O80:H2 as a New Therapeutic Challenge

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Soysal, Nurcan ; Mariani-Kurkdjian, Patricia ; Smail, Yasmine ; Liguori, Sandrine ; Gouali, Malika ; Loukiadis, Estelle ; Fach, Patrick ; Bruyand, Mathias ; Blanco, Jorge ; Bidet, Philippe ; Bonacorsi, Stéphane
• Description:
  We describe the epidemiology, clinical features, and molecular characterization of enterohemorrhagic Escherichia coli (EHEC) infections caused by the singular hybrid pathotype O80:H2, and we examine the influence of antibiotics on Shiga toxin production. In France, during 2005-2014, a total of 54 patients were infected with EHEC O80:H2; 91% had hemolytic uremic syndrome. Two patients had invasive infections, and 2 died. All strains carried stx2 (variants stx2a, 2c, or 2d); the rare intimin gene (eae-ξ); and at least 4 genes characteristic of pS88, a plasmid associated with extraintestinal virulence. Similar strains were found in Spain. All isolates belonged to the same clonal group. At subinhibitory concentrations, azithromycin decreased Shiga toxin production significantly, ciprofloxacin increased it substantially, and ceftriaxone had no major effect. Antibiotic combinations that included azithromycin also were tested. EHEC O80:H2, which can induce hemolytic uremic syndrome complicated by bacteremia, is emerging in France. However, azithromycin might effectively combat these infections.
• Subjects:
  Adolescent Adult Anti-Bacterial Agents Child Child, Preschool Disease Outbreaks Drug Resistance, Bacterial Enterohemorrhagic Escherichia Coli Female Follow-Up Studies Genotype Geography, Medical Hemolytic-Uremic Syndrome Humans Incidence Infant Male Microbial Sensitivity Tests Multilocus Sequence Typing Serogroup Serotyping Shiga Toxin Virulence Virulence Factors Young Adult

  More +
• Source:
  Emerg Infect Dis. 22(9):1604-1612.
• Pubmed ID:
  27533474
• Pubmed Central ID:
  PMC4994344
• Document Type:
  Journal Article
• Place as Subject:
  France
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8c813b8378e7cee282b6d1f23d146cab87fde50f990a131be6c70387de4770ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/41263/cdc_41263_DS1.pdf
• File Type:
  [PDF - 1.14 MB ]