Details:

Alternative Title:
Cancer Epidemiol Biomarkers Prev
Personal Author:
Gomez, Scarlett Lin ; Yang, Juan ; Lin, Shih-Wen ; McCusker, Margaret ; Sandler, Alan ; ... More +
Gomez, Scarlett Lin ; Yang, Juan ; Lin, Shih-Wen ; McCusker, Margaret ; Sandler, Alan ; Cheng, Iona ; Wakelee, Heather A. ; Patel, Manali ; Clarke, Christina A. Less -
Description:
Background

Lung cancer is the leading cause of cancer-related death among Chinese Americans. A detailed examination of incidence trends by immigration status and histology may inform the etiology of lung cancer in this growing population.

Methods

California Cancer Registry data were enhanced with data on patient nativity. Lung cancer incidence rates for Chinese males and females were computed for the years 1990–2010, and rates by immigration status and histology were computed for 1990–2004. Trends were assessed with annual percentage change (APC) statistics (two-sided P values) based on linear regression.

Results

A total of 8,167 lung cancers were diagnosed among California Chinese from 1990 to 2010. Overall incidence increased nonstatistically among U.S.-born males (APC, 2.1; 95% CI, −4.9 to 9.7), but decreased significantly among foreign-born (APC, −1.7; 95% CI, −2.9 to −0.6). Statistically significant decreasing trends were observed for non–small cell lung cancer (NSCLC), specifically the squamous cell and large cell carcinoma subtypes among foreign-born males. Among females, incidence decreased nonsignificantly among U.S.-born (APC, −2.8; 95% CI, −9.1 to 4.0) but was stable among foreign-born (APC, −0.4; 95% CI, −1.7 to 1.0). A statistically significant decreasing trend was observed for squamous cell among foreign-born females.

Conclusions

These data provide critical evidence base to inform screening, research, and public health priorities in this growing population.

Impact

Given the low smoking prevalence among Chinese Americans, especially females, and few known lung cancer risk factors in U.S. never-smoker populations, additional research of etiologic genetic or biologic factors may elucidate knowledge regarding lung cancer diagnosed in never smokers.


Subject:
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Aged
Article
Asian Americans
Emigration And Immigration
Female
Humans
Incidence
Lung Neoplasms
Male
Middle Aged

Source:
Cancer Epidemiol Biomarkers Prev. 24(8):1157-1164.
Pubmed ID:
25990553
Pubmed Central ID:
PMC5746176
Document Type:
Journal Article
Funding:
HHSN261201000034C/PHS HHS/United States ; U58DP003862-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035C/PC,CA/None/None ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; ... More +
HHSN261201000034C/PHS HHS/United States ; U58DP003862-01/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035C/PC,CA/None/None ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States ; HHSN261201000140C/PHS HHS/United States ; P30 CA124435/CA/NCI NIH HHS/United States ; N01 PC035137/PC/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:84d36e5622eafec6a3554b964dea1ba82842adf44d4af06784e3d40460d5596b
File Type:

Supporting Files

• 	NIHMS927115-supplement-Suppl_Data.pdf	pdf
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