CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Increase in anti-tuberculosis drug resistance in Botswana: results from the fourth National Drug Resistance Survey
-
2014
-
-
Source: Int J Tuberc Lung Dis. 18(9):1026-1033
[PDF-604.13 KB]
Details:
-
Alternative Title:Int J Tuberc Lung Dis
-
Personal Author:
-
Description:SETTING
Although approximately 0.5 million cases of multidrug-resistant tuberculosis (MDR-TB) occur globally each year, surveillance data are limited. Botswana is one of the few high TB burden countries to have carried out multiple anti-tuberculosis drug resistance surveys (in 1995–1996, 1999 and 2002).
OBJECTIVE
In 2007–2008, we conducted the fourth national survey of anti-tuberculosis drug resistance in Botswana to assess anti-tuberculosis drug resistance, including trends over time. In the previous survey, 0.8% (95%CI 0.4–1.5) of new patients and 10.4% (95%CI 5.6–17.3) of previously treated patients had MDR-TB.
DESIGN
During the survey period, eligible specimens from all new sputum-smear positive TB patients and from all TB patients with history of previous anti-tuberculosis treatment underwent mycobacterial culture and anti-tuberculosis drug susceptibility testing (DST).
RESULTS
Of 924 new TB patients and 137 with previous anti-tuberculosis treatment with DST results, respectively 23 (2.5%, 95%CI 1.6–3.7) and 9 (6.6%, 95%CI 3.3–11.7) had MDR-TB. The proportion of new TB patients with MDR-TB has tripled in Botswana since the previous survey.
CONCLUSION
Combatting drug-resistant TB will require the scale-up of MDR-TB diagnosis and treatment to prevent the transmission of MDR-TB and strengthening of general TB control to prevent the emergence of resistance.
-
Subjects:
-
Source:
-
Pubmed ID:25189548
-
Pubmed Central ID:PMC5531285
-
Document Type:
-
Funding:
-
Place as Subject:
-
Volume:18
-
Issue:9
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
