Details:

Alternative Title:
J Allergy (Cairo)
Personal Author:
Chipinda, Itai ; Hettick, Justin M. ; Siegel, Paul D.
Chipinda, Itai ; Hettick, Justin M. ; Siegel, Paul D. Less -
Description:
Low molecular weight chemical (LMW) allergens are commonly referred to as haptens. Haptens must complex with proteins to be recognized by the immune system. The majority of occupationally related haptens are reactive, electrophilic chemicals, or are metabolized to reactive metabolites that form covalent bonds with nucleophilic centers on proteins. Nonelectrophilic protein binding may occur through disulfide exchange, coordinate covalent binding onto metal ions on metalloproteins or of metal allergens, themselves, to the major histocompatibility complex. Recent chemical reactivity kinetic studies suggest that the rate of protein binding is a major determinant of allergenic potency; however, electrophilic strength does not seem to predict the ability of a hapten to skew the response between Th1 and Th2. Modern proteomic mass spectrometry methods that allow detailed delineation of potential differences in protein binding sites may be valuable in predicting if a chemical will stimulate an immediate or delayed hypersensitivity. Chemical aspects related to both reactivity and protein-specific binding are discussed.
Subjects:
[+]
Review Article
Source:
J Allergy (Cairo). 2011; 2011.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b8f2b5a47abfc1375ee7a8260123d83f7e69b68e1ce0d06083d2578d9224f520
Download URL:
https://stacks.cdc.gov/view/cdc/4029/cdc_4029_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	JA2011-839682.001.gif	gif
  	JA2011-839682.001.jpg	jpeg
  	JA2011-839682.002.gif	gif
  	JA2011-839682.002.jpg	jpeg
  	JA2011-839682.nxml	txt
  	JA2011-839682.tab.001.gif	gif
  	JA2011-839682.tab.001.jpg	jpeg

More +