%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Dinanibè Kambiré, Heidi M. Soeters, Rasmata Ouédraogo-Traoré, Isaïe Medah, Lassana Sangare, Issaka Yaméogo, Guetawendé Sawadogo, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Lesley McGee, Velusamy Srinivasan, Flavien Aké, Malika Congo-Ouédraogo, Soufian Sanou, Absatou Ky Ba, Ryan T. Novak, Chris Van Beneden, MenAfriNet Consortium
Nationwide Trends in Bacterial Meningitis before the Introduction of 13-Valent Pneumococcal Conjugate Vaccine—Burkina Faso, 2011–2013
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 15 0 R/Contents 16 0 R/TrimBox[0 0 612 792]>>
endobj
15 0 obj
[17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R]
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref001)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref002)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref003)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref004)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref005)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref011)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref005)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref012)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref004)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref013)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref014)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref004)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref004)>>
endobj
16 0 obj
[33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R]
endobj
33 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 566.153 m
199.9998 566.153 l
199.9998 566.653 l
575.9997 566.653 l
f*
0.83 0.64 0.02 0 k
273.7701 494.9858 m
278.5323 494.9858 l
h
f*
283.011 494.9858 m
287.7165 494.9858 l
h
f*
529.5685 482.0031 m
534.3307 482.0031 l
h
f*
324.737 455.9811 m
329.4992 455.9811 l
h
f*
248.2583 416.9764 m
253.0205 416.9764 l
h
f*
258.1795 416.9764 m
262.9417 416.9764 l
h
f*
248.2583 377.9717 m
257.7827 377.9717 l
h
f*
262.2047 377.9717 m
271.7291 377.9717 l
h
f*
399.7984 364.989 m
409.2661 364.989 l
h
f*
257.9528 352.0063 m
262.715 352.0063 l
h
f*
267.1937 352.0063 m
276.7181 352.0063 l
h
f*
565.4551 339.0236 m
570.2173 339.0236 l
h
f*
200.0126 325.9843 m
209.537 325.9843 l
h
f*
266.9102 300.0189 m
276.4346 300.0189 l
h
f*
386.8157 300.0189 m
391.578 300.0189 l
h
f*
303.4205 222.0094 m
308.1827 222.0094 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(\()Tj
/F12 1 Tf
0 Tc
()Tj
/F0 1 Tf
-0.0042 Tc
(15)Tj
2.4169 0 Td
(years\).)Tj
3.2464 0 Td
(Overall)Tj
3.3538 0 Td
(CFR)Tj
2.2617 0 Td
(was)Tj
1.9813 0 Td
(23%)Tj
2.202 0 Td
(and)Tj
1.862 0 Td
(highest)Tj
3.4075 0 Td
(among)Tj
3.2464 0 Td
(children)Tj
3.6701 0 Td
(aged)Tj
/F6 1 Tf
2.4109 0 Td
[( )]TJ
/F0 1 Tf
(1)Tj
1.3487 0 Td
(year)Tj
2.1484 0 Td
(\(32%\))Tj
2.8585 0 Td
(and)Tj
-36.4146 -1.474 Td
(adults)Tj
/F12 1 Tf
0 Tc
2.8525 0 Td
()Tj
/F0 1 Tf
-0.0042 Tc
(30)Tj
2.0887 0 Td
(years)Tj
2.6436 0 Td
(\(30%\).)Tj
3.1331 0 Td
(Of)Tj
1.277 0 Td
(1,528)Tj
2.6914 0 Td
(cases,)Tj
3.0853 0 Td
(1,036)Tj
2.6914 0 Td
(\(68%\))Tj
2.8585 0 Td
(were)Tj
2.3632 0 Td
(serotyped:)Tj
4.8458 0 Td
(71%)Tj
2.1961 0 Td
(were)Tj
2.3632 0 Td
(PCV13-)Tj
-35.0898 -1.474 Td
(associated)Tj
4.9471 0 Td
(serotypes,)Tj
4.7861 0 Td
(14%)Tj
2.2021 0 Td
(were)Tj
2.3632 0 Td
(non-PCV13-assoc)Tj
8.0324 0 Td
(iated)Tj
2.3572 0 Td
(serotypes,)Tj
4.7861 0 Td
(and)Tj
1.8679 0 Td
(15%)Tj
2.202 0 Td
(were)Tj
2.3632 0 Td
(non-)Tj
-35.9073 -1.474 Td
(typeable)Tj
3.9505 0 Td
(by)Tj
1.2652 0 Td
(PCR.)Tj
2.5959 0 Td
(Serotypes)Tj
4.6787 0 Td
(1)Tj
0.7638 0 Td
(\(45%\))Tj
2.8585 0 Td
(and)Tj
1.8679 0 Td
(12F/12A/12B)Tj
5.7886 0 Td
(/44/46)Tj
2.9659 0 Td
(\(8%\))Tj
2.3095 0 Td
(were)Tj
2.3632 0 Td
(most)Tj
2.3751 0 Td
(common.)Tj
-33.7828 -1.474 Td
(Among)Tj
3.3597 0 Td
(children)Tj
3.6701 0 Td
(aged)Tj
/F6 1 Tf
2.4169 0 Td
[( )]TJ
/F0 1 Tf
(1)Tj
1.3487 0 Td
(year,)Tj
2.4169 0 Td
(serotypes)Tj
4.5116 0 Td
(5)Tj
0.7698 0 Td
(\(15%\),)Tj
3.139 0 Td
(6A/6B)Tj
2.9182 0 Td
(\(13%\))Tj
2.8645 0 Td
(and)Tj
1.8619 0 Td
(1)Tj
0.7698 0 Td
(\(12%\))Tj
2.8585 0 Td
(predominated)Tj
6.0452 0 Td
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 624.6425 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 607.6346 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(In)Tj
1.0443 0 Td
(Burkina)Tj
3.5686 0 Td
(Faso,)Tj
2.7034 0 Td
(the)Tj
1.5993 0 Td
(highest)Tj
3.4016 0 Td
(morbidity)Tj
4.2311 0 Td
(and)Tj
1.8678 0 Td
(mortality)Tj
3.9566 0 Td
(due)Tj
1.8679 0 Td
(to)Tj
1.0443 0 Td
(pneumococcal)Tj
6.5943 0 Td
(meningitis)Tj
-31.8792 -1.474 Td
(occurred)Tj
4.0639 0 Td
(among)Tj
3.2464 0 Td
(children)Tj
3.6701 0 Td
(aged)Tj
/F6 1 Tf
2.4169 0 Td
[( )]TJ
/F0 1 Tf
(1)Tj
1.3487 0 Td
(year.)Tj
2.4229 0 Td
(The)Tj
1.9275 0 Td
(majority)Tj
3.6821 0 Td
(of)Tj
1.0443 0 Td
(cases)Tj
2.8048 0 Td
(were)Tj
2.3632 0 Td
(due)Tj
1.8679 0 Td
(to)Tj
1.0443 0 Td
(PCV13-associ-)Tj
-31.903 -1.474 Td
(ated)Tj
2.1423 0 Td
(serotypes;)Tj
4.7921 0 Td
(introduction)Tj
5.3231 0 Td
(of)Tj
1.0444 0 Td
(PCV13)Tj
3.3597 0 Td
(should)Tj
3.1271 0 Td
(substantially)Tj
5.6514 0 Td
(decrease)Tj
4.2847 0 Td
(this)Tj
1.7605 0 Td
(burden.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 539.0929 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 522.085 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Infection)Tj
3.8607 0 Td
(with)Tj
/F13 1 Tf
2.0013 0 Td
[()10()7()20()2()12()11()4()7()4()7()1()-4( )]TJ
5.4028 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0569 0 Td
(is)Tj
0.8504 0 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(leading)Tj
3.1295 0 Td
(bacterial)Tj
3.6226 0 Td
(causes)Tj
2.7553 0 Td
(of)Tj
1.0148 0 Td
(morbidity)Tj
-31.8782 -1.2982 Td
(and)Tj
1.7291 0 Td
(mortality)Tj
3.9174 0 Td
(worldwide)Tj
4.4561 0 Td
(and)Tj
1.7348 0 Td
(includes)Tj
3.5432 0 Td
(life-threatening)Tj
6.4006 0 Td
(presentations)Tj
5.5786 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(meningitis,)Tj
4.7111 0 Td
(pneu-)Tj
-35.1493 -1.3039 Td
(monia)Tj
2.7949 0 Td
(and)Tj
1.7291 0 Td
(sepsis)Tj
2.5115 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(2)Tj
0 g
(].)Tj
/F13 1 Tf
1.2586 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.057 0 Td
(is)Tj
0.8504 0 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(primary)Tj
3.4526 0 Td
(etiologies)Tj
3.9855 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.33 0 Td
(bacterial)Tj
3.6227 0 Td
(men-)Tj
-34.9566 -1.2983 Td
(ingitis,)Tj
2.9196 0 Td
(along)Tj
2.4208 0 Td
(with)Tj
/F13 1 Tf
1.9956 0 Td
[()28()2()-4( )10( )-3()2()-9()4(\r)]TJ
3.7417 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()31(\r)6()2()6()11()10()18()4()12()-4( )]TJ
5.4198 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
4.2576 0 Td
(type)Tj
1.9162 0 Td
(b)Tj
0.7257 0 Td
(\(Hib\))Tj
2.4378 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.6044 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
-35.3251 -1.2983 Td
(meningitis)Tj
4.4843 0 Td
(belt)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(sub-Saharan)Tj
5.1931 0 Td
(Africa,)Tj
2.914 0 Td
(stretching)Tj
4.2009 0 Td
(from)Tj
2.2053 0 Td
(Senegal)Tj
3.2372 0 Td
(to)Tj
1.0261 0 Td
(Ethiopia)Tj
3.6113 0 Td
(and)Tj
1.7291 0 Td
(including)Tj
4.0422 0 Td
(430)Tj
-35.3534 -1.3039 Td
(million)Tj
3.118 0 Td
(people)Tj
2.8573 0 Td
(in)Tj
1.0375 0 Td
(26)Tj
1.1679 0 Td
(countries)Tj
3.9515 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(],)Tj
1.5987 0 Td
(pneumococcal)Tj
6.0207 0 Td
(meningitis)Tj
4.4844 0 Td
(epidemiology)Tj
5.6466 0 Td
(is)Tj
0.8504 0 Td
(characterized)Tj
5.5559 0 Td
(by)Tj
-36.2889 -1.2982 Td
(relatively)Tj
3.838 0 Td
(high)Tj
2.007 0 Td
(incidence)Tj
4.0761 0 Td
(in)Tj
1.0319 0 Td
(all)Tj
1.1508 0 Td
(age)Tj
1.542 0 Td
(groups,)Tj
3.1918 0 Td
(high)Tj
2.007 0 Td
(case)Tj
1.8651 0 Td
(fatality,)Tj
3.1635 0 Td
(a)Tj
0.6576 0 Td
(predominance)Tj
6.0264 0 Td
(of)Tj
1.0205 0 Td
(serotype)Tj
3.5716 0 Td
(1)Tj
-35.1493 -1.2983 Td
(after)Tj
2.0352 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8029 0 Td
(five)Tj
1.6554 0 Td
(years)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(life,)Tj
1.6668 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6576 0 Td
(seasonality)Tj
4.5524 0 Td
(more)Tj
2.3414 0 Td
(typically)Tj
3.566 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(meningococcal)Tj
-31.0108 -1.3039 Td
(meningitis)Tj
4.4843 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
-3.2881 -1.2983 Td
(Burkina)Tj
3.4469 0 Td
(Faso,)Tj
2.2733 0 Td
(a)Tj
0.6577 0 Td
(landlocked)Tj
4.5977 0 Td
(West)Tj
2.2677 0 Td
(African)Tj
3.2372 0 Td
(country)Tj
3.3505 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(population)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(approximately)Tj
5.9754 0 Td
(19)Tj
-35.2627 -1.2983 Td
(million,)Tj
3.3448 0 Td
(is)Tj
0.8504 0 Td
(entirely)Tj
3.2542 0 Td
(located)Tj
3.0784 0 Td
(within)Tj
2.8119 0 Td
(the)Tj
1.4683 0 Td
(meningitis)Tj
4.4901 0 Td
(belt)Tj
1.6951 0 Td
(and)Tj
1.7291 0 Td
(experiences)Tj
4.8699 0 Td
(hyper-endemic)Tj
6.2986 0 Td
(rates)Tj
2.1033 0 Td
(of)Tj
-35.9941 -1.3039 Td
(meningitis)Tj
4.4843 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(11)Tj
0 g
(].)Tj
1.7405 0 Td
(Historically,)Tj
5.0853 0 Td
(about)Tj
2.4945 0 Td
(90%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(meningitis)Tj
4.4901 0 Td
(cases)Tj
2.2223 0 Td
(during)Tj
2.9254 0 Td
(epidemics)Tj
4.2519 0 Td
(in)Tj
1.0375 0 Td
(Burkina)Tj
-33.4089 -1.2982 Td
(Faso)Tj
2.0466 0 Td
(were)Tj
2.1259 0 Td
(caused)Tj
2.914 0 Td
(by)Tj
/F13 1 Tf
1.1849 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(serogroup)Tj
4.269 0 Td
(A)Tj
0.9071 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
1.8481 0 Td
(and,)Tj
1.9559 0 Td
(more)Tj
2.3414 0 Td
(recently)Tj
3.4129 0 Td
(by)Tj
/F13 1 Tf
1.1792 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
-31.5153 -1.2983 Td
(serogroup)Tj
4.2689 0 Td
(W)Tj
1.1849 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(12)Tj
0 g
(].)Tj
1.7348 0 Td
(Prior)Tj
2.2961 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(introduction)Tj
5.3121 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(serogroup)Tj
4.2746 0 Td
(A)Tj
0.9014 0 Td
(meningococcal)Tj
6.2588 0 Td
(conjugate)Tj
-32.4734 -1.2983 Td
(vaccine)Tj
3.1917 0 Td
(\(MenAfriVac\))Tj
5.9301 0 Td
(in)Tj
1.0375 0 Td
(2010,)Tj
2.347 0 Td
(national)Tj
3.5036 0 Td
(bacterial)Tj
3.6227 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance)Tj
4.9492 0 Td
(was)Tj
1.7008 0 Td
(strengthened)Tj
5.4368 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-36.2038 -1.3039 Td
(13)Tj
0 g
(])Tj
1.508 0 Td
(through)Tj
3.4469 0 Td
(improvements)Tj
6.0321 0 Td
(in)Tj
1.0374 0 Td
(specimen)Tj
4.0025 0 Td
(collection,)Tj
4.337 0 Td
(laboratory)Tj
4.3483 0 Td
(confirmation)Tj
5.4992 0 Td
(of)Tj
1.0148 0 Td
(bacterial)Tj
3.6283 0 Td
(etiolo-)Tj
-34.8545 -1.2982 Td
(gies,)Tj
1.9615 0 Td
(data)Tj
1.9106 0 Td
(transmission,)Tj
5.5898 0 Td
