Details:

Alternative Title:
Vaccine
Personal Author:
Lin, Xia ; Fiebelkorn, Amy Parker ; Pabst, Laura J.
Lin, Xia ; Fiebelkorn, Amy Parker ; Pabst, Laura J. Less -
Description:
Background

Children aged 6 months through 8 years may require two doses of influenza vaccine for adequate immune response against the disease. However, poor two-dose compliance has been reported in the literature.

Methods

We analyzed data for >2.6 million children from six immunization information system (IIS) sentinel sites, and assessed full vaccination coverage and two-dose compliance in the 2010–2015 influenza vaccination seasons. Full vaccination was defined as having received at least the recommended number of influenza vaccine doses (one or two), based on recommendations from the Advisory Committee on Immunization Practices. Two-dose compliance was defined as the percentage of children during each season who received at least two doses of influenza vaccine among those who required two doses and initiated the series.

Results

Across seasons, ≥1-dose influenza vaccination coverage was mainly unchanged among 6–23 month olds (range: 60.9%–66.6%), 2–4 year olds (range: 44.8%–47.4%), and 5–8 year olds (range: 34.5%–38.9%). However, full vaccination coverage showed increasing trends from 2010–11 season to 2014–15 season (6–23 months: 43.0%–46.5%; 2–4 year olds: 26.3% to 39.7%; 5–8 year olds, 18.5% to 33.9%). Across seasons, two-dose compliance remained modest in children 6–23 months (range: 63.3%–67.6%) and very low in older children (range: 11.6%–18.7% in children 2–4 years and 6.8%–13.3% in children 5–8 years). In the 2014–15 season, among children who required and received 2 doses, only half completed the two-dose series before influenza activity peaked.

Conclusions

Improved messaging of the two-dose influenza vaccine recommendations is needed for providers and parents. Providers are encouraged to determine a child’s eligibility for two doses of influenza vaccine using the child’s vaccination history, and to vaccinate children early in the season so that two-dose series are completed before influenza peaks.


Subjects:
[+]
Article Children Full Influenza Vaccination Coverage Immunization Information Systems Influenza Vaccine Timing Of Dose Administration Two-dose Compliance
Source:
Vaccine. 34(46):5623-5628.
Pubmed ID:
27670074
Pubmed Central ID:
PMC5327653
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:95fe16d843858f4a9b978527331f15dd1bf60dd3c772b3de49a2488a8f65cea8
Download URL:
https://stacks.cdc.gov/view/cdc/44430/cdc_44430_DS1.pdf
File Type:

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