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Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
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Published Date:
Apr 2018
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Source:Emerg Infect Dis. 24(4):746-750.
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Language:English
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Details:
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
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Subject:
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Pubmed ID:29553313
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Pubmed Central ID:PMC5875272
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