(and)Tj
1.7348 0 Td
(data)Tj
1.9106 0 Td
(management.)Tj
5.6636 0 Td
(Following)Tj
4.2179 0 Td
(the)Tj
1.4683 0 Td
(successful)Tj
4.1613 0 Td
(introduction)Tj
5.312 0 Td
(of)Tj
1.0148 0 Td
(Hib)Tj
-34.9452 -1.2983 Td
(vaccine)Tj
3.1917 0 Td
(in)Tj
1.0375 0 Td
(2006)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
1.7291 0 Td
(MenAfriVac)Tj
5.2497 0 Td
(in)Tj
1.0318 0 Td
(2010)Tj
2.126 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(],)Tj
/F13 1 Tf
1.5987 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.057 0 Td
(became)Tj
3.2542 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4582 0 Td
(cause)Tj
2.3868 0 Td
(of)Tj
-36.4646 -1.3039 Td
(bacterial)Tj
3.6226 0 Td
(meningitis.)Tj
4.7112 0 Td
(On)Tj
1.5193 0 Td
(October)Tj
3.4923 0 Td
(31,)Tj
1.4003 0 Td
(2013,)Tj
2.3471 0 Td
(the)Tj
1.4683 0 Td
(government)Tj
5.0796 0 Td
(of)Tj
1.0148 0 Td
(Burkina)Tj
3.447 0 Td
(Faso)Tj
2.0466 0 Td
(introduced)Tj
4.6431 0 Td
(the)Tj
-34.7922 -1.2983 Td
(13-valent)Tj
3.9231 0 Td
(pneumococcal)Tj
6.0264 0 Td
(conjugate)Tj
4.1045 0 Td
(vaccine)Tj
3.1918 0 Td
(\(PCV13\))Tj
3.7701 0 Td
(into)Tj
1.8425 0 Td
(the)Tj
1.4683 0 Td
(routine)Tj
3.1635 0 Td
(childhood)Tj
4.2803 0 Td
(immunization)Tj
-31.7705 -1.2983 Td
(program,)Tj
3.9287 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(administered)Tj
5.4879 0 Td
(to)Tj
1.0261 0 Td
(children)Tj
3.5546 0 Td
(at)Tj
0.9525 0 Td
(8,)Tj
0.9241 0 Td
(12,)Tj
1.3946 0 Td
(and)Tj
1.7291 0 Td
(16)Tj
1.1736 0 Td
(weeks)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(age.)Tj
-24.7746 -1.3039 Td
(Through)Tj
3.7587 0 Td
(the)Tj
1.474 0 Td
(improved)Tj
4.1045 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance)Tj
4.9493 0 Td
(system)Tj
2.9366 0 Td
(and)Tj
1.7348 0 Td
(further)Tj
3.0274 0 Td
(expansion)Tj
4.2916 0 Td
(of)Tj
1.0148 0 Td
(national)Tj
-32.9723 -1.2982 Td
(capacity)Tj
3.4695 0 Td
(to)Tj
1.0262 0 Td
(confirm)Tj
3.4469 0 Td
(and)Tj
1.7291 0 Td
(serotype)Tj
3.5773 0 Td
(or)Tj
1.0998 0 Td
(serogroup)Tj
4.269 0 Td
(all)Tj
1.1452 0 Td
(major)Tj
2.6078 0 Td
(bacterial)Tj
3.6284 0 Td
(etiologies)Tj
3.9854 0 Td
(of)Tj
1.0148 0 Td
(meningitis,)Tj
-30.9994 -1.2983 Td
(including)Tj
/F13 1 Tf
4.0421 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.8958 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0626 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(],)Tj
1.5987 0 Td
(we)Tj
1.3323 0 Td
(provide)Tj
3.2882 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8029 0 Td
(nationwide)Tj
4.7281 0 Td
(population-based)Tj
7.1943 0 Td
(description)Tj
4.7338 0 Td
(of)Tj
-36.1471 -1.2983 Td
(bacterial)Tj
3.6226 0 Td
(meningitis)Tj
4.4844 0 Td
(and)Tj
1.7348 0 Td
(pneumococcal)Tj
6.0207 0 Td
(meningitis)Tj
4.4844 0 Td
(trends)Tj
2.7496 0 Td
(in)Tj
1.0375 0 Td
(Burkina)Tj
3.4469 0 Td
(Fasoone)Tj
4.4503 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(few)Tj
-34.5144 -1.3039 Td
(African)Tj
3.2371 0 Td
(countries)Tj
3.9458 0 Td
(to)Tj
1.0261 0 Td
(successfully)Tj
4.8643 0 Td
(implement)Tj
4.5807 0 Td
(case-based)Tj
4.4674 0 Td
(surveillance)Tj
4.9492 0 Td
(across)Tj
2.6759 0 Td
(the)Tj
1.4684 0 Td
(entire)Tj
2.5511 0 Td
(country.)Tj
-33.766 -1.2983 Td
(We)Tj
1.61 0 Td
(describe)Tj
3.5206 0 Td
(nationwide)Tj
4.7282 0 Td
(case-based)Tj
4.4674 0 Td
(meningitis)Tj
4.4843 0 Td
(surveillance)Tj
4.9493 0 Td
(data)Tj
1.9105 0 Td
(from)Tj
2.2054 0 Td
(2011)Tj
2.126 0 Td
(to)Tj
1.0204 0 Td
(2013,)Tj
2.3528 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
-35.6256 -1.2982 Td
(the)Tj
1.4683 0 Td
(introduction)Tj
5.3121 0 Td
(of)Tj
1.0148 0 Td
(PCV13)Tj
3.0897 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(setting)Tj
2.8799 0 Td
(of)Tj
1.0148 0 Td
(widespread)Tj
4.7565 0 Td
(use)Tj
1.5364 0 Td
(of)Tj
1.0148 0 Td
(Hib)Tj
1.7575 0 Td
(vaccine)Tj
3.1974 0 Td
(and)Tj
-31.2772 -1.3039 Td
(MenAfriVac.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 131.0173 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(National)Tj
3.8362 0 Td
(surveillance)Tj
5.4237 0 Td
(system)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Burkina)Tj
3.4412 0 Td
(Faso's)Tj
2.6305 0 Td
(nationwide)Tj
4.7225 0 Td
(bacterial)Tj
3.6283 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance)Tj
4.9493 0 Td
(system)Tj
2.9367 0 Td
(collects)Tj
3.1464 0 Td
(case-level)Tj
4.0082 0 Td
(demo-)Tj
-33.9475 -1.2982 Td
(graphic)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(information,)Tj
5.3007 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(results)Tj
2.8062 0 Td
(of)Tj
1.0148 0 Td
(cerebrospinal)Tj
5.6239 0 Td
(fluid)Tj
2.075 0 Td
(\(CSF\))Tj
2.5682 0 Td
(examination)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Bacterial)Tj
4.0394 0 Td
(Meningi)Tj
3.4299 0 Td
(tis)Tj
1.2047 0 Td
(in)Tj
0.978 0 Td
(Burkina)Tj
3.5504 0 Td
(Faso)Tj
2.4095 0 Td
(before)Tj
3.0047 0 Td
(PCV13)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(384)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(10,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(16)Tj
/F11 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(analysis)Tj
2.9623 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-16.1221 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F10 1 Tf
-6.7606 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F11 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
48 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 51 0 R/Contents 52 0 R/TrimBox[0 0 612 792]>>
endobj
51 0 obj
[53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref004)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref015)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref016)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref017)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref018)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref018)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref019)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref020)>>
endobj
61 0 obj
<>/Border[0 0 0]/A 65 0 R>>
endobj
65 0 obj
<>
endobj
62 0 obj
<>/Border[0 0 0]/A 66 0 R>>
endobj
66 0 obj
<>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref021)>>
endobj
64 0 obj
<>/Border[0 0 0]/A 67 0 R>>
endobj
67 0 obj
<>
endobj
52 0 obj
[68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R]
endobj
68 0 obj
<>stream
q
0.83 0.64 0.02 0 k
533.4236 706.337 m
538.1858 706.337 l
h
f*
542.6646 706.337 m
552.189 706.337 l
h
f*
335.1118 680.315 m
344.6362 680.315 l
h
f*
426.2173 610.8661 m
435.7417 610.8661 l
h
f*
481.2661 346.3937 m
490.7906 346.3937 l
h
f*
288.4535 320.3717 m
297.9213 320.3717 l
h
f*
326.211 307.389 m
335.6787 307.389 l
h
f*
452.4661 268.3843 m
461.9906 268.3843 l
h
f*
466.4126 268.3843 m
548.0504 268.3843 l
h
f*
200.0126 255.4016 m
269.178 255.4016 l
h
f*
242.7591 229.3795 m
252.2835 229.3795 l
h
f*
256.7622 229.3795 m
407.5087 229.3795 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(laboratory)Tj
4.3483 0 Td
(testing,)Tj
3.1124 0 Td
(using)Tj
2.3868 0 Td
(Integrated)Tj
4.3483 0 Td
(Disease)Tj
3.2258 0 Td
(Surveillance)Tj
5.0626 0 Td
(and)Tj
1.7348 0 Td
(Response)Tj
3.9799 0 Td
(\(IDSR\))Tj
3.0727 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(15)Tj
0 g
(])Tj
-34.2649 -1.3039 Td
(instruments)Tj
5.0456 0 Td
(in)Tj
1.0318 0 Td
(all)Tj
1.1509 0 Td
(63)Tj
1.1678 0 Td
(districts.)Tj
3.6227 0 Td
(World)Tj
2.8346 0 Td
(Health)Tj
2.9197 0 Td
(Organization)Tj
5.5218 0 Td
(\(WHO\))Tj
3.3789 0 Td
(case-based)Tj
4.4674 0 Td
(surveillance)Tj
-31.1412 -1.2982 Td
(guidelines)Tj
4.2746 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(African)Tj
3.2371 0 Td
(region)Tj
2.8006 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(])Tj
1.8539 0 Td
(were)Tj
2.1203 0 Td
(revised)Tj
3.05 0 Td
(in)Tj
1.0375 0 Td
(2015)Tj
2.1203 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(MenAfriNet)Tj
5.1534 0 Td
(Consortium)Tj
-31.1582 -1.2983 Td
(based)Tj
2.4717 0 Td
(upon)Tj
2.3188 0 Td
(the)Tj
1.474 0 Td
(Burkina)Tj
3.4412 0 Td
(Faso)Tj
2.0523 0 Td
(Ministry)Tj
3.6793 0 Td
(of)Tj
1.0148 0 Td
(Health)Tj
2.9197 0 Td
(experience)Tj
4.5071 0 Td
(with)Tj
1.9955 0 Td
(successful)Tj
4.1613 0 Td
(implementation)Tj
6.6387 0 Td
(of)Tj
-36.6744 -1.2983 Td
(nationwide)Tj
4.7224 0 Td
(case-based)Tj
4.4674 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 628.9511 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Case)Tj
2.5275 0 Td
(identification)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 611.9433 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Cases)Tj
2.4604 0 Td
(were)Tj
2.126 0 Td
(classified)Tj
3.8154 0 Td
(based)Tj
2.4718 0 Td
(upon)Tj
2.3244 0 Td
(WHO)Tj
2.6985 0 Td
(case)Tj
1.8596 0 Td
(definitions)Tj
4.524 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0806 0 Td
(A)Tj
0.9015 0 Td
(case)Tj
1.8651 0 Td
(of)Tj
1.0148 0 Td
(suspected)Tj
4.0819 0 Td
(meningitis)Tj
4.4844 0 Td
(is)Tj
-36.7084 -1.2982 Td
(defined)Tj
3.2144 0 Td
(as)Tj
1.0091 0 Td
(sudden)Tj
3.1295 0 Td
(onset)Tj
2.347 0 Td
(of)Tj
1.0092 0 Td
(fever)Tj
/F12 1 Tf
0 Tc
2.1713 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(38.5C)Tj
3.6907 0 Td
(with)Tj
1.9899 0 Td
(one)Tj
1.6894 0 Td
(of)Tj
1.0092 0 Td
(the)Tj
1.4626 0 Td
(following)Tj
3.9685 0 Td
(signs:)Tj
2.4435 0 Td
(neck)Tj
2.1032 0 Td
(stiffness,)Tj
3.634 0 Td
(altered)Tj
-34.8715 -1.3039 Td
(consciousness,)Tj
6.0661 0 Td
(or)Tj
1.0941 0 Td
(other)Tj
2.3528 0 Td
(meningeal)Tj
4.3936 0 Td
(signs)Tj
2.2224 0 Td
(\(including)Tj
4.3823 0 Td
(flaccid)Tj
2.829 0 Td
(neck,)Tj
2.3357 0 Td
(bulging)Tj
3.2485 0 Td
(fontanel,)Tj
3.7417 0 Td
(or)Tj
1.0998 0 Td
(convul-)Tj
-33.766 -1.2983 Td
(sions)Tj
2.262 0 Td
(in)Tj
1.0375 0 Td
(young)Tj
2.7212 0 Td
(children\).)Tj
4.1215 0 Td
(Probable)Tj
3.7758 0 Td
(bacterial)Tj
3.6226 0 Td
(meningitis)Tj
4.4901 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(suspected)Tj
4.0819 0 Td
(case)Tj
1.8595 0 Td
(with)Tj
2.0013 0 Td
(turbid,)Tj
2.9423 0 Td
(cloudy,)Tj
-34.418 -1.2983 Td
(purulent,)Tj
3.9061 0 Td
(or)Tj
1.0998 0 Td
(xanthrochromic)Tj
6.7067 0 Td
(CSF;)Tj
2.1147 0 Td
(or)Tj
1.0998 0 Td
(presence)Tj
3.7077 0 Td
(of)Tj
1.0148 0 Td
(Gram)Tj
2.5625 0 Td
(negative)Tj
3.5376 0 Td
(diplococci,)Tj
4.5524 0 Td
(Gram)Tj
2.5625 0 Td
(positive)Tj
-32.8646 -1.3039 Td
(diplococci,)Tj
4.5524 0 Td
(or)Tj
1.0998 0 Td
(Gram)Tj
2.5625 0 Td
(negative)Tj
3.5319 0 Td
(bacilli)Tj
2.6136 0 Td
(on)Tj
1.2756 0 Td
(microscopic)Tj
5.108 0 Td
(examination)Tj
5.2327 0 Td
(of)Tj
1.0148 0 Td
(CSF;)Tj
2.1089 0 Td
(or)Tj
1.0999 0 Td
(a)Tj
0.6519 0 Td
(CSF)Tj
1.8879 0 Td
(white)Tj
2.4208 0 Td
(cell)Tj
-35.1607 -1.2982 Td
(count)Tj
/F14 1 Tf
0 Tc
2.5228 0 Td
(>)Tj
/F9 1 Tf
-0.004 Tc
(10/mm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 262.148 538.3559 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 265.7196 533.9338 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
0.4478 0 Td
(A)Tj
0.9014 0 Td
(confirmed)Tj
4.3994 0 Td
(case)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(meningitis)Tj
