Immediately Dangerous to Life or Health (IDLH) Value Profile: Furan (CAS No. 110-00-9)

Details

• Alternative Title:
  IDLH Immediately dangerous to life or health value profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Dotson, G. Scott ; Maier, Andrew ; Parker, Ann ; Haber, Lynn T.
• Description:
  A single acute lethality study in the rat provides the only adequate toxicity data for development of an IDLH value. The study investigators reported a 1-hour LC50 value of 3,464 ppm for both sexes combined [Terrill et al. 1989]. This study also identified a LOAEL of 1,014 ppm for a 1-hour exposure for potential escape-impairing effects, such as respiratory distress, decreased blood pressure, convulsions, and complete anesthesia. This LOAEL is more appropriate as the basis of the IDLH value because it protects against potential escape-impairing effects such as respiratory distress. The 30-minute-duration adjusted concentration for the LOAEL is 1,278 ppm. Applying a composite uncertainty factor of 100 to account for extrapolation from a concentration that causes an escape-impairing effect in animals, severity of effects, interspecies differences, and human variability results in an IDLH value of 13 ppm. [Description provided by NIOSH]
• Subjects:
  Anesthesia Animals Chemistry Environmental Exposure Furans Hazardous Substances Irritants Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Chemicals; Chemical properties; Chemical hazards; Chemical composition; Chemical reactions; Hazards; Exposure levels; Risk factors; Animals; Laboratory animals; IDLH; Immediately Dangerous to Life or Health; Irritants; Respiratory irritants; Respiratory system disorders; Pulmonary system; Pulmonary system disorders; Furans; Blood pressure; Anesthesia
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2016-171, 2016 Sep; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2016171
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  24 pdf pages
• NIOSHTIC Number:
  nn:20048754
• CAS Registry Number:
  Furan (CAS RN 110-00-9)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Toxicology Excellence for Risk Assessment
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00162a7cb95c5e46319e51744aac16a4596f6a81995dba615db32b79a542a61422aea4a7cafb16f9d2c3f9b62d2e2f4de22eaddd7af216c37ab66ac1b5a80f78
• Download URL:
  https://stacks.cdc.gov/view/cdc/41589/cdc_41589_DS1.pdf
• File Type:
  [PDF - 395.25 KB ]