Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA

Poowanawittayakom, Nongnooch; Dutta, Anamika; Stock, Shannon; Touray, Sunkaru; Ellison, Richard T.; Levitz, Stuart M.

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Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA

Published Date:

Apr 2018

Source:

Emerg Infect Dis. 24(4):631-637.

Language:

English

[PDF-1.31 MB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Poowanawittayakom, Nongnooch ; Dutta, Anamika ; Stock, Shannon ; Touray, Sunkaru ; Ellison, Richard T. ; ... More ▼

Description:

The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure brown heroin in the 1970s-1990s; however, candidiasis accompanying IVDU became considerably rarer as the purity of the heroin supply increased. We reviewed cases of candidemia occurring over a recent 7-year period in persons >14 years of age at a tertiary care hospital in central Massachusetts. Of the 198 patients with candidemia, 24 cases occurred in patients with a history of IVDU. Compared with non-IVDU patients, those with a history of IVDU were more likely to have non-albicans Candida, be co-infected with hepatitis C, and have end-organ involvement, including endocarditis and osteomyelitis. Thus, IVDU appears to be reemerging as a risk factor for invasive candidiasis.

Subject:

[+]

Pubmed ID:

29553923

Pubmed Central ID:

PMC5875264

Document Type:

Journal Article

Place as Subject:

Massachusetts

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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	17-1807-F.jpg	image/jpeg
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MMWR. Surveillance summaries : Morbidity and mortality weekly report. Surveillance summaries ; v. 68, no. SS-8

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