4.4844 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(suspected)Tj
4.0876 0 Td
(or)Tj
1.0941 0 Td
(probable)Tj
3.7361 0 Td
(case)Tj
1.8595 0 Td
(with)Tj
/F13 1 Tf
1.9956 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()]TJ
-34.8545 -1.2982 Td
[()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(,)Tj
/F13 1 Tf
3.3619 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
(,)Tj
5.2779 0 Td
(or)Tj
/F13 1 Tf
1.0942 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1849 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
4.2576 0 Td
(isolated)Tj
3.2825 0 Td
(from)Tj
2.2053 0 Td
(CSF)Tj
1.8879 0 Td
(by)Tj
1.1792 0 Td
(culture)Tj
3.0387 0 Td
(or)Tj
1.0999 0 Td
(detected)Tj
3.5659 0 Td
(in)Tj
1.0375 0 Td
(CSF)Tj
1.8879 0 Td
(by)Tj
-35.5008 -1.3039 Td
(real-time)Tj
3.8551 0 Td
(polymerase)Tj
4.7734 0 Td
(chain)Tj
2.4208 0 Td
(reaction)Tj
3.4979 0 Td
(\(rt-PCR\))Tj
3.7644 0 Td
(or)Tj
1.0941 0 Td
(latex)Tj
2.0863 0 Td
(agglutination.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 481.4929 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Laboratory)Tj
4.9417 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 464.485 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(CSF)Tj
1.8878 0 Td
(specimens)Tj
4.3653 0 Td
(are)Tj
1.4457 0 Td
(transported)Tj
4.8812 0 Td
(from)Tj
2.2054 0 Td
(healthcare)Tj
4.3256 0 Td
(facilities)Tj
3.4979 0 Td
(to)Tj
1.0262 0 Td
(district)Tj
3.033 0 Td
(laboratories,)Tj
5.1761 0 Td
(which)Tj
2.6475 0 Td
(con-)Tj
-34.4917 -1.3039 Td
(duct)Tj
1.9955 0 Td
(preliminary)Tj
4.9436 0 Td
(lab)Tj
1.406 0 Td
(testing)Tj
2.88 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(cytology,)Tj
3.7984 0 Td
(Gram)Tj
2.5625 0 Td
(stain,)Tj
2.3527 0 Td
(and)Tj
1.7292 0 Td
(latex)Tj
2.0862 0 Td
(agglutination)Tj
5.5276 0 Td
(\(Pastorex,)Tj
-32.3601 -1.2982 Td
(Bio-Rad\).)Tj
4.0705 0 Td
(The)Tj
1.7858 0 Td
(remaining)Tj
4.3653 0 Td
(CSF)Tj
1.8822 0 Td
(is)Tj
0.8504 0 Td
(inoculated)Tj
4.422 0 Td
(in)Tj
1.0375 0 Td
(trans-isolate)Tj
5.1193 0 Td
(media)Tj
2.6929 0 Td
(when)Tj
2.4038 0 Td
(available)Tj
3.668 0 Td
(\(stored)Tj
3.0501 0 Td
(at)Tj
-35.3478 -1.2983 Td
(room)Tj
2.4207 0 Td
(temperature\))Tj
5.4709 0 Td
(and)Tj
1.7291 0 Td
(also)Tj
1.7688 0 Td
(aliquoted)Tj
3.9571 0 Td
(into)Tj
1.8425 0 Td
(a)Tj
0.652 0 Td
(cryotube)Tj
3.736 0 Td
(\(stored)Tj
3.0501 0 Td
(at)Tj
0.9524 0 Td
(-20C\))Tj
2.914 0 Td
(for)Tj
1.389 0 Td
(transportation)Tj
5.9811 0 Td
(to)Tj
-35.8637 -1.3039 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(five)Tj
1.6554 0 Td
(national)Tj
3.5036 0 Td
(reference)Tj
3.9174 0 Td
(laboratories)Tj
4.9493 0 Td
(for)Tj
1.3833 0 Td
(culture)Tj
3.0387 0 Td
(and)Tj
1.7291 0 Td
(rt-PCR)Tj
3.0841 0 Td
(testing.)Tj
-24.7746 -1.2983 Td
(Once)Tj
2.364 0 Td
(a)Tj
0.652 0 Td
(CSF)Tj
1.8879 0 Td
(specimen)Tj
4.0081 0 Td
(reaches)Tj
3.1805 0 Td
(a)Tj
0.6576 0 Td
(reference)Tj
3.9118 0 Td
(laboratory,)Tj
4.5808 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(visually)Tj
3.2088 0 Td
(observed)Tj
3.7984 0 Td
(for)Tj
1.3833 0 Td
(turbidity)Tj
-32.4621 -1.2982 Td
(and)Tj
1.7291 0 Td
(plated)Tj
2.6645 0 Td
(on)Tj
1.2756 0 Td
(chocolate)Tj
4.0138 0 Td
(agar.)Tj
2.1487 0 Td
(Plates)Tj
2.5398 0 Td
(are)Tj
1.4513 0 Td
(incubated)Tj
4.1783 0 Td
(at)Tj
0.9524 0 Td
(3537C)Tj
3.6964 0 Td
(with)Tj
1.9956 0 Td
(5%)Tj
1.4513 0 Td
(CO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 495.0992 384.7748 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 500.8251 386.4755 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7347 0 Td
(examined)Tj
4.1273 0 Td
(up)Tj
-35.943 -1.2982 Td
(to)Tj
1.0261 0 Td
(72)Tj
1.1679 0 Td
(hours.)Tj
2.7439 0 Td
(Genomic)Tj
3.9231 0 Td
(DNA)Tj
2.3754 0 Td
(is)Tj
0.8504 0 Td
(extracted)Tj
3.8835 0 Td
(from)Tj
2.2053 0 Td
(200)Tj
/F15 1 Tf
1.6498 0 Td
[()]TJ
/F9 1 Tf
(l)Tj
0.9694 0 Td
(of)Tj
1.0148 0 Td
(CSF)Tj
1.8879 0 Td
(or)Tj
1.0998 0 Td
(cultures)Tj
3.3959 0 Td
(using)Tj
2.3923 0 Td
(the)Tj
1.4684 0 Td
(Qiagen)Tj
3.1067 0 Td
(DNA)Tj
-35.1606 -1.3039 Td
(Mini)Tj
2.194 0 Td
(kit)Tj
1.2812 0 Td
(\(Qiagen,)Tj
3.6737 0 Td
(Valencia,)Tj
3.9118 0 Td
(CA,)Tj
1.7972 0 Td
(USA\))Tj
2.4547 0 Td
(following)Tj
3.9799 0 Td
(an)Tj
1.2018 0 Td
(initial)Tj
2.5455 0 Td
(bacterial)Tj
3.6284 0 Td
(lysis)Tj
1.9105 0 Td
(step)Tj
1.8197 0 Td
(with)Tj
1.9956 0 Td
(lysozyme)Tj
-32.394 -1.2983 Td
(\(Sigma,)Tj
3.2485 0 Td
(USA\))Tj
2.4548 0 Td
(and)Tj
1.7291 0 Td
(mutanolysin)Tj
5.2327 0 Td
(\(Sigma,)Tj
3.2485 0 Td
(USA\))Tj
2.4548 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
4.3483 0 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0749 0 Td
(rt-PCR)Tj
3.084 0 Td
(is)Tj
0.8504 0 Td
(used)Tj
2.058 0 Td
(to)Tj
-35.8523 -1.2983 Td
(identify)Tj
/F13 1 Tf
3.2938 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.057 0 Td
(through)Tj
3.4469 0 Td
(targeting)Tj
3.7927 0 Td
(the)Tj
/F13 1 Tf
1.4684 0 Td
[()15()-15()]TJ
/F9 1 Tf
1.8425 0 Td
(gene)Tj
2.0806 0 Td
(using)Tj
2.3868 0 Td
(primers)Tj
3.3505 0 Td
(and)Tj
1.7348 0 Td
(probes)Tj
2.9025 0 Td
(described)Tj
4.0536 0 Td
(by)Tj
-36.3115 -1.3039 Td
(Carvalho)Tj
3.8551 0 Td
(et)Tj
0.9411 0 Td
(al)Tj
0.9014 0 Td
(\(2007\))Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0749 0 Td
(Similarly,)Tj
4.0252 0 Td
(the)Tj
/F13 1 Tf
1.474 0 Td
[( )-3()4()]TJ
/F9 1 Tf
2.1316 0 Td
(and)Tj
/F13 1 Tf
1.7292 0 Td
[()15()4()]TJ
/F9 1 Tf
2.1656 0 Td
(genes)Tj
2.4378 0 Td
(are)Tj
1.4513 0 Td
(targeted)Tj
3.4639 0 Td
(for)Tj
/F13 1 Tf
1.3832 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1396 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
-31.9802 -1.2982 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1792 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
(,)Tj
4.4844 0 Td
(respectively)Tj
4.8869 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.0749 0 Td
(DNA)Tj
2.3755 0 Td
(with)Tj
1.9955 0 Td
(equivocal)Tj
4.0139 0 Td
(values)Tj
2.6645 0 Td
(is)Tj
0.8504 0 Td
(diluted)Tj
3.0387 0 Td
(four-fold)Tj
3.8323 0 Td
(and)Tj
1.7292 0 Td
(ten-)Tj
-34.8545 -1.2983 Td
(fold)Tj
1.7858 0 Td
(and)Tj
1.7348 0 Td
(retested.)Tj
-2.3244 -1.3039 Td
(Serotyping)Tj
4.5467 0 Td
(of)Tj
/F13 1 Tf
1.0092 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.8957 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.057 0 Td
(positive)Tj
3.3108 0 Td
(samples)Tj
3.3789 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.4674 0 Td
(using)Tj
2.3867 0 Td
(a)Tj
0.6463 0 Td
(series)Tj
2.4264 0 Td
(of)Tj
1.0091 0 Td
(seven)Tj
2.4264 0 Td
(sequen-)Tj
-34.4519 -1.2983 Td
(tial)Tj
1.4626 0 Td
(triplex)Tj
2.812 0 Td
(rt-PCR)Tj
3.0841 0 Td
(assays)Tj
2.6248 0 Td
(targeting)Tj
3.7928 0 Td
(37)Tj
1.1678 0 Td
(pneumococcal)Tj
6.0208 0 Td
(serotypes)Tj
3.9401 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(;)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(http://www.cdc.gov/)Tj
-26.6398 -1.2983 Td
(streplab/pcr.html)Tj
0 g
(].)Tj
7.7045 0 Td
(Samples)Tj
3.4923 0 Td
(with)Tj
2.0012 0 Td
(Ct)Tj
1.1792 0 Td
(values)Tj
2.6702 0 Td
(of)Tj
/F12 1 Tf
0 Tc
1.0148 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(30)Tj
1.9389 0 Td
(that)Tj
1.7802 0 Td
(were)Tj
2.1203 0 Td
(non-typeable)Tj
5.4821 0 Td
(by)Tj
1.1791 0 Td
(rt-PCR)Tj
3.0841 0 Td
(were)Tj
2.126 0 Td
(fur-)Tj
-35.7729 -1.3039 Td
(ther)Tj
1.8425 0 Td
(analyzed)Tj
3.6963 0 Td
(by)Tj
1.1849 0 Td
(conventional)Tj
5.4255 0 Td
(multiplex)Tj
4.0308 0 Td
(PCR)Tj
2.0636 0 Td
(serotyping,)Tj
4.6602 0 Td
(which)Tj
2.6532 0 Td
(can)Tj
1.6214 0 Td
(detect)Tj
2.6192 0 Td
(an)Tj
1.2018 0 Td
(additional)Tj
4.2746 0 Td
(33)Tj
-35.274 -1.2982 Td
(serotypes)Tj
3.9344 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(;)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(http://www.cdc.gov/streplab/pcr.)Tj
13.1867 0 Td
(html)Tj
0 g
(].)Tj
2.6759 0 Td
(If)Tj
0.8504 0 Td
(samples)Tj
3.3788 0 Td
(were)Tj
/F13 1 Tf
2.126 0 Td
[()15()-15()]TJ
/F9 1 Tf
(-positive)Tj
5.2837 0 Td
(and)Tj
1.7291 0 Td
(sero-)Tj
-34.9055 -1.2983 Td
(type-negative)Tj
5.5785 0 Td
(both)Tj
2.058 0 Td
(on)Tj
1.2755 0 Td
(rt-PCR)Tj
3.0841 0 Td
(and)Tj
1.7291 0 Td
(conventional)Tj
5.4312 0 Td
(PCR,)Tj
2.2904 0 Td
(they)Tj
1.9219 0 Td
(were)Tj
2.1203 0 Td
(classified)Tj
3.821 0 Td
(as)Tj
1.0147 0 Td
(non-typeable)Tj
/F13 1 Tf
5.4765 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
-35.8012 -1.2983 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 178.0157 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.4504 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 161.0078 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(analyzed)Tj
3.702 0 Td
(national)Tj
3.5036 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance)Tj
4.9493 0 Td
(data)Tj
1.9105 0 Td
(from)Tj
2.2054 0 Td
(January)Tj
3.3221 0 Td
(1,)Tj
0.9185 0 Td
(2011)Tj
2.1259 0 Td
(to)Tj
1.0262 0 Td
(December)Tj
4.3483 0 Td
(31,)Tj
-34.1062 -1.2982 Td
(2013.)Tj
2.347 0 Td
(By)Tj
1.2529 0 Td
(December)Tj
4.3483 0 Td
(31,)Tj
1.4004 0 Td
(2013)Tj
2.1203 0 Td
(\(two)Tj
2.0466 0 Td
(months)Tj
3.2825 0 Td
(after)Tj
2.0352 0 Td
(PCV13)Tj
3.0898 0 Td
(introduction\),)Tj
5.879 0 Td
(31.1%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5546 0 Td
(aged)Tj
-35.0019 -1.3039 Td
(011)Tj
2.1656 0 Td
(months)Tj
3.2768 0 Td
(had)Tj
1.7122 0 Td
(received)Tj
3.5376 0 Td
(one)Tj
1.6951 0 Td
(dose)Tj
2.0409 0 Td
(and)Tj
1.7291 0 Td
(8.7%)Tj
2.1543 0 Td
(two)Tj
1.7122 0 Td
(doses)Tj
2.3981 0 Td
(of)Tj
1.0148 0 Td
(PCV13.)Tj
3.3108 0 Td
(Given)Tj
2.6305 0 Td
(that)Tj
1.7802 0 Td
(no)Tj
1.2756 0 Td
(children)Tj
3.5546 0 Td
(had)Tj
-35.9884 -1.2983 Td
(received)Tj
3.5319 0 Td
(the)Tj
1.474 0 Td
(full)Tj
1.525 0 Td
(3-dose)Tj
2.863 0 Td
(series)Tj
2.4321 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(end)Tj
1.7234 0 Td
(of)Tj
1.0148 0 Td
(2013)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(approximately)Tj
5.9754 0 Td
(two)Tj
1.7121 0 Td
(weeks)Tj
2.6079 0 Td
(are)Tj
1.4457 0 Td
(needed)Tj
3.0954 0 Td
(to)Tj
-35.8977 -1.2983 Td
(mount)Tj
2.9196 0 Td
(an)Tj
1.2019 0 Td
(effective)Tj
3.5093 0 Td
(immune)Tj
3.6283 0 Td
(response,)Tj
3.9571 0 Td
(data)Tj
1.9162 0 Td
(through)Tj
3.4413 0 Td
(December)Tj
4.3483 0 Td
(31,)Tj
1.4003 0 Td
(2013)Tj
2.1203 0 Td
(was)Tj
1.7008 0 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
-34.8885 -1.3039 Td
(pre-PCV13)Tj
4.7508 0 Td
(analysis.)Tj
3.5489 0 Td
(Residents)Tj
4.0536 0 Td
(of)Tj
1.0148 0 Td
(countries)Tj
3.9458 0 Td
(outside)Tj
3.1351 0 Td
(of)Tj
1.0148 0 Td
(Burkina)Tj
3.4469 0 Td
(Faso)Tj
2.0466 0 Td
(were)Tj
2.1259 0 Td
(excluded)Tj
3.7814 0 Td
(from)Tj
-32.8646 -1.2982 Td
(analyses.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Bacterial)Tj
4.0394 0 Td
(Meningi)Tj
3.4299 0 Td
(tis)Tj
1.2047 0 Td
(in)Tj
0.978 0 Td
(Burkina)Tj
3.5504 0 Td
(Faso)Tj
2.4095 0 Td
(before)Tj
3.0047 0 Td
(PCV13)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(384)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(10,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
BT
66.402 0 Td
(16)Tj
ET
Q
endstream
endobj
