Details:

Alternative Title:
BMC Public Health
Personal Author:
McCrickard, Lindsey S. ; Crim, Stacy M. ; Kim, Sunkyung ; Bowen, Anna
McCrickard, Lindsey S. ; Crim, Stacy M. ; Kim, Sunkyung ; Bowen, Anna Less -
Description:
Background

Shigella causes approximately 500,000 illnesses, 6000 hospitalizations, and 40 deaths in the United States annually, but incidence and populations at risk for severe shigellosis among adults are unclear. This study describes severe shigellosis among US adults.

Methods

We analyzed Foodborne Diseases Active Surveillance Network data for infections caused by Shigella among adults ≥18 years old during 2002–2014. Criteria to define severe shigellosis included hospitalization, bacteremia, or death. We estimated annual incidence of shigellosis per 100,000 among adult populations, and conducted multivariable mixed-effects logistic regression to assess associations between severe shigellosis, demographic factors and Shigella species among adults with shigellosis.

Results

Among 9968 shigellosis cases, 2764 (28%) were severe. Restricting to cases due to S. sonnei and S. flexneri, median annual incidence of severe shigellosis among adults was 0.56 and highest overall incidence was among black males 18–49 years old (1.58). Among adults with shigellosis, odds of severe disease were higher among males than females aged 18–49 years old (OR [95% CI] = 1.32 [1.15–1.52], p < 0.001) and among males than females with S. flexneri infections (OR [95% CI] =1.39 [1.10–1.75], p = 0.005). The odds of severe shigellosis were higher among blacks than whites (OR [95% CI] = 1.36 [1.22–1.52], p < 0.001).

Conclusions

Among adults, men 18–49 years old, particularly blacks, have the highest incidence of severe shigellosis. Among adults with shigellosis, severe shigellosis was associated with being male in age group 18–49 years, with infections caused by S. flexneri, and with black race. Future research should assess associations between severe shigellosis and sexual practices, antimicrobial resistance, comorbidities, and access to care.


Subjects:
[+]
Adolescent Adult Black Or African American Dysentery, Bacillary Female Foodborne Diseases Health Status Disparities Homosexuality, Male Humans Incidence Male Middle Aged Population Surveillance Risk Factors Severity Of Illness Index Sex Distribution Young Adult
Source:
BMC Public Health. 18.
Pubmed ID:
29415691
Pubmed Central ID:
PMC5803893
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a46741f217b0aacece91d3f63632672cad7d1d2e377ede12ed1810c948b842cc
Download URL:
https://stacks.cdc.gov/view/cdc/61200/cdc_61200_DS1.pdf
File Type:

Supporting Files

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