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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties manuscript?><front><journal-meta><journal-id journal-id-type="nlm-journal-id">8002646</journal-id><journal-id journal-id-type="pubmed-jr-id">557</journal-id><journal-id journal-id-type="nlm-ta">Ann Emerg Med</journal-id><journal-id journal-id-type="iso-abbrev">Ann Emerg Med</journal-id><journal-title-group><journal-title>Annals of emergency medicine</journal-title></journal-title-group><issn pub-type="ppub">0196-0644</issn><issn pub-type="epub">1097-6760</issn></journal-meta><article-meta><article-id pub-id-type="pmid">29753521</article-id><article-id pub-id-type="pmc">6224131</article-id><article-id pub-id-type="doi">10.1016/j.annemergmed.2018.03.045</article-id><article-id pub-id-type="manuscript">HHSPA993799</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Emergency Department Implementation of the Centers for Disease Control and Prevention Pediatric Mild Traumatic Brain Injury Guideline Recommendations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lumba-Brown</surname><given-names>Angela</given-names></name><degrees>MD</degrees><xref rid="CR1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>David W.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Sarmiento</surname><given-names>Kelly</given-names></name><degrees>MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Houry</surname><given-names>Debra</given-names></name><degrees>MD, MPH</degrees></contrib><aff id="A1">Stanford University, Stanford, CA (Lumba-Brown); Emory University, Atlanta, GA (Wright); and the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA (Sarmiento, Houry)</aff></contrib-group><author-notes><fn id="FN1"><p id="P1"><italic>Authorship:</italic> All authors attest to meeting the four ICMJE.org authorship criteria: (1) Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND (2) Drafting the work or revising it critically for important intellectual content; AND (3) Final approval of the version to be published; AND (4) Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.</p></fn><corresp id="CR1"><label>*</label><italic>Corresponding Author.</italic><email>alumba@aol.com.</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>10</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>10</day><month>5</month><year>2018</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2018</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2019</year></pub-date><volume>72</volume><issue>5</issue><fpage>581</fpage><lpage>585</lpage><!--elocation-id from pubmed: 10.1016/j.annemergmed.2018.03.045--></article-meta></front><body><sec id="S1"><title>INTRODUCTION</title><p id="P2">From 2005 to 2009, children made more than 2 million outpatient visits and almost 3 million emergency department (ED) visits for mild traumatic brain injury.<sup><xref rid="R1" ref-type="bibr">1</xref></sup> The actual number of mild traumatic brain injury cases is difficult to assess because patients may seek treatment in a variety of medical or school settings, or not at all. However, there is evidence that these numbers are increasing; in 2007, there were 461,000 ED visits for traumatic brain injury among children aged 14 years and younger; by 2013, that number had increased to 642,000.<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref></sup></p><p id="P3">The detection, evaluation, and management of pediatric patients with mild traumatic brain injury is complicated by the lack of standardization and evidenced-based guidance. The short- and potential long-term effects of mild traumatic brain injury can have significant consequences that affect a child&#x02019;s ability to function physically, cognitively, and psychologically.<sup><xref rid="R4" ref-type="bibr">4</xref>&#x02013;<xref rid="R6" ref-type="bibr">6</xref></sup> Although most pediatric patients no longer experience symptoms within 1 to 3 months, a subset of patients may have protracted symptoms.<sup><xref rid="R7" ref-type="bibr">7</xref></sup> The ED clinician plays a critical role by recognizing patients with mild traumatic brain injury, conducting and documenting an appropriate focused examination, providing symptom management, guiding preventive measures, and providing sound discharge instructions.</p></sec><sec id="S2"><title>DEVELOPMENT OF AN EVIDENCE-BASED GUIDELINE ON PEDIATRIC MILD TRAUMATIC BRAIN INJURY</title><p id="P4">The Centers for Disease Control and Prevention&#x02019;s (CDC&#x02019;s) recent guideline optimizes and standardizes evidence-based acute clinical care for injured children.<sup><xref rid="R8" ref-type="bibr">8</xref></sup> This guideline draws on a methodologically rigorous<sup><xref rid="R9" ref-type="bibr">9</xref></sup> systematic review of a search encompassing more than 34,000 articles spanning 25 years of research.<sup><xref rid="R10" ref-type="bibr">10</xref></sup> Two public comment periods, one round of external peer review, and 2 rounds of review by academic organizations such as the American College of Emergency Physicians informed the final guideline.</p><p id="P5">The guideline focused on 6 clinically relevant questions that addressed decisionmaking in the diagnosis of mild traumatic brain injury, prognostic indicators in the pediatric population with mild traumatic brain injury, and management and treatments (<xref rid="F1" ref-type="fig">Figure 1</xref>). Nineteen evidence-based recommendation sets were developed with these 6 questions as a foundation. The clinical questions and guideline recommendations use the term &#x0201c;mild traumatic brain injury.&#x0201d; However, in recognition of the heterogeneity of patient presentations, the research reviewed for the guideline encompassed a functional definition of mild traumatic brain injury. The definition used was inclusive of concussive signs or symptoms after direct or indirect head injury, as well as a Glasgow Coma Scale score of 13 to 15, with or without the complication of intracranial injury on neuroimaging, and regardless of the potential to require a hospital admission or neurosurgical intervention.