80 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 81 0 R/Contents 82 0 R/TrimBox[0 0 612 792]>>
endobj
81 0 obj
[83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R]
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t001)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.g001)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.s002)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t003)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.g002)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.ref022)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.s003)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.g002)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t003)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
82 0 obj
[97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R]
endobj
97 0 obj
<>stream
q
0.83 0.64 0.02 0 k
478.9417 375.0803 m
508.0819 375.0803 l
h
f*
321.1087 336.0756 m
340.6677 336.0756 l
h
f*
345.1465 336.0756 m
379.0488 336.0756 l
h
f*
229.4929 263.9055 m
258.6331 263.9055 l
h
f*
393.052 250.9228 m
422.2488 250.9228 l
h
f*
203.4142 224.9008 m
222.9732 224.9008 l
h
f*
231.9307 224.9008 m
241.4551 224.9008 l
h
f*
203.4142 185.8961 m
232.5543 185.8961 l
h
f*
474.0661 172.9134 m
507.9685 172.9134 l
h
f*
203.4142 146.948 m
232.5543 146.948 l
h
f*
237.0331 146.948 m
256.5921 146.948 l
h
f*
425.1969 146.948 m
454.337 146.948 l
h
f*
413.915 120.926 m
443.0551 120.926 l
h
f*
467.6598 107.9433 m
496.8 107.9433 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 211.9748 707.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(All)Tj
1.4003 0 Td
(cases)Tj
2.2223 0 Td
(were)Tj
2.1203 0 Td
(categorized)Tj
4.7735 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(their)Tj
2.109 0 Td
(date)Tj
1.8992 0 Td
(of)Tj
1.0148 0 Td
(specimen)Tj
4.0082 0 Td
(collection.)Tj
4.3369 0 Td
(Pneumococcal)Tj
-30.2964 -1.3039 Td
(meningitis)Tj
4.4843 0 Td
(cases)Tj
2.2224 0 Td
(were)Tj
2.1259 0 Td
(categorized)Tj
4.7736 0 Td
(as)Tj
1.0147 0 Td
(either)Tj
2.5285 0 Td
(being)Tj
2.4321 0 Td
(caused)Tj
2.9197 0 Td
(by)Tj
1.1792 0 Td
(PCV13-associated)Tj
7.4778 0 Td
(serotypes)Tj
3.9344 0 Td
(\(1,)Tj
1.2643 0 Td
(3,)Tj
-36.3569 -1.2982 Td
(4,)Tj
0.9185 0 Td
(5,)Tj
0.9239 0 Td
(6A,)Tj
1.6044 0 Td
(6B,)Tj
1.5024 0 Td
(7F,)Tj
1.4457 0 Td
(9V,)Tj
1.6157 0 Td
(14,)Tj
1.3946 0 Td
(18C,)Tj
2.0636 0 Td
(19A,)Tj
2.0807 0 Td
(19F,)Tj
1.9218 0 Td
(or)Tj
1.0999 0 Td
(23F\))Tj
2.0409 0 Td
(or)Tj
1.0942 0 Td
(non-PCV13-associated)Tj
9.4336 0 Td
(serotypes.)Tj
4.1612 0 Td
(Annual)Tj
-33.3011 -1.2983 Td
(incidence)Tj
4.0648 0 Td
(rates)Tj
2.1033 0 Td
(\(cases)Tj
2.5568 0 Td
(per)Tj
1.5251 0 Td
(100,000)Tj
3.2938 0 Td
(persons\))Tj
3.6453 0 Td
(were)Tj
2.1147 0 Td
(calculated)Tj
4.2009 0 Td
(using)Tj
2.3811 0 Td
(age-stratified)Tj
5.4254 0 Td
(population)Tj
4.5808 0 Td
(esti-)Tj
-35.892 -1.2983 Td
(mates)Tj
2.5568 0 Td
(obtained)Tj
3.7303 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
/F13 1 Tf
1.4683 0 Td
[()39(\n )9()7()14()7()14()]TJ
3.1011 0 Td
[()28(\r)22()7()4()11(\n)6(\r)11()]TJ
3.6793 0 Td
[()4()]TJ
1.1112 0 Td
[()4(\r)]TJ
0.9411 0 Td
[()10()11(\r)22()7()-4( )9()7()4()14()4()]TJ
4.3143 0 Td
[()8()]TJ
0.9128 0 Td
[()4()]TJ
1.1055 0 Td
[()4(\r)]TJ
0.9411 0 Td
[()-6()2()6()2()-8()20(\r)12()10()18()4()]TJ
/F9 1 Tf
5.4538 0 Td
(census.)Tj
3.0897 0 Td
(Dis-)Tj
-34.6107 -1.3039 Td
(tricts)Tj
2.2393 0 Td
(that)Tj
1.7801 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.5704 0 Td
(report)Tj
2.7099 0 Td
(case-based)Tj
4.4673 0 Td
(meningitis)Tj
4.4844 0 Td
(surveillance)Tj
4.9493 0 Td
(data)Tj
1.9105 0 Td
(were)Tj
2.126 0 Td
(excluded)Tj
3.7814 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
-33.766 -1.2982 Td
(incidence)Tj
4.0705 0 Td
(calculation)Tj
4.5751 0 Td
(denominator)Tj
5.4765 0 Td
(for)Tj
1.3833 0 Td
(that)Tj
1.7801 0 Td
(year.)Tj
2.126 0 Td
(For)Tj
1.627 0 Td
(suspected)Tj
4.0876 0 Td
(and)Tj
1.7291 0 Td
(probable)Tj
3.7304 0 Td
(bacterial)Tj
3.6283 0 Td
(menin-)Tj
-34.2139 -1.2983 Td
(gitis)Tj
1.8765 0 Td
(cases,)Tj
2.4491 0 Td
(crude)Tj
2.4945 0 Td
(incidence)Tj
4.0705 0 Td
(rates)Tj
2.1089 0 Td
(were)Tj
2.126 0 Td
(reported.)Tj
3.8835 0 Td
(For)Tj
1.627 0 Td
(laboratory-confirmed)Tj
8.8781 0 Td
(cases,)Tj
2.4434 0 Td
(annual)Tj
2.9594 0 Td
(inci-)Tj
-34.9169 -1.3039 Td
(dence)Tj
2.5681 0 Td
(was)Tj
1.6951 0 Td
(adjusted)Tj
3.5773 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(age-stratified)Tj
5.4312 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0147 0 Td
(cases)Tj
2.2224 0 Td
(with)Tj
1.9956 0 Td
(CSF)Tj
1.8878 0 Td
(tested)Tj
2.5512 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(national)Tj
-32.0369 -1.2983 Td
(laboratory,)Tj
4.575 0 Td
(where)Tj
2.6476 0 Td
(culture)Tj
3.0387 0 Td
(and)Tj
1.7348 0 Td
(rt-PCR)Tj
3.0841 0 Td
(were)Tj
2.1203 0 Td
(performed.)Tj
4.6941 0 Td
(Within)Tj
3.0954 0 Td
(each)Tj
2.0296 0 Td
(age)Tj
1.542 0 Td
(strata)Tj
2.4151 0 Td
(\()Tj
/F14 1 Tf
0 Tc
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.8085 0 Td
(years,)Tj
2.4888 0 Td
(14)Tj
-35.274 -1.2983 Td
(years,)Tj
2.4887 0 Td
(59)Tj
1.6895 0 Td
(years,)Tj
2.4888 0 Td
(1014)Tj
2.6419 0 Td
(years,)Tj
2.4888 0 Td
(and)Tj
/F12 1 Tf
0 Tc
1.7291 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(15)Tj
1.9445 0 Td
(years\),)Tj
2.829 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(cases)Tj
2.2223 0 Td
(confirmed)Tj
4.3994 0 Td
(by)Tj
1.1792 0 Td
(culture)Tj
3.0387 0 Td
(or)Tj
1.0998 0 Td
(rt-)Tj
-36.1414 -1.3039 Td
(PCR)Tj
2.0635 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6577 0 Td
(specific)Tj
3.1918 0 Td
(pathogen)Tj
3.9401 0 Td
(was)Tj
1.6951 0 Td
(divided)Tj
3.2201 0 Td
(by)Tj
1.1793 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(cases)Tj
2.2224 0 Td
(with)Tj
2.0012 0 Td
(CSF)Tj
1.8822 0 Td
(tested)Tj
2.5569 0 Td
(via)Tj
1.3719 0 Td
(culture)Tj
3.0388 0 Td
(or)Tj
-36.3059 -1.2982 Td
(rt-PCR)Tj
3.084 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(national)Tj
3.5036 0 Td
(laboratory;)Tj
4.5751 0 Td
(this)Tj
1.6781 0 Td
(proportion)Tj
4.6318 0 Td
(was)Tj
1.6951 0 Td
(then)Tj
2.0182 0 Td
(applied)Tj
3.1522 0 Td
(to)Tj
1.0261 0 Td
(cases)Tj
2.2223 0 Td
(lacking)Tj
3.1011 0 Td
(any)Tj
1.6611 0 Td
(test)Tj
-33.9531 -1.2983 Td
(results)Tj
2.8062 0 Td
(within)Tj
2.812 0 Td
(that)Tj
1.7801 0 Td
(age)Tj
1.5421 0 Td
(strata.)Tj
2.6418 0 Td
(We)Tj
1.6101 0 Td
(calculated)Tj
4.2066 0 Td
(the)Tj
1.4683 0 Td
(positivity)Tj
3.9118 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(diagnostic)Tj
4.32 0 Td
(test)Tj
1.5987 0 Td
(among)Tj
2.999 0 Td
(total)Tj
-34.7411 -1.3039 Td
(cases)Tj
2.2223 0 Td
(confirmed)Tj
4.3937 0 Td
(as)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0626 0 Td
(by)Tj
1.1792 0 Td
(any)Tj
1.6554 0 Td
(method,)Tj
3.549 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(sensitivity)Tj
4.2236 0 Td
(among)Tj
2.9934 0 Td
(the)Tj
1.4683 0 Td
(subset)Tj
2.6986 0 Td
(of)Tj
-35.2117 -1.2983 Td
(culture-positive)Tj
6.4856 0 Td
(cases.)Tj
2.4434 0 Td
(SAS)Tj
1.8595 0 Td
(version)Tj
3.1521 0 Td
(9.3)Tj
1.3947 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(for)Tj
1.389 0 Td
(analyses.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 483.2503 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.7543 0 Td
(approval)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 466.2425 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(analysis)Tj
3.3278 0 Td
(of)Tj
1.0148 0 Td
(surveillance)Tj
4.9493 0 Td
(data)Tj
1.9105 0 Td
(was)Tj
1.7008 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(Burkina)Tj
3.4469 0 Td
(Faso)Tj
2.0466 0 Td
(Ministry)Tj
3.685 0 Td
(of)Tj
1.0148 0 Td
(Health)Tj
2.914 0 Td
(ethical)Tj
-33.1481 -1.2982 Td
(committee)Tj
4.5013 0 Td
(and)Tj
1.7292 0 Td
(was)Tj
1.7007 0 Td
(determined)Tj
4.8473 0 Td
(not)Tj
1.576 0 Td
(to)Tj
1.0261 0 Td
(require)Tj
3.1068 0 Td
(Centers)Tj
3.3108 0 Td
(for)Tj
1.389 0 Td
(Disease)Tj
3.2258 0 Td
(Control)Tj
3.3619 0 Td
(and)Tj
1.7291 0 Td
(Prevention)Tj
-31.504 -1.2983 Td
(Institutional)Tj
5.159 0 Td
(Review)Tj
3.0954 0 Td
(Board)Tj
2.6419 0 Td
(review.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 411.137 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(Data)Tj
2.3102 0 Td
(completeness)Tj
6.3166 0 Td
(and)Tj
1.8661 0 Td
(quality)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 376.1574 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(numbers)Tj
3.7814 0 Td
(of)Tj
1.0148 0 Td
(districts)Tj
3.3959 0 Td
(submitting)Tj
4.5751 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(specimens)Tj
4.3653 0 Td
(are)Tj
1.4513 0 Td
(shown)Tj
2.846 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Table)Tj
2.4434 0 Td
(1)Tj
0 g
(.)Tj
0.9185 0 Td
(CSF)Tj
1.8878 0 Td
(was)Tj
1.7008 0 Td
(col-)Tj
-34.8432 -1.3039 Td
(lected)Tj
2.5625 0 Td
(from)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(majority)Tj
3.6283 0 Td
(\(97%\))Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(reported)Tj
3.6624 0 Td
(suspected)Tj
4.0818 0 Td
(meningitis)Tj
4.4901 0 Td
(cases;)Tj
2.4491 0 Td
(90%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(CSF)Tj
1.8821 0 Td
(specimens)Tj
-32.1786 -1.2982 Td
(were)Tj
2.1203 0 Td
(tested)Tj
2.5511 0 Td
(by)Tj
1.1849 0 Td
(Gram)Tj
2.5568 0 Td
(stain)Tj
2.1317 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(district)Tj
3.0387 0 Td
(laboratory)Tj
4.3483 0 Td
(and)Tj
1.7291 0 Td
(46%)Tj
1.9276 0 Td
(were)Tj
2.1259 0 Td
(subsequently)Tj
5.4028 0 Td
(tested)Tj
2.5512 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
-34.2252 -1.2983 Td
(national)Tj
3.5035 0 Td
(reference)Tj
3.9175 0 Td
(laboratory)Tj
4.3483 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.924 0 Td
(S1)Tj
1.1679 0 Td
(Table)Tj
0 g
(\).)Tj
3.0104 0 Td
(Twenty-four)Tj
5.2837 0 Td
(percent)Tj
3.2258 0 Td
(of)Tj
1.0148 0 Td
(CSFs)Tj
2.2451 0 Td
(were)Tj
2.1259 0 Td
(tested)Tj
2.5512 0 Td
(by)Tj
-35.138 -1.3039 Td
(latex)Tj
2.0862 0 Td
(agglutination,)Tj
5.7543 0 Td
(25%)Tj
1.9276 0 Td
(by)Tj
1.1792 0 Td
(culture,)Tj
3.2655 0 Td
(and)Tj
1.7291 0 Td
(36%)Tj
1.9275 0 Td
(by)Tj
1.1849 0 Td
(rt-PCR.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 294.9732 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(National)Tj
3.8362 0 Td
(meningitis)Tj
4.6583 0 Td
(surveillance)Tj
5.4284 0 Td
(data)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 278.022 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Over)Tj
2.2166 0 Td
(the)Tj
1.4684 0 Td
(three)Tj
2.262 0 Td
(years)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(surveillance,)Tj
5.1704 0 Td
(12,169)Tj
2.8232 0 Td
(cases)Tj
2.2224 0 Td
(of)Tj
1.0148 0 Td
(suspected)Tj
4.0875 0 Td
(meningitis)Tj
4.4844 0 Td
(and)Tj
1.7291 0 Td
(1,344)Tj
2.3471 0 Td
(deaths)Tj
-33.1084 -1.3039 Td
(\(11%\))Tj
2.6078 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\))Tj
1.0318 0 Td
(were)Tj
2.126 0 Td
(reported,)Tj
3.8834 0 Td
(corresponding)Tj
6.0605 0 Td
(to)Tj
1.0261 0 Td
(an)Tj
1.2019 0 Td
(average)Tj
3.2258 0 Td
(annual)Tj
