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<article xmlns:ali="http://www.niso.org/schemas/ali/1.0" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties open_access?><front><journal-meta><journal-id journal-id-type="nlm-ta">MMWR Morb Mortal Wkly Rep</journal-id><journal-id journal-id-type="iso-abbrev">MMWR Morb. Mortal. Wkly. Rep</journal-id><journal-id journal-id-type="publisher-id">MMWR</journal-id><journal-title-group><journal-title>MMWR. Morbidity and Mortality Weekly Report</journal-title></journal-title-group><issn pub-type="ppub">0149-2195</issn><issn pub-type="epub">1545-861X</issn><publisher><publisher-name>U.S. Centers for Disease Control</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25674992</article-id><article-id pub-id-type="pmc">4584686</article-id><article-id pub-id-type="publisher-id">117-120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Silicosis Mortality Trends and New Exposures to Respirable Crystalline Silica &#x02014; United States, 2001&#x02013;2010</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bang</surname><given-names>Ki Moon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="af1-117-120">1</xref></contrib><contrib contrib-type="author"><name><surname>Mazurek</surname><given-names>Jacek M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af1-117-120">1</xref><xref ref-type="corresp" rid="c1-117-120"/></contrib><contrib contrib-type="author"><name><surname>Wood</surname><given-names>John M.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="af1-117-120">1</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Gretchen E.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="af1-117-120">1</xref></contrib><contrib contrib-type="author"><name><surname>Hendricks</surname><given-names>Scott A.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="af2-117-120">2</xref></contrib><contrib contrib-type="author"><name><surname>Weston</surname><given-names>Ainsley</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="af1-117-120">1</xref></contrib></contrib-group><aff id="af1-117-120"><label>1</label>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC</aff><aff id="af2-117-120"><label>2</label>Divison of Safety Research, National Institute for Occupational Safety and Health, CDC</aff><author-notes><corresp id="c1-117-120">Corresponding author: Jacek Mazurek, <email>jmazurek1@cdc.gov</email>, 304-285-5983</corresp></author-notes><pub-date pub-type="collection"><day>13</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>13</day><month>2</month><year>2015</year></pub-date><volume>64</volume><issue>5</issue><fpage>117</fpage><lpage>119</lpage><permissions><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/about/cc0"><license-p>All material in the MMWR Series is in the public domain and may be used and reprinted without permission; citation as to source, however, is appreciated.</license-p></license></permissions></article-meta></front><body><p>Silicosis is a preventable occupational lung disease caused by the inhalation of respirable crystalline silica dust and can progress to respiratory failure and death (<xref rid="b1-117-120" ref-type="bibr">1</xref>). No effective specific treatment for silicosis is available; patients are provided supportive care, and some patients may be considered for lung transplantation. Chronic silicosis can develop or progress even after occupational exposure has ceased (<xref rid="b1-117-120" ref-type="bibr">1</xref>). The number of deaths from silicosis declined from 1,065 in 1968 to 165 in 2004 (<xref rid="b2-117-120" ref-type="bibr">2</xref>). Hazardous occupational exposures to silica dust have long been known to occur in a variety of industrial operations, including mining, quarrying, sandblasting, rock drilling, road construction, pottery making, stone masonry, and tunneling operations (<xref rid="b1-117-120" ref-type="bibr">1</xref>). Recently, hazardous silica exposures have been newly documented during hydraulic fracturing of gas and oil wells and during fabrication and installation of engineered stone countertops (<xref rid="b3-117-120" ref-type="bibr">3</xref>,<xref rid="b4-117-120" ref-type="bibr">4</xref>). To describe temporal trends in silicosis mortality in the United States, CDC analyzed annual multiple cause-of-death data for 2001&#x02013;2010 for decedents aged &#x02265;15 years.