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NIOSH skin notation (SK) profile :Â tetraethyl lead (TEL) [CAS No. 78-00-2]
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August 2017
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Description:"Although the predictive mathematical model did not indicate that the chemical can be absorbed through the skin, toxicokinetic [Kehoe and Thamann 1931; Laug and Kunze 1948] and acute toxicity data indicate tetraethyl lead demonstrated the ability to be absorbed through the skin [Kehoe 1927] and has the potential to cause hyperglycemia, marked reduction in body weight, porphyrinuria, and marked reduction in liver function at high doses [Akatsura 1973]. No reliable information was identified upon which to evaluate the potential of TEL to cause skin irritation/corrosion or skin sensitization. Therefore, on the basis of these assessments, TEL is assigned a composite skin notation of SK: SYS. Table 3 summarizes the skin hazard designations for TEL previously issued by NIOSH and other organizations. No dermal designation based on the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals was identified for TEL [European Parliament 2008]." - NIOSHTIC-2
Suggested citation: NIOSH [2017]. NIOSH skin notation profile: Tetraethyl lead. By Hudson NL, Dotson GS. Cin- cinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-190..
NIOSHTIC no. 20050233
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