Investigation of an Outbreak of Variant Influenza A(H3N2) Virus Infection Associated With an Agricultural Fair—Ohio, August 2012

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Greenbaum, Adena ; Quinn, Celia ; Bailer, Jennifer ; Su, Su ; Havers, Fiona ; Durand, Lizette O. ; Jiang, Victoria ; Page, Shannon ; Budd, Jeremy ; Shaw, Michael ; Biggerstaff, Matthew ; de Fijter, Sietske ; Smith, Kathleen ; Reed, Carrie ; Epperson, Scott ; Brammer, Lynnette ; Feltz, Dave ; Sohner, Kevin ; Ford, Jared ; Jain, Seema ; Gargiullo, Paul ; Weiss, Edward ; Burg, Pat ; DiOrio, Mary ; Fowler, Brian ; Finelli, Lyn ; Jhung, Michael A.
• Description:
  Background
  
  In 2012, one third of cases in a multistate outbreak of variant influenza A(H3N2) virus ([H3N2]v) infection occurred in Ohio. We conducted an investigation of (H3N2)v cases associated with agricultural Fair A in Ohio.
  
  Methods
  
  We surveyed Fair A swine exhibitors and their household members. Confirmed cases had influenza-like illness (ILI) and a positive laboratory test for (H3N2)v, and probable cases had ILI. We calculated attack rates. We determined risk factors for infection, using multivariable log-binomial regression.
  
  Results
  
  We identified 20 confirmed and 94 probable cases associated with Fair A. Among 114 cases, the median age was 10 years, there were no hospitalizations or deaths, and 82% had swine exposure. In the exhibitor household cohort of 359 persons (83 households), we identified 6 confirmed cases (2%) and 40 probable cases (11%). An age of <10 years was a significant risk factor (P < .01) for illness. One instance of likely human-to-human transmission was identified.
  
  Conclusions
  
  In this (H3N2)v outbreak, no evidence of sustained human-to-human (H3N2)v transmission was found. Our risk factor analysis contributed to the development of the recommendation that people at increased risk of influenza-associated complications, including children aged <5 years, avoid swine barns at fairs during the 2012 fair season.
  
  
• Subjects:
  Adolescent Adult Aged Age Factors Animals Article Child Child, Preschool Cohort Studies Crowding Disease Outbreaks Disease Transmission, Infectious Female Humans Infant Influenza, Human Influenza A Virus, H3N2 Subtype Male Middle Aged Occupational Exposure Risk Factors Swine Young Adult

  More +
• Source:
  J Infect Dis. 212(10):1592-1599.
• Pubmed ID:
  25948864
• Pubmed Central ID:
  PMC5928505
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Ohio
• Volume:
  212
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a4e42352ffe055c3a5581c18743b26527bdb65f4e5772a15d0adb91203a417a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/53694/cdc_53694_DS1.pdf
• File Type:
  [PDF - 1.52 MB ]