<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties manuscript?><front><journal-meta><journal-id journal-id-type="nlm-journal-id">7809641</journal-id><journal-id journal-id-type="pubmed-jr-id">3685</journal-id><journal-id journal-id-type="nlm-ta">Fam Community Health</journal-id><journal-id journal-id-type="iso-abbrev">Fam Community Health</journal-id><journal-title-group><journal-title>Family &#x00026; community health</journal-title></journal-title-group><issn pub-type="ppub">0160-6379</issn><issn pub-type="epub">1550-5057</issn></journal-meta><article-meta><article-id pub-id-type="pmid">30134335</article-id><article-id pub-id-type="pmc">6107309</article-id><article-id pub-id-type="doi">10.1097/FCH.0000000000000200</article-id><article-id pub-id-type="manuscript">NIHMS978773</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>E-Cigarettes in Baltimore Alcohol Outlets: Geographic and Demographic Correlates of Availability</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fakunle</surname><given-names>David O.</given-names></name><degrees>PhD</degrees><role>Post-Doctoral Fellow</role><aff id="A1">School of Community Health &#x00026; Policy &#x02013; Morgan State University, <italic>Baltimore, Maryland</italic></aff></contrib><contrib contrib-type="author"><name><surname>Eck</surname><given-names>Raimee</given-names></name><degrees>PhD, MPA, MPH</degrees><role>Associate</role><!--<email>reck1@jhu.edu</email>--><aff id="A2">Department of Health, Behavior &#x00026; Society &#x02013; Johns Hopkins Bloomberg School of Public Health, <italic>Baltimore, Maryland</italic></aff></contrib><contrib contrib-type="author"><name><surname>Milam</surname><given-names>Adam J.</given-names></name><degrees>MD, PhD</degrees><role>Associate</role><!--<email>amilam3@jhu.edu</email>--><aff id="A3">Department of Mental Health &#x02013; Johns Hopkins Bloomberg School of Public Health, <italic>Baltimore, Maryland</italic></aff></contrib><contrib contrib-type="author"><name><surname>Thorpe</surname><given-names>Roland J.</given-names><suffix>jr.</suffix></name><degrees>PhD</degrees><role>Associate Professor</role><!--<email>rthorpe@jhu.edu</email>--><aff id="A4">Department of Health, Behavior &#x00026; Society &#x02013; Johns Hopkins Bloomberg School of Public Health, <italic>Baltimore, Maryland</italic></aff></contrib><contrib contrib-type="author"><name><surname>Furr-Holden</surname><given-names>C. Debra M.</given-names></name><degrees>PhD</degrees><role>Professor</role><!--<email>debra.furr-holden@hc.msu.edu</email>--><aff id="A5">Department of Prevention Science and Public Health &#x02013; Michigan State University College of Human Medicine, <italic>Flint, Michigan</italic></aff></contrib></contrib-group><author-notes><corresp id="CR1"><email>david.fakunle@morgan.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>7</month><year>2018</year></pub-date><pub-date pub-type="ppub"><season>Oct-Dec</season><year>2018</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2019</year></pub-date><volume>41</volume><issue>4</issue><fpage>205</fpage><lpage>213</lpage><!--elocation-id from pubmed: 10.1097/FCH.0000000000000200--><abstract id="ABS1"><p id="P1">There is limited research on e-cigarette availability despite increased use. E-cigarette availability within Baltimore alcohol outlets was analyzed for disparities among residential neighborhoods. Data were obtained via field surveys of alcohol outlets, then spatially merged with sociodemographic data. 18.8% of alcohol outlets had any e-cigarette availability. Regression models showed greater odds ratios for e-cigarette availability when cigarettes, cigars or hookah paraphernalia were sold, and lower odds ratios when alcohol outlets had an on-site consumption license. Outlets with e-cigarette availability were in predominantly lower-income, non-White neighborhoods. It is important to assess exposure of another potentially damaging substance among perpetually disadvantaged populations.</p></abstract><kwd-group><kwd>e-cigarettes</kwd><kwd>alcohol outlets</kwd><kwd>racial/ethnic groups</kwd><kwd>income</kwd><kwd>census tract</kwd></kwd-group></article-meta></front><body><sec id="S1"><title>Introduction</title><p id="P2">There has been a sharp rise in the presence of electronic cigarettes (&#x0201c;e-cigarettes&#x0201d;) since its introduction in the mid-2000s. Similarly, there has been a considerable increase in e-cigarette research. Many studies have focused on the pharmacokinetics, specifically how nicotine is transferred from device to user.<sup><xref rid="R1" ref-type="bibr">1</xref></sup> Studies have also considered whether or not e-cigarettes are more or less harmful than traditional cigarettes, which still remains without a satisfactory determination.<sup><xref rid="R2" ref-type="bibr">2</xref></sup> Research has contemplated policy implications of e-cigarettes, including how to properly classify, regulate, and limit access to the products, and has brought attention to e-cigarette use and demographics, specifically for consumer impressions and youth use.<sup><xref rid="R3" ref-type="bibr">3</xref>&#x02013;<xref rid="R14" ref-type="bibr">14</xref></sup></p><p id="P3">Recent estimates show the highest prevalence of e-cigarette use among individuals ages 18&#x02013;24 and 25&#x02013;44 (21.6% and 16.6%, respectively), and surveys suggest that consumers perceive e-cigarettes to be a healthier alternative to traditional tobacco products and even a viable method for cessation of traditional, combustible tobacco products.<sup><xref rid="R15" ref-type="bibr">15</xref>&#x02013;<xref rid="R16" ref-type="bibr">16</xref></sup> Along with understanding e-cigarettes&#x02019; mechanics, potential for harm or smoking cessation, and appeal to particular racial/ethnic and age groups, it is important to identify where e-cigarettes are physically available for purchase and consumption. Research shows that traditional tobacco products are more likely to be available and marketed in non-White and low-income neighborhoods, and significant health disparities exist among tobacco users.<sup><xref rid="R17" ref-type="bibr">17</xref>&#x02013;<xref rid="R20" ref-type="bibr">20</xref></sup> For example, populations with a history of disadvantage in the United States &#x02013; specifically Blacks and low-income people &#x02013; experience adverse health outcomes due to cigarette smoking and tobacco use at disproportionately higher rates. The Centers for Disease Control and Prevention (CDC), the U.S. Department of Health and Human Services (HHS), and organizations such as the American Lung Association continue to report racial and socioeconomic disparities in tobacco-related health outcomes. While Blacks tend to initiate tobacco use later in life and smoke fewer cigarettes than Whites, Blacks are more likely to die from smoking-related diseases than Whites.<sup><xref rid="R21" ref-type="bibr">21</xref></sup> Similarly, people with a lower income are more likely to suffer from smoking-related diseases than people with a higher income.<sup><xref rid="R21" ref-type="bibr">21</xref></sup> Additionally, people with a lower income smoke more heavily than people with a higher income.<sup><xref rid="R21" ref-type="bibr">21</xref></sup> While lower-income people and Blacks are as likely and more likely, respectively, to attempt quitting smoking than their socioeconomic and racial counterparts, both groups are less likely to succeed in quitting. Taxation of products, policies banning public use, stringent monitoring of youth access, and awareness/counter-advertising initiatives are major mechanisms that are used to reduce smoking and tobacco use. HHS currently has a national media campaign, &#x0201c;Tips from Former Smokers,&#x0201d; that highlights various people who deal with, have dealt with, or have died due to complications related to their tobacco use or exposure to tobacco use. Another HHS campaign, &#x0201c;The Real Cost,&#x0201d; focuses on health consequences associated with tobacco use by youth.<sup><xref rid="R22" ref-type="bibr">22</xref></sup> The &#x0201c;truth&#x0201d; campaign, a nationwide anti-tobacco campaign funded and produced by the American Legacy Foundation, has recently aired commercials highlighting the disproportionate number of tobacco advertisements found in low-income, predominantly Black neighborhoods.<sup><xref rid="R23" ref-type="bibr">23</xref></sup> Additionally, many local and state municipalities have banned tobacco use in indoor and outdoor public areas and establishments such as restaurants, bars, and government buildings. Disparate health outcomes associated with tobacco use persist among Black and lower-income populations despite targeted anti-tobacco use campaigns, policies that have restricted tobacco use, and financial deterrents from tobacco use such as taxes.