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Risk factors for childhood enteric infection in urban Maputo, Mozambique: A cross-sectional study
  • Published Date:
    Nov 12 2018
  • Source:
    PLoS Negl Trop Dis. 12(11)
  • Language:
    English
Filetype[PDF-553.35 KB]


Details:
  • Alternative Title:
    PLoS Negl Trop Dis
  • Description:
    Background

    Enteric infections are common where public health infrastructure is lacking. This study assesses risk factors for a range of enteric infections among children living in low-income, unplanned communities of urban Maputo, Mozambique.

    Methods & findings

    We conducted a cross-sectional survey in 17 neighborhoods of Maputo to assess the prevalence of reported diarrheal illness and laboratory-confirmed enteric infections in children. We collected stool from children aged 1–48 months, independent of reported symptoms, for molecular detection of 15 common enteric pathogens by multiplex RT-PCR. We also collected survey and observational data related to water, sanitation, and hygiene (WASH) characteristics; other environmental factors; and social, economic, and demographic covariates.

    Conclusions

    We found a high prevalence of enteric infections, primarily among children without diarrhea, and weak associations between bacterial and protozoan infections and environmental risk factors including WASH. Findings suggest that environmental health interventions to limit infections would need to be transformative given the high prevalence of enteric pathogen shedding and poor sanitary conditions observed.

    Trial registration

    ClinicalTrials.gov NCT02362932

  • Pubmed ID:
    30419034
  • Pubmed Central ID:
    PMC6258421
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