<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article"><?properties manuscript?><front><journal-meta><journal-id journal-id-type="nlm-journal-id">9815751</journal-id><journal-id journal-id-type="pubmed-jr-id">21797</journal-id><journal-id journal-id-type="nlm-ta">Nicotine Tob Res</journal-id><journal-id journal-id-type="iso-abbrev">Nicotine Tob. Res.</journal-id><journal-title-group><journal-title>Nicotine &#x00026; tobacco research : official journal of the Society for Research on Nicotine and Tobacco</journal-title></journal-title-group><issn pub-type="ppub">1462-2203</issn><issn pub-type="epub">1469-994X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26980860</article-id><article-id pub-id-type="pmc">5104347</article-id><article-id pub-id-type="doi">10.1093/ntr/ntv203</article-id><article-id pub-id-type="manuscript">HHSPA826813</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The African American Youth Smoking Experience: An Overview</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Garrett</surname><given-names>Bridgette E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gardiner</surname><given-names>Phillip S.</given-names></name><degrees>DrPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>La Tanisha C.</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pechacek</surname><given-names>Terry F.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA</aff><aff id="A2"><label>2</label>Tobacco Related Disease Research Program, University of California Office of the President, Oakland, CA</aff><aff id="A3"><label>3</label>Follow the Signs: Raise Awareness, Atlanta, GA</aff><aff id="A4"><label>4</label>Health Management and Policy Division, Georgia State University, Atlanta, GA</aff><author-notes><corresp id="FN1">Corresponding Author: Bridgette E. Garrett, PhD, Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F-79, Atlanta, GA 30341, USA. Telephone: 770-488-5715; Fax: 770-488-5767; <email>bgarrett@cdc.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>11</month><year>2016</year></pub-date><volume>18</volume><issue>Suppl 1</issue><fpage>S11</fpage><lpage>S15</lpage><!--elocation-id from pubmed: 10.1093/ntr/ntv203--><abstract><sec id="S1"><title>Introduction</title><p id="P1">Beginning in the late 1970s, a very sharp decline in cigarette smoking prevalence was observed among African American (AA) high school seniors compared with a more modest decline among whites. This historic decline resulted in a lower prevalence of cigarette smoking among AA youth that has persisted for several decades.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We synthesized information contained in the research literature and tobacco industry documents to provide an account of past influences on cigarette smoking behavior among AA youth to help understand the reasons for these historically lower rates of cigarette smoking.</p></sec><sec id="S3"><title>Results</title><p id="P3">While a number of protective factors including cigarette price increases, religiosity, parental opposition, sports participation, body image, and negative attitudes towards cigarette smoking may have all played a role in maintaining lower rates of cigarette smoking among AA youth as compared to white youth, the efforts of the tobacco industry seem to have prevented the effectiveness of these factors from carrying over into adulthood.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Continuing public health efforts that prevent cigarette smoking initiation and maintain lower cigarette smoking rates among AA youth throughout adulthood have the potential to help reduce the negative health consequences of smoking in this population.</p></sec><sec id="S5"><title>Implications</title><p id="P5">While AA youth continue to have a lower prevalence of cigarette smoking than white youth, they are still at risk of increasing their smoking behavior due to aggressive targeted marketing by the tobacco industry. Because AAs suffer disproportionately from tobacco-related disease, and have higher incidence and mortality rates from lung cancer, efforts to prevent smoking initiation and maintain lower cigarette smoking rates among AA youth have the potential to significantly lower lung cancer death rates among AA adults.</p></sec></abstract></article-meta></front><body><sec sec-type="intro" id="S6"><title>Introduction</title><p id="P6">The current prevalence of cigarette smoking is similar among African American (AA) and white adults at approximately 18%<sup><xref rid="R1" ref-type="bibr">1</xref></sup>; however; AAs historically have had a cumulative lower consumption of cigarettes than whites. For example, AA youth persistently have had lower rates of cigarette smoking since the late 1970s in comparison to white youth.<sup><xref rid="R2" ref-type="bibr">2</xref>&#x02013;<xref rid="R4" ref-type="bibr">4</xref></sup> A similar trend has been observed among AA young adults.<sup><xref rid="R3" ref-type="bibr">3</xref></sup> AAs also initiate cigarette smoking at a later age than whites.<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R4" ref-type="bibr">4</xref></sup> Despite these differences in cigarette smoking behavior between AAs and whites, AAs suffer disproportionately from tobacco-related disease and death and have higher incidence and mortality rates from lung cancer compared to whites.<sup><xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R5" ref-type="bibr">5</xref>&#x02013;<xref rid="R9" ref-type="bibr">9</xref></sup></p><p id="P7">While there are other potential causes of the disparity in lung cancer risk among AAs (eg, socioeconomic status, environmental exposures, genetics, and access to diagnosis and treatment),<sup><xref rid="R8" ref-type="bibr">8</xref></sup> nearly all cases of lung cancer are attributable to cigarette smoking.<sup><xref rid="R7" ref-type="bibr">7</xref>&#x02013;<xref rid="R9" ref-type="bibr">9</xref></sup> For this reason, it will be important to understand how to maintain lower cigarette smoking in AA youth throughout adulthood to help reduce the negative health consequences of smoking in this population.