<sup><xref rid="R24" ref-type="bibr">24</xref>&#x02013;<xref rid="R25" ref-type="bibr">25</xref></sup> Therefore an important line of inquiry to consider is the availability and access to tobacco products. Ashe and colleagues argued that the threshold needed to convince lawmakers to reduce availability and access to tobacco via &#x0201c;police power&#x0201d; is lower than that of alcohol.<sup><xref rid="R26" ref-type="bibr">26</xref></sup> However, many local and state municipalities are slow to utilize their full legislative ability to reduce tobacco outlet density despite evidence that constitutional challenges would not be a major issue, and despite evidence that shows reduction in tobacco outlet density does lead to reductions in smoking.<sup><xref rid="R27" ref-type="bibr">27</xref>&#x02013;<xref rid="R31" ref-type="bibr">31</xref></sup> Given this research, and while studies have investigated e-cigarette availability via the Internet, there are few published studies that have focused on physical e-cigarette availability and marketing.<sup><xref rid="R32" ref-type="bibr">32</xref>&#x02013;<xref rid="R36" ref-type="bibr">36</xref></sup></p><p id="P4">Alcohol outlets are a prevalent and salient retail space for the purchase and consumption of not only alcohol products, but also processed foods, lottery tickets, and tobacco products such as cigarettes and cigarillos in Baltimore, Maryland.<sup><xref rid="R37" ref-type="bibr">37</xref>&#x02013;<xref rid="R38" ref-type="bibr">38</xref></sup> The abundance of alcohol outlets in Baltimore and the consequential widespread availability of alcohol and other products provides a practical analog for the availability of e-cigarettes in the city.<sup><xref rid="R39" ref-type="bibr">39</xref>&#x02013;<xref rid="R40" ref-type="bibr">40</xref></sup> Therefore, this study investigates the presence of e-cigarettes within licensed alcohol outlets in Baltimore. Additionally, we explore the sociodemographics &#x02013; specifically, median household income and race/ethnicity profiles &#x02013; of neighborhoods where alcohol outlets are located and examine the relationship between e-cigarette availability and the selling of other products within outlets. Influenced by the findings of previous research on relationships between sociodemographics and the availability of tobacco products, the hypothesis was that the availability of e-cigarettes within alcohol outlets would be greater in areas of Baltimore with a higher-than-average non-White population and a lower-than-average median household income.<sup><xref rid="R19" ref-type="bibr">19</xref>&#x02013;<xref rid="R20" ref-type="bibr">20</xref></sup></p></sec><sec id="S2"><title>Methods</title><sec id="S3"><title>Overview</title><p id="P5">This study was part of a larger study that sought to determine the adherence of Baltimore alcohol retail outlets to the requirements under alcohol outlet licenses administered by the Board of Liquor License Commissioners for Baltimore City (BLLC). Oversaturation of alcohol outlets has long been a public health challenge in Baltimore, and recent research has shown positive associations between outlet density and proximity to detrimental behavioral outcomes such as violent crime and substance use.<sup><xref rid="R37" ref-type="bibr">37</xref>&#x02013;<xref rid="R40" ref-type="bibr">40</xref></sup> This has catalyzed zoning reform initiatives and policy recommendations to reduce alcohol outlets and further prevent alcohol sales to youth, a highly vulnerable population.<sup><xref rid="R41" ref-type="bibr">41</xref></sup> The larger study aimed to provide substantial evidence of pervasive fraudulent license use as well as failure to take established measures to prevent youth from obtaining alcohol and other prohibited products.</p></sec><sec id="S4"><title>Data</title><p id="P6">Data on the location and license types of all establishments licensed to sell alcohol in Baltimore were obtained from the Board of Liquor License Commissioners for Baltimore City. There are 12 liquor license types administered by the BLLC.<sup><xref rid="R42" ref-type="bibr">42</xref></sup> Observational data assessing alcohol outlets were obtained via field surveys in the summer of 2014 to determine if licensing requirements were adequately being fulfilled for the 667 alcohol licenses in the following three license classes:</p><list list-type="order" id="L1"><list-item><p id="P7">Beer, Wine &#x00026; Liquor Class A (LA): Off-sale package goods, no on-premises consumption &#x02013; 6 days, 6:00 a.m.-Midnight. No Sunday sales except Sundays between Thanksgiving Day and New Year&#x02019;s Day upon issuance of a special license for each Sunday.</p></list-item><list-item><p id="P8">Beer, Wine &#x00026; Liquor Class A-2 (LA2): Off-sale package goods &#x02013; 6 days, 9:00 a.m.-Midnight. No Sunday sales except Sundays between Thanksgiving Day and New Year&#x02019;s Day upon issuance of a special license for each Sunday.</p></list-item><list-item><p id="P9">Beer, Wine &#x00026; Liquor Class BD-7 (LBD7): Taverns for off-sale package goods and on-sale consumption &#x02013; 7 days, 6:00 a.m.&#x02212;2:00 a.m.</p></list-item></list></sec><sec id="S5"><title>Assessment Tool</title><p id="P10">The tool for assessing the alcohol outlets was created from a review of existing observational tools and preliminary observations of 50 Baltimore packaged goods stores. The goal was to identify common characteristics of alcohol outlets related to licensing compliance or the lack thereof. The tool was divided into an assessment of the exterior and interior environment. The exterior assessment included alcohol and tobacco product advertisements, outside visibility of the interior environment, and signage cautioning against underage alcohol consumption. The interior assessment included whether the store had Plexiglas barriers, video monitoring devices, and signage cautioning against underage alcohol consumption. The interior assessment was further stratified to measure items above and below 3.5 feet from the floor &#x02013; a line of demarcation for adult versus youth advertising.<sup><xref rid="R43" ref-type="bibr">43</xref>&#x02013;<xref rid="R44" ref-type="bibr">44</xref></sup> The above and below 3.5 feet assessment included identical items related to tobacco and drug paraphernalia divided into the following subcategories: smoking pipes (i.e., crack pipes), hookah paraphernalia, bongs, synthetic cannabinoids, vaporizers, scales and small zipper bags, cigarettes and cigars, and flavored cigar papers (e.g., blunt wrappers); sex paraphernalia (e.g., condoms, sex enhancement supplements and pleasure pills), youth and minority-oriented alcohol and tobacco advertising, adherence to anti-smoking ordinances, business practices to prevent underage tobacco and alcohol purchases, and products being sold in the establishment including produce, candy, and chips.</p></sec><sec id="S6"><title>Field Assessment Results</title><p id="P11">The 2014 field assessments revealed that of the 667 alcohol outlet licenses, six were dual licenses, resulting in 661 unique alcohol outlets. Nine additional outlets were removed due to exclusionary criteria (see <xref rid="S7" ref-type="sec">Exclusions</xref> section below). Research assistants visited outlets up to seven times during various days and hours, and if necessary, project supervisors made an additional three visits on Thursday, Friday, and Saturday evenings between 9:00pm and 2:00am, depending on the venue (e.g., clubs typically have later hours of operation than bars or packaged goods stores) to ensure the establishment was not in operation during these peak times before determining they were chronically closed. As a result, assessments deemed 82 outlets closed (e.g., never open, abandoned, or in reconstruction) during the entire period of data collection, resulting in 570 valid alcohol outlets with interior and exterior assessments. LA (n = 204) and LA-2 (n = 12) license types were combined because of the small number of LA-2 licenses, similar days/times of sales (a 3-hour difference in opening time), and prohibition of on-premise consumption. LBD7s allow on-premise consumption in addition to off-premise carryout sales including Sundays. For the purposes of this study, LBD7 outlets were categorized as on-premise.</p></sec><sec id="S7"><title>Exclusions</title><p id="P12">The goal was to assess all establishments licensed to sell packaged goods, including establishments licensed to sell only beer and wine. Restaurants (Beer &#x00026; Wine/Beer, Wine &#x00026; Liquor Class B), hotels/motels (Beer, Wine &#x00026; Liquor Class B) and non-profit private clubs (Beer, Wine &#x00026; Liquor Class C) were not included in this study as these establishments only allow on-premise alcohol consumption and do not sell other products other than alcohol to onsite patrons. Arenas (n = 3), theaters (n = 3), and performance halls (n = 3) have one of the four Class A or Class B designations but were excluded from this study; these venues do not reflect the typical packaged goods store with limited hours of operation where alcohol is sold only during events for on-premise consumption.