<xref ref-type="fn" rid="fn1-117-120">*</xref> During 2001&#x02013;2010, a total of 1,437 decedents had silicosis coded as an underlying or contributing cause of death. The annual number of silicosis deaths declined from 164 (death rate<xref ref-type="fn" rid="fn2-117-120">&#x02020;</xref> = 0.74 per 1 million population) in 2001 to 101 (0.39 per 1 million) in 2010 (p = 0.002). Because of new operations and tasks placing workers at risk for silicosis, efforts to limit workplace exposure to crystalline silica need to be maintained.</p><p>For this analysis, decedents for whom the <italic>International Classification of Diseases, 10th Revision</italic> code J62 (pneumoconiosis due to dust containing silica [silicosis]<xref ref-type="fn" rid="fn3-117-120">&#x000a7;</xref>) was assigned as either the underlying<xref ref-type="fn" rid="fn4-117-120">&#x000b6;</xref> or contributing cause of death were identified from 2001&#x02013;2010 mortality data. Deaths of persons aged &#x02265;15 years were analyzed. Trends in annual age-adjusted death rates per 1 million population were examined using a first-order autoregressive linear regression model. Differences in death rates were considered to be statistically significant if 95% confidence intervals did not overlap.</p><p>During 2001&#x02013;2010, 1,437 decedents had silicosis coded as the underlying or contributing cause of death. Of these, 28 (1.9%) were aged 15&#x02013;44 years, 1,370 (95.3%) were males, and 1,236 (86.0%) were whites (<xref ref-type="table" rid="t1-117-120">Table</xref>). The overall age-adjusted silicosis death rate for blacks (0.87 per 1 million) was significantly higher than the rate for whites (0.59) and other races (0.16). The age-adjusted silicosis death rate for males (1.39 per 1 million) was significantly higher than the rate for females. The annual number of silicosis deaths declined from 164 (0.74 per 1 million) in 2001 to 101 (0.39) in 2010 (p for trend = 0.002).</p><sec sec-type="discussion"><title>Discussion</title><p>A statistically significant decline in silicosis death rates was observed during 2001&#x02013;2010. However, silicosis deaths still occurred among persons aged 15&#x02013;44 years. Of 28 decedents aged 15&#x02013;44 years, the youngest was aged 19 years. This would be consistent with the decedent developing acute silicosis after an extremely high exposure to respirable crystalline silica. Such findings indicate the importance of educating at-risk workers and their employers regarding the dangers of exposure to respirable crystalline silica in the workplace. The disparities by sex and by race reflect differences in the composition of the workforces in the industries and occupations placing workers at risk for exposure to crystalline silica dust.<xref ref-type="fn" rid="fn5-117-120">**</xref></p><p>Approximately 2 million U.S. workers remain potentially exposed to respirable crystalline silica (<xref rid="b5-117-120" ref-type="bibr">5</xref>). Occupational exposures to dust containing crystalline silica have long been known to occur in mining, quarrying, sandblasting, pottery making, rock drilling, road construction, stone masonry, and tunneling operations (<xref rid="b1-117-120" ref-type="bibr">1</xref>,<xref rid="b5-117-120" ref-type="bibr">5</xref>). Despite enforceable limits<xref ref-type="fn" rid="fn6-117-120">&#x02020;&#x02020;</xref> on worker exposure to respirable crystalline silica, substantial overexposures continue to occur in the United States (<xref rid="b3-117-120" ref-type="bibr">3</xref>)<italic>.</italic> Moreover, new job tasks that place workers at risk for silicosis continue to emerge.</p><p>In 2004, occupational disease surveillance programs in Michigan, New Jersey, Massachusetts, New York, and Ohio reported nine confirmed cases of silicosis among technicians who performed sandblasting in dental laboratories (<xref rid="b6-117-120" ref-type="bibr">6</xref>); in 2013, there were approximately 37,000 dental laboratory technicians in the United States.<xref ref-type="fn" rid="fn7-117-120">&#x000a7;&#x000a7;</xref> In a 2012 report from Israel, a 2014 report from Spain, and a 2015 report from the United States, silicosis has been documented among workers exposed to respirable crystalline silica dust during the fabrication and installation of quartz-containing engineered stone products used primarily for kitchen and bathroom countertops (<xref rid="b4-117-120" ref-type="bibr">4</xref>,<xref rid="b7-117-120" ref-type="bibr">7</xref>,<xref rid="b8-117-120" ref-type="bibr">8</xref>). A 2013 report documented high levels of exposure to respirable crystalline silica during hydraulic fracturing of gas and oil wells (<xref rid="b3-117-120" ref-type="bibr">3</xref>). Moreover, a 2010 study reported an excess risk for silicosis in coal miners that was associated with silica as a component of coal mine dust formed during drilling, crushing, and loading of mine material (<xref rid="b9-117-120" ref-type="bibr">9</xref>). In 2013, there were approximately 204,000 oil and gas extraction industry workers and approximately 80,000 coal mining industry workers in the United States.