</p><p id="P8">To shed light on measures that can be taken to maintain these lower rates, this brief report will provide an overview of past influences of cigarette smoking behavior among AA youth.</p></sec><sec sec-type="methods" id="S7"><title>Methods</title><p id="P9">Information for this brief report was synthesized from the research literature and tobacco industry documents to provide an overview of possible factors that contributed to the rapid decline in cigarette smoking that occurred among AA youth starting in the late 1970s until the early 1980s, and the reversal of this trend beginning in the 1990s. The tobacco industry documents were retrieved from the Legacy Tobacco Documents Library (LTDL), University of California, San Francisco. The following search terms were used to search the tobacco industry documents: AA youth, AA youth marketing, Black youth, marketing to Black youth, menthol marketing, AA menthol marketing, and menthol cigarette campaigns.</p></sec><sec sec-type="results" id="S8"><title>Results</title><p id="P10">While a number of protective factors including cigarette price increases, religiosity, parental opposition, sports participation, body image, and negative attitudes towards cigarette smoking may have all played a role in maintaining lower rates of cigarette smoking among AA youth as compared to white youth (<xref rid="F1" ref-type="fig">Figure 1</xref>), the efforts of the tobacco industry seem to have prevented the effectiveness of these factors from carrying over into adulthood.</p><sec id="S9" sec-type="background"><title>History of Youth Cigarette Smoking in the United States</title><p id="P11">Beginning in the mid-1970s in the United States, the cigarette smoking prevalence for both AA and white high school seniors was similar at approximately 40%.<sup><xref rid="R10" ref-type="bibr">10</xref></sup> This trend began to change during the late 1970s to early 1980s, when cigarette smoking prevalence among both groups started to decline; however, this decline occurred much faster among AA students.<sup><xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R4" ref-type="bibr">4</xref></sup> While the decline that occurred among white youth stabilized in the early 1980s, the decline among AA youth continued until the early 1990s<sup><xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R10" ref-type="bibr">10</xref></sup>; this decline was even more striking among AA female youth.<sup><xref rid="R10" ref-type="bibr">10</xref></sup></p><p id="P12">However, in the early 1990s, the decline in cigarette smoking among both AA and white youth started to reverse. From 1991 to 1997, current cigarette smoking increased among both AA and white youth.<sup><xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R11" ref-type="bibr">11</xref>&#x02013;<xref rid="R13" ref-type="bibr">13</xref></sup> While the cigarette smoking prevalence among AA youth remained lower than whites, the magnitude of the increase was much greater among AA youth (particularly males) during this time period,<sup><xref rid="R13" ref-type="bibr">13</xref></sup> with research showing the prevalence of cigarette smoking among AA youth almost doubling from 12.6% in 1991 to 22.7% in 1997.<sup><xref rid="R13" ref-type="bibr">13</xref>,<xref rid="R14" ref-type="bibr">14</xref></sup> Cigarette smoking prevalence started to decline again in the late 1990s, but the rate of decline began to slow down in 2003 for both AA and white youth. Since 2003, the rate of decline in current cigarette smoking slowed or leveled off for both AA and white youth.<sup><xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R13" ref-type="bibr">13</xref></sup></p></sec><sec id="S10"><title>Influence of Protective Factors</title><p id="P13">Multiple protective factors appear to be responsible for the sharper decline in cigarette smoking prevalence that occurred in the late 1970s and continued until the early 1990s among AA youth.<sup><xref rid="R3" ref-type="bibr">3</xref>,<xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R15" ref-type="bibr">15</xref></sup> One important factor that has been identified as being especially impactful on AA youth smoking behavior is cigarette price increases.<sup><xref rid="R10" ref-type="bibr">10</xref>,<xref rid="R16" ref-type="bibr">16</xref></sup> Cigarette prices have risen dramatically over the years since the late 1970s.<sup><xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R17" ref-type="bibr">17</xref></sup> Younger AA smokers are more responsive to price increases and are more likely than white smokers to reduce or quit smoking in response to a price increase.<sup><xref rid="R16" ref-type="bibr">16</xref></sup></p><p id="P14">Another factor that could have contributed to lower cigarette smoking prevalence among AA youth during this time period is religiosity. The Black church historically has played an important role in the health of AAs.<sup><xref rid="R15" ref-type="bibr">15</xref></sup> Religion has been found to be a stronger protective factor against smoking among AA youth compared with whites.<sup><xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R15" ref-type="bibr">15</xref></sup> AA youth attribute more importance to religion in their lives, and have a higher frequency of church attendance and involvement in religious activities than white youth.<sup><xref rid="R4" ref-type="bibr">4</xref></sup> Increased religiosity among AA youth is probably largely due to parental influence.<sup><xref rid="R4" ref-type="bibr">4</xref></sup> Parental opposition to cigarette smoking in AA households may have also played a role in curtailing the uptake of cigarette smoking among AA youth.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> Moreover, negative attitudes toward cigarette smoking have been generally held by AA youth, their peers, and the community as a whole.