</p></sec></sec><sec id="S8"><title>Methods</title><sec id="S9"><title>Geocoding</title><p id="P13">U.S. census tracts were used as the geographical unit of analysis to explore the racial/ethnicity profiles and median household income in this study. Generally containing between 1,200 and 8,000 people with an optimal size of 4,000, they are considered a stable unit for analysis.<sup><xref rid="R45" ref-type="bibr">45</xref></sup> Race/ethnicity and median household income at the census tract level were obtained from the 2009&#x02013;2013 American Community Survey (ACS).<sup><xref rid="R46" ref-type="bibr">46</xref></sup> The ACS is an annual national survey that collects vital household information from nearly 2 million addresses each year. Public Use Microdata Sample (PUMS) files provided datasets for academic use in 1-year, 3-year, and 5-year files; the dataset with five-year estimates (2009&#x02013;2013) was used as it provides information for areas as small as census tracts and block groups.<sup><xref rid="R47" ref-type="bibr">47</xref></sup></p><p id="P14">The street addresses and ZIP codes of the alcohol outlets provided by the Board of Liquor License Commissioners for Baltimore City were geocoded with ArcGIS 10.2.2.<sup><xref rid="R48" ref-type="bibr">48</xref></sup> There are 200 census tracts in Baltimore City, but two were excluded due to lack of housing units. Additionally, no outlets with e-cigarette availability were located within either tract, and race/ethnicity and population data were not included in calculations.</p><p id="P15">Baltimore City has a population of 616,833 (not including census tracts 1003 and 2506), is 69.6% non-White (which includes Black, American Indian/Alaska Native, Asian, Hawaiian/Pacific Islander, Other, and 2+ Races), and has a median household income of $41,385. Each address of the included alcohol outlets was geocoded via ArcMap and supplemented with Google Maps to manually match the unmatched licenses, yielding 100% matching of addresses (n = 570).</p></sec><sec id="S10"><title>Analysis Plan</title><p id="P16">The basic descriptive statistic was the number of alcohol outlets with e-cigarette availability. The percentage was calculated using the number of alcohol outlets that met the inclusion criteria (n = 570). Outlets with e-cigarette availability above and below 3.5 feet from the ground were counted once.</p><p id="P17">Analysis of the survey data was conducted via a multivariate logistic regression, in which the outcome measure was any e-cigarette availability (either above or below 3.5 feet) within an alcohol outlet. To reflect the environments of the alcohol outlets surveyed, the covariates included in the model were outlet license type (LA/LA2 vs. LBD7) and the availability of the following products: smoking pipes, hookah paraphernalia, synthetic cannabinoids, vaporizers, cigarettes/cigars, flavored cigar papers, bongs, and scales/small zipper bags. Due to the low prevalence, bongs and scales/small zipper bags were removed from the final regression. All analyses were conducted in SPSS.<sup><xref rid="R49" ref-type="bibr">49</xref></sup></p></sec></sec><sec id="S11"><title>Results</title><sec id="S12"><title>Descriptive Statistics</title><p id="P18">Of the 570 valid alcohol outlets, 107 (18.8%) had e-cigarette availability on their premises; 36.6% (n = 79) of all off-premise outlets (LA/LA2) sold e-cigarettes, compared to 7.9% (n = 28) of on-premise outlets (LBD7) (<xref rid="T1" ref-type="table">Table 1</xref>). E-cigarettes were located within 84 out of 198 residential census tracts. Of the 84 tracts with e-cigarette availability, 64 contained one outlet, 17 contained two outlets, 2 contained three outlets, and 1 contained four outlets. The majority of e-cigarette availability among outlets (n = 92; 86.0%) was exclusively above the 3.5&#x02019; line of advertising demarcation. Most alcohol outlets with e-cigarette availability (n = 63; 58.3%) were in census tracts with a higher non-White population percentage than the city-wide average of 69.6% (<xref rid="F1" ref-type="fig">Figure 1</xref>). A similar pattern emerged when median household income was highlighted: most alcohol outlets with e-cigarette availability (n = 70; 65.4%) were located in neighborhoods with a lower median household income than the city-wide median of $41,385 (<xref rid="F2" ref-type="fig">Figure 2</xref>). E-cigarette availability was lower than the availability of traditional tobacco products: 78.2% of off-premise outlets sold cigarettes/cigars compared to 36.6% that sold e-cigarettes. Likewise, for on-premise outlets, there was a greater availability of tobacco products than that of e-cigarettes (22.6% vs. 7.9%).</p></sec><sec id="S13"><title>Multivariate Logistic Regression</title><p id="P19">Compared to off-premise outlets, on-premise outlets are associated with lower odds of e-cigarette availability (AOR = 0.45, 95% CI: [0.26, 0.79]). Additionally, the logistic model shows greater odds of e-cigarette availability when either cigarettes or cigars (AOR = 12.39, 95% CI: [5.11, 30.02]) or hookah paraphernalia (AOR = 3.49, 95% CI: [1.32, 9.20]) were also sold in an alcohol outlet (<xref rid="T2" ref-type="table">Table 2</xref>).</p></sec></sec><sec id="S14"><title>Discussion</title><p id="P20">This exploratory study investigated the availability of e-cigarettes within alcohol outlets in Baltimore and demonstrated that overall availability was relatively sparse in comparison to the availability of cigarettes and other combustible tobacco products in the same retailers. Specifically, e-cigarettes were primarily found within off-premise outlets where patrons purchase alcoholic beverages and cannot consume them on the property. Among alcohol outlets with e-cigarette availability, nearly all were visible only at a height physically accessible to adults, while very few had e-cigarettes available at heights physically accessible and visible for youth only or physically accessible and visible for both adults and youth.</p><p id="P21">Low income and urban non-White neighborhoods often have higher rates of tobacco and alcohol availability.<sup><xref rid="R19" ref-type="bibr">19</xref>&#x02013;<xref rid="R20" ref-type="bibr">20</xref>;<xref rid="R50" ref-type="bibr">50</xref>&#x02013;<xref rid="R51" ref-type="bibr">51</xref></sup> Consistent with those previous studies, a similar pattern of e-cigarette availability within alcohol outlets was found. This is contrary to Rose et al., who found that e-cigarettes were more likely to be found in higher income and lower percent non-White neighborhoods; however, they evaluated a much greater availability than just liquor stores (gas stations, convenience marts, etc.).<sup><xref rid="R22" ref-type="bibr">22</xref></sup> It is possible those results may reflect a greater availability of services such as supermarkets and pharmacies in higher income areas that also happen to sell e-cigarettes. Our findings suggest that within alcohol outlets, which are already found in higher concentrations within non-White and low-income neighborhoods, e-cigarettes are being sold as a complement, rather than a replacement, to existing tobacco and drug products.</p><p id="P22">There were limitations to this study. Notably, the decision was made to focus on basic descriptives via spatial mapping as opposed to spatial analyses due to the exploratory nature of the study. It is acknowledged that the hypothesis was due to the researchers&#x02019; understanding of Baltimore&#x02019;s sociodemographic dynamics and that statistical methodology such as spatial regression does allow researchers to parse through multifaceted relationships such as the contextual interaction of race and socioeconomic status. However, it was determined that examining such an inherently complex relationship would be better suited for subsequent research influenced by the findings of this study. Additionally, it was also determined that this study would also focus on the relationship between established drug products and paraphernalia, including traditional tobacco products, and the availability of e-cigarettes within salient retail spaces, in this case alcohol outlets.</p><p id="P23">This study contributes to a limited literature on physical e-cigarette availability and illustrates the relationships with sociodemographics and availability of drug/tobacco products in a major urban U.S. city. In Baltimore, alcohol outlets are a primary location for many residents &#x02013; including youth and those in lower-income neighborhoods &#x02013; to purchase goods, alcohol or otherwise. As a result, they are establishments in which many residents are introduced to new products such as e-cigarettes, which due to acclimation could lead to curiosity and ultimately use of the product. With the growing but still limited knowledge of how e-cigarettes may affect health, there could be a potential hazard if availability grows within Baltimore alcohol outlets and exposure increases for populations who are potentially most disadvantaged by its consumption. In May 2016, the U.S. Food and Drug Administration (FDA) announced efforts to regulate e-cigarettes and other tobacco products in the same manner as traditional cigarettes and smokeless tobacco, including the restriction of purchase to individuals aged 18 years and older.<sup><xref rid="R52" ref-type="bibr">52</xref></sup> This is an important step in limiting access to e-cigarettes at the point of purchase, particularly for minors, but additional policy may be needed to address product availability. Currently within the Maryland Business Regulation, Title 16 (Cigarettes) and Title 16.5 (Other Tobacco Products Licenses), there exists no language that provides a framework or restrictions on retailer locations as a condition for issuance of a cigarette or other tobacco product (OTP) license. Additionally, per the Baltimore City charter and zoning codes, there is no language that provides guidelines for the physical location of businesses and retailers that sell cigarettes and OTP such as e-cigarettes.<sup><xref rid="R53" ref-type="bibr">53</xref>&#x02013;<xref rid="R54" ref-type="bibr">54</xref></sup></p><p id="P24">In addition to the access to e-cigarettes through alcohol outlets, future studies should determine the extent of e-cigarette availability in other venues throughout Baltimore, including in convenience stores, shopping center kiosks, and &#x0201c;vape&#x0201d; shops, which have seen a sharp increase in popularity along with e-cigarettes.<sup><xref rid="R55" ref-type="bibr">55</xref></sup> Additionally, an investigation of e-cigarette sales among alcohol outlets and other establishments should be conducted to elucidate whether or not current e-cigarette availability is supported by consumer demand. Finally, research is inconsistent as to racial differences in e-cigarette use despite advertising that appears tailored towards younger White individuals.<sup><xref rid="R14" ref-type="bibr">14</xref></sup> Giovenco and colleagues&#x02019; recent study provides evidence that e-cigarettes are not targeted at non-White consumers in regards to availability, showing that New Jersey census tracts with a higher proportion of non-Hispanic black residents had significantly lower odds of having a vape shop.<sup><xref rid="R56" ref-type="bibr">56</xref></sup> Therefore, further study is warranted to examine for potential racial differences in e-cigarette advertising influence.</p><p id="P25">This study successfully mapped the presence of e-cigarettes within Baltimore alcohol outlets and provides insight into substances and products that relate to its availability. Additionally, this study provides key findings for the genesis of future research of e-cigarettes&#x02019; impact on various sociodemographic populations, especially as more evidence is presented to elucidate our understanding of the pharmacokinetic effects of e-cigarette consumption on the human body.</p></sec></body><back><ack id="S15"><title>Acknowledgements</title><p id="P26">This study was funded by the National Institute on Drug Abuse grant number T32DA007292 and the Centers for Disease Control and Prevention grant number 1U49CE000728.</p></ack><ref-list><title>References</title><ref id="R1"><label>1.</label><mixed-citation publication-type="journal"><name><surname>Adkison</surname><given-names>SE</given-names></name>, <name><surname>O&#x02019;Connor</surname><given-names>RJ</given-names></name>, <name><surname>Bansal-Travers</surname><given-names>M</given-names></name>, <name><surname>Hyland</surname><given-names>A</given-names></name>, <name><surname>Borland</surname><given-names>R</given-names></name>, <name><surname>Yong</surname><given-names>H-H</given-names></name>, <etal/>
<article-title>Electronic nicotine delivery systems: International tobacco control four-country survey</article-title>. <source>Am J Prev Med</source>. <year>2013</year>;<volume>44</volume>(<issue>3</issue>):<fpage>207</fpage>&#x02013;<lpage>15</lpage>.<pub-id pub-id-type="pmid">23415116</pub-id></mixed-citation></ref><ref id="R2"><label>2.</label><mixed-citation publication-type="journal"><name><surname>Farsalinos</surname><given-names>KE</given-names></name>, <name><surname>Romagna</surname><given-names>G</given-names></name>, <name><surname>Tsiapras</surname><given-names>D</given-names></name>, <name><surname>Kyrzopoulos</surname><given-names>S</given-names></name>, <name><surname>Voudris</surname><given-names>V</given-names></name>. <article-title>Characteristics, perceived side effects and benefits of electronic cigarette use: A worldwide survey of more than 19,000 consumers</article-title>. <source>Int J Environ Res Public Health</source>. <year>2014</year>;<volume>11</volume>(<issue>4</issue>):<fpage>4356</fpage>&#x02013;<lpage>73</lpage>.<pub-id pub-id-type="pmid">24758891</pub-id></mixed-citation></ref><ref id="R3"><label>3.</label><mixed-citation publication-type="journal"><name><surname>Lempert</surname><given-names>LK</given-names></name>, <name><surname>Grana</surname><given-names>R</given-names></name>, <name><surname>Glantz</surname><given-names>SA</given-names></name>. <article-title>The importance of product definitions in us e-cigarette laws and regulations</article-title>. <source>Tob Control</source>. <year>2014</year>:<comment>tobaccocontrol-2014&#x02013;051913.</comment></mixed-citation></ref><ref id="R4"><label>4.</label><mixed-citation publication-type="journal"><name><surname>Marynak</surname><given-names>K</given-names></name>, <name><surname>Holmes</surname><given-names>CB</given-names></name>, <name><surname>King</surname><given-names>BA</given-names></name>, <name><surname>Promoff</surname><given-names>G</given-names></name>, <name><surname>Bunnell</surname><given-names>R</given-names></name>, <name><surname>McAfee</surname><given-names>T</given-names></name>. <article-title>State laws prohibiting sales to minors and indoor use of electronic nicotine delivery systems--united states, november 2014</article-title>. <source>MMWR</source>. <year>2014</year>;<volume>63</volume>(<issue>49</issue>):<fpage>1145</fpage>&#x02013;<lpage>50</lpage>.<pub-id pub-id-type="pmid">25503916</pub-id></mixed-citation></ref><ref id="R5"><label>5.</label><mixed-citation publication-type="journal"><name><surname>Pokhrel</surname><given-names>P</given-names></name>, <name><surname>Fagan</surname><given-names>P</given-names></name>, <name><surname>Kehl</surname><given-names>L</given-names></name>, <name><surname>Herzog</surname><given-names>TA</given-names></name>. <article-title>Receptivity to e-cigarette marketing, harm perceptions, and e-cigarette use</article-title>. <source>Am J Health Behav</source>. <year>2015</year>;<volume>39</volume>(<issue>1</issue>):<fpage>121</fpage>&#x02013;<lpage>31</lpage>.<pub-id pub-id-type="pmid">25290604</pub-id></mixed-citation></ref><ref id="R6"><label>6.</label><mixed-citation publication-type="journal"><name><surname>Trumbo</surname><given-names>CW</given-names></name>, <name><surname>Harper</surname><given-names>R</given-names></name>. <article-title>Perceived characteristics of e-cigarettes as an innovation by young adults</article-title>. <source>Health Behav Policy Rev</source>. <year>2015</year>;<volume>2</volume>(<issue>2</issue>):<fpage>154</fpage>&#x02013;<lpage>62</lpage>.<pub-id pub-id-type="pmid">25729752</pub-id></mixed-citation></ref><ref id="R7"><label>7.</label><mixed-citation publication-type="journal"><collab>Centers for Disease Control and Prevention (CDC)</collab>. <article-title>Notes from the field: Electronic cigarette use among middle and high school students-united states, 2011&#x02013;2012</article-title>. <source>MMWR</source>. <year>2013</year>;<volume>62</volume>(<issue>35</issue>):<fpage>729</fpage>.<pub-id pub-id-type="pmid">24005229</pub-id></mixed-citation></ref><ref id="R8"><label>8.</label><mixed-citation publication-type="journal"><name><surname>Cho</surname><given-names>JH</given-names></name>, <name><surname>Shin</surname><given-names>E</given-names></name>, <name><surname>Moon</surname><given-names>S-S</given-names></name>. <article-title>Electronic-cigarette smoking experience among adolescents</article-title>. <source>J Adolesc Health</source>. <year>2011</year>;<volume>49</volume>(<issue>5</issue>):<fpage>542</fpage>&#x02013;<lpage>6</lpage>.<pub-id pub-id-type="pmid">22018571</pub-id></mixed-citation></ref><ref id="R9"><label>9.</label><mixed-citation publication-type="journal"><name><surname>Goniewicz</surname><given-names>ML</given-names></name>, <name><surname>Zielinska-Danch</surname><given-names>W</given-names></name>. <article-title>Electronic cigarette use among teenagers and young adults in poland</article-title>. <source>J Pediatr</source>. <year>2012</year>;<volume>130</volume>(<issue>4</issue>):<fpage>e879</fpage>&#x02013;<lpage>e85</lpage>.</mixed-citation></ref><ref id="R10"><label>10.</label><mixed-citation publication-type="journal"><name><surname>Hughes</surname><given-names>K</given-names></name>, <name><surname>Bellis</surname><given-names>MA</given-names></name>, <name><surname>Hardcastle</surname><given-names>KA</given-names></name>, <name><surname>McHale</surname><given-names>P</given-names></name>, <name><surname>Bennett</surname><given-names>A</given-names></name>, <name><surname>Ireland</surname><given-names>R</given-names></name>, <etal/>
