Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Assessing the Potential Cost-Effectiveness of Microneedle Patches in Childhood Measles Vaccination Programs: The Case for Further Research and Development

Filetype[PDF-710.07 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Drugs R D
    • Personal Author:
    • Description:
      Objective

      Currently available measles vaccines are administered by subcutaneous injections and require reconstitution with a diluent and a cold chain, which is resource intensive and challenging to maintain. To overcome these challenges and potentially increase vaccination coverage, microneedle patches are being developed to deliver the measles vaccine. This study compares the cost-effectiveness of using microneedle patches with traditional vaccine delivery by syringe-and-needle (subcutaneous vaccination) in children’s measles vaccination programs.

      Methods

      We built a simple spreadsheet model to compute the vaccination costs for using microneedle patch and syringe-and-needle technologies. We assumed that microneedle vaccines will be, compared with current vaccines, more heat stable and require less expensive cool chains when used in the field. We used historical data on the incidence of measles among communities with low measles vaccination rates.

      Results

      The cost of microneedle vaccination was estimated at US$0.95 (range US$0.71–US$1.18) for the first dose, compared with US$1.65 (range US$1.24–US$2.06) for the first dose delivered by subcutaneous vaccination. At 95 % vaccination coverage, microneedle patch vaccination was estimated to cost US$1.66 per measles case averted (range US$1.24–US$2.07) compared with an estimated cost of US$2.64 per case averted (range US$1.98–US$3.30) using subcutaneous vaccination.

      Conclusions

      Use of microneedle patches may reduce costs; however, the cost-effectiveness of patches would depend on the vaccine recipients’ acceptability and vaccine effectiveness of the patches relative to the existing conventional vaccine-delivery method. This study emphasizes the need to continue research and development of this vaccine-delivery method that could boost measles elimination efforts through improved access to vaccines and increased vaccination coverage.

      Electronic supplementary material

      The online version of this article (doi:10.1007/s40268-016-0144-x) contains supplementary material, which is available to authorized users.

    • Subjects:
    • Source:
      Drugs R D. 16(4):327-338.
    • Pubmed ID:
      27696306
    • Pubmed Central ID:
      PMC5114202
    • Document Type:
      Journal Article
    • Collection(s):
    • Main Document Checksum:
    • Download URL:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov