Details:

Personal Author:
Hudson, Naomi ; Dotson, G. Scott
Hudson, Naomi ; Dotson, G. Scott Less -
Corporate Authors:
National Institute for Occupational Safety and Health.
Description:
"The mathematical model predicted that 1-BP was absorbed by the skin. Additionally, there was an in vitro dermal penetration study identified that indicates that 1-BP has the potential for substantial dermal penetration dependent on type and duration of exposure [Frasch et al. 2011]. A review of the available literature indicates that 1-BP is capable of inducing a wide array of adverse systemic health effects, including neurotoxicity, hepatotoxicity, hematotoxicity, reproductive toxicity, and developmental toxicity, regardless of exposure route [ClinTrials Bioresearch 1997; Zhao et al. 1999; Ichihara et al. 2000a, 2000b; WIL Research Laboratory 2001; Wang et al. 2002, 2003; Lee et al. 2005, 2007; Banu et al. 2007; Fueta et al. 2007]. Although the exact systemic hazards associated with skin contact and absorption of 1-BP are unknown, 1-BP is assigned the SK: SYS notation; this notation is based on the recognition of adverse health effects in test animals exposed via the inhalation, oral, and subcutaneous injection routes. Although a study using the EpiDerm human reconstructed epidermis model [Frasch et al. 2011] indicated that 1-BP is not corrosive to the skin following exposure to 1-BP, two in vivo tests, conducted with standard methods [Jacobs et al. 1987; Pálovics 2004], provide sufficient evidence that 1-BP is irritating to the skin of rabbits. Although no human patch tests that evaluated the sensitization potential of 1-BP were identified, one guinea pig maximization test [Elf Atochem 1995b] showed that the substance is not a skin sensitizer. Therefore, on the basis of this assessment, 1-BP is assigned the composite skin notation SK: SYS-DIR (IRR). Table 3 summarizes the skin designations for 1-BP from NIOSH and other organizations. The equivalent skin designation for 1-BP from the Globally Harmonized System (GHS) of Classification and Labelling is Reproductive Category 1B (Presumed human reproductive toxicant) and Skin Irritation Category 2 (Causes skin irritation) [European Parliament 2008]." - NIOSHTIC-2

Suggested citation: NIOSH [2017]. NIOSH skin notation profile: 1-Bromopropane. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2017-187.

NIOSHTIC no. 20050228


Subjects:
[+]
1-bromopropane Dermatitis, Occupational Dermatotoxicology Environmental Exposure Hazardous Substances/adverse Effects Hydrocarbons, Brominated Industrial Toxicology Occupational Exposure Skin Absorption Skin Diseases/chemically Induced
Series:
DHHS publication ; no. (NIOSH) 2017-187
Document Type:
Pamphlet (or booklet)
Collection(s):
Stephen B. Thacker CDC Library collection
Main Document Checksum:
[+]
urn:sha256:e1b700cf90b1ce2cd64ea388940afe0a2a43c0b63bf27cb890bd4d02db14ddf7
Download URL:
https://stacks.cdc.gov/view/cdc/47680/cdc_47680_DS1.pdf
File Type:

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