<article-title>Associations between e-cigarette access and smoking and drinking behaviours in teenagers</article-title>. <source>BMC Public Health</source>. <year>2015</year>;<volume>15</volume>(<issue>1</issue>):<fpage>1</fpage>.<pub-id pub-id-type="pmid">25563658</pub-id></mixed-citation></ref><ref id="R11"><label>11.</label><mixed-citation publication-type="journal"><name><surname>Kristjansson</surname><given-names>AL</given-names></name>, <name><surname>Sigfusdottir</surname><given-names>ID</given-names></name>. <article-title>E-cigarette use and relations to tobacco and alcohol use among adolescents</article-title>. <source>BMC Med</source>
<year>2015</year>;<volume>13</volume>(<issue>1</issue>):<fpage>1</fpage>.<pub-id pub-id-type="pmid">25563062</pub-id></mixed-citation></ref><ref id="R12"><label>12.</label><mixed-citation publication-type="journal"><name><surname>Sutfin</surname><given-names>EL</given-names></name>, <name><surname>McCoy</surname><given-names>TP</given-names></name>, <name><surname>Morrell</surname><given-names>HE</given-names></name>, <name><surname>Hoeppner</surname><given-names>BB</given-names></name>, <name><surname>Wolfson</surname><given-names>M</given-names></name>. <article-title>Electronic cigarette use by college students</article-title>. <source>Drug Alcohol Depend</source>. <year>2013</year>;<volume>131</volume>(<issue>3</issue>):<fpage>214</fpage>&#x02013;<lpage>21</lpage>.<pub-id pub-id-type="pmid">23746429</pub-id></mixed-citation></ref><ref id="R13"><label>13.</label><mixed-citation publication-type="journal"><name><surname>White</surname><given-names>J</given-names></name>, <name><surname>Li</surname><given-names>J</given-names></name>, <name><surname>Newcombe</surname><given-names>R</given-names></name>, <name><surname>Walton</surname><given-names>D</given-names></name>. <article-title>Tripling use of electronic cigarettes among new zealand adolescents between 2012 and 2014</article-title>. <source>J Adolesc Health</source>. <year>2015</year>;<volume>56</volume>(<issue>5</issue>):<fpage>522</fpage>&#x02013;<lpage>8</lpage>.<pub-id pub-id-type="pmid">25907651</pub-id></mixed-citation></ref><ref id="R14"><label>14.</label><mixed-citation publication-type="journal"><name><surname>Chapman</surname><given-names>SLC</given-names></name>, <name><surname>Wu</surname><given-names>L-T</given-names></name>. <article-title>E-cigarette prevalence and correlates of use among adolescents versus adults: A review and comparison</article-title>. <source>J Psychiatr Res</source>. <year>2014</year>;<volume>54</volume>:<fpage>43</fpage>&#x02013;<lpage>54</lpage>.<pub-id pub-id-type="pmid">24680203</pub-id></mixed-citation></ref><ref id="R15"><label>15.</label><mixed-citation publication-type="journal"><name><surname>Schoenborn</surname><given-names>CA</given-names></name>, <name><surname>Gindi</surname><given-names>RM</given-names></name>. <article-title>Electronic cigarette use among adults: United states, 2014</article-title>. <source>NCHS data brief</source>. <year>2015</year>;<volume>217</volume>:<fpage>1</fpage>&#x02013;<lpage>8</lpage>.</mixed-citation></ref><ref id="R16"><label>16.</label><mixed-citation publication-type="journal"><name><surname>Goniewicz</surname><given-names>ML</given-names></name>, <name><surname>Lingas</surname><given-names>EO</given-names></name>, <name><surname>Hajek</surname><given-names>P</given-names></name>. <article-title>Patterns of electronic cigarette use and user beliefs about their safety and benefits: An internet survey</article-title>. <source>Drug Alcohol Rev</source>. <year>2013</year>;<volume>32</volume>(<issue>2</issue>):<fpage>133</fpage>&#x02013;<lpage>40</lpage>.<pub-id pub-id-type="pmid">22994631</pub-id></mixed-citation></ref><ref id="R17"><label>17.</label><mixed-citation publication-type="journal"><name><surname>Fagan</surname><given-names>P</given-names></name>, <name><surname>King</surname><given-names>G</given-names></name>, <name><surname>Lawrence</surname><given-names>D</given-names></name>, <name><surname>Petrucci</surname><given-names>SA</given-names></name>, <name><surname>Robinson</surname><given-names>RG</given-names></name>, <name><surname>Banks</surname><given-names>D</given-names></name>, <etal/>
<article-title>Eliminating tobacco-related health disparities: Directions for future research</article-title>. <source>Am J Public Health</source>. <year>2004</year>;<volume>94</volume>(<issue>2</issue>):<fpage>211</fpage>&#x02013;<lpage>7</lpage>.<pub-id pub-id-type="pmid">14759929</pub-id></mixed-citation></ref><ref id="R18"><label>18.</label><mixed-citation publication-type="journal"><name><surname>Fagan</surname><given-names>P</given-names></name>, <name><surname>Moolchan</surname><given-names>ET</given-names></name>, <name><surname>Lawrence</surname><given-names>D</given-names></name>, <name><surname>Fernander</surname><given-names>A</given-names></name>, <name><surname>Ponder</surname><given-names>PK</given-names></name>. <article-title>Identifying health disparities across the tobacco continuum</article-title>. <source>Addiction</source>. <year>2007</year>;<volume>102</volume>(<issue>s2</issue>):<fpage>5</fpage>&#x02013;<lpage>29</lpage>.</mixed-citation></ref><ref id="R19"><label>19.</label><mixed-citation publication-type="journal"><name><surname>Fakunle</surname><given-names>D</given-names></name>, <name><surname>Morton</surname><given-names>CM</given-names></name>, <name><surname>Peterson</surname><given-names>NA</given-names></name>. <article-title>The importance of income in the link between tobacco outlet density and demographics at the tract level of analysis in new jersey</article-title>. <source>J Ethn Subst Abuse</source>. <year>2010</year>;<volume>9</volume>(<issue>4</issue>):<fpage>249</fpage>&#x02013;<lpage>59</lpage>.<pub-id pub-id-type="pmid">21161808</pub-id></mixed-citation></ref><ref id="R20"><label>20.</label><mixed-citation publication-type="journal"><name><surname>Fakunle</surname><given-names>DO</given-names></name>, <name><surname>Milam</surname><given-names>AJ</given-names></name>, <name><surname>Furr-Holden</surname><given-names>CDM</given-names></name>, <name><surname>Butler III</surname><given-names>J</given-names></name>, <name><surname>Thorpe</surname><given-names>RJ</given-names><suffix>Jr</suffix></name>., <name><surname>LaVeist</surname><given-names>TA</given-names></name>. <article-title>The inequitable distribution of tobacco outlet density: The role of income in two black Mid-Atlantic geopolitical areas</article-title>. <source>Public Health</source>. <year>2016</year>;<volume>136</volume>:<fpage>35</fpage>&#x02013;<lpage>40</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.puhe.2016.02.032</pub-id><comment>.</comment><pub-id pub-id-type="pmid">27076440</pub-id></mixed-citation></ref><ref id="R21"><label>21.</label><mixed-citation publication-type="web"><collab>Centers for Disease Control and Prevention (CDC)</collab>. <source>African Americans and tobacco use</source>. <comment><ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/tobacco/disparities/african-americans/index.htm#prevalence">http://www.cdc.gov/tobacco/disparities/african-americans/index.htm#prevalence</ext-link>.</comment>
<comment>Accessed</comment>
<date-in-citation>September 17, 2015</date-in-citation>.</mixed-citation></ref><ref id="R22"><label>22.</label><mixed-citation publication-type="journal"><name><surname>Duke</surname><given-names>JC</given-names></name>, <name><surname>Farrelly</surname><given-names>MC</given-names></name>, <name><surname>Alexander</surname><given-names>TN</given-names></name>, <name><surname>MacMonegle</surname><given-names>AJ</given-names></name>, <name><surname>Zhao</surname><given-names>X</given-names></name>, <name><surname>Allen</surname><given-names>JA</given-names></name>, <etal/>