<sup><xref rid="R4" ref-type="bibr">4</xref></sup></p><p id="P15">Often overlooked in assessing the protective factors against cigarette smoking among AA youth is the role of high school sports. Davis and colleagues found that AA male high school athletes were less likely to use tobacco compared to white male high school athletes.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> In addition, they found that AAs involved in high-intensity sports were less likely to be heavy smokers than those participating in low intensity sports.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> This is consistent with what Gardiner observed in his review of AA teen smoking; that is, many young AA males see participation in football, basketball, and track and field (high-intensity sports) as a means toward future employment and avenues for escaping depressed inner cities.<sup><xref rid="R15" ref-type="bibr">15</xref></sup></p></sec><sec id="S11"><title>Tobacco Industry Influence</title><p id="P16">Because tobacco industry marketing has been pervasive in AA communities for several decades, tobacco industry marketing may have played a major role in the larger increase in cigarette smoking prevalence that occurred among AA youth in the 1990s. For example, from 1992 to 1998, there was a 31% increase in cigarette smoking prevalence among white high school seniors compared to a 71% increase among AA high school seniors (<xref rid="F1" ref-type="fig">Figure 1</xref>). This more marked increase in the prevalence of cigarette smoking among AA youth may reflect the increased targeted marketing to this population by the tobacco industry to establish the AA youth market during the &#x0201c;menthol wars&#x0201d; of the 1980s.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> The &#x0201c;menthol wars&#x0201d; were waged in inner city communities where the major tobacco companies (ie, Lorillard, Brown and Williamson, Philip Morris and RJ Reynolds) dispatched company vans to give away free cigarettes in high traffic areas including community parks and street corners.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> By the 1990s, the tobacco industry launched additional campaigns specifically targeted to AA youth. For example, the Marlboro Menthol Inner City Black Bar Program, developed in the late 1980s, expanded in the 1990s and included games, giveaways, and amateur Marlboro Music talent contests.<sup><xref rid="R21" ref-type="bibr">21</xref></sup> In 1990, RJ Reynolds test-marketed Uptown menthol cigarettes in Philadelphia with the slogan &#x0201c;the uptown flavor with the downtown price&#x0201d; and sponsored several cultural and inner-city nightclub events with free pack giveaways. The Uptown theme focused on style, music, nightlife, and entertainment and was specifically targeted to the AA community.<sup><xref rid="R22" ref-type="bibr">22</xref>,<xref rid="R23" ref-type="bibr">23</xref></sup> Community anti-tobacco advocates formed a coalition to block the marketing of Uptown cigarettes. As a result of this public pressure, RJ Reynolds withdrew this product from the market.<sup><xref rid="R24" ref-type="bibr">24</xref>,<xref rid="R25" ref-type="bibr">25</xref></sup></p><p id="P17">The Fat Boys campaign, a Black inner city targeted brand, was launched by RJ Reynolds in the early 1990s.<sup><xref rid="R26" ref-type="bibr">26</xref></sup> The Fat Boys campaign focused on the &#x0201c;environment and interests of inner-city Blacks&#x0201d; as well as rap music. The product packaging had a brick wall and graffiti design. Advertising for the product featured young AA males that strongly resembled leading characters of the <italic>Fresh Prince of Bel-Air</italic>&#x02014;a popular 1990s sitcom that appealed to many urban youth.<sup><xref rid="R26" ref-type="bibr">26</xref></sup> Like Uptown, Fat Boys were mentholated and available in packages of 10 to address price sensitivity for AA smokers.<sup><xref rid="R26" ref-type="bibr">26</xref></sup></p><p id="P18">During Black History Month in 1995, Menthol X cigarettes were launched by Stowebridge Brook Distributors in stores around Massachusetts.<sup><xref rid="R27" ref-type="bibr">27</xref></sup> This &#x0201c;new Black brand&#x0201d; featured red, black, and green colors, representing the Black liberation colors and displayed a large &#x0201c;X&#x0201d; on the front of the pack, a symbol that gained popularity after the 1992 movie <italic>Malcolm X</italic> debuted. During the late 1990s, Brown and Williamson&#x02019;s B KOOL campaign featured &#x0201c;House of Menthol&#x0201d; promotions including playing cards featuring young, hip AAs, and concerts and music events at AA bars and nightclubs.<sup><xref rid="R28" ref-type="bibr">28</xref></sup> Even though tobacco control advocacy efforts in the AA community were successful in curtailing or stopping some of the tobacco industry activities (eg, Uptown and Menthol X), AA youth cigarette smoking rates still rose starkly in the 1990s.</p><p id="P19">The steeper decline in the prevalence of cigarette smoking observed among white youth during the late 1990s may have been the result of the enactment of the 1998 Master Settlement Agreement. As part of the Master Settlement Agreement between the state Attorneys General of 46 states, five US territories, the District of Columbia and the major US cigarette companies, both indirect and direct tobacco advertising targeting youth were prohibited. The types of targeted advertising that were restricted included advertising on billboards as well as advertising on or around public transit, stadiums, arenas, shopping malls, and video arcades.<sup><xref rid="R29" ref-type="bibr">29</xref></sup></p><p id="P20">While the Master Settlement Agreement banned tobacco advertising in certain media outlets and venues that are highly noticeable by youth, it did not restrict outdoor or indoor advertising at the point-of-sale (POS) on retailer property.