Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Silver, Sharon R. ; Pinkerton, Lynne E. ; Rocheleau, Carissa M. ; Deddens, James A. ; Michalski, Adrian M. ; ... More +
Silver, Sharon R. ; Pinkerton, Lynne E. ; Rocheleau, Carissa M. ; Deddens, James A. ; Michalski, Adrian M. ; Van Zutphen, Alissa R. Less -
Description:
Background

Concerns about solvent releases from a microelectronics/business machine manufacturing facility in upstate New York led to interest in the health of former workers, including this investigation of birth defects in children of male and female employees.

Methods

Children born 1983 to 2001 to facility employees were enumerated and matched to New York State’s Congenital Malformations Registry. Reported structural birth defects were compared with numbers expected from state rates (excluding New York City), generating standardized prevalence ratios (SPRs). Exposure assessors classified employees as ever/never potentially exposed at the facility to metals, chlorinated hydrocarbons, and other hydrocarbons during windows critical to organogenesis (female workers) or spermatogenesis (male workers). Among workers, adjusted prevalence ratios were generated to evaluate associations between potential exposures and specific birth defects.

Results

External comparisons for structural defects were at expectation for infants of male workers (SPR = 1.01; 95% confidence interval [CI], 0.77–1.29; n = 60) and lower for births to female workers (SPR = 0.84; 95% CI, 0.50–1.33; n = 18). Among full-term infants of male workers, ventricular septal defects (VSDs) were somewhat elevated compared with the general population (SPR = 1.58; 95% CI, 0.99–2.39; n = 22). Within the cohort, potential paternal metal exposure was associated with increased VSD risk (adjusted prevalence ratio = 2.70; 95% CI, = 1.09–6.67; n = 7).

Conclusion

While overall SPRs were near expectation, paternal exposure to metals (primarily lead) appeared to be associated with increased VSD risk in infants. Take-home of occupational exposures, nonoccupational exposures, and chance could not be ruled out as causes. Case numbers for many defects were small, limiting assessment of the role of occupational exposures.


Subjects:
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Article Chlorinated Hydrocarbons Congenital Heart Defects Lead Metals Occupational Exposure Paternal Exposure
Source:
Birth Defects Res A Clin Mol Teratol. 106(8):696-707.
Pubmed ID:
27224896
Pubmed Central ID:
PMC5577556
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:72141b9eb04f788e4f6e4223551bacd87beae6e6f31a603393d66a03b6c96dcf
Download URL:
https://stacks.cdc.gov/view/cdc/47879/cdc_47879_DS1.pdf
File Type:

Supporting Files

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