Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Popovici, Jean ; Vantaux, Amelie ; Primault, Lyse ; Samreth, Reingsey ; Piv, Eak Por ; Bin, Sophalai ; Kim, Saorin ; Lek, Dysoley ; Serre, David ; Menard, Didier
• Description:
  We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.
• Subjects:
  Adolescent Adult Antimalarials Artemisinins Chloroquine Dispatch Drug Combinations Female Humans Malaria, Vivax Male Middle Aged Quinolines Young Adult

  More +
• Source:
  Emerg Infect Dis. 24(8):1516-1519
• Pubmed ID:
  29798745
• Pubmed Central ID:
  PMC6056113
• Document Type:
  Journal Article
• Funding:
  R01 AI103228/AI/NIAID NIH HHS/United States
• Place as Subject:
  Cambodia
• Location:
  Asia
• Volume:
  24
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:05a4c9fd9189c04c2ccca512bae5e62f70416fa384460b84c3219e5662d0e7d5
• Download URL:
  https://stacks.cdc.gov/view/cdc/57943/cdc_57943_DS1.pdf
• File Type:
  [PDF - 685.41 KB ]