Details:

Alternative Title:
Epidemiol Infect
Personal Author:
Hennessy, T.W. ; Bruden, D. ; Castrodale, L. ; Komatsu, K. ; Erhart, L.M. ; ... More +
Hennessy, T.W. ; Bruden, D. ; Castrodale, L. ; Komatsu, K. ; Erhart, L.M. ; Thompson, D. ; Bradley, K. ; O’Leary, D. R. ; McLaughlin, J. ; Landen, M. Less -
Corporate Authors:
Investigative Team
Description:
Historically, American Indian/Alaska Native (AI/AN) populations have suffered excess morbidity and mortality from influenza. We investigated the risk factors for death from 2009 pandemic influenza A(H1N1) in persons residing in five states with substantial AI/AN populations. We conducted a case-control investigation using pandemic influenza fatalities from 2009 in Alaska, Arizona, New Mexico, Oklahoma and Wyoming. Controls were outpatients with influenza. We reviewed medical records and interviewed case proxies and controls. We used multiple imputation to predict missing data and multivariable conditional logistic regression to determine risk factors. We included 145 fatal cases and 236 controls; 22% of cases were AI/AN. Risk factors (P 45 years vs. <18 years], pre-existing medical conditions (mOR 7·1), smoking (mOR 3·0), delayed receipt of antivirals (mOR 6·5), and barriers to healthcare access (mOR 5·3). AI/AN race was not significantly associated with death. The increased influenza mortality in AI/AN individuals was due to factors other than racial status. Prevention of influenza deaths should focus on modifiable factors (smoking, early antiviral use, access to care) and identifying high-risk persons for immunization and prompt medical attention.
Keywords:
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Adolescent Adult Aged Case-Control Studies Child Child, Preschool Humans Indians, North American Infant Infant, Newborn Influenza, Human Influenza A Virus, H1N1 Subtype Middle Aged Pandemics Risk Factors United States Young Adult
Source:
Epidemiol Infect. 144(2):315-324
Pubmed ID:
26118767
Pubmed Central ID:
PMC5222627
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/ ; U38 HM000414/HM/NCHM CDC HHSUnited States/ ; 1U38HM000414/HM/NCHM CDC HHSUnited States/
CC999999/Intramural CDC HHSUnited States/ ; U38 HM000414/HM/NCHM CDC HHSUnited States/ ; 1U38HM000414/HM/NCHM CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8f67cbab4bb07207f76449414a427e40065e090dbf9d4172c01221daef69917b
Download URL:
https://stacks.cdc.gov/view/cdc/43778/cdc_43778_DS1.pdf
File Type:

Supporting Files

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