<xref ref-type="fn" rid="fn8-117-120">&#x000b6;&#x000b6;</xref> Finally, although not in the United States, silicosis cases have been reported in other occupational settings, including among denim sandblasters (<xref rid="b10-117-120" ref-type="bibr">10</xref>).</p><boxed-text position="float"><p><bold>What is already known on this topic?</bold></p><p>Silicosis is an occupational lung disease caused by inhalation of respirable crystalline silica in a variety of industrial operations, including mining, quarrying, road construction, masonry, and tunneling. From 1968 to 2004, silicosis deaths in the United States declined from 1,065 per year to 165.</p><p><bold>What is added by this report?</bold></p><p>Although silicosis deaths decreased significantly from 164 in 2001 to 101 in 2010, they continued to occur among young persons, with 28 deaths reported among persons aged 15&#x02013;44 years during 2001&#x02013;2010. New work tasks, including hydraulic fracturing, sandblasting denim, and engineered stone countertop fabrication and installation, can lead to overexposure to respirable crystalline silica.</p><p><bold>What are the implications for public health practice?</bold></p><p>Because of the serious health and socioeconomic consequences of silicosis, new operations and tasks placing workers at risk for silicosis, and the continuing occurrence of silicosis deaths, efforts to limit workplace exposure to crystalline silica need to be maintained. In addition, the long latency of silicosis warrants continuing surveillance. The Occupational Safety and Health Administration and CDC recommend best practices for protecting workers, including the use of engineering controls and respiratory protection.</p></boxed-text><p>In 1999, the Council of State and Territorial Epidemiologists made silicosis a nationally notifiable condition.<xref ref-type="fn" rid="fn9-117-120">***</xref> In addition, because current permissible exposure limits for respirable crystalline silica do not adequately protect workers, the Occupational Safety and Health Administration (OSHA) has proposed amending the current standards. One of the proposed changes is a lower permissible exposure limit (<xref rid="b5-117-120" ref-type="bibr">5</xref>).</p><p>The findings in this report are subject to at least three limitations. First, silicosis deaths were not validated by medical records or follow-up with health care providers, thus findings might be subject to misclassification. Second, no individual work history is reported on death certificates. Therefore, it was not possible to identify those industries and occupations where the decedents&#x02019; exposures to crystalline silica occurred. Finally, inhalation of respirable crystalline silica can cause diseases other than silicosis, such as lung cancer and chronic obstructive pulmonary disease (<xref rid="b1-117-120" ref-type="bibr">1</xref>,<xref rid="b5-117-120" ref-type="bibr">5</xref>), which are not considered in this analysis.</p><p>Effective silicosis prevention strategies for employers recommended by OSHA<xref ref-type="fn" rid="fn10-117-120">&#x02020;&#x02020;&#x02020;</xref> and CDC&#x02019;s National Institute for Occupational Safety and Health<xref ref-type="fn" rid="fn11-117-120">&#x000a7;&#x000a7;&#x000a7;</xref> are available. Comprehensive silicosis prevention programs include substituting less hazardous noncrystalline silica alternatives when possible, implementing engineering controls (e.g., blasting cabinets, local exhaust ventilation, not using compressed air for cleaning surfaces, using water sprays to control airborne dust, and using surface wetting to prevent dust from becoming airborne when cutting, drilling, grinding, etc.), administrative and work practice controls, personal respiratory protective equipment, medical monitoring of exposed workers, and worker training. Because of the serious health and socioeconomic consequences of silicosis, new operations and tasks placing workers at risk for silicosis, and the continuing occurrence of silicosis deaths among young workers, effective primary prevention through elimination of exposure to respirable crystalline silica is critical. At the same time, because of the sometimes long latency of silicosis, with cases diagnosed years after exposure and often in retirement, ongoing silicosis surveillance is needed to track its prevalence in the United States.