Bacterial Infections in Neonates, Madagascar, 2012–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Huynh, Bich-Tram ; Kermorvant-Duchemin, Elsa ; Herindrainy, Perlinot ; Padget, Michael ; Rakotoarimanana, Feno Manitra Jacob ; Feno, Herisoa ; Hariniaina-Ratsima, Elisoa ; Raheliarivao, Tanjona ; Ndir, Awa ; Goyet, Sophie ; Piola, Patrice ; Randrianirina, Frederique ; Garin, Benoit ; Collard, Jean-Marc ; Guillemot, Didier ; Delarocque-Astagneau, Elisabeth
• Description:
  Severe bacterial infections are a leading cause of death among neonates in low-income countries, which harbor several factors leading to emergence and spread of multidrug-resistant bacteria. Low-income countries should prioritize interventions to decrease neonatal infections; however, data are scarce, specifically from the community. To assess incidence, etiologies, and antimicrobial drug-resistance patterns of neonatal infections, during 2012-2014, we conducted a community-based prospective investigation of 981 newborns in rural and urban areas of Madagascar. The incidence of culture-confirmed severe neonatal infections was high: 17.7 cases/1,000 live births. Most (75%) occurred during the first week of life. The most common (81%) bacteria isolated were gram-negative. The incidence rate for multidrug-resistant neonatal infection was 7.7 cases/1,000 live births. In Madagascar, interventions to improve prevention, early diagnosis, and management of bacterial infections in neonates should be prioritized.
• Subjects:
  Age Factors Anti-Bacterial Agents Bacteria / Drug Effects Bacterial Infections/epidemiology Bacterial Infections/history Bacterial Infections/microbiology Drug Resistance, Bacterial Follow-Up Studies Geography, Medical History, 21st Century Humans Incidence Infant, Newborn Infant, Newborn, Diseases/epidemiology Infant, Newborn, Diseases/history Infant, Newborn, Diseases/microbiology Microbial Sensitivity Tests Patient Outcome Assessment Research

  More +
• Source:
  Emerg Infect Dis. 24(4):710-717.
• Pubmed ID:
  29553312
• Pubmed Central ID:
  PMC5875286
• Document Type:
  Journal Article
• Place as Subject:
  Madagascar
• Location:
  Africa
• Volume:
  24
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:997b8f9f6609ca1a20df0471c11d1afa25ac6d291f63bd5c5da97e4daddcbd82
• Download URL:
  https://stacks.cdc.gov/view/cdc/53049/cdc_53049_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]