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Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA
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Published Date:
Apr 2018
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Source:Emerg Infect Dis. 24(4):631-637.
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Language:English
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[PDF-1.31 MB]
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Alternative Title:Emerg Infect Dis
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Description:The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure brown heroin in the 1970s-1990s; however, candidiasis accompanying IVDU became considerably rarer as the purity of the heroin supply increased. We reviewed cases of candidemia occurring over a recent 7-year period in persons >14 years of age at a tertiary care hospital in central Massachusetts. Of the 198 patients with candidemia, 24 cases occurred in patients with a history of IVDU. Compared with non-IVDU patients, those with a history of IVDU were more likely to have non-albicans Candida, be co-infected with hepatitis C, and have end-organ involvement, including endocarditis and osteomyelitis. Thus, IVDU appears to be reemerging as a risk factor for invasive candidiasis.
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Subject:
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Pubmed ID:29553923
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Pubmed Central ID:PMC5875264
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