</p></sec></body><back><ack><title>Acknowledgments</title><p>Kathleen Kreiss, MD, Robert M. Castellan, MD, National Institute for Occupational Safety and Health, CDC.</p></ack><fn-group><fn id="fn1-117-120"><label>*</label><p>Additional information available at <ext-link ext-link-type="uri" xlink:href="http://webappa.cdc.gov/ords/norms.html">http://webappa.cdc.gov/ords/norms.html</ext-link>.</p></fn><fn id="fn2-117-120"><label>&#x02020;</label><p>Death rates were age-adjusted to the 2000 standard U.S. population. The age intervals used were 15&#x02013;34, 35&#x02013;44, 45&#x02013;54, 55&#x02013;64, 65&#x02013;74, 75&#x02013;84, and &#x02265;85 years.</p></fn><fn id="fn3-117-120"><label>&#x000a7;</label><p>Classic (chronic) silicosis results from exposure to respirable crystalline silica for &#x0003e;10 years; exposure to higher concentrations of silica for 5&#x02013;10 years can cause accelerated silicosis, and symptoms of acute silicosis can sometimes develop within weeks of initial exposure to extremely high concentrations of silica.</p></fn><fn id="fn4-117-120"><label>&#x000b6;</label><p>Underlying cause of death is defined as &#x0201c;the disease or injury which initiated the train of morbid events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury.&#x0201d;</p></fn><fn id="fn5-117-120"><label>**</label><p>Additional information available at <ext-link ext-link-type="uri" xlink:href="http://www.bls.gov/cps/wlf-databook-2013.pdf">http://www.bls.gov/cps/wlf-databook-2013.pdf</ext-link>.</p></fn><fn id="fn6-117-120"><label>&#x02020;&#x02020;</label><p>Additional information available in &#x0201c;Lowering Miners&#x02019; Exposure to Respirable Coal Mine Dust, Including Continuous Personal Dust Monitors; Final Rule&#x0201d; (<ext-link ext-link-type="uri" xlink:href="http://www.gpo.gov/fdsys/pkg/FR-2014-05-01/pdf/2014-09084.pdf">http://www.gpo.gov/fdsys/pkg/FR-2014-05-01/pdf/2014-09084.pdf</ext-link>) and &#x0201c;Criteria for a Recommended Standard: Occupational Exposure to Respirable Coal Mine Dust&#x0201d; (<ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/niosh/docs/95-106/pdfs/95-106.pdf">http://www.cdc.gov/niosh/docs/95-106/pdfs/95-106.pdf</ext-link>).</p></fn><fn id="fn7-117-120"><label>&#x000a7;&#x000a7;</label><p>Additional information available at <ext-link ext-link-type="uri" xlink:href="http://www.bls.gov/oes/current/oes_nat.htm">http://www.bls.gov/oes/current/oes_nat.htm</ext-link>.</p></fn><fn id="fn8-117-120"><label>&#x000b6;&#x000b6;</label><p>Additional information available at <ext-link ext-link-type="uri" xlink:href="http://www.bls.gov/opub/ee/2014/ces/table1a_201401.pdf">http://www.bls.gov/opub/ee/2014/ces/table1a_201401.pdf</ext-link>.</p></fn><fn id="fn9-117-120"><label>***</label><p>Available at <ext-link ext-link-type="uri" xlink:href="http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/09-oh-01.pdf">http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/09-oh-01.pdf</ext-link>.</p></fn><fn id="fn10-117-120"><label>&#x02020;&#x02020;&#x02020;</label><p>Available at <ext-link ext-link-type="uri" xlink:href="https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=standards&#x00026;p_id=12716">https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=standards&#x00026;p_id=12716</ext-link>.</p></fn><fn id="fn11-117-120"><label>&#x000a7;&#x000a7;&#x000a7;</label><p>Available at <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/niosh/topics/silica">http://www.cdc.gov/niosh/topics/silica</ext-link>.</p></fn></fn-group><ref-list><title>References</title><ref id="b1-117-120"><label>1</label><element-citation publication-type="book"><collab>National Institute for Occupational Safety and Health</collab><source>NIOSH hazard review Health effects of occupational exposure to respirable crystalline silica</source><publisher-loc>Washington, DC</publisher-loc><publisher-name>US Department of Health and Human Services, CDC, National Institute for Occupational Safety and Health</publisher-name><year>2002</year><comment>DHHS (NIOSH) publication no. 2002-129. Available at <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/niosh/docs/2002-129/pdfs/2002-129.pdf">http://www.cdc.gov/niosh/docs/2002-129/pdfs/2002-129.pdf</ext-link></comment></element-citation></ref><ref id="b2-117-120"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mazurek</surname><given-names>JM</given-names></name><name><surname>Attfield</surname><given-names>MD</given-names></name></person-group><article-title>Silicosis