<sup><xref rid="R29" ref-type="bibr">29</xref></sup> An overwhelming body of evidence has shown that tobacco advertising influences youth to initiate cigarette smoking as well as to continue its use, and that there is a positive association between exposure to POS tobacco promotion and increased smoking.<sup><xref rid="R10" ref-type="bibr">10</xref>,<xref rid="R30" ref-type="bibr">30</xref>&#x02013;<xref rid="R33" ref-type="bibr">33</xref></sup> Exterior signage and interior POS advertising for tobacco products are especially pervasive in AA neighborhoods, particularly advertisements for mentholated cigarette brands. For example, several reports have documented how the tobacco industry has aggressively targeted the marketing of menthol cigarettes to AAs through placement of large numbers of interior and exterior signs in low income, AA communities.<sup><xref rid="R34" ref-type="bibr">34</xref>&#x02013;<xref rid="R37" ref-type="bibr">37</xref></sup></p><p id="P21">Tobacco retail advertising at the POS encourages youth to smoke,<sup><xref rid="R30" ref-type="bibr">30</xref>&#x02013;<xref rid="R33" ref-type="bibr">33</xref></sup> and there is more POS advertising in predominately AA communities.<sup><xref rid="R32" ref-type="bibr">32</xref>,<xref rid="R36" ref-type="bibr">36</xref>&#x02013;<xref rid="R38" ref-type="bibr">38</xref></sup> Therefore, differential exposure to in-store marketing might have contributed to the different trends in cigarette smoking prevalence observed among white and AA youth. The protective factors that may have contributed to the larger decline in smoking among AA youth in the late 1970s and early 1980s might have lost some of their impact due in large part to more aggressive and effective tobacco industry marketing practices targeted toward this population.</p></sec></sec><sec sec-type="conclusions" id="S12"><title>Conclusion</title><p id="P22">The protective factors that may have kept cigarette smoking among AA youth significantly lower than whites seem to not carry over into adulthood as cigarette smoking prevalence rapidly rises among AA adults to be similar to that of whites.<sup><xref rid="R1" ref-type="bibr">1</xref></sup> This &#x0201c;great leap forward&#x0201d; may be also attributed to the targeted marketing of AA adults by the tobacco industry.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> The persistent targeted marketing to the AA community by the tobacco industry promoting menthol cigarettes and other flavored products<sup><xref rid="R10" ref-type="bibr">10</xref>,<xref rid="R28" ref-type="bibr">28</xref>,<xref rid="R30" ref-type="bibr">30</xref>,<xref rid="R33" ref-type="bibr">33</xref>,<xref rid="R35" ref-type="bibr">35</xref>,<xref rid="R39" ref-type="bibr">39</xref></sup> emphasize the importance of tobacco prevention and control efforts in countering this targeted marketing to help reduce the negative health consequences of smoking in this population.</p></sec></body><back><ack id="S13"><p><bold>Funding</bold></p><p>Dr Pechacek receives unrestricted support from Pfizer, Inc. (&#x0201c;Diffusion of Tobacco Control Fundamentals to Other Large Chinese Cities&#x0201d; - Michael Eriksen, Principal Investigator).</p><p>The authors would like to acknowledge Dr Stacy Thorne and Ms Brandi Martell at the Centers for Disease Control and Prevention&#x02019;s Office on Smoking and Health for their technical assistance in preparing this manuscript.</p></ack><fn-group><fn fn-type="COI-statement" id="FN2"><p><bold>Declaration of Interests</bold></p><p>None declared.</p></fn><fn id="FN3"><p><bold>Disclaimer</bold></p><p>The findings and conclusions are the author&#x02019;s, not necessarily the CDC&#x02019;s.</p></fn><fn id="FN4"><p><bold>Supplement Sponsorship</bold></p><p>This article appears as part of the supplement &#x0201c;Critical Examination of Factors Related to the Smoking Trajectory among African American Youth and Young Adults,&#x0201d; sponsored by the Centers for Disease Control and Prevention contract no. 200-2014-M-58879.</p></fn></fn-group><ref-list><ref id="R1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jamal</surname><given-names>A</given-names></name><name><surname>Agaku</surname><given-names>IT</given-names></name><name><surname>O&#x02019;Connor</surname><given-names>E</given-names></name><name><surname>King</surname><given-names>BA</given-names></name><name><surname>Kenemer</surname><given-names>JB</given-names></name><name><surname>Neff</surname><given-names>L</given-names></name></person-group><article-title>Current cigarette smoking among adults&#x02014;United States, 2005&#x02013;2013</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>2014</year><volume>63</volume><issue>47</issue><fpage>1108</fpage><lpage>1112</lpage><comment><ext-link ext-link-type="uri" xlink:href="www.cdc.gov/mmwr/preview/mmwrhtml/mm6347a4.htm">www.cdc.gov/mmwr/preview/mmwrhtml/mm6347a4.htm</ext-link></comment><date-in-citation>Accessed July 7, 2015</date-in-citation><pub-id pub-id-type="pmid">25426653</pub-id></element-citation></ref><ref id="R2"><label>2</label><element-citation publication-type="book"><collab>US Department of Health and Human Services</collab><source>Tobacco Use Among U.S. Racial/Ethnic Minority Groups&#x02014;African Americans, American Indians and Alaska Natives, Asian Americans and Pacific Islanders, and Hispanics: A report of the Surgeon General</source><publisher-loc>Atlanta, GA</publisher-loc><publisher-name>US Department of Health and Human Services</publisher-name><year>1998</year><comment><ext-link ext-link-type="uri" xlink:href="www.cdc.gov/tobacco/data_statistics/sgr/1998">www.cdc.gov/tobacco/data_statistics/sgr/1998</ext-link></comment><date-in-citation>Accessed July 7, 2015</date-in-citation></element-citation></ref><ref id="R3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nelson</surname><given-names>DE</given-names></name><name><surname>Mowery</surname><given-names>P</given-names></name><name><surname>Asman</surname><given-names>K</given-names></name><etal/></person-group><article-title>Long-term