</p></sec><sec id="S3"><title>CDC RECOMMENDATIONS ON PEDIATRIC MILD TRAUMATIC BRAIN INJURY APPLICABLE TO ED CLINICIANS</title><p id="P6">Although the CDC guideline is intended for use in a variety of clinical settings and by different categories of health care providers, several strongly supported recommendations are critical for ED clinicians in their practice setting. These recommendations are described below and listed in <xref rid="F2" ref-type="fig">Figure 2</xref>. Broadly, these recommendations encompass diagnosis, prognosis, management and treatment. A modified Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess confidence in the evidence and reflect a strength of recommendation.</p><sec id="S4"><title>Diagnostic Recommendations</title><p id="P7">Mild traumatic brain injury in children is a clinical diagnosis that usually does not require neuroimaging in the acute care setting. Computed tomography (CT) imaging should be considered when there is a suspicion of more severe forms of traumatic brain injury. ED clinicians should adhere to recommendations based on validated clinical decision rules that evaluate a variety of risk factors.</p><p id="P8">Although it is not commonplace for ED clinicians to use postconcussion symptom rating scales, these may be helpful in the diagnosis of traumatic brain injury in children in the ED. These scales can assist ED clinicians with documenting their patients&#x02019; presenting symptoms and inform symptom-based counseling of children and their families on prognosis.</p></sec><sec id="S5"><title>Prognostic Recommendations</title><p id="P9">Prognostic counseling in regards to a diagnosis made in the ED is a core component of emergency medicine. By using best evidence, the systematic review and metaanalyses identified premorbid history and other risk factors for prolonged recovery that can be easily assessed in the acute care setting. These recommendations are described further in <xref rid="F2" ref-type="fig">Figure 2</xref>. This guideline provides recommendations to counsel children with mild traumatic brain injury, as well as their families, about their likely recovery, but also stresses that everyone&#x02019;s recovery trajectory is unique.</p></sec><sec id="S6"><title>Management and Treatment Recommendations</title><p id="P10">The clinical management and treatment of mild traumatic brain injury in children is grounded in symptom control, which includes establishing a healthy return to cognitive and physical activity. In the acute care setting, children with mild traumatic brain injury and their families need guidance on their next steps in activity reintegration. This guideline provides specific recommendations for ED counseling, including the use of discharge instructions for return to activity, inclusive of school and sports activities.</p></sec></sec><sec id="S7"><title>TOOLS TO HELP ED CLINICIANS IMPLEMENT CDC RECOMMENDATIONS</title><p id="P11">A guideline does not have influence if not implemented into practice. To facilitate implementation, CDC has developed free and publicly available guideline implementation tools applicable to ED management and discharge, available at <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/HEADSUP">http://www.cdc.gov/HEADSUP</ext-link>. These tools range from validated screening tools to assess young patients to discharge instructions and symptombased recovery tips for parents to support their child&#x02019;s recovery (<xref rid="F3" ref-type="fig">Figure 3</xref>).</p></sec><sec id="S8"><title>CONCLUSION</title><p id="P12">The ED clinician plays an important role in the recognition and management of mild traumatic brain injury because he or she may be the first health care provider to evaluate an injured child. The new CDC evidence-based guideline provides strong support for intervention in the ED through a structured framework of recommendations. Key practice-changing features include using validated and age-appropriate postconcussion symptom rating scales to aid in diagnosis and prognosis, and incorporating specific recommendations for counseling at ED discharge. To learn more about the guideline and the methodology for developing it, visit <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/HEADSUP">http://www.cdc.gov/HEADSUP</ext-link>.</p></sec></body><back><ack id="S9"><p id="P13"><italic>Funding and support</italic>: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see <ext-link ext-link-type="uri" xlink:href="http://www.icmje.org/">www.icmje.org</ext-link>). The authors have stated that no such relationships exist.</p></ack><fn-group><fn id="FN2"><p id="P14">The findings and conclusions in this article are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Dr. Wright reports receiving grants from National Institutes of Health, National Highway Traffic Safety Administration, Marcus Foundation, NICO Corporation, and the Department of Defense. He also serves on the Scientific Advisory Board for Astrocyte Pharma. Dr. Lumba-Brown reports receiving a grant from the Department of Defense. Neither Dr. Wright nor Dr. Lumba-Brown was funded by grants for this submitted work. Drs. Wright and Lumba-Brown were on the expert committee work group that drafted the guideline. 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<comment>Accessed</comment> February 6, 2018.</mixed-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1.</label><caption><p id="P15">Clinical questions contained in the CDC guideline. <italic>mTBI</italic>, Mild traumatic brain injury.</p></caption><graphic xlink:href="nihms-993799-f0001"/></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2.</label><caption><p id="P16">Overview of clinical recommendations contained in the CDC guideline.</p></caption><graphic xlink:href="nihms-993799-f0002"/></fig><fig id="F3" orientation="portrait" position="float"><label>Figure 3.</label><caption><p id="P17">Educational tools for ED clinicians.</p></caption><graphic xlink:href="nihms-993799-f0003"/></fig></floats-group></article>