebellum2 95626.2
Brainstem1 43812.7
Other brain2 08318.4
Other CNS9208.1
HistologydPilocytic astrocytoma3 48030.8
Diffuse astrocytoma1 19610.6
Anaplastic astrocytoma3553.1
Unique astrocytoma variants2131.9
Glioblastoma5414.8
Oligodendroglioma2812.5
Anaplastic oligodendroglioma520.5
Oligoastrocytic tumors1731.5
Ependymal tumors9888.7
Glioma malignant, not otherwise specified5484.8
Choroid plexus tumors1050.9
Neuronal and mixed neuronal glial tumors970.9
Medulloblastoma1 68014.9
Peripheral neuroectodermal tumor5584.9
Atypical teratoid/rhabdoid tumor2882.5
Other embryonal tumors2272.0
Tumors of meninges1141.0
Germ cell tumors and cysts3072.7
Unclassified tumors690.6

Data were compiled from 34 population-based registries that participate in the Centers for Disease Control and Prevention’s National Program of Cancer Registries, and meet high-quality data criteria. The registries in the Survival Analysis Dataset cover approximately 67% of the US population. For more information, see US Cancer Statistics technical notes (http://www.cdc.gov/cancer/npcr/uscs/technical_notes/stat_methods/survival.htm).

Percentage is calculated with the denominator of 11,302.

Excludes 316 missing cases.

Excludes histology categories with <16 cases.

CNS, central nervous system.

Five-year relative survival of pediatric brain and central nervous system cancer overall and by race/ethnicity, United States, cases diagnosed during 2001–2008

TotalWhite, Non-Hispanic N = 7 506Black, Non-Hispanic N = 1 378Hispanic N = 1 951Other, Non-Hispanic N = 467
CharacteristicNo.RS(95%CI)No.RS (95% Cl)No.RS(95%CI)No.RS(95%CI)No.RS(95%CI)
Total11 30275.5 (74.7–76.3)7 50677.6(76.6–78.5)137869.8 (67.3–72.1)1 95172.9(70.8–74.8)46771.2(66.9–75.1)
Sex
 Male6 15375.2(74.1–76.3)4 15177.3 (76.0–78.6)71567.9(64.3–71.2)1 04872.2(69.4–74.8)23974.3 (68.2–79.3)
 Female5 14975.9 (74.7–77.1)3 35577.9 (76.4–79.2)66371.8(68.2–75.1)90373.6(70.6–76.4)22868.1(61.6–73.7)
Age (years)
 0–43 68770.2 (68.7–71.6)2 28972.8(71.0–74.6)46963.4(58.9–67.6)77267.4 (63.9–70.5)15765.1(57.1–72.0)
 5–92 81876.8 (75.2–78.4)1 86778.5 (76.5–80.3)36070.1(65.0–74.5)48375.2(71.1–78.8)10878.7(69.8–85.3)
 10–142 56080.1(78.5–81.6)1 76581.7 (79.8–83.5)29173.4 (67.9–78.1)39079.3(75.0–83.0)11473.8 (64.7–80.9)
 15–192 23777.6(75.8–79.2)1 58578.7(76.5–80.6)25876.8 (71.1–81.5)30674.8 (69.5–79.3)8869.5 (58.7–78.0)
US census region
 Northeast2 54576.7 (75.0–78.3)1 86477.5 (75.5–79.3)26473.0 (67.1–77.9)32674.1 (68.9–78.5)9181.4(71.7–88.0)
 Midwest2 49577.5 (75.8–79.1)1 94779.2(77.4–81.0)25773.8 (67.9–78.8)22670.9(64.5–76.4)6561.7 (48.7–72.3)
 South3 33274.7(73.2–76.1)2 19577.3 (75.4–79.0)71665.8 (62.1–69.1)36077.1(72.4–81.1)6172.2(59.1–81.7)
 West2 93073.8 (72.2–75.4)1 50075.9 (73.6–78.0)14176.8 (68.9–83.0)1 03971.4 (68.6–74.1)25069.8(63.6–75.1)
Economic status by countya
 Bottom 25%1 45773.0 (70.7–75.2)79476.3(73.1–79.1)27268.3(62.4–73.5)33469.6(64.3–74.2)5770.4(56.7–80.6)
 25–75%6 72375.7 (74.7–76.7)4 28277.8 (76.5–79.0)90870.0(66.9–72.9)1 27773.7(71.2–76.1)25671.2(65.2–76.4)
 Top 25%2 80675.7(74.1–77.3)2 15277.0 (75.1–78.7)18870.9(63.8–76.9)32672.2 (67.0–76.7)14070.8 (62.5–77.6)
Stage
 Localized8 27379.9 (79.0–80.7)5 55681.7 (80.7–82.7)101173.6 (70.7–76.2)1 36178.3 (76.0–80.4)34574.6(69.7–78.9)
 Regional1 37163.2 (60.6–65.7)85666.1 (62.9–69.2)15855.3 (47.1–62.6)30259.4 (53.6–64.7)5561.9 (47.8–73.3)
 Distant80851.7(48.2–55.1)53452.0 (47.7–56.1)8848.0 (37.2–58.0)14552.5 (44.1–60.3)4153.7(37.5–67.5)
 Unknown85075.9 (72.9–78.7)56078.2(74.5–81.4)12172.9 (64.0–80.0)14370.1(61.8–76.9)2673.2 (51.7–86.3)
Anatomic site
 Lobe2 34875.9(74.1–77.6)1 57977.9(75.7–79.9)29270.1(64.5–75.1)37273.5 (68.7–77.7)10569.6(59.8–77.5)
 Cerebrum91562.4(59.2–65.5)59165.1(61.1–68.8)13053.2(44.3–61.4)16160.4(52.4–67.5)3360.7 (42.0–75.0)
 Ventricle64273.5 (69.9–76.8)41177.3(72.9–81.1)7170.7(58.5–79.8)13567.5 (58.9–74.7)2552.1(31.3–69.3)
 Cerebellum2 95682.3 (80.9–83.7)1 99283.7(82.0–85.3)31780.4(75.5–84.4)51679.8 (76.0–83.0)13175.7 (67.4–82.2)
 Brainstem1 43867.0 (64.5–69.4)95269.2 (66.2–72.1)16460.6(52.6–67.6)26763.8 (57.7–69.2)5563.7 (49.6–74.9)
 Other brain2 08375.6 (73.7–77.4)1 34277.2 (74.9–79.4)28668.8 (63.0–73.9)37474.4 (69.7–78.6)8178.0 (67.3–85.6)
 Other CNS92080.5 (77.8–83.0)63982.4(79.2–85.1)11873.2 (64.1–80.3)12678.7 (70.4–84.9)3778.5 (61.5–88.7)
Histologyb
 Pilocytic astrocytoma3 48096.7(96.0–97.2)2 42397.2 (96.5–97.8)40994.4(91.6–96.3)53895.5 (93.3–97.0)11098.3(92.8–99.6)
 Diffuse astrocytoma1 19682.6 (80.3–84.7)82583.6 (80.8–85.9)14275.7(67.7–82.0)18582.8(76.6–87.6)4486.6(72.2–93.8)
 Anaplastic astrocytoma35527.4(22.9–32.1)22629.3 (23.5–35.3)4920.5(10.6–32.7)-26.5 (16.7–37.3)--
 Unique astrocytoma variants21377.2 (70.9–82.3)13277.4 (69.3–83.7)3979.7(63.3–89.4)-73.8(56.7–85.0)--
 Glioblastoma54120.8 (17.5–24.3)32521.6 (17.3–26.2)9615.7(9.3–23.7)8724.2(15.8–33.6)3318.2 (7.4–32.9)
 Oligodendroglioma28194.5 (91.0–96.7)20095.2(91.0–97.4)3792.1(76.9–97.4)-94.8(80.5–98.7)--
 Anaplastic Oligodendroglioma5246.3 (32.4–59.1)3354.7 (36.4–69.8)-----
 Oligoastrocytic tumors17380.6 (73.8–85.8)13279.8 (71.8–85.7)--2085.1(60.3–95.0)--
 Ependymal tumors98875.3 (72.4–77.8)60479.6 (76.2–82.6)12769.5 (60.7–76.8)20764.4(57.4–70.5)5082.1(68.3–90.3)
 Glioma malignant, not otherwise specified54868.4 (64.3–72.1)38271.1 (66.2–75.4)6560.1(47.2–70.9)8264.7 (53.3–74.0)1958.0 (33.2–76.3)
 Choroid plexus tumors10560.2 (50.2–68.9)5660.9 (46.9–72.3)--3470.7 (52.3–83.1)--
 Neuronal and mixed neuronal glial tumors9779.6 (70.0–86.3)6479.8 (67.7–87.8)1883.5 (56.7–94.4)---
 Medulloblastoma1 68072.0 (69.8–74.1)1 12472.5 (69.8–75.0)16274.3 (66.8–80.4)31269.7 (64.2–74.4)8269.6 (58.4–78.4)
 Peripheral neuroectodermal tumor55849.6 (45.3–53.6)34052.4 (47.0–57.6)6734.4(23.4–45.8)12253.4(44.1–61.7)2934.5(18.2–51.5)
 Atypical teratoid/rhabdoid tumor28827.5 (22.5–32.8)17829.9 (23.3–36.7)4216.8 (7.4–29.5)-31.0(19.4–43.3)--
 Other embryonal tumors22770.3 (63.9–75.8)14472.5 (64.3–79.0)3858.3 (41.0–72.1)-75.2 (58.6–85.9)--
 Tumors of meninges11462.4 (52.8–70.6)8258.7 (47.2–68.5)-~1764.8 (37.7–82.4)--
 Germ cell tumors and cysts30784.6 (80.0–88.2)17583.6 (77.2–88.4)2692.4(72.5–98.1)7482.6 (71.8–89.5)3287.5(70.1–95.1)
 Unclassified tumors6956.7 (44.2–67.4)4557.9 (42.2–70.7)1662.7 (34.9–81.3)----