trends in adolescent and young adult smoking in the United States: metapatterns and implications</article-title><source>Am J Public Health</source><year>2008</year><volume>98</volume><issue>5</issue><fpage>905</fpage><lpage>915</lpage><pub-id pub-id-type="doi">10.2105/AJPH.2007.115931</pub-id><pub-id pub-id-type="pmid">18382001</pub-id></element-citation></ref><ref id="R4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oredein</surname><given-names>T</given-names></name><name><surname>Foulds</surname><given-names>J</given-names></name></person-group><article-title>Causes of the decline in cigarette smoking among African American youths from the 1970s to the 1990s</article-title><source>Am J Public Health</source><year>2011</year><volume>101</volume><issue>10</issue><fpage>e4</fpage><lpage>e14</lpage><pub-id pub-id-type="doi">10.2105/AJPH.2011.300289</pub-id></element-citation></ref><ref id="R5"><label>5</label><element-citation publication-type="book"><collab>American Cancer Society</collab><source>Cancer Facts &#x00026; Figures for African Americans 2013&#x02013;2014</source><publisher-loc>Atlanta, GA</publisher-loc><publisher-name>American Cancer Society</publisher-name><year>2013</year></element-citation></ref><ref id="R6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haiman</surname><given-names>CA</given-names></name><name><surname>Stram</surname><given-names>DO</given-names></name><name><surname>Wilkens</surname><given-names>LR</given-names></name><etal/></person-group><article-title>Ethnic and racial differences in the smoking-related risk of lung cancer</article-title><source>N Engl J Med</source><year>2006</year><volume>354</volume><issue>4</issue><fpage>333</fpage><lpage>342</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa033250</pub-id><pub-id pub-id-type="pmid">16436765</pub-id></element-citation></ref><ref id="R7"><label>7</label><element-citation publication-type="journal"><collab>Centers for Disease Control and Prevention</collab><article-title>Racial/Ethnic disparities and geographic differences in lung cancer incidence&#x02014;38 States and the District of Columbia, 1998&#x02013;2006</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>2010</year><volume>59</volume><issue>44</issue><fpage>1434</fpage><lpage>1438</lpage><comment><ext-link ext-link-type="uri" xlink:href="www.cdc.gov/mmwr/preview/mmwrhtml/mm5944a2.htm">www.cdc.gov/mmwr/preview/mmwrhtml/mm5944a2.htm</ext-link></comment><date-in-citation>Accessed July 7, 2015</date-in-citation><pub-id pub-id-type="pmid">21063273</pub-id></element-citation></ref><ref id="R8"><label>8</label><element-citation publication-type="book"><collab>American Lung Association</collab><source>Too Many Cases, Too Many Death: Lung Cancer in African Americans</source><publisher-loc>Washington, DC</publisher-loc><publisher-name>American Lung Association</publisher-name><year>2010</year><comment><ext-link ext-link-type="uri" xlink:href="www.lung.org/assets/documents/publications/lung-disease-data/ala-lung-cancer-in-african.pdf">www.lung.org/assets/documents/publications/lung-disease-data/ala-lung-cancer-in-african.pdf</ext-link></comment><date-in-citation>Accessed July 7, 2015</date-in-citation></element-citation></ref><ref id="R9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jemal</surname><given-names>A</given-names></name><name><surname>Center</surname><given-names>MM</given-names></name><name><surname>Ward</surname><given-names>E</given-names></name></person-group><article-title>The convergence of lung cancer rates between blacks and whites under the age of 40, United States</article-title><source>Cancer Epidemiol Biomarkers Prev</source><year>2009</year><volume>18</volume><issue>12</issue><fpage>3349</fpage><lpage>3352</lpage><pub-id pub-id-type="doi">10.1158/1055-9965.EPI-09-0740</pub-id><pub-id pub-id-type="pmid">19959681</pub-id></element-citation></ref><ref id="R10"><label>10</label><element-citation publication-type="book"><collab>US Department of Health and Human Services</collab><source>Preventing Tobacco Use Among Youth and Young Adults: A Report of the Surgeon General</source><publisher-loc>Washington, DC</publisher-loc><publisher-name>U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion</publisher-name><year>2012</year><comment><ext-link ext-link-type="uri" xlink:href="www.cdc.gov/tobacco/data_statistics/sgr/2012/">www.cdc.gov/tobacco/data_statistics/sgr/2012/</ext-link></comment><date-in-citation>Accessed July 9, 2015</date-in-citation></element-citation></ref><ref id="R11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nelson</surname><given-names>DE</given-names></name><name><surname>Giovino</surname><given-names>GA</given-names></name><name><surname>Shopland</surname><given-names>DR</given-names></name><name><surname>Mowery</surname><given-names>PD</given-names></name><name><surname>Mills</surname><given-names>SL</given-names></name><name><surname>Eriksen</surname><given-names>MP</given-names></name></person-group><article-title>Trends in cigarette smoking among US adolescents, 1974 through 1991</article-title><source>Am J Public Health</source><year>1995</year><volume>85</volume><issue>1</issue><fpage>34</fpage><lpage>40</lpage><pub-id pub-id-type="doi">10.2105/AJPH.85.1.34</pub-id><pub-id pub-id-type="pmid">7832259</pub-id></element-citation></ref><ref id="R12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wallace</surname><given-names>JM</given-names><suffix>Jr</suffix></name><name><surname>Bachman</surname><given-names>JG</given-names></name><name><surname>O&#x02019;Malley</surname><given-names>PM</given-names></name><name><surname>Johnston</surname><given-names>LD</given-names></name><name><surname>Schulenberg</surname><given-names>JE</given-names></name><name><surname>Cooper</surname><given-names>SM</given-names></name></person-group><article-title>Tobacco, alcohol, and illicit drug use: racial and ethnic differences among U.S. high school seniors, 