<article-title>Effect of a national tobacco public education campaign on youth&#x02019;s risk perceptions and beliefs about smoking</article-title>. <source>Am J Health Promot</source>. <year>2017</year>;<comment>890117117720745.</comment> doi: <pub-id pub-id-type="doi">10.1177/0890117117720745</pub-id></mixed-citation></ref><ref id="R23"><label>23.</label><mixed-citation publication-type="web"><collab>Truth Initiative</collab>. <source>truth Campaign official website</source>. <comment><ext-link ext-link-type="uri" xlink:href="https://www.thetruth.com/">https://www.thetruth.com/</ext-link>.</comment>
<comment>Accessed</comment>
<date-in-citation>August 12, 2017</date-in-citation>.</mixed-citation></ref><ref id="R24"><label>24.</label><mixed-citation publication-type="journal"><name><surname>Peterson</surname><given-names>DE</given-names></name>, <name><surname>Zeger</surname><given-names>SL</given-names></name>, <name><surname>Remington</surname><given-names>PL</given-names></name>, <name><surname>Anderson</surname><given-names>HA</given-names></name>. <article-title>The effect of state cigarette tax increases on cigarette sales, 1955 to 1988</article-title>. <source>Am J Public Health</source>. <year>1992</year>
<month>1</month>;<volume>82</volume>(<issue>1</issue>):<fpage>94</fpage>&#x02013;<lpage>6</lpage>.<pub-id pub-id-type="pmid">1536343</pub-id></mixed-citation></ref><ref id="R25"><label>25.</label><mixed-citation publication-type="journal"><name><surname>Chaloupka</surname><given-names>FJ</given-names></name>, <name><surname>Cummings</surname><given-names>KM</given-names></name>, <name><surname>Morley</surname><given-names>CP</given-names></name>, <name><surname>Horan</surname><given-names>JK</given-names></name>. <article-title>Tax, price and cigarette smoking: evidence from the tobacco documents and implications for tobacco company marketing strategies</article-title>. <source>Tob Control</source>. <year>2002</year>
<month>3</month>;<volume>11</volume>
<issue>Suppl 1</issue>:<fpage>I62</fpage>&#x02013;<lpage>72</lpage>.<pub-id pub-id-type="pmid">11893816</pub-id></mixed-citation></ref><ref id="R26"><label>26.</label><mixed-citation publication-type="journal"><name><surname>Ashe</surname><given-names>M</given-names></name>, <name><surname>Jernigan</surname><given-names>D</given-names></name>, <name><surname>Kline</surname><given-names>R</given-names></name>, <name><surname>Galaz</surname><given-names>R</given-names></name>. <article-title>Land use planning and the control of alcohol, tobacco, firearms, and fast food restaurants</article-title>. <source>Am J Public Health</source>. <year>2003</year>
<month>9</month>;<volume>93</volume>(<issue>9</issue>):<fpage>1404</fpage>&#x02013;<lpage>8</lpage>.<pub-id pub-id-type="pmid">12948952</pub-id></mixed-citation></ref><ref id="R27"><label>27.</label><mixed-citation publication-type="journal"><name><surname>Ackerman</surname><given-names>A</given-names></name>, <name><surname>Etow</surname><given-names>A</given-names></name>, <name><surname>Bartel</surname><given-names>S</given-names></name>, <name><surname>Ribisl</surname><given-names>KM</given-names></name>. <article-title>Reducing the density and number of tobacco retailers: policy solutions and legal issues</article-title>. <source>Nicotine Tob Res</source>. <year>2017</year>
<month>2</month>
<day>1</day>;<volume>19</volume>(<issue>2</issue>):<fpage>133</fpage>&#x02013;<lpage>40</lpage>.<pub-id pub-id-type="pmid">27127232</pub-id></mixed-citation></ref><ref id="R28"><label>28.</label><mixed-citation publication-type="journal"><name><surname>Polinski</surname><given-names>JM</given-names></name>, <name><surname>Howell</surname><given-names>B</given-names></name>, <name><surname>Gagnon</surname><given-names>MA</given-names></name>, <name><surname>Kymes</surname><given-names>SM</given-names></name>, <name><surname>Brennan</surname><given-names>TA</given-names></name>, <name><surname>Shrank</surname><given-names>WH</given-names></name>. <article-title>Impact of CVS Pharmacy&#x02019;s discontinuance of tobacco sales on cigarette purchasing (2012&#x02013;2014)</article-title>. <source>Am J Public Health</source>. <year>2017</year>
<month>4</month>;<volume>107</volume>(<issue>4</issue>):<fpage>556</fpage>&#x02013;<lpage>562</lpage>. doi: <pub-id pub-id-type="doi">10.2105/AJPH.2016.303612</pub-id><comment>.</comment><pub-id pub-id-type="pmid">28207340</pub-id></mixed-citation></ref><ref id="R29"><label>29.</label><mixed-citation publication-type="journal"><name><surname>Ribisl</surname><given-names>KM</given-names></name>, <name><surname>Luke</surname><given-names>DA</given-names></name>, <name><surname>Bohannon</surname><given-names>DL</given-names></name>, <name><surname>Sorg</surname><given-names>AA</given-names></name>, <name><surname>Moreland-Russell</surname><given-names>S</given-names></name>. <article-title>Reducing disparities in tobacco retailer density by banning tobacco product sales near schools</article-title>. <source>Nicotine Tob Res</source>. <year>2017</year>
<month>2</month>;<volume>19</volume>(<issue>2</issue>):<fpage>239</fpage>&#x02013;<lpage>244</lpage>. doi: <pub-id pub-id-type="doi">10.1093/ntr/ntw185</pub-id><comment>.</comment><pub-id pub-id-type="pmid">27613900</pub-id></mixed-citation></ref><ref id="R30"><label>30.</label><mixed-citation publication-type="journal"><name><surname>Luke</surname><given-names>DA</given-names></name>, <name><surname>Sorg</surname><given-names>AA</given-names></name>, <name><surname>Combs</surname><given-names>T</given-names></name>, <name><surname>Robichaux</surname><given-names>CB</given-names></name>, <name><surname>Moreland-Russell</surname><given-names>S</given-names></name>, <name><surname>Ribisl</surname><given-names>KM</given-names></name>, <etal/>
<article-title>Tobacco retail policy landscape: a longitudinal survey of US states</article-title>. <source>Tob Control</source>. <year>2016</year>
<month>10</month>;<volume>25</volume>(<issue>Suppl 1</issue>):<fpage>i44</fpage>&#x02013;<lpage>i51</lpage>. doi: <pub-id pub-id-type="doi">10.1136/tobaccocontrol-2016-053075</pub-id><comment>.</comment><pub-id pub-id-type="pmid">27697947</pub-id></mixed-citation></ref><ref id="R31"><label>31.</label><mixed-citation publication-type="journal"><name><surname>Cohen</surname><given-names>JE</given-names></name>, <name><surname>Anglin</surname><given-names>L</given-names></name>. <article-title>Outlet density: a new frontier for tobacco control</article-title>. <source>Addiction</source>. <year>2009</year>
<month>1</month>
<day>1</day>;<volume>104</volume>(<issue>1</issue>):<fpage>2</fpage>&#x02013;<lpage>3</lpage>.<pub-id pub-id-type="pmid">19133881</pub-id></mixed-citation></ref><ref id="R32"><label>32.</label><mixed-citation publication-type="journal"><name><surname>Grana</surname><given-names>RA</given-names></name>, <name><surname>Ling</surname><given-names>PM</given-names></name><article-title>. &#x0201c;Smoking revolution&#x0201d;: A content analysis of electronic cigarette retail websites</article-title>. <source>Am J Prev Med</source>. <year>2014</year>;<volume>46</volume>(<issue>4</issue>):<fpage>395</fpage>&#x02013;<lpage>403</lpage>.<pub-id pub-id-type="pmid">24650842</pub-id></mixed-citation></ref><ref id="R33"><label>33.</label><mixed-citation publication-type="journal"><name><surname>Hsu</surname><given-names>R</given-names></name>, <name><surname>Myers</surname><given-names>AE</given-names></name>, <name><surname>Ribisl</surname><given-names>KM</given-names></name>, <name><surname>Marteau</surname><given-names>TM</given-names></name>. <article-title>An observational study of retail availability and in-store marketing of e-cigarettes in london: Potential to undermine recent tobacco control gains?</article-title>
<source>BMJ Open</source>. <year>2013</year>;<volume>3</volume>(<issue>12</issue>):<fpage>e004085</fpage>.</mixed-citation></ref><ref id="R34"><label>34.</label><mixed-citation publication-type="journal"><name><surname>Rose</surname><given-names>SW</given-names></name>, <name><surname>Barker</surname><given-names>DC</given-names></name>, <name><surname>D&#x02019;Angelo</surname><given-names>H</given-names></name>, <name><surname>Khan</surname><given-names>T</given-names></name>, <name><surname>Huang</surname><given-names>J</given-names></name>, <name><surname>Chaloupka</surname><given-names>FJ</given-names></name>, <etal/>
<article-title>The availability of electronic cigarettes in U.S. retail outlets, 2012: Results of two national studies</article-title>. <source>Tob Control</source>. <year>2014</year>;<volume>23</volume>
<issue>Suppl 3</issue>:<fpage>iii10</fpage>&#x02013;<lpage>6</lpage>. <comment>Epub 2014/06/18.</comment> doi: <pub-id pub-id-type="doi">10.1136/tobaccocontrol-2013-051461</pub-id><comment>.</comment>
<comment>PubMed PMID</comment>: ; <comment>PubMed Central PMCID: PMCPmc4078712.</comment><pub-id pub-id-type="pmid">24935892</pub-id></mixed-citation></ref><ref id="R35"><label>35.</label><mixed-citation publication-type="journal"><name><surname>Wagoner</surname><given-names>KG</given-names></name>, <name><surname>Song</surname><given-names>EY</given-names></name>, <name><surname>Egan</surname><given-names>KL</given-names></name>, <name><surname>Sutfin</surname><given-names>EL</given-names></name>, <name><surname>Reboussin</surname><given-names>BA</given-names></name>, <name><surname>Spangler</surname><given-names>J</given-names></name>, <etal/>