mortality among young adults in the United States, 1968&#x02013;2004</article-title><source>Am J Ind Med</source><year>2008</year><volume>51</volume><fpage>568</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">18521821</pub-id></element-citation></ref><ref id="b3-117-120"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esswein</surname><given-names>EJ</given-names></name><name><surname>Breitenstein</surname><given-names>M</given-names></name><name><surname>Snawder</surname><given-names>J</given-names></name><name><surname>Kiefer</surname><given-names>M</given-names></name><name><surname>Sieber</surname><given-names>WK</given-names></name></person-group><article-title>Occupational exposure to respirable crystalline silica during hydraulic fracturing</article-title><source>J Occup Environ Hyg</source><year>2013</year><volume>10</volume><fpage>347</fpage><lpage>56</lpage><pub-id pub-id-type="pmid">23679563</pub-id></element-citation></ref><ref id="b4-117-120"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kramer</surname><given-names>MR</given-names></name><name><surname>Blanc</surname><given-names>PD</given-names></name><name><surname>Fireman</surname><given-names>E</given-names></name><etal/></person-group><article-title>Artificial stone silicosis: disease resurgence among artificial stone workers</article-title><source>Chest</source><year>2012</year><volume>142</volume><fpage>419</fpage><lpage>24</lpage><pub-id pub-id-type="pmid">22383661</pub-id></element-citation></ref><ref id="b5-117-120"><label>5</label><element-citation publication-type="webpage"><collab>Occupational Safety and Health Administration, US Department of Labor</collab><source>Occupational exposure to respirable crystalline silica; proposed rule</source><comment>Available at <ext-link ext-link-type="uri" xlink:href="http://www.gpo.gov/fdsys/pkg/FR-2013-09-12/pdf/2013-20997.pdf">http://www.gpo.gov/fdsys/pkg/FR-2013-09-12/pdf/2013-20997.pdf</ext-link></comment></element-citation></ref><ref id="b6-117-120"><label>6</label><element-citation publication-type="journal"><collab>CDC</collab><article-title>Silicosis in dental laboratory technicians&#x02014;five states, 1994&#x02013;2000</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>2004</year><volume>53</volume><fpage>195</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">15017375</pub-id></element-citation></ref><ref id="b7-117-120"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Friedman</surname><given-names>GK</given-names></name><name><surname>Harrison</surname><given-names>R</given-names></name><name><surname>Bojes</surname><given-names>H</given-names></name><name><surname>Worthington</surname><given-names>K</given-names></name><name><surname>Filios</surname><given-names>M</given-names></name></person-group><article-title>Notes from the field: silicosis in a countertop fabricator&#x02014;Texas, 2014</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>2015</year><volume>64</volume><fpage>129</fpage><lpage>30</lpage><pub-id pub-id-type="pmid">25674996</pub-id></element-citation></ref><ref id="b8-117-120"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>P&#x000e9;rez-Alonso</surname><given-names>A</given-names></name><name><surname>C&#x000f3;rdoba-Do&#x000f1;a</surname><given-names>JA</given-names></name><name><surname>Millares-Lorenzo</surname><given-names>JL</given-names></name><name><surname>Figueroa-Murillo</surname><given-names>E</given-names></name><name><surname>Garc&#x000ed;a-Vadillo</surname><given-names>C</given-names></name><name><surname>Romero-Morillos</surname><given-names>J</given-names></name></person-group><article-title>Outbreak of silicosis in Spanish quartz conglomerate workers</article-title><source>Int J Occup Environ Health</source><year>2014</year><volume>20</volume><fpage>26</fpage><lpage>32</lpage><pub-id pub-id-type="pmid">24804337</pub-id></element-citation></ref><ref id="b9-117-120"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Laney</surname><given-names>AS</given-names></name><name><surname>Petsonk</surname><given-names>EL</given-names></name><name><surname>Attfield</surname><given-names>MD</given-names></name></person-group><article-title>Pneumoconiosis among underground bituminous coal miners in the United States: is silicosis becoming more frequent?