1976&#x02013;2000</article-title><source>Public Health Rep</source><year>2002</year><volume>117</volume><issue>suppl 1</issue><fpage>S67</fpage><lpage>75</lpage><comment><ext-link ext-link-type="uri" xlink:href="www.ncbi.nlm.nih.gov/pmc/articles/PMC1913705/">www.ncbi.nlm.nih.gov/pmc/articles/PMC1913705/</ext-link></comment><date-in-citation>Accessed July 9, 2015</date-in-citation><pub-id pub-id-type="pmid">12435829</pub-id></element-citation></ref><ref id="R13"><label>13</label><element-citation publication-type="journal"><collab>Centers for Disease Contol and Prevention</collab><article-title>Cigarette use among high school students&#x02014;United States, 1991&#x02013;2009</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>2010</year><volume>59</volume><issue>26</issue><fpage>797</fpage><lpage>801</lpage><comment><ext-link ext-link-type="uri" xlink:href="www.cdc.gov/mmwr/preview/mmwrhtml/mm5926a1.htm">www.cdc.gov/mmwr/preview/mmwrhtml/mm5926a1.htm</ext-link></comment><date-in-citation>Accessed July 9, 2015</date-in-citation><pub-id pub-id-type="pmid">20613702</pub-id></element-citation></ref><ref id="R14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mermelstein</surname><given-names>R</given-names></name></person-group><article-title>Ethnicity, gender and risk factors for smoking initiation: an overview</article-title><source>Nicotine Tob Res</source><year>1999</year><volume>1</volume><issue>suppl 2</issue><fpage>S39</fpage><lpage>43</lpage><comment>discussion S69&#x02013;70</comment><pub-id pub-id-type="doi">10.1080/14622299050011791</pub-id><pub-id pub-id-type="pmid">11768185</pub-id></element-citation></ref><ref id="R15"><label>15</label><element-citation publication-type="web"><person-group person-group-type="author"><name><surname>Gardiner</surname><given-names>PS</given-names></name></person-group><article-title>African American teen cigarette smoking: a review. Changing adolescent smoking prevalence: where it is and why</article-title><source>Smoking and Tobacco Control Monograph</source><year>2001</year><issue>14</issue><fpage>213</fpage><lpage>226</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://cancercontrol.cancer.gov/Brp/tcrb/monographs/14/m14_14.pdf">http://cancercontrol.cancer.gov/Brp/tcrb/monographs/14/m14_14.pdf</ext-link></comment><date-in-citation>Accessed July 10, 2015</date-in-citation></element-citation></ref><ref id="R16"><label>16</label><element-citation publication-type="journal"><collab>Centers for Disease Control and Prevention</collab><article-title>Response to increases in cigarette prices by race/ethnicity, income, and age groups&#x02014;United States, 1976&#x02013;1993</article-title><source>MMWR Morb Mortal Wkly Rep</source><year>1998</year><volume>47</volume><issue>29</issue><fpage>605</fpage><lpage>609</lpage><comment><ext-link ext-link-type="uri" xlink:href="www.ncbi.nlm.nih.gov/pubmed/9699809">www.ncbi.nlm.nih.gov/pubmed/9699809</ext-link></comment><date-in-citation>Accessed July 9, 2015</date-in-citation><pub-id pub-id-type="pmid">9699809</pub-id></element-citation></ref><ref id="R17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gilpin</surname><given-names>EA</given-names></name><name><surname>Pierce</surname><given-names>JP</given-names></name></person-group><article-title>Trends in adolescent smoking initiation in the United States: is tobacco marketing an influence?</article-title><source>Tob Control</source><year>1997</year><volume>6</volume><issue>2</issue><fpage>122</fpage><lpage>127</lpage><pub-id pub-id-type="doi">10.1136/tc.6.2.122</pub-id><pub-id pub-id-type="pmid">9291221</pub-id></element-citation></ref><ref id="R18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Skinner</surname><given-names>ML</given-names></name><name><surname>Haggerty</surname><given-names>KP</given-names></name><name><surname>Catalano</surname><given-names>RF</given-names></name></person-group><article-title>Parental and peer influences on teen smoking: Are White and Black families different?</article-title><source>Nicotine Tob Res</source><year>2009</year><volume>11</volume><issue>5</issue><fpage>558</fpage><lpage>563</lpage><pub-id pub-id-type="doi">10.1093/ntr/ntp034</pub-id><pub-id pub-id-type="pmid">19351778</pub-id></element-citation></ref><ref id="R19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Davis</surname><given-names>TC</given-names></name><name><surname>Arnold</surname><given-names>C</given-names></name><name><surname>Nandy</surname><given-names>I</given-names></name><etal/></person-group><article-title>Tobacco use among male high school athletes</article-title><source>J Adolesc Health</source><year>1997</year><volume>21</volume><issue>2</issue><fpage>97</fpage><lpage>101</lpage><pub-id pub-id-type="doi">10.1016/S1054-139X(97)00032-3</pub-id><pub-id pub-id-type="pmid">9248934</pub-id></element-citation></ref><ref id="R20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yerger</surname><given-names>VB</given-names></name><name><surname>Przewoznik</surname><given-names>J</given-names></name><name><surname>Malone</surname><given-names>RE</given-names></name></person-group><article-title>Racialized geography, corporate activity, and health disparities: tobacco industry targeting of inner cities</article-title><source>J Health Care Poor Underserved</source><year>2007</year><volume>18</volume><issue>suppl 4</issue><fpage>10</fpage><lpage>38</lpage><pub-id pub-id-type="doi">10.1353/hpu.2007.0120</pub-id><pub-id pub-id-type="pmid">18065850</pub-id></element-citation></ref><ref id="R21"><label>21</label><element-citation publication-type="book"><source>Menthol&#x02014;Event Sponsorship Marlboro Menthol Inner City Bar Nights</source><publisher-name>Philip Morris</publisher-name><year>1989</year><comment><ext-link ext-link-type="uri" xlink:href="https://industrydocuments.library.ucsf.edu/tobacco/docs/#id=hzbw0125">https://industrydocuments.library.ucsf.edu/tobacco/docs/#id=hzbw0125</ext-link></comment><date-in-citation>Accessed July 10, 