2.9593 0 Td
(incidence)Tj
4.0706 0 Td
(of)Tj
1.0148 0 Td
(24.7)Tj
1.8708 0 Td
(sus-)Tj
-33.8624 -1.2982 Td
(pected)Tj
2.8346 0 Td
(meningitis)Tj
4.4844 0 Td
(cases)Tj
2.2223 0 Td
(per)Tj
1.5307 0 Td
(100,000)Tj
3.2995 0 Td
(population)Tj
4.5921 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(3)Tj
0 g
(\).)Tj
1.2586 0 Td
(The)Tj
1.7801 0 Td
(elevated)Tj
3.4526 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(suspected)Tj
-32.6719 -1.2983 Td
(cases)Tj
2.2223 0 Td
(in)Tj
1.0375 0 Td
(2012)Tj
2.1203 0 Td
(was)Tj
1.7008 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(nationwide)Tj
4.7281 0 Td
(outbreak)Tj
3.7871 0 Td
(of)Tj
1.0148 0 Td
(serogroup)Tj
4.2689 0 Td
(W)Tj
1.1849 0 Td
(meningococcal)Tj
6.2589 0 Td
(meningitis)Tj
-31.6968 -1.3039 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2)Tj
0 g
(\))Tj
1.0375 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0749 0 Td
(Overall,)Tj
3.3675 0 Td
(10,036)Tj
2.8233 0 Td
(\(82%\))Tj
2.6079 0 Td
(suspected)Tj
4.0819 0 Td
(cases)Tj
2.2223 0 Td
(occurred)Tj
3.7984 0 Td
(during)Tj
2.9253 0 Td
(meningitis)Tj
4.4901 0 Td
(season)Tj
2.8516 0 Td
(\(epide-)Tj
-34.1005 -1.2983 Td
(miologic)Tj
3.719 0 Td
(weeks)Tj
2.6135 0 Td
(124\).)Tj
2.7269 0 Td
(A)Tj
0.9014 0 Td
(fifth)Tj
1.8936 0 Td
(of)Tj
1.0148 0 Td
(suspected)Tj
4.0818 0 Td
(cases)Tj
2.2224 0 Td
(\(20%,)Tj
2.4944 0 Td
(n)Tj
0.7711 0 Td
(=)Tj
0.7993 0 Td
(2,384\))Tj
2.6873 0 Td
(occurred)Tj
3.7927 0 Td
(among)Tj
2.9934 0 Td
(children)Tj
-32.7116 -1.2982 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0692 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4684 0 Td
(year,)Tj
2.1259 0 Td
(and)Tj
1.7292 0 Td
(nearly)Tj
2.6985 0 Td
(half)Tj
1.7178 0 Td
(\(48%,)Tj
2.4945 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7994 0 Td
(5,799\))Tj
2.6872 0 Td
(occurred)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(5)Tj
0.6973 0 Td
(years)Tj
2.2621 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
-33.5393 -1.304 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(Few)Tj
1.8539 0 Td
(cases)Tj
2.2223 0 Td
(were)Tj
2.126 0 Td
(reported)Tj
3.6567 0 Td
(in)Tj
1.0374 0 Td
(infants)Tj
2.9651 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0692 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4684 0 Td
(month)Tj
2.9196 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(15\))Tj
1.508 0 Td
(or)Tj
1.0998 0 Td
(persons)Tj
3.3109 0 Td
(aged)Tj
/F12 1 Tf
0 Tc
2.0693 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(65)Tj
-34.2593 -1.2982 Td
(years)Tj
2.262 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7993 0 Td
(149\);)Tj
2.211 0 Td
(the)Tj
1.4684 0 Td
(epidemiology)Tj
5.6465 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
2.2507 0 Td
(two)Tj
1.7121 0 Td
(groups)Tj
2.9707 0 Td
(is)Tj
0.8447 0 Td
(described)Tj
4.0536 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(S2)Tj
1.1679 0 Td
(Table)Tj
0 g
(.)Tj
-27.3768 -1.2983 Td
(Fifty-four)Tj
4.1045 0 Td
(percent)Tj
3.2258 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7994 0 Td
(6,592\))Tj
2.6929 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(suspected)Tj
4.0818 0 Td
(cases)Tj
2.2224 0 Td
(met)Tj
1.7631 0 Td
(the)Tj
1.4684 0 Td
(probable)Tj
3.736 0 Td
(case)Tj
1.8595 0 Td
(definition)Tj
-30.4155 -1.2983 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9241 0 Td
(Fig)Tj
1.4796 0 Td
(2)Tj
0 g
(\),)Tj
1.2586 0 Td
(for)Tj
1.389 0 Td
(an)Tj
1.2019 0 Td
(average)Tj
3.2258 0 Td
(annual)Tj
2.9593 0 Td
(incidence)Tj
4.0762 0 Td
(of)Tj
1.0148 0 Td
(13.1)Tj
1.8709 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(3)Tj
0 g
(\).)Tj
1.2643 0 Td
(Among)Tj
3.2428 0 Td
(suspected)Tj
4.0818 0 Td
(cases,)Tj
-33.5449 -1.3039 Td
(2,858)Tj
2.347 0 Td
(\(23%\))Tj
2.6079 0 Td
(were)Tj
2.1203 0 Td
(laboratory-confirmed)Tj
8.878 0 Td
(via)Tj
1.3777 0 Td
(latex,)Tj
2.313 0 Td
(culture,)Tj
3.2655 0 Td
(or)Tj
1.0942 0 Td
(rt-PCR)Tj
3.0841 0 Td
(as)Tj
1.0148 0 Td
(either)Tj
/F13 1 Tf
2.5341 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1792 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
-31.8158 -1.2982 Td
(\(2%\),)Tj
/F13 1 Tf
2.3584 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(\(44%\),)Tj
2.8346 0 Td
(or)Tj
/F13 1 Tf
1.0942 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0626 0 Td
(\(53%\))Tj
2.6079 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(\).)Tj
1.2643 0 Td
(All)Tj
/F13 1 Tf
1.3946 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1849 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
4.2576 0 Td
(cases)Tj
2.2223 0 Td
(were)Tj
-34.1515 -1.2983 Td
(serotype)Tj
3.5773 0 Td
(b;)Tj
/F13 1 Tf
0.9524 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(serogroups)Tj
4.6318 0 Td
(are)Tj
1.4457 0 Td
(reported)Tj
3.6623 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(footnote)Tj
3.6 0 Td
(of)Tj
0.83 0.64 0.02 0 k
1.0148 0 Td
(Table)Tj
2.4378 0 Td
(2)Tj
0 g
(.)Tj
-28.0061 -1.3039 Td
(In)Tj
1.1111 0 Td
(2011,)Tj
2.3471 0 Td
(2012,)Tj
2.3471 0 Td
(and)Tj
1.7291 0 Td
(2013,)Tj
2.3527 0 Td
(relative)Tj
3.1351 0 Td
(proportions)Tj
4.9947 0 Td
(of)Tj
1.0148 0 Td
(laboratory-confirmed)Tj
8.878 0 Td
(bacterial)Tj
3.6227 0 Td
(meningitis)Tj
-32.7286 -1.2983 Td
(cases)Tj
2.2223 0 Td
(that)Tj
1.7801 0 Td
(were)Tj
2.1203 0 Td
(caused)Tj
2.9197 0 Td
(by)Tj
/F13 1 Tf
1.1792 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.057 0 Td
(\(75%,)Tj
2.4945 0 Td
(36%,)Tj
2.1543 0 Td
(60%\))Tj
2.2677 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(\(22%,)Tj
2.4945 0 Td
(63%,)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Bacterial)Tj
4.0394 0 Td
(Meningi)Tj
3.4299 0 Td
(tis)Tj
1.2047 0 Td
(in)Tj
0.978 0 Td
(Burkina)Tj
3.5504 0 Td
(Faso)Tj
2.4095 0 Td
(before)Tj
3.0047 0 Td
(PCV13)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(384)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(10,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
98 0 obj
<>stream
endstream
endobj
99 0 obj
<>stream
endstream
endobj
100 0 obj
<>stream
endstream
endobj
101 0 obj
<>stream
endstream
endobj
102 0 obj
<>stream
endstream
endobj
103 0 obj
<>stream
endstream
endobj
104 0 obj
<>stream
endstream
endobj
105 0 obj
<>stream
endstream
endobj
106 0 obj
<>stream
endstream
endobj
107 0 obj
<>stream
endstream
endobj
108 0 obj
<>stream
endstream
endobj
109 0 obj
<>stream
BT
66.402 0 Td
(16)Tj
ET
Q
endstream
endobj
110 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 111 0 R/Contents 112 0 R/TrimBox[0 0 612 792]>>
endobj
111 0 obj
[113 0 R 114 0 R 115 0 R 116 0 R 117 0 R]
endobj
113 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t002)>>
endobj
114 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t003)>>
endobj
115 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t003)>>
endobj
116 0 obj
<>/Border[0 0 0]/Dest(Rpone.0166384.t004)>>
endobj
117 0 obj
<>/Border[0 0 0]/Dest(Lpone.0166384.t001)>>
endobj
112 0 obj
[118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R]
endobj
118 0 obj
<>stream
q
0.83 0.64 0.02 0 k
316.6299 374.3433 m
345.8268 374.3433 l
h
f*
312.1512 322.3559 m
341.348 322.3559 l
h
f*
480.4724 257.3291 m
509.6126 257.3291 l
h
f*
504.8504 146.948 m
533.9906 146.948 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 388.4031 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(37%,)Tj
2.1543 0 Td
(respectively\))Tj
5.2214 0 Td
(varied,)Tj
2.9253 0 Td
(reflecting)Tj
3.9741 0 Td
(the)Tj
1.4684 0 Td
(meningococcal)Tj
6.2588 0 Td
(outbreak)Tj
3.7871 0 Td
(in)Tj
1.0318 0 Td
(2012,)Tj
2.3527 0 Td
(while)Tj
2.3641 0 Td
(those)Tj
2.3414 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
/F13 1 Tf
1.0262 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
-36.6007 -1.2982 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
4.2576 0 Td
(were)Tj
2.1203 0 Td
(rare)Tj
1.8198 0 Td
(\(13%\))Tj
3.1238 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
/F13 1 Tf
1.2642 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.8957 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0627 0 Td
(had)Tj
1.7064 0 Td
(the)Tj
1.474 0 Td
(highest)Tj
3.0898 0 Td
(CFR)Tj
2.0296 0 Td
(\(23%\),)Tj
2.8346 0 Td
(as)Tj
1.0148 0 Td
(compared)Tj
-33.4769 -1.3039 Td
(to)Tj
/F13 1 Tf
1.0261 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
5.0513 0 Td
(\(9%\))Tj
2.1317 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1848 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
4.252 0 Td
(\(7%\).)Tj
2.3584 0 Td
(Overall,)Tj
/F13 1 Tf
3.3732 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.8958 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0626 0 Td
(caused)Tj
2.914 0 Td
(76%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
-34.0608 -1.2983 Td
(deaths)Tj
2.7892 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(laboratory-confirmed)Tj
8.8781 0 Td
(bacterial)Tj
3.6226 0 Td
(meningitis.)Tj
4.7112 0 Td
(The)Tj
1.7858 0 Td
(average)Tj
3.2258 0 Td
(annual)Tj
2.9594 0 Td
(adjusted)Tj
3.5716 0 Td
(inci-)Tj
-34.2706 -1.2983 Td
(dence)Tj
2.5681 0 Td
(for)Tj
/F13 1 Tf
1.3833 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(,)Tj
/F13 1 Tf
5.2838 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1395 0 Td
[()6()2(\n)18()12(\n)13()-8()14()7()4()12()-4( )]TJ
/F9 1 Tf
(,)Tj
5.2781 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
1.1849 0 Td
[()12(\n)11()-36()12()4()2(\n)-3(\r)6()]TJ
/F9 1 Tf
(,)Tj
4.4787 0 Td
(respectively,)Tj
5.1137 0 Td
(were)Tj
2.1203 0 Td
(5.6,)Tj
1.6214 0 Td
(4.8,)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(0.2)Tj
-36.1528 -1.2982 Td
(per)Tj
1.5306 0 Td
(100,000)Tj
3.2996 0 Td
(among)Tj
2.9933 0 Td
(all)Tj
1.1452 0 Td
(ages)Tj
1.9049 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(3)Tj
0 g
(\))Tj
1.0318 0 Td
(and)Tj
1.7348 0 Td
(26.9,)Tj
2.0976 0 Td
(10.8,)Tj
2.0976 0 Td
(and)Tj
1.7292 0 Td
(2.2)Tj
1.3946 0 Td
(per)Tj
1.5307 0 Td
(100,000)Tj
3.2995 0 Td
(among)Tj
2.999 0 Td
(children)Tj
3.5547 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
-35.1267 -1.3039 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4683 0 Td
(year.)Tj
-0.2721 -1.2983 Td
(Of)Tj
1.2585 0 Td
(the)Tj
1.4684 0 Td
(1,528)Tj
2.347 0 Td
(confirmed)Tj
4.3994 0 Td
(pneumococcal)Tj
6.0207 0 Td
(meningitis)Tj
4.4844 0 Td
(cases)Tj
2.2224 0 Td
(reported)Tj
3.6623 0 Td
(in)Tj
1.0318 0 Td
(20112013,)Tj
4.7679 0 Td
(276)Tj
1.6497 0 Td
(\(18%\))Tj
-34.5087 -1.2983 Td
(occurred)Tj
3.7927 0 Td
(among)Tj
2.9933 0 Td
(children)Tj
3.5603 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0693 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4684 0 Td
(year,)Tj
2.1259 0 Td
(and)Tj
1.7292 0 Td
(478)Tj
1.6497 0 Td
(\(31%\))Tj
2.6079 0 Td
(occurred)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(5)Tj
0.6973 0 Td
(years)Tj
2.262 0 Td
(of)Tj
-35.96 -1.3039 Td
(age.)Tj
1.7688 0 Td
(Median)Tj
3.3108 0 Td
(age)Tj
1.542 0 Td
(was)Tj
1.7008 0 Td
(9)Tj
0.6973 0 Td
(years)Tj
2.2621 0 Td
(\(interquartile)Tj
5.5445 0 Td
(range:)Tj
2.6872 0 Td
(216,)Tj
2.3925 0 Td
(range:)Tj
2.6872 0 Td