</article-title><source>Occup Environ Med</source><year>2010</year><volume>67</volume><fpage>652</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">19773275</pub-id></element-citation></ref><ref id="b10-117-120"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bakan</surname><given-names>ND</given-names></name><name><surname>&#x000d6;zkan</surname><given-names>G</given-names></name><name><surname>&#x000c7;amsari</surname><given-names>G</given-names></name><etal/></person-group><article-title>Silicosis in denim sandblasters</article-title><source>Chest</source><year>2011</year><volume>140</volume><fpage>1300</fpage><lpage>4</lpage><pub-id pub-id-type="pmid">21546437</pub-id></element-citation></ref></ref-list></back><floats-group><table-wrap id="t1-117-120" position="float"><label>TABLE</label><caption><p>Number and rate<xref ref-type="table-fn" rid="tfn2-117-120">*</xref> of silicosis deaths, by selected characteristics and year &#x02014; United States, 2001&#x02013;2010</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="bottom" rowspan="5" align="left" colspan="1">Characteristic</th><th colspan="6" valign="bottom" align="center" rowspan="1">Age group (yrs)</th><th colspan="3" valign="bottom" rowspan="3" align="center">Overall</th></tr><tr><th colspan="6" valign="bottom" align="left" rowspan="1">
<hr/></th></tr><tr><th colspan="3" valign="bottom" align="center" rowspan="1">15&#x02013;44</th><th colspan="3" valign="bottom" align="center" rowspan="1">&#x02265;45</th></tr><tr><th colspan="3" valign="bottom" align="left" rowspan="1">
<hr/></th><th colspan="3" valign="bottom" align="left" rowspan="1">
<hr/></th><th colspan="3" valign="bottom" align="left" rowspan="1">
<hr/></th></tr><tr><th valign="bottom" align="center" rowspan="1" colspan="1">No.</th><th valign="bottom" align="center" rowspan="1" colspan="1">Rate</th><th valign="bottom" align="center" rowspan="1" colspan="1">(95% CI)</th><th valign="bottom" align="right" rowspan="1" colspan="1">No.</th><th valign="bottom" align="left" rowspan="1" colspan="1">Rate</th><th valign="bottom" align="center" rowspan="1" colspan="1">(95% CI)</th><th valign="bottom" align="right" rowspan="1" colspan="1">No.</th><th valign="bottom" align="left" rowspan="1" colspan="1">Rate</th><th valign="bottom" align="center" rowspan="1" colspan="1">(95% CI)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1"><bold>Total</bold></td><td valign="top" align="right" rowspan="1" colspan="1"><bold>28</bold></td><td valign="top" align="right" rowspan="1" colspan="1"><bold>0.01</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>(0.01&#x02013;0.01)</bold></td><td valign="top" align="right" rowspan="1" colspan="1"><bold>1,409</bold></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>0.58</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>(0.55&#x02013;0.61)</bold></td><td valign="top" align="right" rowspan="1" colspan="1"><bold>1,437</bold></td><td valign="top" align="left" rowspan="1" colspan="1"><bold>0.59</bold></td><td valign="top" align="center" rowspan="1" colspan="1"><bold>(0.56&#x02013;0.62)</bold></td></tr><tr><td colspan="10" valign="top" align="left" rowspan="1"><bold>Sex</bold></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;Male</td><td valign="top" align="right" rowspan="1" colspan="1">23</td><td valign="top" align="right" rowspan="1" colspan="1">0.02</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.03)</td><td valign="top" align="right" rowspan="1" colspan="1">1,347</td><td valign="top" align="left" rowspan="1" colspan="1">1.37</td><td valign="top" align="center" rowspan="1" colspan="1">(1.30&#x02013;1.44)</td><td valign="top" align="right" rowspan="1" colspan="1">1,370</td><td valign="top" align="left" rowspan="1" colspan="1">1.39</td><td valign="top" align="center" rowspan="1" colspan="1">(1.32&#x02013;1.46)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;Female</td><td valign="top" align="right" rowspan="1" colspan="1">5</td><td valign="top" align="right" rowspan="1" colspan="1">0.00</td><td valign="top" align="center" rowspan="1" colspan="1">&#x02014;</td><td valign="top" align="right" rowspan="1" colspan="1">62</td><td valign="top" align="left" rowspan="1" colspan="1">0.04</td><td valign="top" align="center" rowspan="1" colspan="1">(0.03&#x02013;0.05)</td><td valign="top" align="right" rowspan="1" colspan="1">67</td><td valign="top" align="left" rowspan="1" colspan="1">0.05</td><td valign="top" align="center" rowspan="1" colspan="1">(0.04&#x02013;0.06)</td></tr><tr><td colspan="10" valign="top" align="left" rowspan="1"><bold>Race</bold></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;White</td><td valign="top" align="right" rowspan="1" colspan="1">22</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.02)</td><td valign="top" align="right" rowspan="1" colspan="1">1,214</td><td