2015</date-in-citation></element-citation></ref><ref id="R22"><label>22</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Hawkins</surname><given-names>SC</given-names></name><name><surname>Reynolds</surname><given-names>RJ</given-names></name></person-group><source>Project Ut Creative Qualitative Research</source><publisher-loc>Salem, NC</publisher-loc><publisher-name>Marketing Research Department, RJ Reynolds</publisher-name><year>1989</year><comment><ext-link ext-link-type="uri" xlink:href="http://legacy-dc.ucsf.edu/tid/ipf63a00/pdf">http://legacy-dc.ucsf.edu/tid/ipf63a00/pdf</ext-link></comment><date-in-citation>Accessed July 10, 2015</date-in-citation></element-citation></ref><ref id="R23"><label>23</label><element-citation publication-type="web"><person-group person-group-type="author"><name><surname>Reynolds</surname><given-names>RJ</given-names></name></person-group><source>Q&#x00026;A for Leave Behind</source><year>1989</year><comment><ext-link ext-link-type="uri" xlink:href="http://legacy-dc.ucsf.edu/tid/gcv61d00/pdf;jsessionid=FC2D28586E9D0DE65CF9A8525F5B2002.tobacco03">http://legacy-dc.ucsf.edu/tid/gcv61d00/pdf;jsessionid=FC2D28586E9D0DE65CF9A8525F5B2002.tobacco03</ext-link></comment><date-in-citation>Accessed July 10, 2015</date-in-citation></element-citation></ref><ref id="R24"><label>24</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Robinson</surname><given-names>RG</given-names></name><name><surname>Pertschuk</surname><given-names>M</given-names></name><name><surname>Sutton</surname><given-names>C</given-names></name></person-group><article-title>Smoking and African Americans: spotlighting the effects of smoking and tobacco prevention in the African American Community</article-title><person-group person-group-type="editor"><name><surname>Samuels</surname><given-names>SE</given-names></name><name><surname>Smith</surname><given-names>M</given-names></name></person-group><source>Improving the Health of the Poor: Strategies for Prevention</source><publisher-loc>Menlo Park, CA</publisher-loc><publisher-name>Henry J. Kaiser Family Foundation</publisher-name><year>1992</year><fpage>123</fpage><lpage>181</lpage></element-citation></ref><ref id="R25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yerger</surname><given-names>VB</given-names></name><name><surname>Malone</surname><given-names>RE</given-names></name></person-group><article-title>African American leadership groups: smoking with the enemy</article-title><source>Tob Control</source><year>2002</year><volume>11</volume><fpage>336</fpage><lpage>345</lpage><pub-id pub-id-type="doi">10.1136/tc.11.4.336</pub-id><pub-id pub-id-type="pmid">12432159</pub-id></element-citation></ref><ref id="R26"><label>26</label><element-citation publication-type="book"><source>1990 New Marketing Ideas</source><publisher-name>Joe Camel</publisher-name><publisher-loc>Mangini Lawsuit</publisher-loc><year>1989</year><comment><ext-link ext-link-type="uri" xlink:href="https://industrydocuments.library.ucsf.edu/tobacco/docs/#id=hfdv0095">https://industrydocuments.library.ucsf.edu/tobacco/docs/#id=hfdv0095</ext-link></comment><date-in-citation>Accessed July 10, 2015</date-in-citation></element-citation></ref><ref id="R27"><label>27</label><element-citation publication-type="web"><collab>Los Angeles Times</collab><source>Maker of Menthol X Agrees to Pull It After Protests</source><year>1995</year><comment><ext-link ext-link-type="uri" xlink:href="https://industrydocuments.library.ucsf.edu/tobacco/docs/qklm0085">https://industrydocuments.library.ucsf.edu/tobacco/docs/qklm0085</ext-link></comment><date-in-citation>Accessed August 31, 2015</date-in-citation></element-citation></ref><ref id="R28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hafez</surname><given-names>N</given-names></name><name><surname>Ling</surname><given-names>PM</given-names></name></person-group><article-title>Finding the Kool Mixx: how Brown &#x00026; Williamson used music marketing to sell cigarettes</article-title><source>Tob Control</source><year>2006</year><volume>15</volume><issue>5</issue><fpage>359</fpage><lpage>366</lpage><pub-id pub-id-type="doi">10.1136/tc.2005.014258</pub-id><pub-id pub-id-type="pmid">16998169</pub-id></element-citation></ref><ref id="R29"><label>29</label><element-citation publication-type="web"><article-title>Settling States and Participating Manufacturers</article-title><source>Master Settlement Agreement</source><year>1998</year><comment><ext-link ext-link-type="uri" xlink:href="www.naag.org/naag/about_naag/naag-center-for-tobacco-and-public-health/master-settlement-agreement/master-settlement-agreement-msa.php?">www.naag.org/naag/about_naag/naag-center-for-tobacco-and-public-health/master-settlement-agreement/master-settlement-agreement-msa.php?</ext-link></comment><date-in-citation>Accessed May 24, 2015</date-in-citation></element-citation></ref><ref id="R30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Henriksen</surname><given-names>L</given-names></name><name><surname>Feighery</surname><given-names>EC</given-names></name><name><surname>Schleicher</surname><given-names>NC</given-names></name><name><surname>Cowling</surname><given-names>DW</given-names></name><name><surname>Kline</surname><given-names>RS</given-names></name><name><surname>Fortmann</surname><given-names>SP</given-names></name></person-group><article-title>Is adolescent smoking related to the density and proximity of tobacco outlets and retail cigarette advertising near schools?