(090\).)Tj
2.7269 0 Td
(Adjusted)Tj
3.8267 0 Td
(average)Tj
3.2258 0 Td
(annual)Tj
-34.3726 -1.2983 Td
(incidence)Tj
4.0648 0 Td
(was)Tj
1.6951 0 Td
(highest)Tj
3.0841 0 Td
(among)Tj
2.9877 0 Td
(children)Tj
3.5489 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0636 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.457 0 Td
(year)Tj
1.8992 0 Td
(\(26.9)Tj
2.2054 0 Td
(per)Tj
1.525 0 Td
(100,000,)Tj
0.83 0.64 0.02 0 k
3.515 0 Td
(Table)Tj
2.4377 0 Td
(3)Tj
0 g
(\).)Tj
1.2529 0 Td
(CFR)Tj
2.0296 0 Td
(was)Tj
1.6895 0 Td
(high-)Tj
-35.4555 -1.2982 Td
(est)Tj
1.3039 0 Td
(among)Tj
2.9933 0 Td
(infants)Tj
2.9651 0 Td
(and)Tj
1.7291 0 Td
(adults:)Tj
2.8403 0 Td
(32%)Tj
1.9275 0 Td
(in)Tj
1.0375 0 Td
(children)Tj
3.5546 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0693 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4683 0 Td
(year,)Tj
2.1317 0 Td
(15%)Tj
1.9275 0 Td
(in)Tj
1.0318 0 Td
(children)Tj
3.5603 0 Td
(aged)Tj
2.0693 0 Td
(14)Tj
1.6894 0 Td
(years,)Tj
-34.2989 -1.3039 Td
(21%)Tj
1.9275 0 Td
(in)Tj
1.0375 0 Td
(persons)Tj
3.3051 0 Td
(aged)Tj
2.075 0 Td
(529)Tj
2.16 0 Td
(years,)Tj
2.4888 0 Td
(and)Tj
1.7348 0 Td
(30%)Tj
1.9275 0 Td
(in)Tj
1.0375 0 Td
(persons)Tj
3.3052 0 Td
(aged)Tj
/F12 1 Tf
0 Tc
2.0693 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(30)Tj
1.9445 0 Td
(years.)Tj
2.4888 0 Td
(While)Tj
2.6532 0 Td
(the)Tj
1.4684 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
-36.2548 -1.2983 Td
(persons)Tj
3.3108 0 Td
(aged)Tj
/F14 1 Tf
0 Tc
2.0693 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
(1)Tj
1.4683 0 Td
(year,)Tj
2.126 0 Td
(14)Tj
1.6894 0 Td
(years,)Tj
2.4888 0 Td
(529)Tj
2.1657 0 Td
(years,)Tj
2.4888 0 Td
(or)Tj
/F12 1 Tf
0 Tc
1.0998 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
(30)Tj
1.9389 0 Td
(years)Tj
2.2677 0 Td
(who)Tj
1.9389 0 Td
(recovered)Tj
4.1442 0 Td
(were)Tj
2.126 0 Td
(64%,)Tj
2.1486 0 Td
(75%,)Tj
2.1544 0 Td
(69%,)Tj
-35.6256 -1.2983 Td
(and)Tj
1.7291 0 Td
(66%,)Tj
2.1543 0 Td
(respectively,)Tj
5.108 0 Td
(12%,)Tj
2.1543 0 Td
(14%,)Tj
2.1543 0 Td
(16%,)Tj
2.1543 0 Td
(and)Tj
1.7292 0 Td
(13%)Tj
1.9275 0 Td
(were)Tj
2.126 0 Td
(recorded)Tj
3.7927 0 Td
(as)Tj
1.0148 0 Td
(`on)Tj
1.5024 0 Td
(treatment')Tj
4.3483 0 Td
(and)Tj
1.7348 0 Td
(have)Tj
2.0579 0 Td
(an)Tj
-35.6879 -1.2982 Td
(unknown)Tj
4.0818 0 Td
(final)Tj
2.0013 0 Td
(outcome,)Tj
3.9514 0 Td
(and)Tj
1.7292 0 Td
(0.00.6%)Tj
3.8494 0 Td
(in)Tj
1.0375 0 Td
(each)Tj
2.0295 0 Td
(age)Tj
1.5421 0 Td
(group)Tj
2.6078 0 Td
(left)Tj
1.474 0 Td
(against)Tj
3.0274 0 Td
(medical)Tj
3.3619 0 Td
(advice.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Pneumococcal)Tj
6.7039 0 Td
(diagnostic)Tj
4.6631 0 Td
(test)Tj
1.8189 0 Td
(results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 148.0251 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(ability)Tj
2.6929 0 Td
(of)Tj
1.0148 0 Td
(latex,)Tj
2.313 0 Td
(culture,)Tj
3.2655 0 Td
(and)Tj
1.7292 0 Td
(rt-PCR)Tj
3.084 0 Td
(tests)Tj
1.9616 0 Td
(to)Tj
1.0261 0 Td
(detect)Tj
/F13 1 Tf
2.6136 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
5.0626 0 Td
(varied)Tj
2.6986 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(4)Tj
0 g
(\).)Tj
1.2643 0 Td
(Overall,)Tj
-34.1856 -1.3039 Td
(642)Tj
1.6384 0 Td
(\(84.7%\))Tj
3.3051 0 Td
(of)Tj
1.0092 0 Td
(758)Tj
1.6384 0 Td
(laboratory-confirmed)Tj
8.8724 0 Td
(\(using)Tj
2.7212 0 Td
(any)Tj
1.6554 0 Td
(of)Tj
1.0092 0 Td
(the)Tj
1.4626 0 Td
(three)Tj
2.2564 0 Td
(diagnostic)Tj
4.3143 0 Td
(methods\))Tj
4.0195 0 Td
(pneumo-)Tj
-33.9021 -1.2982 Td
(coccal)Tj
2.6758 0 Td
(meningitis)Tj
4.4844 0 Td
(cases)Tj
2.2224 0 Td
(tested)Tj
2.5568 0 Td
(using)Tj
2.3868 0 Td
(latex)Tj
2.0862 0 Td
(agglutination)Tj
5.5276 0 Td
(were)Tj
2.1259 0 Td
(positive)Tj
3.3166 0 Td
(for)Tj
/F13 1 Tf
1.3833 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(,)Tj
5.2837 0 Td
(and)Tj
-34.9509 -1.2983 Td
(217)Tj
1.644 0 Td
(\(41.1%\))Tj
3.3109 0 Td
(of)Tj
1.0148 0 Td
(528)Tj
1.6497 0 Td
(tested)Tj
2.5512 0 Td
(by)Tj
1.1792 0 Td
(culture)Tj
3.0387 0 Td
(grew)Tj
/F13 1 Tf
2.1657 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(.)Tj
5.2837 0 Td
(The)Tj
1.7802 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(pneumococcal)Tj
6.0208 0 Td
(men-)Tj
-35.1834 -1.3039 Td
(ingitis)Tj
2.6928 0 Td
(cases)Tj
2.2224 0 Td
(were)Tj
2.1203 0 Td
(confirmed)Tj
4.3993 0 Td
(using)Tj
2.3868 0 Td
(rt-PCR:)Tj
3.3108 0 Td
(1,210)Tj
2.3471 0 Td
(\(96.3%\))Tj
3.3109 0 Td
(of)Tj
1.0148 0 Td
(1,256)Tj
2.347 0 Td
(pneumococcal)Tj
6.0208 0 Td
(cases)Tj
2.2223 0 Td
(tested)Tj
-34.3953 -1.2983 Td
(by)Tj
1.1792 0 Td
(rt-PCR)Tj
3.084 0 Td
(were)Tj
2.126 0 Td
(positive)Tj
3.3108 0 Td
(for)Tj
/F13 1 Tf
1.389 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9014 0 Td
[()11(\n)6()2()12()6()11(\n)18()4(\r)6()]TJ
/F9 1 Tf
(.)Tj
5.2838 0 Td
(Using)Tj
2.5965 0 Td
(culture)Tj
3.0387 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(gold)Tj
1.9673 0 Td
(standard,)Tj
3.9514 0 Td
(the)Tj
1.4684 0 Td
(sensitivities)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 706.7594 m
576 706.7594 l
576 706.2593 l
36 706.2593 l
f*
222.7745 706.2593 m
222.7745 693.2594 l
222.2745 693.7594 l
222.2745 706.2593 l
f*
222.7745 693.2594 m
36 693.2594 l
36 693.7594 l
222.2745 693.7594 l
f*
304.5807 706.2593 m
304.5807 693.2594 l
304.0807 693.7594 l
304.0807 706.2593 l
f*
304.5807 693.2594 m
222.7745 693.2594 l
222.7745 693.7594 l
304.0807 693.7594 l
f*
397.4352 706.2593 m
397.4352 693.2594 l
396.9351 693.7594 l
396.9351 706.2593 l
f*
397.4352 693.2594 m
304.5807 693.2594 l
304.5807 693.7594 l
396.9351 693.7594 l
f*
483.6441 706.2593 m
483.6441 693.2594 l
483.1441 693.7594 l
483.1441 706.2593 l
f*
483.6441 693.2594 m
397.4352 693.2594 l
397.4352 693.7594 l
483.1441 693.7594 l
f*
575.9986 693.2594 m
483.6441 693.2594 l
483.6441 693.7594 l
575.9986 693.7594 l
f*
222.7745 693.2594 m
222.7745 680.2594 l
222.2745 680.7594 l
222.2745 693.2594 l
f*
222.7745 680.2594 m
36 680.2594 l
36 680.7594 l
222.2745 680.7594 l
f*
304.5807 693.2594 m
304.5807 680.2594 l
304.0807 680.7594 l
304.0807 693.2594 l
f*
304.5807 680.2594 m
222.7745 680.2594 l
222.7745 680.7594 l
304.0807 680.7594 l
f*
397.4352 693.2594 m
397.4352 680.2594 l
396.9351 680.7594 l
396.9351 693.2594 l
f*
397.4352 680.2594 m
304.5807 680.2594 l
304.5807 680.7594 l
396.9351 680.7594 l
f*
483.6441 693.2594 m
483.6441 680.2594 l
483.1441 680.7594 l
483.1441 693.2594 l
f*
483.6441 680.2594 m
397.4352 680.2594 l
397.4352 680.7594 l
483.1441 680.7594 l
f*
575.9986 680.2594 m
483.6441 680.2594 l
483.6441 680.7594 l
575.9986 680.7594 l
f*
222.7745 680.2594 m
222.7745 667.7595 l
222.2745 668.2595 l
222.2745 680.2594 l
f*
222.7745 667.7595 m
36 667.7595 l
36 668.2595 l
222.2745 668.2595 l
f*
270.9462 680.2594 m
270.9462 667.7595 l
270.4462 668.2595 l
270.4462 680.2594 l
f*
270.9462 667.7595 m
222.7745 667.7595 l
222.7745 668.2595 l
270.4462 668.2595 l
f*
304.5807 680.2594 m
304.5807 667.7595 l
304.0807 668.2595 l
304.0807 680.2594 l
f*
304.5807 667.7595 m
270.9462 667.7595 l
270.9462 668.2595 l
304.0807 668.2595 l
f*
359.3979 680.2594 m
359.3979 667.7595 l
358.8979 668.2595 l
358.8979 680.2594 l
f*
359.3979 667.7595 m
304.5807 667.7595 l
304.5807 668.2595 l
358.8979 668.2595 l
f*
397.4352 680.2594 m
397.4352 667.7595 l
396.9351 668.2595 l
396.9351 680.2594 l
f*
397.4352 667.7595 m
359.3979 667.7595 l
359.3979 668.2595 l
396.9351 668.2595 l
f*
445.6069 680.2594 m
445.6069 667.7595 l
445.1068 668.2595 l
445.1068 680.2594 l
f*
445.6069 667.7595 m
397.4352 667.7595 l
397.4352 668.2595 l
445.1068 668.2595 l
f*
483.6441 680.2594 m
483.6441 667.7595 l
483.1441 668.2595 l
483.1441 680.2594 l
f*
483.6441 667.7595 m
445.6069 667.7595 l
445.6069 668.2595 l
483.1441 668.2595 l
f*
538.4614 680.2594 m
538.4614 667.7595 l
537.9613 668.2595 l
537.9613 680.2594 l
f*
538.4614 667.7595 m
483.6441 667.7595 l
483.6441 668.2595 l
537.9613 668.2595 l
f*
575.9986 667.7595 m
538.4614 667.7595 l
538.4614 668.2595 l
575.9986 668.2595 l
f*
222.7745 667.7595 m
222.7745 655.2595 l
222.2745 655.7596 l
222.2745 667.7595 l
f*
222.7745 655.2595 m
36 655.2595 l
36 655.7596 l
222.2745 655.7596 l
f*
270.9462 667.7595 m
270.9462 655.2595 l
270.4462 655.7596 l
270.4462 667.7595 l
f*
270.9462 655.2595 m
222.7745 655.2595 l
222.7745 655.7596 l
270.4462 655.7596 l
f*
304.5807 667.7595 m
304.5807 655.2595 l
304.0807 655.7596 l
304.0807 667.7595 l
f*
304.5807 655.2595 m
270.9462 655.2595 l
270.9462 655.7596 l
304.0807 655.7596 l
f*
359.3979 667.7595 m
359.3979 655.2595 l
358.8979 655.7596 l
358.8979 667.7595 l
f*
359.3979 655.2595 m
304.5807 655.2595 l
304.5807 655.7596 l
358.8979 655.7596 l
f*
397.4352 667.7595 m
397.4352 655.2595 l
396.9351 655.7596 l
396.9351 667.7595 l
f*
397.4352 655.2595 m
359.3979 655.2595 l
359.3979 655.7596 l
396.9351 655.7596 l
f*
445.6069 667.7595 m
445.6069 655.2595 l
445.1068 655.7596 l
445.1068 667.7595 l
f*
445.6069 655.2595 m
397.4352 655.2595 l
397.4352 655.7596 l
445.1068 655.7596 l
f*
483.6441 667.7595 m
483.6441 655.2595 l
483.1441 655.7596 l
483.1441 667.7595 l
f*
483.6441 655.2595 m
445.6069 655.2595 l
445.6069 655.7596 l
483.1441 655.7596 l
f*
538.4614 667.7595 m
538.4614 655.2595 l
537.9613 655.7596 l
537.9613 667.7595 l
f*
538.4614 655.2595 m
483.6441 655.2595 l
483.6441 655.7596 l
537.9613 655.7596 l
f*
575.9986 655.2595 m
538.4614 655.2595 l
538.4614 655.7596 l
575.9986 655.7596 l
f*
222.7745 655.2595 m
222.7745 642.7596 l
222.2745 643.2596 l
222.2745 655.2595 l
f*
222.7745 642.7596 m
36 642.7596 l
36 643.2596 l
222.2745 643.2596 l
f*
270.9462 655.2595 m
270.9462 642.7596 l
270.4462 643.2596 l
270.4462 655.2595 l
f*
270.9462 642.7596 m
222.7745 642.7596 l
222.7745 643.2596 l
270.4462 643.2596 l
f*
304.5807 655.2595 m
304.5807 642.7596 l
304.0807 643.2596 l
304.0807 655.2595 l
f*
304.5807 642.7596 m
270.9462 642.7596 l
270.9462 643.2596 l
304.0807 643.2596 l
f*
359.3979 655.2595 m
359.3979 642.7596 l
358.8979 643.2596 l
358.8979 655.2595 l
f*
359.3979 642.7596 m
304.5807 642.7596 l
304.5807 643.2596 l
358.8979 643.2596 l
f*
397.4352 655.2595 m
397.4352 642.7596 l
396.9351 643.2596 l
396.9351 655.2595 l
f*
397.4352 642.7596 m
359.3979 642.7596 l
359.3979 643.2596 l
396.9351 643.2596 l
f*
445.6069 655.2595 m
445.6069 642.7596 l
445.1068 643.2596 l
445.1068 655.2595 l
f*
445.6069 642.7596 m
397.4352 642.7596 l
397.4352 643.2596 l
445.1068 643.2596 l
f*
483.6441 655.2595 m
483.6441 642.7596 l
483.1441 643.2596 l
483.1441 655.2595 l
f*
483.6441 642.7596 m
445.6069 642.7596 l
445.6069 643.2596 l
483.1441 643.2596 l
f*
538.4614 655.2595 m
538.4614 642.7596 l
537.9613 643.2596 l
537.9613 655.2595 l
f*
538.4614 642.7596 m
483.6441 642.7596 l
483.6441 643.2596 l
537.9613 643.2596 l
f*
575.9986 642.7596 m
538.4614 642.7596 l
538.4614 643.2596 l
575.9986 643.2596 l
f*
222.7745 642.7596 m
222.7745 630.2597 l
222.2745 630.7597 l
222.2745 642.7596 l
f*
222.7745 630.2597 m
36 630.2597 l
36 630.7597 l