<article-title>E-cigarette availability and promotion among retail outlets near college campuses in two southeastern states</article-title>. <source>Nicotine Tob Res</source>. <year>2014</year>;<volume>16</volume>(<issue>8</issue>):<fpage>1150</fpage>&#x02013;<lpage>5</lpage>.<pub-id pub-id-type="pmid">24847099</pub-id></mixed-citation></ref><ref id="R36"><label>36.</label><mixed-citation publication-type="journal"><name><surname>Williams</surname><given-names>RS</given-names></name>, <name><surname>Derrick</surname><given-names>J</given-names></name>, <name><surname>Ribisl</surname><given-names>KM</given-names></name>. <article-title>Electronic cigarette sales to minors via the internet</article-title>. <source>JAMA Pediatr</source>. <year>2015</year>;<volume>169</volume>(<issue>3</issue>):<fpage>e1563</fpage>&#x02013;<lpage>e</lpage>.<pub-id pub-id-type="pmid">25730697</pub-id></mixed-citation></ref><ref id="R37"><label>37.</label><mixed-citation publication-type="journal"><name><surname>Milam</surname><given-names>AJ</given-names></name>, <name><surname>Furr&#x02010;Holden</surname><given-names>CD</given-names></name>, <name><surname>Bradshaw</surname><given-names>CP</given-names></name>, <name><surname>Webster</surname><given-names>DW</given-names></name>, <name><surname>Cooley&#x02010;Strickland</surname><given-names>MC</given-names></name>, <name><surname>Leaf</surname><given-names>PJ</given-names></name>. <article-title>Alcohol environment, perceived safety, and exposure to alcohol, tobacco, and other drugs in early adolescence</article-title>. <source>J Community Psychol</source>. <year>2013</year>;<volume>41</volume>(<issue>7</issue>):<fpage>867</fpage>&#x02013;<lpage>83</lpage>.<pub-id pub-id-type="pmid">25125766</pub-id></mixed-citation></ref><ref id="R38"><label>38.</label><mixed-citation publication-type="journal"><name><surname>Milam</surname><given-names>A</given-names></name>, <name><surname>Furr-Holden</surname><given-names>C</given-names></name>, <name><surname>Cooley-Strickland</surname><given-names>M</given-names></name>, <name><surname>Bradshaw</surname><given-names>C</given-names></name>, <name><surname>Leaf</surname><given-names>P</given-names></name>. <article-title>Risk for exposure to alcohol, tobacco, and other drugs on the route to and from school: The role of alcohol outlets</article-title>. <source>Prev Sci</source>. <year>2014</year>;<volume>15</volume>(<issue>1</issue>):<fpage>12</fpage>&#x02013;<lpage>21</lpage>.<pub-id pub-id-type="pmid">23408286</pub-id></mixed-citation></ref><ref id="R39"><label>39.</label><mixed-citation publication-type="journal"><name><surname>Jennings</surname><given-names>JM</given-names></name>, <name><surname>Milam</surname><given-names>AJ</given-names></name>, <name><surname>Greiner</surname><given-names>A</given-names></name>, <name><surname>Furr-Holden</surname><given-names>CD</given-names></name>, <name><surname>Curriero</surname><given-names>FC</given-names></name>, <name><surname>Thornton</surname><given-names>RJ</given-names></name>. <article-title>Neighborhood alcohol outlets and the association with violent crime in one mid-atlantic city: The implications for zoning policy</article-title>. <source>J Urban Health</source>. <year>2014</year>;<volume>91</volume>(<issue>1</issue>):<fpage>62</fpage>&#x02013;<lpage>71</lpage>. <comment>Epub 2013/09/05.</comment> doi: <pub-id pub-id-type="doi">10.1007/s11524-013-9821-z</pub-id><comment>.</comment><pub-id pub-id-type="pmid">24002723</pub-id></mixed-citation></ref><ref id="R40"><label>40.</label><mixed-citation publication-type="journal"><name><surname>Furr-Holden</surname><given-names>CD</given-names></name>, <name><surname>Milam</surname><given-names>AJ</given-names></name>, <name><surname>Nesoff</surname><given-names>ED</given-names></name>, <name><surname>Johnson</surname><given-names>RM</given-names></name>, <name><surname>Fakunle</surname><given-names>DO</given-names></name>, <name><surname>Jennings</surname><given-names>JM</given-names></name>, <etal/>
<article-title>Not in my back yard: A comparative analysis of crime around publicly funded drug treatment centers, liquor stores, convenience stores, and corner stores in one mid-atlantic city</article-title>. <source>J Stud Alcohol Drugs</source>. <year>2016</year>;<volume>77</volume>(<issue>1</issue>):<fpage>17</fpage>&#x02013;<lpage>24</lpage>.<pub-id pub-id-type="pmid">26751351</pub-id></mixed-citation></ref><ref id="R41"><label>41.</label><mixed-citation publication-type="web"><source>City of Baltimore. Department of planning: Transform Baltimore</source>. <comment><ext-link ext-link-type="uri" xlink:href="https://planning.baltimorecity.gov/programs/transform-baltimore">https://planning.baltimorecity.gov/programs/transform-baltimore</ext-link>.</comment>
<comment>Accessed</comment>
<date-in-citation>June 11, 2018</date-in-citation>.</mixed-citation></ref><ref id="R42"><label>42.</label><mixed-citation publication-type="web"><source>City of Baltimore. Liquor license board: License types</source>. <comment><ext-link ext-link-type="uri" xlink:href="http://llb.baltimorecity.gov/license-types">http://llb.baltimorecity.gov/license-types</ext-link></comment>
<comment>Updated</comment>
<month>11</month>
<year>2016</year><comment>. Accessed</comment>
<date-in-citation>January 18, 2017</date-in-citation>.</mixed-citation></ref><ref id="R43"><label>43.</label><mixed-citation publication-type="journal"><name><surname>Pucci</surname><given-names>LG</given-names></name>, <name><surname>Joseph</surname><given-names>HM</given-names><suffix>Jr.</suffix></name>, <name><surname>Siegel</surname><given-names>M</given-names></name>. <article-title>Outdoor tobacco advertising in six boston neighborhoods. Evaluating youth exposure</article-title>. <source>Am J Prev Med</source>. <year>1998</year>;<volume>15</volume>(<issue>2</issue>):<fpage>155</fpage>&#x02013;<lpage>9</lpage>.<pub-id pub-id-type="pmid">9713672</pub-id></mixed-citation></ref><ref id="R44"><label>44.</label><mixed-citation publication-type="journal"><name><surname>Terry-McElrath</surname><given-names>YM</given-names></name>, <name><surname>Harwood</surname><given-names>EM</given-names></name>, <name><surname>Wagenaar</surname><given-names>AC</given-names></name>, <name><surname>Slater</surname><given-names>S</given-names></name>, <name><surname>Chaloupka</surname><given-names>FJ</given-names></name>, <name><surname>Brewer</surname><given-names>RD</given-names></name>, <etal/>
<article-title>Point-of-purchase alcohol marketing and promotion by store type - united states, 2000&#x02013;2001</article-title>. <source>MMWR</source>. <year>2003</year>;<volume>52</volume>(<issue>14</issue>):<fpage>307</fpage>&#x02013;<lpage>10</lpage>.<pub-id pub-id-type="pmid">12731701</pub-id></mixed-citation></ref><ref id="R45"><label>45.</label><mixed-citation publication-type="book"><collab>US Census Bureau</collab>. <source>Geographic terms and concepts - census tracts</source>: <publisher-name>US Census Bureau</publisher-name>; <comment>2012</comment>
<comment><ext-link ext-link-type="uri" xlink:href="https://www.census.gov/geo/reference/gtc/gtc_ct.html?cssp=SERP">https://www.census.gov/geo/reference/gtc/gtc_ct.html?cssp=SERP</ext-link>.</comment>
<comment>Updated</comment>
<month>12</month>
<day>6</day>, <year>2012</year><comment>. Accessed</comment>
<date-in-citation>December 11, 2015</date-in-citation>.</mixed-citation></ref><ref id="R46"><label>46.</label><mixed-citation publication-type="web"><collab>US Census Bureau</collab>. <source>American Community Survey, 2009&#x02013;2013 5-year estimates</source>. <comment><ext-link ext-link-type="uri" xlink:href="http://factfinder.census.gov">http://factfinder.census.gov</ext-link>.</comment>
<comment>Accessed</comment>
<date-in-citation>June 9, 2015</date-in-citation>.</mixed-citation></ref><ref id="R47"><label>47.</label><mixed-citation publication-type="book"><collab>U.S. Census Bureau</collab>. <source>A Compass for Understanding and Using American Community Survey Data: What PUMS Data Users Need to Know</source>. <publisher-loc>Washington, D.C</publisher-loc>: <publisher-name>U.S. Government Printing Office</publisher-name>; <year>2009</year>.</mixed-citation></ref><ref id="R48"><label>48.</label><mixed-citation publication-type="book"><source>ArcGIS Desktop [computer program]</source>. <comment>Version 10.2.2.</comment>
<publisher-loc>Redlands, CA</publisher-loc>; <publisher-name>Environmental Systems Research Institute</publisher-name>: <year>2014</year>.</mixed-citation></ref><ref id="R49"><label>49.</label><mixed-citation publication-type="book"><source>SPSS Statistics [computer program]</source>. <comment>Version 25.</comment>
