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Vitamin D and albuminuria in youth with and without type 1 diabetes
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May 29 2017
Source: Horm Res Paediatr. 87(6):385-395. -
Alternative Title:Horm Res Paediatr
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Description:BACKGROUND/AIMS
In adults, lower Vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes.
METHODS
We examined the cross-sectional association between vitamin D and albuminuria (urine albumin/creatinine ratio [ACR] ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6-19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes.
RESULTS
In NHANES, 5.3%, 19.5%, and 53.7% had vitamin D levels less than 30, 50 and 80 nmol/L. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. In SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria, in unadjusted or adjusted analyses.
CONCLUSION
We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.
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Pubmed ID:28554178
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Pubmed Central ID:PMC5568007
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