222.2745 630.7597 l
f*
270.9462 642.7596 m
270.9462 630.2597 l
270.4462 630.7597 l
270.4462 642.7596 l
f*
270.9462 630.2597 m
222.7745 630.2597 l
222.7745 630.7597 l
270.4462 630.7597 l
f*
304.5807 642.7596 m
304.5807 630.2597 l
304.0807 630.7597 l
304.0807 642.7596 l
f*
304.5807 630.2597 m
270.9462 630.2597 l
270.9462 630.7597 l
304.0807 630.7597 l
f*
359.3979 642.7596 m
359.3979 630.2597 l
358.8979 630.7597 l
358.8979 642.7596 l
f*
359.3979 630.2597 m
304.5807 630.2597 l
304.5807 630.7597 l
358.8979 630.7597 l
f*
397.4352 642.7596 m
397.4352 630.2597 l
396.9351 630.7597 l
396.9351 642.7596 l
f*
397.4352 630.2597 m
359.3979 630.2597 l
359.3979 630.7597 l
396.9351 630.7597 l
f*
445.6069 642.7596 m
445.6069 630.2597 l
445.1068 630.7597 l
445.1068 642.7596 l
f*
445.6069 630.2597 m
397.4352 630.2597 l
397.4352 630.7597 l
445.1068 630.7597 l
f*
483.6441 642.7596 m
483.6441 630.2597 l
483.1441 630.7597 l
483.1441 642.7596 l
f*
483.6441 630.2597 m
445.6069 630.2597 l
445.6069 630.7597 l
483.1441 630.7597 l
f*
538.4614 642.7596 m
538.4614 630.2597 l
537.9613 630.7597 l
537.9613 642.7596 l
f*
538.4614 630.2597 m
483.6441 630.2597 l
483.6441 630.7597 l
537.9613 630.7597 l
f*
575.9986 630.2597 m
538.4614 630.2597 l
538.4614 630.7597 l
575.9986 630.7597 l
f*
222.7745 630.2597 m
222.7745 617.7597 l
222.2745 618.2597 l
222.2745 630.2597 l
f*
222.7745 617.7597 m
36 617.7597 l
36 618.2597 l
222.2745 618.2597 l
f*
270.9462 630.2597 m
270.9462 617.7597 l
270.4462 618.2597 l
270.4462 630.2597 l
f*
270.9462 617.7597 m
222.7745 617.7597 l
222.7745 618.2597 l
270.4462 618.2597 l
f*
304.5807 630.2597 m
304.5807 617.7597 l
304.0807 618.2597 l
304.0807 630.2597 l
f*
304.5807 617.7597 m
270.9462 617.7597 l
270.9462 618.2597 l
304.0807 618.2597 l
f*
359.3979 630.2597 m
359.3979 617.7597 l
358.8979 618.2597 l
358.8979 630.2597 l
f*
359.3979 617.7597 m
304.5807 617.7597 l
304.5807 618.2597 l
358.8979 618.2597 l
f*
397.4352 630.2597 m
397.4352 617.7597 l
396.9351 618.2597 l
396.9351 630.2597 l
f*
397.4352 617.7597 m
359.3979 617.7597 l
359.3979 618.2597 l
396.9351 618.2597 l
f*
445.6069 630.2597 m
445.6069 617.7597 l
445.1068 618.2597 l
445.1068 630.2597 l
f*
445.6069 617.7597 m
397.4352 617.7597 l
397.4352 618.2597 l
445.1068 618.2597 l
f*
483.6441 630.2597 m
483.6441 617.7597 l
483.1441 618.2597 l
483.1441 630.2597 l
f*
483.6441 617.7597 m
445.6069 617.7597 l
445.6069 618.2597 l
483.1441 618.2597 l
f*
538.4614 630.2597 m
538.4614 617.7597 l
537.9613 618.2597 l
537.9613 630.2597 l
f*
538.4614 617.7597 m
483.6441 617.7597 l
483.6441 618.2597 l
537.9613 618.2597 l
f*
575.9986 617.7597 m
538.4614 617.7597 l
538.4614 618.2597 l
575.9986 618.2597 l
f*
222.7745 617.7597 m
222.7745 605.2598 l
222.2745 605.7598 l
222.2745 617.7597 l
f*
222.7745 605.2598 m
36 605.2598 l
36 605.7598 l
222.2745 605.7598 l
f*
270.9462 617.7597 m
270.9462 605.2598 l
270.4462 605.7598 l
270.4462 617.7597 l
f*
270.9462 605.2598 m
222.7745 605.2598 l
222.7745 605.7598 l
270.4462 605.7598 l
f*
304.5807 617.7597 m
304.5807 605.2598 l
304.0807 605.7598 l
304.0807 617.7597 l
f*
304.5807 605.2598 m
270.9462 605.2598 l
270.9462 605.7598 l
304.0807 605.7598 l
f*
359.3979 617.7597 m
359.3979 605.2598 l
358.8979 605.7598 l
358.8979 617.7597 l
f*
359.3979 605.2598 m
304.5807 605.2598 l
304.5807 605.7598 l
358.8979 605.7598 l
f*
397.4352 617.7597 m
397.4352 605.2598 l
396.9351 605.7598 l
396.9351 617.7597 l
f*
397.4352 605.2598 m
359.3979 605.2598 l
359.3979 605.7598 l
396.9351 605.7598 l
f*
445.6069 617.7597 m
445.6069 605.2598 l
445.1068 605.7598 l
445.1068 617.7597 l
f*
445.6069 605.2598 m
397.4352 605.2598 l
397.4352 605.7598 l
445.1068 605.7598 l
f*
483.6441 617.7597 m
483.6441 605.2598 l
483.1441 605.7598 l
483.1441 617.7597 l
f*
483.6441 605.2598 m
445.6069 605.2598 l
445.6069 605.7598 l
483.1441 605.7598 l
f*
538.4614 617.7597 m
538.4614 605.2598 l
537.9613 605.7598 l
537.9613 617.7597 l
f*
538.4614 605.2598 m
483.6441 605.2598 l
483.6441 605.7598 l
537.9613 605.7598 l
f*
575.9986 605.2598 m
538.4614 605.2598 l
538.4614 605.7598 l
575.9986 605.7598 l
f*
222.7745 605.2598 m
222.7745 592.7598 l
222.2745 593.2599 l
222.2745 605.2598 l
f*
222.7745 592.7598 m
36 592.7598 l
36 593.2599 l
222.2745 593.2599 l
f*
270.9462 605.2598 m
270.9462 592.7598 l
270.4462 593.2599 l
270.4462 605.2598 l
f*
270.9462 592.7598 m
222.7745 592.7598 l
222.7745 593.2599 l
270.4462 593.2599 l
f*
304.5807 605.2598 m
304.5807 592.7598 l
304.0807 593.2599 l
304.0807 605.2598 l
f*
304.5807 592.7598 m
270.9462 592.7598 l
270.9462 593.2599 l
304.0807 593.2599 l
f*
359.3979 605.2598 m
359.3979 592.7598 l
358.8979 593.2599 l
358.8979 605.2598 l
f*
359.3979 592.7598 m
304.5807 592.7598 l
304.5807 593.2599 l
358.8979 593.2599 l
f*
397.4352 605.2598 m
397.4352 592.7598 l
396.9351 593.2599 l
396.9351 605.2598 l
f*
397.4352 592.7598 m
359.3979 592.7598 l
359.3979 593.2599 l
396.9351 593.2599 l
f*
445.6069 605.2598 m
445.6069 592.7598 l
445.1068 593.2599 l
445.1068 605.2598 l
f*
445.6069 592.7598 m
397.4352 592.7598 l
397.4352 593.2599 l
445.1068 593.2599 l
f*
483.6441 605.2598 m
483.6441 592.7598 l
483.1441 593.2599 l
483.1441 605.2598 l
f*
483.6441 592.7598 m
445.6069 592.7598 l
445.6069 593.2599 l
483.1441 593.2599 l
f*
538.4614 605.2598 m
538.4614 592.7598 l
537.9613 593.2599 l
537.9613 605.2598 l
f*
538.4614 592.7598 m
483.6441 592.7598 l
483.6441 593.2599 l
537.9613 593.2599 l
f*
575.9986 592.7598 m
538.4614 592.7598 l
538.4614 593.2599 l
575.9986 593.2599 l
f*
222.7745 592.7598 m
222.7745 580.2599 l
222.2745 580.7599 l
222.2745 592.7598 l
f*
222.7745 580.2599 m
36 580.2599 l
36 580.7599 l
222.2745 580.7599 l
f*
270.9462 592.7598 m
270.9462 580.2599 l
270.4462 580.7599 l
270.4462 592.7598 l
f*
270.9462 580.2599 m
222.7745 580.2599 l
222.7745 580.7599 l
270.4462 580.7599 l
f*
304.5807 592.7598 m
304.5807 580.2599 l
304.0807 580.7599 l
304.0807 592.7598 l
f*
304.5807 580.2599 m
270.9462 580.2599 l
270.9462 580.7599 l
304.0807 580.7599 l
f*
359.3979 592.7598 m
359.3979 580.2599 l
358.8979 580.7599 l
358.8979 592.7598 l
f*
359.3979 580.2599 m
304.5807 580.2599 l
304.5807 580.7599 l
358.8979 580.7599 l
f*
397.4352 592.7598 m
397.4352 580.2599 l
396.9351 580.7599 l
396.9351 592.7598 l
f*
397.4352 580.2599 m
359.3979 580.2599 l
359.3979 580.7599 l
396.9351 580.7599 l
f*
445.6069 592.7598 m
445.6069 580.2599 l
445.1068 580.7599 l
445.1068 592.7598 l
f*
445.6069 580.2599 m
397.4352 580.2599 l
397.4352 580.7599 l
445.1068 580.7599 l
f*
483.6441 592.7598 m
483.6441 580.2599 l
483.1441 580.7599 l
483.1441 592.7598 l
f*
483.6441 580.2599 m
445.6069 580.2599 l
445.6069 580.7599 l
483.1441 580.7599 l
f*
538.4614 592.7598 m
538.4614 580.2599 l
537.9613 580.7599 l
537.9613 592.7598 l
f*
538.4614 580.2599 m
483.6441 580.2599 l
483.6441 580.7599 l
537.9613 580.7599 l
f*
575.9986 580.2599 m
538.4614 580.2599 l
538.4614 580.7599 l
575.9986 580.7599 l
f*
222.7745 580.2599 m
222.7745 567.76 l
222.2745 568.26 l
222.2745 580.2599 l
f*
222.7745 567.76 m
36 567.76 l
36 568.26 l
222.2745 568.26 l
f*
270.9462 580.2599 m
270.9462 567.76 l
270.4462 568.26 l
270.4462 580.2599 l
f*
270.9462 567.76 m
222.7745 567.76 l
222.7745 568.26 l
270.4462 568.26 l
f*
304.5807 580.2599 m
304.5807 567.76 l
304.0807 568.26 l
304.0807 580.2599 l
f*
304.5807 567.76 m
270.9462 567.76 l
270.9462 568.26 l
304.0807 568.26 l
f*
359.3979 580.2599 m
359.3979 567.76 l
358.8979 568.26 l
358.8979 580.2599 l
f*
359.3979 567.76 m
304.5807 567.76 l
304.5807 568.26 l
358.8979 568.26 l
f*
397.4352 580.2599 m
397.4352 567.76 l
396.9351 568.26 l
396.9351 580.2599 l
f*
397.4352 567.76 m
359.3979 567.76 l
359.3979 568.26 l
396.9351 568.26 l
f*
445.6069 580.2599 m
445.6069 567.76 l
445.1068 568.26 l
445.1068 580.2599 l
f*
445.6069 567.76 m
397.4352 567.76 l
397.4352 568.26 l
445.1068 568.26 l
f*
483.6441 580.2599 m
483.6441 567.76 l
483.1441 568.26 l
483.1441 580.2599 l
f*
483.6441 567.76 m
445.6069 567.76 l
445.6069 568.26 l
483.1441 568.26 l
f*
538.4614 580.2599 m
538.4614 567.76 l
537.9613 568.26 l
537.9613 580.2599 l
f*
538.4614 567.76 m
483.6441 567.76 l
483.6441 568.26 l
537.9613 568.26 l
f*
575.9986 567.76 m
538.4614 567.76 l
538.4614 568.26 l
575.9986 568.26 l
f*
222.7745 567.76 m
222.7745 555.26 l
222.2745 555.7601 l
222.2745 567.76 l
f*
222.7745 555.26 m
36 555.26 l
36 555.7601 l
222.2745 555.7601 l
f*
270.9462 567.76 m
270.9462 555.26 l
270.4462 555.7601 l
270.4462 567.76 l
f*
270.9462 555.26 m
222.7745 555.26 l
222.7745 555.7601 l
270.4462 555.7601 l
f*
304.5807 567.76 m
304.5807 555.26 l
304.0807 555.7601 l
304.0807 567.76 l
f*
304.5807 555.26 m
270.9462 555.26 l
270.9462 555.7601 l
304.0807 555.7601 l
f*
359.3979 567.76 m
359.3979 555.26 l
358.8979 555.7601 l
358.8979 567.76 l
f*
359.3979 555.26 m
304.5807 555.26 l
304.5807 555.7601 l
358.8979 555.7601 l
f*
397.4352 567.76 m
397.4352 555.26 l
396.9351 555.7601 l
396.9351 567.76 l
f*
397.4352 555.26 m
359.3979 555.26 l
359.3979 555.7601 l
396.9351 555.7601 l
f*
445.6069 567.76 m
445.6069 555.26 l
445.1068 555.7601 l
445.1068 567.76 l
f*
445.6069 555.26 m
397.4352 555.26 l
397.4352 555.7601 l
445.1068 555.7601 l
f*
483.6441 567.76 m
483.6441 555.26 l
483.1441 555.7601 l
483.1441 567.76 l
f*
483.6441 555.26 m
445.6069 555.26 l
445.6069 555.7601 l
483.1441 555.7601 l
f*
538.4614 567.76 m
538.4614 555.26 l
537.9613 555.7601 l
537.9613 567.76 l
f*
538.4614 555.26 m
483.6441 555.26 l
483.6441 555.7601 l
537.9613 555.7601 l
f*
575.9986 555.26 m
538.4614 555.26 l
538.4614 555.7601 l
575.9986 555.7601 l
f*
222.7745 555.26 m
222.7745 542.7601 l
222.2745 543.2601 l
222.2745 555.26 l
f*
222.7745 542.7601 m
36 542.7601 l
36 543.2601 l
222.2745 543.2601 l
f*
270.9462 555.26 m
270.9462 542.7601 l
270.4462 543.2601 l
270.4462 555.26 l
f*
270.9462 542.7601 m
222.7745 542.7601 l
222.7745 543.2601 l
270.4462 543.2601 l
f*
304.5807 555.26 m
304.5807 542.7601 l
304.0807 543.2601 l
304.0807 555.26 l
f*
304.5807 542.7601 m
270.9462 542.7601 l
270.9462 543.2601 l
304.0807 543.2601 l
f*
359.3979 555.26 m
359.3979 542.7601 l
358.8979 543.2601 l
358.8979 555.26 l
f*
359.3979 542.7601 m
304.5807 542.7601 l
304.5807 543.2601 l
358.8979 543.2601 l
f*
397.4352 555.26 m
397.4352 542.7601 l
396.9351 543.2601 l
396.9351 555.26 l
f*
397.4352 542.7601 m
359.3979 542.7601 l
359.3979 543.2601 l
396.9351 543.2601 l
f*
445.6069 555.26 m
445.6069 542.7601 l
445.1068 543.2601 l
445.1068 555.26 l
f*
445.6069 542.7601 m
397.4352 542.7601 l
397.4352 543.2601 l
445.1068 543.2601 l
f*
483.6441 555.26 m
483.6441 542.7601 l
483.1441 543.2601 l
483.1441 555.26 l
f*
483.6441 542.7601 m
445.6069 542.7601 l
445.6069 543.2601 l
483.1441 543.2601 l
f*
538.4614 555.26 m
538.4614 542.7601 l
537.9613 543.2601 l
537.9613 555.26 l
f*
538.4614 542.7601 m
483.6441 542.7601 l
483.6441 543.2601 l
537.9613 543.2601 l
f*
575.9986 542.7601 m
538.4614 542.7601 l
538.4614 543.2601 l
575.9986 543.2601 l
f*
575.9986 425.0106 m
36 425.0106 l
36 425.5106 l
575.9986 425.5106 l
f*
0 g
