Immediately Dangerous to Life or Health (IDLH) Value Profile: Chlorine Pentafluoride (CAS No. 13637-63-3)

Details

• Alternative Title:
  IDLH Immediately dangerous to life or health value profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Dotson, G. Scott ; Maier, Andrew ; Parker, Ann ; Haber, Lynn T.
• Description:
  In the absence of adequate human data, the IDLH value is based on potentially escape-impairing effects including severe respiratory irritation in multiple species, including monkey, dog, mouse, and rat [MacEwen and Vernot 1972]. Test animals (i.e., monkey, dog, mouse, and rat) exposed to chlorine pentafluoride at concentrations ranging from 10 to 30 ppm for durations up to 30 minutes experienced immediate salivation, eye irritation, lacrimation, rhinorrhea, and respiratory irritation. More specifically, exposure to 30 ppm chlorine pentafluoride for 10 ppm was associated with severe respiratory irritation, which is considered escape-impairing. Duration-adjusting yielded a 30-minute-equivalent value of 17.3 ppm. Application of a composite uncertainty factor to account for adjusting from an escape-impairing effect, interspecies differences, and human variability results in an IDLH value of 1.7 ppm for chlorine pentafluoride. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Environmental Exposure Fluorides Hazardous Substances Irritants Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Chemicals; Chemical properties; Chemical hazards; Chemical composition; Chemical reactions; Hazards; Exposure levels; Risk factors; Animals; Laboratory animals; IDLH; Immediately Dangerous to Life or Health; Irritants; Respiratory irritants; Respiratory system disorders; Pulmonary system; Pulmonary system disorders; Chlorine compounds
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2016-170, 2016 Sep; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2016170
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  24 pdf pages
• NIOSHTIC Number:
  nn:20048753
• CAS Registry Number:
  Chlorine fluoride (ClF5) (CAS RN 13637-63-3)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Toxicology Excellence for Risk Assessment
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:04c7569f0babba6581cc221190b6858e3b894792f1d6f22c6d86306cfd8b8a352a0c2cc34433ab4d4fd9859f5b601d1b1192e8d4a8416715ee8cd4dd73115853
• Download URL:
  https://stacks.cdc.gov/view/cdc/41590/cdc_41590_DS1.pdf
• File Type:
  [PDF - 400.67 KB ]