</article-title><source>Prev Med</source><year>2008</year><volume>47</volume><issue>2</issue><fpage>210</fpage><lpage>214</lpage><pub-id pub-id-type="doi">10.1016/j.ypmed.2008.04.008</pub-id><pub-id pub-id-type="pmid">18544462</pub-id></element-citation></ref><ref id="R31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paynter</surname><given-names>J</given-names></name><name><surname>Edwards</surname><given-names>R</given-names></name></person-group><article-title>The impact of tobacco promotion at the point of sale: a systematic review</article-title><source>Nicotine Tob Res</source><year>2009</year><volume>11</volume><issue>1</issue><fpage>25</fpage><lpage>35</lpage><pub-id pub-id-type="doi">10.1093/ntr/ntn002</pub-id><pub-id pub-id-type="pmid">19246438</pub-id></element-citation></ref><ref id="R32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Henriksen</surname><given-names>L</given-names></name><name><surname>Schleicher</surname><given-names>NC</given-names></name><name><surname>Feighery</surname><given-names>EC</given-names></name><name><surname>Fortmann</surname><given-names>SP</given-names></name></person-group><article-title>A longitudinal study of exposure to retail cigarette advertising and smoking initiation</article-title><source>Pediatrics</source><year>2010</year><volume>126</volume><issue>2</issue><fpage>232</fpage><lpage>238</lpage><pub-id pub-id-type="doi">10.1542/peds.2009-3021</pub-id><pub-id pub-id-type="pmid">20643725</pub-id></element-citation></ref><ref id="R33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Robertson</surname><given-names>L</given-names></name><name><surname>McGee</surname><given-names>R</given-names></name><name><surname>Marsh</surname><given-names>L</given-names></name><name><surname>Hoek</surname><given-names>J</given-names></name></person-group><article-title>A systematic review on the impact of point-of-sale tobacco promotion on smoking</article-title><source>Nicotine Tob Res</source><year>2015</year><volume>17</volume><issue>1</issue><fpage>2</fpage><lpage>17</lpage><pub-id pub-id-type="doi">10.1093/ntr/ntu168</pub-id><pub-id pub-id-type="pmid">25173775</pub-id></element-citation></ref><ref id="R34"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gardiner</surname><given-names>PS</given-names></name></person-group><article-title>The African Americanization of menthol cigarette use in the United States</article-title><source>Nicotine Tob Res</source><year>2004</year><volume>6</volume><issue>suppl 1</issue><fpage>S55</fpage><lpage>65</lpage><pub-id pub-id-type="doi">10.1080/14622200310001649478</pub-id><pub-id pub-id-type="pmid">14982709</pub-id></element-citation></ref><ref id="R35"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cruz</surname><given-names>TB</given-names></name><name><surname>Wright</surname><given-names>LT</given-names></name><name><surname>Crawford</surname><given-names>G</given-names></name></person-group><article-title>The menthol marketing mix: targeted promotions for focus communities in the United States</article-title><source>Nicotine Tob Res</source><year>2010</year><volume>12</volume><issue>suppl 2</issue><fpage>S147</fpage><lpage>153</lpage><pub-id pub-id-type="doi">10.1093/ntr/ntq201</pub-id><pub-id pub-id-type="pmid">21177371</pub-id></element-citation></ref><ref id="R36"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seidenberg</surname><given-names>AB</given-names></name><name><surname>Caughey</surname><given-names>RW</given-names></name><name><surname>Rees</surname><given-names>VW</given-names></name><name><surname>Connolly</surname><given-names>GN</given-names></name></person-group><article-title>Storefront cigarette advertising differs by community demographic profile</article-title><source>Am J Health Promot</source><year>2010</year><volume>24</volume><issue>6</issue><fpage>e26</fpage><lpage>31</lpage><pub-id pub-id-type="doi">10.4278/ajhp.090618-QUAN-196</pub-id><pub-id pub-id-type="pmid">20594091</pub-id></element-citation></ref><ref id="R37"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Henriksen</surname><given-names>L</given-names></name><name><surname>Schleicher</surname><given-names>NC</given-names></name><name><surname>Dauphinee</surname><given-names>AL</given-names></name><name><surname>Fortmann</surname><given-names>SP</given-names></name></person-group><article-title>Targeted advertising, promotion, and price for menthol cigarettes in California high school neighborhoods</article-title><source>Nicotine Tob Res</source><year>2012</year><volume>14</volume><issue>1</issue><fpage>116</fpage><lpage>121</lpage><pub-id pub-id-type="doi">10.1093/ntr/ntr122</pub-id><pub-id pub-id-type="pmid">21705460</pub-id></element-citation></ref><ref id="R38"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hyland</surname><given-names>A</given-names></name><name><surname>Travers</surname><given-names>MJ</given-names></name><name><surname>Cummings</surname><given-names>KM</given-names></name><name><surname>Bauer</surname><given-names>J</given-names></name><name><surname>Alford</surname><given-names>T</given-names></name><name><surname>Wieczorek</surname><given-names>WF</given-names></name></person-group><article-title>Tobacco outlet density and demographics in Erie County, New York</article-title><source>Am J Public Health</source><year>2003</year><volume>93</volume><issue>7</issue><fpage>1075</fpage><lpage>1076</lpage><pub-id pub-id-type="doi">10.2105/AJPH.93.7.1075</pub-id><pub-id pub-id-type="pmid">12835184</pub-id></element-citation></ref><ref id="R39"><label>39</label><element-citation publication-type="book"><collab>US Department of Health and Human Services</collab><source>The Health Consequences of Smoking&#x02014;50 Years of Progress: A Report of the Surgeon General</source><publisher-loc>Atlanta, GA</publisher-loc><publisher-name>US Department of Health and Human Services</publisher-name><year>2014</year><comment><ext-link ext-link-type="uri" xlink:href="www.surgeongeneral.gov/library/reports/50-years-of-progress/index.html">www.surgeongeneral.gov/library/reports/50-years-of-progress/index.html</ext-link></comment><date-in-citation>Accessed July 7, 2015</date-in-citation></element-citation></ref></ref-list></back><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Trends in prevalence of past month cigarette smoking among high school seniors by race&#x02014;United States, 1977&#x02013;2014.</p></caption><graphic xlink:href="nihms826813f1"/></fig></floats-group></article>