7.9999 0 0 7.9999 36 711.6094 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(National)Tj
4.1174 0 Td
(meningitis)Tj
5.1661 0 Td
(data)Tj
2.2465 0 Td
(quality)Tj
3.4016 0 Td
(and)Tj
1.9772 0 Td
(completen)Tj
4.9394 0 Td
(ess)Tj
1.8567 0 Td
(indicators,)Tj
5.2158 0 Td
(Burkina)Tj
3.8906 0 Td
(Faso,)Tj
2.7992 0 Td
(20112013.)Tj
0 Tc
-12.345 -1.8567 Td
(2011)Tj
10.9206 0 Td
(2012)Tj
11.1899 0 Td
(2013)Tj
11.0977 0 Td
(Total)Tj
-33.3499 -1.6228 Td
(N)Tj
0.9425 0 Td
(\(%\))Tj
9.971 0 Td
(N)Tj
0.9496 0 Td
(\(%\))Tj
10.2402 0 Td
(N)Tj
0.9497 0 Td
(\(%\))Tj
10.2473 0 Td
(N)Tj
0.9425 0 Td
(\(%\))Tj
/F0 1 Tf
-61.4272 -1.6299 Td
(Districts)Tj
3.7701 0 Td
(submitting)Tj
4.7551 0 Td
(case-based)Tj
5.3646 0 Td
(surveillan)Tj
4.1812 0 Td
(ce)Tj
1.2826 0 Td
(data)Tj
7.0938 0 Td
(57/63)Tj
3.2953 0 Td
(\(90\))Tj
7.7599 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
7.4835 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
8.3127 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
-63.1847 -1.5591 Td
(Districts)Tj
3.7701 0 Td
(submitting)Tj
4.7551 0 Td
(CSF)Tj
2.2252 0 Td
(specimens)Tj
15.697 0 Td
(57/63)Tj
3.2953 0 Td
(\(90\))Tj
7.7599 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
7.4835 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
8.3127 0 Td
(63/63)Tj
3.2953 0 Td
(\(100\))Tj
-63.1847 -1.5662 Td
(Suspected)Tj
4.9252 0 Td
(mening)Tj
3.2457 0 Td
(itis)Tj
1.4457 0 Td
(cases)Tj
2.8275 0 Td
(with)Tj
1.9985 0 Td
(a)Tj
0.7795 0 Td
(LP)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 167.4708 649.3039 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 247.5779 645.7322 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2,766)Tj
3.2953 0 Td
(\(97\))Tj
7.7599 0 Td
(6,302)Tj
3.2953 0 Td
(\(97\))Tj
7.4835 0 Td
(2,758)Tj
3.2953 0 Td
(\(97\))Tj
7.7599 0 Td
(11,826)Tj
3.848 0 Td
(\(97\))Tj
-62.2633 -1.559 Td
(CSFs)Tj
2.7212 0 Td
(assessed)Tj
4.4221 0 Td
(for)Tj
1.3961 0 Td
(appearan)Tj
4.1811 0 Td
(ce)Tj
12.8056 0 Td
(2,417)Tj
3.2953 0 Td
(\(87\))Tj
7.7599 0 Td
(5,723)Tj
3.2953 0 Td
(\(91\))Tj
7.4835 0 Td
(2,585)Tj
3.2953 0 Td
(\(94\))Tj
7.7599 0 Td
(10,725)Tj
3.848 0 Td
(\(91\))Tj
-62.2633 -1.5591 Td
(CSFs)Tj
2.7212 0 Td
(with)Tj
1.9914 0 Td
(a)Tj
0.7866 0 Td
(Gram)Tj
2.7213 0 Td
(stain)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 125.9149 624.3023 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(b)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 247.5779 620.7874 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2,508)Tj
3.2953 0 Td
(\(91\))Tj
7.7599 0 Td
(5,626)Tj
3.2953 0 Td
(\(89\))Tj
7.4835 0 Td
(2,460)Tj
3.2953 0 Td
(\(89\))Tj
7.7599 0 Td
(10,594)Tj
3.848 0 Td
(\(90\))Tj
-62.2633 -1.5661 Td
(CSFs)Tj
2.7212 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2756 0 Td
(cytology)Tj
18.8717 0 Td
(1217)Tj
3.0119 0 Td
(\(44\))Tj
7.7599 0 Td
(2,473)Tj
3.2953 0 Td
(\(39\))Tj
7.4835 0 Td
(1,271)Tj
3.2953 0 Td
(\(46\))Tj
8.3126 0 Td
(4,961)Tj
3.2953 0 Td
(\(42\))Tj
-62.2633 -1.5591 Td
(CSFs)Tj
2.7212 0 Td
(tested)Tj
2.941 0 Td
(at)Tj
1.063 0 Td
(a)Tj
0.7795 0 Td
(nationa)Tj
3.2457 0 Td
(l)Tj
0.4465 0 Td
(laboratory)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 168.2645 599.3007 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c,d)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 247.5779 595.7858 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1,242)Tj
3.2953 0 Td
(\(45\))Tj
7.7599 0 Td
(2,379)Tj
3.2953 0 Td
(\(38\))Tj
7.4835 0 Td
(1,836)Tj
3.2953 0 Td
(\(67\))Tj
8.3126 0 Td
(5,457)Tj
3.2953 0 Td
(\(46\))Tj
-62.2633 -1.5661 Td
(CSFs)Tj
2.7212 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2756 0 Td
(latex)Tj
18.5883 0 Td
(1,146)Tj
3.2953 0 Td
(\(41\))Tj
7.7599 0 Td
(1,205)Tj
3.2953 0 Td
(\(19\))Tj
8.3126 0 Td
(513)Tj
2.4662 0 Td
(\(19\))Tj
8.3126 0 Td
(2,864)Tj
3.2953 0 Td
(\(24\))Tj
-62.2633 -1.5591 Td
(CSFs)Tj
2.7212 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2756 0 Td
(culture)Tj
19.4174 0 Td
(722)Tj
2.4662 0 Td
(\(26\))Tj
7.7599 0 Td
(1,552)Tj
3.2953 0 Td
(\(25\))Tj
8.3126 0 Td
(637)Tj
2.4662 0 Td
(\(23\))Tj
8.3126 0 Td
(2,911)Tj
3.2953 0 Td
(\(25\))Tj
-62.2633 -1.5661 Td
(CSFs)Tj
2.7212 0 Td
(cultured)Tj
3.7631 0 Td
(but)Tj
1.6086 0 Td
(found)Tj
2.7142 0 Td
(to)Tj
1.056 0 Td
(be)Tj
1.3322 0 Td
(contamina)Tj
4.578 0 Td
(ted)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 196.611 561.8267 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(e)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 238.7905 558.2551 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(190/722)Tj
4.3937 0 Td
(\(26\))Tj
5.8323 0 Td
(275/1,552)Tj
5.2229 0 Td
(\(18\))Tj
6.3851 0 Td
(107/637)Tj
4.3937 0 Td
(\(17\))Tj
6.378 0 Td
(572/2,911)Tj
5.23 0 Td
(\(20\))Tj
-62.2634 -1.559 Td
(CSFs)Tj
2.7213 0 Td
(tested)Tj
2.9409 0 Td
(by)Tj
1.2756 0 Td
(rt-PCR)Tj
18.5883 0 Td
(1,133)Tj
3.2953 0 Td
(\(41\))Tj
7.7599 0 Td
(1,396)Tj
3.2953 0 Td
(\(22\))Tj
7.4835 0 Td
(1,704)Tj
3.2953 0 Td
(\(62\))Tj
8.3127 0 Td
(4,233)Tj
3.2953 0 Td
(\(36\))Tj
-63.1847 -2.3457 Td
(Abbrevia)Tj
3.9119 0 Td
(tions:)Tj
2.6079 0 Td
(CSF,)Tj
2.5086 0 Td
(cerebrospi)Tj
4.6276 0 Td
(nal)Tj
1.552 0 Td
(uid;)Tj
2.3245 0 Td
(LP,)Tj
1.7291 0 Td
(lumbar)Tj
3.2599 0 Td
(puncture;)Tj
4.3723 0 Td
(rt-PCR,)Tj
3.5505 0 Td
(real-time)Tj
4.0961 0 Td
(polymeras)Tj
4.5779 0 Td
(e)Tj
0.7796 0 Td
(chain)Tj
2.6008 0 Td
(reaction.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 518.57 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 514.9984 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1,166)Tj
2.7071 0 Td
(\(10%\))Tj
2.8842 0 Td
(of)Tj
1.0559 0 Td
(CSFs)Tj
2.7213 0 Td
(were)Tj
2.3811 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2756 0 Td
(latex)Tj
2.3315 0 Td
(only,)Tj
2.3245 0 Td
(742)Tj
1.885 0 Td
(\(6%\))Tj
2.3244 0 Td
(by)Tj
1.2827 0 Td
(culture)Tj
3.2103 0 Td
(only,)Tj
2.3244 0 Td
(2,017)Tj
2.7142 0 Td
(\(17%\))Tj
2.8772 0 Td
(by)Tj
1.2756 0 Td
(rt-PCR)Tj
3.274 0 Td
(only,)Tj
2.3316 0 Td
(482)Tj
1.8779 0 Td
(\(4%\))Tj
2.3245 0 Td
(by)Tj
1.2826 0 Td
(latex)Tj
2.3245 0 Td
(and)Tj
1.885 0 Td
(culture,)Tj
3.4867 0 Td
(529)Tj
1.885 0 Td
(\(4%\))Tj
2.3244 0 Td
(by)Tj
1.2827 0 Td
(latex)Tj
2.3245 0 Td
(and)Tj
-65.7642 -1.4952 Td
(rt-PCR,)Tj
3.5503 0 Td
(1,000)Tj
2.7142 0 Td
(\(8%\))Tj
2.3244 0 Td
(by)Tj
1.2827 0 Td
(culture)Tj
3.2103 0 Td
(and)Tj
1.8779 0 Td
(rt-PCR,)Tj
3.5575 0 Td
(and)Tj
1.878 0 Td
(687)Tj
1.8851 0 Td
(\(6%\))Tj
2.3244 0 Td
(by)Tj
1.2756 0 Td
(all)Tj
1.2189 0 Td
(three)Tj
2.4945 0 Td
(methods.)Tj
4.3229 0 Td
(5,203)Tj
2.7071 0 Td
(\(44%\))Tj
2.8772 0 Td
(were)Tj
2.3811 0 Td
(not)Tj
1.6157 0 Td
(tested)Tj
2.9339 0 Td
(by)Tj
1.2827 0 Td
(any)Tj
1.8284 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.6086 0 Td
(three)Tj
2.4946 0 Td
(methods.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 494.5889 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(b)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 491.0173 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Possible)Tj
3.9756 0 Td
(reasons)Tj
3.763 0 Td
(why)Tj
1.9913 0 Td
(an)Tj
1.3323 0 Td
(LP)Tj
1.4457 0 Td
(may)Tj
2.1119 0 Td
(not)Tj
1.6086 0 Td
(reach)Tj
2.7142 0 Td
(a)Tj
0.7796 0 Td
(district)Tj
3.1039 0 Td
(laboratory)Tj
4.6418 0 Td
(for)Tj
1.3961 0 Td
(gram)Tj
2.4945 0 Td
(staining:)Tj
3.926 0 Td
(difculty)Tj
3.8197 0 Td
(with)Tj
1.9984 0 Td
(specimen)Tj
4.4788 0 Td
(transport,)Tj
4.4363 0 Td
(geograp)Tj
3.6283 0 Td
(hic)Tj
1.5024 0 Td
(inacces)Tj
3.3591 0 Td
(sibility)Tj
2.9339 0 Td
(of)Tj
1.063 0 Td
(certain)Tj
-63.1492 -1.5023 Td
(health)Tj
2.9267 0 Td
(centers,)Tj
3.7772 0 Td
(insufc)Tj
3.0897 0 Td
(ient)Tj
1.8284 0 Td
(transport)Tj
4.1599 0 Td
(media)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 470.5511 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 40.8188 467.0362 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Dened)Tj
3.6496 0 Td
(as)Tj
1.2756 0 Td
(being)Tj
2.6504 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2827 0 Td
(culture)Tj
3.2102 0 Td
(and/or)Tj
3.0402 0 Td
(rt-PCR)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 458.5889 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(d)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 455.0173 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Possible)Tj
3.9756 0 Td
(reasons)Tj
3.763 0 Td
(why)Tj
1.9913 0 Td
(an)Tj
1.3323 0 Td
(LP)Tj
1.4457 0 Td
(may)Tj
2.1119 0 Td
(not)Tj
1.6086 0 Td
(reach)Tj
2.7142 0 Td
(a)Tj
0.7796 0 Td
(national)Tj
3.6992 0 Td
(reference)Tj
4.4221 0 Td
(laboratory:)Tj
4.9252 0 Td
(insufcient)Tj
4.9252 0 Td
(transport)Tj
4.1528 0 Td
(media,)Tj
3.2103 0 Td
(insufcient)Tj
4.9252 0 Td
(quantity)Tj
3.7064 0 Td
(of)Tj
1.063 0 Td
(CSF)Tj
2.2252 0 Td
(that)Tj
1.885 0 Td
(was)Tj
1.9985 0 Td
(entirely)Tj
3.4299 0 Td
(used)Tj
-64.935 -1.5023 Td
(for)Tj
1.3959 0 Td
(Gram)Tj
2.7213 0 Td
(staining)Tj
3.6426 0 Td
(and)Tj
1.885 0 Td
(cytology.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 434.5511 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(e)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 431.0362 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(447)Tj
1.8779 0 Td
(\(78%\))Tj
2.8772 0 Td
(of)Tj
1.063 0 Td
(CSFs)Tj
2.7213 0 Td
(cultured)Tj
3.763 0 Td
(but)Tj
1.6087 0 Td
(found)Tj
2.7142 0 Td
(to)Tj
1.0559 0 Td
(be)Tj
1.3323 0 Td
(contamina)Tj
4.578 0 Td
(ted)Tj
1.6157 0 Td
(were)Tj
2.3812 0 Td
(also)Tj
2.0409 0 Td
(tested)Tj
2.941 0 Td
(by)Tj
1.2827 0 Td
(rt-PCR.)Tj
/F11 1 Tf
-0.005 Tc
-34.4978 -2.2535 Td
(doi:)Tj
-0.025 Tc
(10.137)Tj
4.0322 0 Td
(1/journal.pone.)Tj
5.5559 0 Td
(0166384.t)Tj
3.7914 0 Td
(001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 402.0661 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Bacterial)Tj
4.0394 0 Td
(Meningi)Tj
3.4299 0 Td
(tis)Tj
1.2047 0 Td
(in)Tj
0.978 0 Td
(Burkina)Tj
3.5504 0 Td
(Faso)Tj
2.4095 0 Td
(before)Tj
3.0047 0 Td
(PCV13)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0166)Tj
3.5434 0 Td
(384)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(10,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
BT
66.402 0 Td
(16)Tj
ET
Q
endstream
endobj
124 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 127 0 R/Contents 128 0 R/TrimBox[0 0 612 792]>>
endobj
126 0 obj
<>stream
JFIF C
$, !$4.763.22:ASF:=N>22HbINVX]^]8EfmeZlS[]Y C**Y;2;YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY r"
} !1AQa"q2#BR$3br
%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz
w !1AQaq"2B #3Rbr
$4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? ߇ 7Zt$ArX$5 @oȧ[t @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@?
h OA U[tP'"z?m | @oD[5E b' *=Vm@~Xi:mVN%/),3]ax~ a( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( wzgqX OL " ( jZs1<MKeyoj6I]zq@(u[^_d$38S隽6u_N4z(u+KaXd!88ZJC(e 2@hi"Y݂Um2uQfԎuf8\[E7UwtL*p%`qæ3].-Mʸ%vAHM nP\gm%̩1CO\,b28'Z բ}}k[5+՜fɱ&ݭRAN:5q5Gdt7qG@"! z>u nsz EeXxHnRA!A8Zm_OyȮSyzAjw+覘.틜: (x|OOvjV36cCkb
+"ĺ6rz1̃,>j^!Ӡ0JF:POV]:ŕN ( KЋ-I2623M57Vi9<G@4VJxEm#ԭwmgkPEd\EkY(emOA+Wrی