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Light-Triggered Release of Bioactive Molecules from DNA Nanostructures

Published Date:

Mar 03 2016

Publisher's site:

http://dx.doi.org/10.1021/acs.nanolett.6b00530 New Site Icon

Source:

Nano Lett. 16(4):2781-2785.

[PDF-844.24 KB]

Details:

Personal Authors:

Kohman, Richie E. ; Cha, Susie S. ; Man, Heng-Ye ; Han, Xue ;

Keywords:

[+]

Pubmed ID:

26935839

Pubmed Central ID:

PMC4959465

Description:

Recent innovations in DNA nanofabrication allow the creation of intricately shaped nanostructures ideally suited for many biological applications. To advance the use of DNA nanotechnology for the controlled release of bioactive molecules, we report a general strategy that uses light to liberate encapsulated cargoes from DNA nanostructures with high spatiotemporal precision. Through the incorporation of a custom, photolabile cross-linker, we encapsulated cargoes ranging in size from small molecules to full-sized proteins within DNA nanocages and then released such cargoes upon brief exposure to light. This novel molecular uncaging technique offers a general approach for precisely releasing a large variety of bioactive molecules, allowing investigation into their mechanism of action, or finely tuned delivery with high temporal precision for broad biomedical and materials applications.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP2NS082126/DP/NCCDPHP CDC HHS/United States
DP2 NS082126/NS/NINDS NIH HHS/United States
NIHMH079407/PHS HHS/United States

Main Document Checksum:

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Supporting Files:

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