valign="top" align="left" rowspan="1" colspan="1">0.57</td><td valign="top" align="center" rowspan="1" colspan="1">(0.54&#x02013;0.60)</td><td valign="top" align="right" rowspan="1" colspan="1">1,236</td><td valign="top" align="left" rowspan="1" colspan="1">0.59</td><td valign="top" align="center" rowspan="1" colspan="1">(0.56&#x02013;0.62)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;Black</td><td valign="top" align="right" rowspan="1" colspan="1">5</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.05)</td><td valign="top" align="right" rowspan="1" colspan="1">181</td><td valign="top" align="left" rowspan="1" colspan="1">0.85</td><td valign="top" align="center" rowspan="1" colspan="1">(0.72&#x02013;0.98)</td><td valign="top" align="right" rowspan="1" colspan="1">186</td><td valign="top" align="left" rowspan="1" colspan="1">0.87</td><td valign="top" align="center" rowspan="1" colspan="1">(0.74&#x02013;1.00)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;Other</td><td valign="top" align="right" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.00&#x02013;0.06)</td><td valign="top" align="right" rowspan="1" colspan="1">14</td><td valign="top" align="left" rowspan="1" colspan="1">0.15</td><td valign="top" align="center" rowspan="1" colspan="1">(0.08&#x02013;0.25)</td><td valign="top" align="right" rowspan="1" colspan="1">15</td><td valign="top" align="left" rowspan="1" colspan="1">0.16</td><td valign="top" align="center" rowspan="1" colspan="1">(0.09&#x02013;0.26)</td></tr><tr><td colspan="10" valign="top" align="left" rowspan="1"><bold>Year</bold></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2001</td><td valign="top" align="right" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">0.00</td><td valign="top" align="center" rowspan="1" colspan="1">&#x02014;</td><td valign="top" align="right" rowspan="1" colspan="1">163</td><td valign="top" align="left" rowspan="1" colspan="1">0.74</td><td valign="top" align="center" rowspan="1" colspan="1">(0.63&#x02013;0.85)</td><td valign="top" align="right" rowspan="1" colspan="1">164</td><td valign="top" align="left" rowspan="1" colspan="1">0.74</td><td valign="top" align="center" rowspan="1" colspan="1">(0.63&#x02013;0.85)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2002</td><td valign="top" align="right" rowspan="1" colspan="1">5</td><td valign="top" align="right" rowspan="1" colspan="1">0.02</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.05)</td><td valign="top" align="right" rowspan="1" colspan="1">143</td><td valign="top" align="left" rowspan="1" colspan="1">0.64</td><td valign="top" align="center" rowspan="1" colspan="1">(0.54&#x02013;0.74)</td><td valign="top" align="right" rowspan="1" colspan="1">148</td><td valign="top" align="left" rowspan="1" colspan="1">0.66</td><td valign="top" align="center" rowspan="1" colspan="1">(0.55&#x02013;0.77)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2003</td><td valign="top" align="right" rowspan="1" colspan="1">6</td><td valign="top" align="right" rowspan="1" colspan="1">0.02</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.07)</td><td valign="top" align="right" rowspan="1" colspan="1">173</td><td valign="top" align="left" rowspan="1" colspan="1">0.76</td><td valign="top" align="center" rowspan="1" colspan="1">(0.65&#x02013;0.87)</td><td valign="top" align="right" rowspan="1" colspan="1">179</td><td valign="top" align="left" rowspan="1" colspan="1">0.78</td><td valign="top" align="center" rowspan="1" colspan="1">(0.67&#x02013;0.89)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2004</td><td valign="top" align="right" rowspan="1" colspan="1">3</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.00&#x02013;0.03)</td><td valign="top" align="right" rowspan="1" colspan="1">163</td><td valign="top" align="left" rowspan="1" colspan="1">0.70</td><td valign="top" align="center" rowspan="1" colspan="1">(0.59&#x02013;0.81)</td><td valign="top" align="right" rowspan="1" colspan="1">166</td><td valign="top" align="left" rowspan="1" colspan="1">0.71</td><td valign="top" align="center" rowspan="1" colspan="1">(0.60&#x02013;0.82)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2005</td><td valign="top" align="right" rowspan="1" colspan="1">2</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.00&#x02013;0.04)</td><td valign="top" align="right" rowspan="1" colspan="1">159</td><td valign="top" align="left" rowspan="1" colspan="1">0.67</td><td valign="top" align="center" rowspan="1" colspan="1">(0.57&#x02013;0.77)</td><td valign="top" align="right" rowspan="1" colspan="1">161</td><td