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Influence of Parity and Sexual History on Cytomegalovirus Seroprevalence among Women 20-49 Years-old in the United States, 1999-2004

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  • Alternative Title:
    Int J Gynaecol Obstet
  • Description:
    Objectives To assess the influence of parity, as a proxy for exposure to children, and sexual history on cytomegalovirus (CMV) seroprevalence among women in the United States. Methods We analyzed data of 3710 women 20-49 years-old who were tested for CMV IgG antibodies in the 1999-2004 National Health and Nutrition Examination Survey, a nationally representative, cross-sectional survey of the non-institutionalized U.S. population. We performed logistic regression to determine independent variables associated with CMV seroprevalence. Results In age-adjusted univariate analysis, women who had given birth to ≥1 child had a higher overall CMV seroprevalence (66.0%; 95% confidence interval [CI]: 63.1-68.9%) compared to those who had not (49.0%; 95% CI: 44.4-53.7%) (p<0.001). Higher CMV seroprevalence was independently associated with increasing number of live births (adjusted Odds Ratio [aOR]=1.2, 95%CI=1.1-1.3, for each additional live birth), age at first sexual intercourse <18 vs. ≥18 years (aOR=1.3, 95%CI=1.1-1.6), number of life time sexual partners ≥10 vs. <10 (aOR=1.4, 95%CI=1.1-1.9), and herpes type II positivity (aOR=1.9, 95%CI=1.5-2.6) after controlling for age group, race/Hispanic origin, place of birth, poverty index ratio, and education level (p<0.05). Conclusions In this population-based sample of U.S. women of reproductive age, parity and sexual exposures were independently associated with higher CMV seroprevalence.
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