Details:

Alternative Title:
Am J Ind Med
Personal Author:
Krieg, Edward F.
Description:
Introduction

Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies.

Methods

Group means from studies of the thyroid function of persons occupationally exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between thyroid hormone concentrations and log10 blood lead concentrations or duration of exposure to lead were estimated using mixed models. The hormones analyzed were thyroid stimulating hormone, total and free thyroxine, and total and free triiodothyronine.

Results

No differences in mean thyroid hormone concentrations were found between the exposed and control groups. No relationships were found between blood lead or the duration of exposure to lead and thyroid hormone concentrations.

Conclusion

The results of the analysis do not provide evidence for an effect of occupational lead exposure on thyroid function in men.


Subjects:
[+]
Article Blood Lead Thyroid Stimulating Hormone Thyroxine Triiodothryonine
Source:
Am J Ind Med. 59(7):583-590.
Pubmed ID:
27094769
Pubmed Central ID:
PMC4934017
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5193ec5fa4b59034db0364f6d25a0dbc19d6e570fa7a7da53ed476015a0e5a2d
Download URL:
https://stacks.cdc.gov/view/cdc/40333/cdc_40333_DS1.pdf
File Type:

Supporting Files

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