valign="top" align="left" rowspan="1" colspan="1">0.68</td><td valign="top" align="center" rowspan="1" colspan="1">(0.57&#x02013;0.79)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2006</td><td valign="top" align="right" rowspan="1" colspan="1">6</td><td valign="top" align="right" rowspan="1" colspan="1">0.02</td><td valign="top" align="center" rowspan="1" colspan="1">(0.01&#x02013;0.07)</td><td valign="top" align="right" rowspan="1" colspan="1">120</td><td valign="top" align="left" rowspan="1" colspan="1">0.49</td><td valign="top" align="center" rowspan="1" colspan="1">(0.40&#x02013;0.58)</td><td valign="top" align="right" rowspan="1" colspan="1">126</td><td valign="top" align="left" rowspan="1" colspan="1">0.52</td><td valign="top" align="center" rowspan="1" colspan="1">(0.43&#x02013;0.61)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2007</td><td valign="top" align="right" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">0.00</td><td valign="top" align="center" rowspan="1" colspan="1">&#x02014;</td><td valign="top" align="right" rowspan="1" colspan="1">122</td><td valign="top" align="left" rowspan="1" colspan="1">0.49</td><td valign="top" align="center" rowspan="1" colspan="1">(0.40&#x02013;0.58)</td><td valign="top" align="right" rowspan="1" colspan="1">123</td><td valign="top" align="left" rowspan="1" colspan="1">0.50</td><td valign="top" align="center" rowspan="1" colspan="1">(0.41&#x02013;0.59)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2008</td><td valign="top" align="right" rowspan="1" colspan="1">2</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.00&#x02013;0.04)</td><td valign="top" align="right" rowspan="1" colspan="1">146</td><td valign="top" align="left" rowspan="1" colspan="1">0.58</td><td valign="top" align="center" rowspan="1" colspan="1">(0.49&#x02013;0.67)</td><td valign="top" align="right" rowspan="1" colspan="1">148</td><td valign="top" align="left" rowspan="1" colspan="1">0.58</td><td valign="top" align="center" rowspan="1" colspan="1">(0.49&#x02013;0.67)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2009</td><td valign="top" align="right" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">0.00</td><td valign="top" align="center" rowspan="1" colspan="1">&#x02014;</td><td valign="top" align="right" rowspan="1" colspan="1">120</td><td valign="top" align="left" rowspan="1" colspan="1">0.47</td><td valign="top" align="center" rowspan="1" colspan="1">(0.39&#x02013;0.55)</td><td valign="top" align="right" rowspan="1" colspan="1">121</td><td valign="top" align="left" rowspan="1" colspan="1">0.48</td><td valign="top" align="center" rowspan="1" colspan="1">(0.39&#x02013;0.57)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">&#x02003;2010</td><td valign="top" align="right" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">0.01</td><td valign="top" align="center" rowspan="1" colspan="1">(0.00&#x02013;0.06)</td><td valign="top" align="right" rowspan="1" colspan="1">100</td><td valign="top" align="left" rowspan="1" colspan="1">0.38</td><td valign="top" align="center" rowspan="1" colspan="1">(0.30&#x02013;0.46)</td><td valign="top" align="right" rowspan="1" colspan="1">101</td><td valign="top" align="left" rowspan="1" colspan="1">0.39</td><td valign="top" align="center" rowspan="1" colspan="1">(0.31&#x02013;0.47)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">p-value<xref ref-type="table-fn" rid="tfn3-117-120">&#x02020;</xref></td><td valign="top" align="right" rowspan="1" colspan="1">&#x02014;<xref ref-type="table-fn" rid="tfn4-117-120">&#x000a7;</xref></td><td valign="top" align="right" rowspan="1" colspan="1">&#x02014;<xref ref-type="table-fn" rid="tfn4-117-120">&#x000a7;</xref></td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="right" rowspan="1" colspan="1">0.012</td><td valign="top" align="left" rowspan="1" colspan="1">0.002</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="right" rowspan="1" colspan="1">0.010</td><td valign="top" align="left" rowspan="1" colspan="1">0.002</td><td valign="top" align="center" rowspan="1" colspan="1"/></tr></tbody></table><table-wrap-foot><fn id="tfn1-117-120"><p><bold>Abbreviation:</bold> CI = confidence interval.</p></fn><fn id="tfn2-117-120"><label>*</label><p>Rate per 1 million persons, age-adjusted to the 2000 U.S. standard population.</p></fn><fn id="tfn3-117-120"><label>&#x02020;</label><p>For 2001&#x02013;2010 trend.</p></fn><fn id="tfn4-117-120"><label>&#x000a7;</label><p>Trend test not performed because of small number of deaths.</p></fn></table-wrap-foot></table-wrap></floats-group></article>