<publisher-loc>Armonk, NY</publisher-loc>: <publisher-name>International Business Machines</publisher-name>: <year>2017</year>.</mixed-citation></ref><ref id="R50"><label>50.</label><mixed-citation publication-type="journal"><name><surname>LaVeist</surname><given-names>TA</given-names></name>, <name><surname>Wallace</surname><given-names>JMJ</given-names></name>. <article-title>Health risk and inequitable distribution of liquor stores in african american neighborhoods</article-title>. <source>Soc Sci Med</source>. <year>2000</year>;<volume>51</volume>:<fpage>613</fpage>&#x02013;<lpage>7</lpage>.<pub-id pub-id-type="pmid">10868674</pub-id></mixed-citation></ref><ref id="R51"><label>51.</label><mixed-citation publication-type="journal"><name><surname>Lowery</surname><given-names>BC</given-names></name>, <name><surname>Sloane</surname><given-names>DC</given-names></name>. <article-title>The prevalence of harmful content on outdoor advertising in los angeles: Land use, community characteristics, and the spatial inequality of a public health nuisance</article-title>. <source>American Journal of Public Health</source>. <year>2014</year>;<volume>104</volume>(<issue>4</issue>):<fpage>658</fpage>&#x02013;<lpage>64</lpage>. doi: <pub-id pub-id-type="doi">10.2105/AJPH.2013.301694</pub-id><comment>.</comment><pub-id pub-id-type="pmid">24524512</pub-id></mixed-citation></ref><ref id="R52"><label>52.</label><mixed-citation publication-type="web"><name><surname>Christensen</surname><given-names>J</given-names></name>
<source>Fda to extend tobacco regulations to e-cigarettes, other products: CNN</source>; <comment>May 5, 2016</comment> [<month>6</month>
<year>2016</year>]<comment>. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.cnn.com/2016/05/05/health/fda-e-cigarettes-regulation/index.html">http://www.cnn.com/2016/05/05/health/fda-e-cigarettes-regulation/index.html</ext-link>.</comment></mixed-citation></ref><ref id="R53"><label>53.</label><mixed-citation publication-type="web"><source>Unannotated code of maryland and rules: Lexis Nexis</source>; [<month>5</month>
<year>2016</year>]. <comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.lexisnexis.com/hottopics/mdcode/">https://www.lexisnexis.com/hottopics/mdcode/</ext-link>.</comment></mixed-citation></ref><ref id="R54"><label>54.</label><mixed-citation publication-type="web"><source>Baltimore city charter &#x00026; codes--city of baltimore</source> [<comment>May</comment>
<year>2016</year>]. <comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://legislativereference.baltimorecity.gov/city-codes">http://legislativereference.baltimorecity.gov/city-codes</ext-link>.</comment></mixed-citation></ref><ref id="R55"><label>55.</label><mixed-citation publication-type="journal"><name><surname>Dareing</surname><given-names>M</given-names></name>
<article-title>Vape industry blows away tobacco industry in growth</article-title>. <source>US Finance Post</source>. <month>4</month>
<day>17</day>, <year>2015</year>.</mixed-citation></ref><ref id="R56"><label>56.</label><mixed-citation publication-type="journal"><name><surname>Giovenco</surname><given-names>DP</given-names></name>, <name><surname>Duncan</surname><given-names>DT</given-names></name>, <name><surname>Coups</surname><given-names>EJ</given-names></name>, <name><surname>Lewis</surname><given-names>MJ</given-names></name>, <name><surname>Delnevo</surname><given-names>CD</given-names></name>. <article-title>Census tract correlates of vape shop locations in new jersey</article-title>. <source>Health Place</source>. <year>2016</year>;<volume>40</volume>:<fpage>123</fpage>&#x02013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.healthplace.2016.05.008</pub-id><comment>.</comment>
<comment>PubMed PMID</comment>: .<pub-id pub-id-type="pmid">27261635</pub-id></mixed-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1:</label><caption><p id="P27">Alcohol Outlets with E-Cigarette Availability by Non-White Population Percentage, Baltimore City, 2014</p></caption><graphic xlink:href="nihms-978773-f0001"/></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2:</label><caption><p id="P28">Alcohol Outlets with E-Cigarette Availability by Median Household Income, Baltimore City, 2014</p></caption><graphic xlink:href="nihms-978773-f0002"/></fig><table-wrap id="T1" position="float" orientation="portrait"><label>Table 1:</label><caption><p id="P29">E-Cigarette and Traditional Cigarette Availability in Baltimore Alcohol Outlets &#x02013; Total and by License Type (LA/LA2 vs. LBD7)</p></caption><table frame="box" rules="all"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="middle" rowspan="1" colspan="1">License Type</th><th align="center" valign="middle" rowspan="1" colspan="1">Total Number of Outlets</th><th align="center" valign="middle" rowspan="1" colspan="1">Number of Outlets with E-Cigarette Availability, n (%)</th><th align="center" valign="middle" rowspan="1" colspan="1">Number of Outlets with Traditional Cigarette Availability, n (%)</th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">LA/LA2</td><td align="center" valign="middle" rowspan="1" colspan="1">216</td><td align="center" valign="middle" rowspan="1" colspan="1">79 (36.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">169 (78.2)</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">LBD7</td><td align="center" valign="middle" rowspan="1" colspan="1">354</td><td align="center" valign="middle" rowspan="1" colspan="1">28 (7.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">80 (22.6)</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">570</td><td align="center" valign="middle" rowspan="1" colspan="1">107 (18.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">249 (43.7)</td></tr></tbody></table></table-wrap><table-wrap id="T2" position="float" orientation="portrait"><label>Table 2:</label><caption><p id="P30">Adjusted Odds Ratios of E-Cigarette Availability within Alcohol Outlets</p></caption><table frame="box" rules="all"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="middle" rowspan="1" colspan="1">Exposure</th><th align="center" valign="middle" rowspan="1" colspan="1">Adjusted Odds Ratio</th><th align="center" valign="middle" rowspan="1" colspan="1"><italic>p</italic></th><th align="center" valign="middle" rowspan="1" colspan="1">CI<sup><xref rid="TFN1" ref-type="table-fn">1</xref></sup></th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Outlet license type (LBD7 vs. LA/LA2)</td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>0.45</bold><xref rid="TFN2" ref-type="table-fn"><sup>2</sup></xref></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>0.01</bold></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>[0.26, 0.79]</bold></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Smoking pipes</td><td align="center" valign="middle" rowspan="1" colspan="1">0.53</td><td align="center" valign="middle" rowspan="1" colspan="1">0.48</td><td align="center" valign="middle" rowspan="1" colspan="1">[0.09, 3.14]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Hookah paraphernalia</td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>3.49</bold></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>0.01</bold></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>[1.32, 9.20]</bold></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Synthetic cannabinoids</td><td align="center" valign="middle" rowspan="1" colspan="1">2.63</td><td align="center" valign="middle" rowspan="1" colspan="1">0.21</td><td align="center" valign="middle" rowspan="1" colspan="1">[0.59, 11.69]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Vaporizers</td><td align="center" valign="middle" rowspan="1" colspan="1">1.55</td><td align="center" valign="middle" rowspan="1" colspan="1">0.38</td><td align="center" valign="middle" rowspan="1" colspan="1">[0.58, 4.12]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Cigarettes/Cigars</td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>12.39</bold></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>&#x0003c;0.001</bold></td><td align="center" valign="middle" rowspan="1" colspan="1"><bold>[5.11, 30.02]</bold></td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/><td align="center" valign="middle" rowspan="1" colspan="1"/></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Flavored cigar papers</td><td align="center" valign="middle" rowspan="1" colspan="1">1.26</td><td align="center" valign="middle" rowspan="1" colspan="1">0.44</td><td align="center" valign="middle" rowspan="1" colspan="1">[0.70, 2.25]</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>1</label><p id="P31">Confidence interval</p></fn><fn id="TFN2"><label>2</label><p id="P32">Bold denotes significance at <italic>p</italic> = 0.05</p></fn></table-wrap-foot></table-wrap></floats-group></article>