CI, confidence interval; CNS, central nervous system; RS, relative survival.

Data were compiled from 34 population-based registries that participate in the Centers for Disease Control and Prevention’s National Program of Cancer Registries, and meet high-quality data criteria. The registries in the Survival Analysis Dataset cover approximately 67% of the US population. For more information, see US Cancer Statistics technical notes (http://www.cdc.gov/cancer/npcr/uscs/technical_notes/stat_methods/survival.htm).

Suppresses any cell with <16 cases. Per National Program of Cancer Registries complementary cell suppression rules—counts for one or more additional cells must be suppressed if a single cell is suppressed.

Bold indicates nonoverlapping 95% CIs when comparing non-Hispanic white to non-Hispanic black, Hispanic, or other, non-Hispanic.

Excludes 316 missing cases.

Excludes histology categories with <16 cases

Risk factors for 5-year survival difference by race in children and adolescents with brain and central nervous system cancer, United States, cases diagnosed during 2001–2008

Risk FactorHazard Ratio95% ClP-value
Sex
 MaleReference
 Female0.960.89–1.050.362
Age of diagnosis (years)
 0–4Reference
 5–90.680.60–0.76<0.001
 10–140.660.58–0.75<0.001
 15–190.770.70–0.86<0.001
Race/ethnicity
 White, non-HispanicReference
 Black, non-Hispanic1.241.10–1.40<0.001
 Hispanic1.020.91–1.140.784
 Other, non-Hispanic1.140.94–1.380.185
US census region
 NortheastReference
 Midwest0.760.66–0.87<0.001
 South1.020.91–1.150.723
 West1.060.94–1.190.380
Economic status
 Bottom 25%Reference
 25–75%0.870.77–0.980.021
 Top 25%0.780.68–0.90<0.001
 Unknown1.170.86–1.600.312
Stage
 LocalizedReference
 Regional1.501.34–1.67<0.001
 Distant2.041.79–2.32<0.001
 Unknown0.980.83–1.160.818
Anatomic site
 LobeReference
 Brainstem2.081.80–2.40<0.001
 Cerebrum1.941.67–2.26<0.001
 Other CNS0.730.59–0.910.004
 Other brain1.321.15–1.52<0.001
 Ventricle1.321.08–1.610.006
 Cerebellum1.191.01–1.400.041
Histology
 Low-grade gliomaReference
 High-grade glioma21.3718.33–24.91<0.001
 Ependymoma3.372.80–4.06<0.001
 Medulloblastoma4.213.55–5.01<0.001
 Other5.874.95–6.95<0.001
 Other glioma4.763.98–5.69<0.001
 Peripheral neuroectodermal tumor8.276.88–9.93<0.001

CI, confidence interval; CNS, central nervous system.

Data were compiled from 34 population-based registries that participate in the Centers for Disease Control and Prevention’s National Program of Cancer Registries, and meet high-quality data criteria. The registries in the Survival Analysis Dataset cover approximately 67% of the US population. For more information, see US Cancer Statistics technical notes (http://www.cdc.gov/cancer/npcr/uscs/technical_notes/stat_methods/survival.htm).

Significant findings are in bold.